Chronic Obstructive Pulmonary Disease research hub
39 indexed studies · 17 currently recruiting
- recruitingPHASE4
Molecular Signatures Associated With Response to ICS Treatment in Patients With COPD Stratified by Eosinophil Levels
This study looks at how a common COPD medication (budesonide) affects people, depending on their eosinophil levels and lung germs. It aims to understand why some patients respond better than others to this treatment.
Germany · Netherlands · Spain - recruitingPHASE4
A Study to Investigate Airway Inflammation With Dupilumab Subcutaneously in Participants Aged ≥40 to ≤85 Years With Chronic Obstructive Pulmonary Disease.
This study looks at a new treatment called dupilumab for people aged 40-85 with a severe lung condition called COPD. It aims to see if the treatment reduces lung inflammation and improves breathing and quality of life.
United States · Argentina · Brazil - active not recruitingPHASE3
A Study to Investigate Long-term Safety and Tolerability of Itepekimab in Participants With COPD
This study looks at the long-term safety of a new medicine, itepekimab, for people with severe lung disease (COPD). It will also check if the medicine continues to help over time. Participants will have already been part of a previous study on this medicine.
United States · Argentina · Brazil - active not recruitingPHASE2
A Study to Assess the Efficacy and Safety of Verekitug in Participants With COPD
This study is testing a new medicine, Verekitug, for people with moderate to severe COPD. It will check how well the medicine works and if it's safe. Participants will take Verekitug or a dummy pill alongside their usual COPD treatments.
United States · Argentina · Bulgaria - active not recruitingPHASE2
Frespaciguat (MK-5475) INSIGNIA-PH-COPD: A Study of the Efficacy and Safety of Frespaciguat (an Inhaled sGC Stimulator) in Adults With PH-COPD
This study is testing a new inhaled medicine, frespaciguat, for people with lung disease (COPD) and high blood pressure in their lungs (pulmonary hypertension). Researchers want to see if it helps people walk further.
United States · Argentina · Australia - recruitingPHASE4
A Study to Investigate the Effect of Budesonide/Glycopyrronium/Formoterol Fumarate Metered Dose Inhaler (BGF MDI) Compared With Placebo MDI on Heart and Lung Function in Participants With Chronic Obstructive Pulmonary Disease (COPD) and Hyperinflation
This study looks at a new inhaler (BGF MDI) for people with COPD and lung hyperinflation. We want to see how it affects heart and lung function compared to a dummy inhaler. It's for people aged 40-80 who smoke or used to smoke.
Germany · United Kingdom - recruitingPHASE3
Efficacy, Safety, and Tolerability Study of Lunsekimig Compared With Placebo in Adult Participants With Inadequately Controlled Chronic Obstructive Pulmonary Disease (COPD) Characterized by an Eosinophilic Phenotype
This study is testing a new medicine, lunsekimig, for adults aged 40-80 with COPD that's not well-controlled. We want to see if it helps improve breathing, is safe, and has manageable side effects compared to a dummy medicine.
United States · Argentina · Brazil - active not recruitingPHASE3
A Study to Evaluate the Long-Term Safety of Astegolimab in Participants With Chronic Obstructive Pulmonary Disease (COPD)
This study looks at the long-term safety of a treatment called astegolimab for people with a lung condition called COPD. It's for people who have already taken part in previous studies of this drug.
United States · Argentina · Australia - ongoing, recruitingPhase III and phase IV (Integrated)
A Double Blind, Multicentre, Randomised Three-Period, Three-Treatment, Cross-Over Study To Evaluate The Effect of BGF MDI, BFF MDI and Placebo MDI on Exercise Parameters In Participants with Chronic Obstructive Pulmonary Disease (ATHLOS)
This study is looking at a new inhaler treatment called Trixeo Aerosphere for people with a lung condition called Chronic Obstructive Pulmonary Disease (COPD). It compares it to another inhaler and a dummy inhaler to see if it helps people exercise more easily.
Germany · Spain - recruitingPHASE4
Chronic Airway Disease, Mucus Rheology and Exacerbations
This study looks at how a medicine called azithromycin can help people with Chronic Obstructive Pulmonary Disease (COPD) manage their flare-ups. We're comparing two ways of giving the medicine: based on symptoms or based on how thick their mucus is.
France - active not recruiting
HomeVent ( Connect) Registry: EU COPD Home NIV Registry
This study looks at how home breathing support (NIV) helps people with a severe lung condition called COPD. It checks how often people use the equipment and if it prevents hospital stays, especially with remote monitoring.
Germany - ongoing, recruitingTherapeutic confirmatory (Phase III)
Randomized, double-blind, placebo-controlled, parallel-group Phase 3 study to evaluate the efficacy, safety, and tolerability of SAR440340/REGN3500/itepekimab (anti-IL-33 mAb) in patients with moderate-to-severe chronic obstructive pulmonary disease (COPD) (AERIFY-1)
This study is testing a new medicine, itepekimab, for people with moderate to severe COPD. We want to see if it can reduce flare-ups of their breathing problems. It's a large study where some people get the new medicine and others get a dummy medicine, to compare the effects.
Romania · Slovakia · Bulgaria - recruitingNA
Home High Flow Oxygen to Reduce Acute Exacerbation of COPD
This study looks at whether using a special type of oxygen machine at home, called High Flow Oxygen, can help people with severe COPD. It aims to see if it reduces serious flare-ups, compared to standard oxygen therapy.
France - recruiting
PASS to Assess Cardiovascular and Cerebrovascular Events in COPD Patients Initiating Fixed Triple Therapy (DPI or pMDI)
This study looks at the safety of two types of inhalers (DPI and pMDI) for people with COPD who are starting a new 'triple therapy' medicine. It checks if there are differences in heart or stroke-related problems between the two inhaler types.
United Kingdom - recruiting
Eosinopenia in Severe COPD Exacerbation
This study looks at how a type of white blood cell, called eosinophils, changes in people with severe COPD flare-ups. We want to find out why some people have low levels of these cells when they're admitted to hospital, and how long it takes for these levels to return to normal.
United Kingdom - recruitingPHASE3
Long-term Safety and Tolerability of Tozorakimab in Patients With COPD and History of Exacerbations
This study, called ROMEO, is testing the long-term safety of a new medicine for people with a lung condition called COPD. It's for people who have had flare-ups of their COPD in the past and have already taken part in an earlier study for this medicine.
France - not yet recruitingNA
Combinaison of Virtual Reality and Rehabilitation to Improve Muscle Function, Exercise Tolerance, Exertional Symptoms and Dyspnea in Patients with Chronic Respiratory Disease: a Randomized Cross-over Trial
This study looks at whether using virtual reality (VR) can help people with long-term breathing problems, like COPD, exercise more easily. VR might distract them from feeling breathless during exercise, improving their fitness and overall well-being.
France - recruiting
Investigating Health Related Quality of Life in Patients With Chronic Respiratory Failure
This study looks at how chronic respiratory failure affects daily life for people in the UK. We want to understand their quality of life and how different treatments help.
United Kingdom - recruitingPHASE2
Oral Sildenafil for Exercise Capacity, Dyspnea and Cardiopulmonary Function in COPD
This study looks into whether a medicine called sildenafil can help people with mild COPD breathe easier and exercise better. We want to see if it improves how their lungs and hearts work during activity.
Canada - recruiting
Supported inspiratory muscle training for people with chronic obstructive pulmonary disease who have declined pulmonary rehabilitation
This study looks at a new way to help people with COPD who haven't joined breathing exercise programmes. It tests if supported breathing muscle training can improve symptoms and help prepare them for future rehabilitation. We're also checking how well our study design works for a bigger trial later.
United Kingdom · England - ongoing, recruitingHuman Pharmacology (Phase I)- Other
An Open-label, Single-group, Three-period, Fixed-sequence, Phase I Study to Assess the Pharmacokinetics of AZD6793 Tablets When Administered Alone and in Combination with Itraconazole Capsules in Healthy Adult Female and Male Participants
This study is looking at how a new medicine, AZD6793, works in the body. We want to see how it's absorbed and processed when given on its own and when taken with another common medicine called itraconazole. This helps us understand how to use it safely and effectively.
Germany - ongoing, recruitingTherapeutic confirmatory (Phase III)
Randomized, double-blind, placebo-controlled, parallel-group Phase 3 study to evaluate the efficacy, safety, and tolerability of SAR440340/REGN3500/itepekimab (anti-IL-33 mAb) in patients with moderate-to-severe chronic obstructive pulmonary disease (COPD)
This study is looking into a new treatment called itepekimab for people with moderate to severe Chronic Obstructive Pulmonary Disease (COPD). It will compare the new drug to a dummy treatment to see if it helps reduce flare-ups of COPD and improves lung function in former smokers.
Czechia · Germany · Poland - authorisedPhase I and Phase II (Integrated)- Other
Efficacy of Morphine in Reducing the Rate of Early Non-Invasive Ventilation Failure in Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Phase I/IIa (MORPHEUS I/IIa)
This study is looking at whether a low dose of morphine can help people with severe lung disease (COPD) who need breathing support. It aims to see if it makes this treatment more successful and comfortable. This is an early stage of research to check safety and initial effects.
France - authorisedHuman Pharmacology (Phase I)- Other
An Open Label Study to Assess the Effect of Patient Use and Robustness on Tiotropium Bromide Spray 2.5μg, Soft Mist Inhaler device
This study is looking at an inhaler used by people with a lung condition called COPD. Researchers want to see how well a specific inhaler works when people use it, and how sturdy the inhaler device is during normal use. It's an early-stage study to understand the inhaler better.
Spain - recruiting
UPTURN feasibility study – A study testing the acceptability and delivery feasibility of a support package designed to help people with COPD attend pulmonary rehabilitation
This study looks at a new support package to help people with breathing problems (COPD) attend a helpful exercise and education programme called Pulmonary Rehabilitation (PR). It checks if the support is easy to use and if people like it, especially those who might find it harder to attend PR.
United Kingdom - authorisedTherapeutic use (Phase IV)
The impact of extra-fine inhalation corticosteroid particles on small-airway disease in Chronic Obstructive Pulmonary Disease (COPD): a randomized, prospective cross-over trial.
This study is looking at how a specific type of asthma and COPD spray (inhaler) with very tiny medicine particles might help people with Chronic Obstructive Pulmonary Disease (COPD). It wants to see if these small particles can reach the smaller airways in the lungs better and improve breathing.
Belgium - ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2a, open-label, two-part study to evaluate the mechanism of action of itepekimab (anti-IL-33 mAb) on airway inflammation in patients with chronic obstructive pulmonary disease (COPD)
This study is looking at a new medicine called itepekimab for people with COPD who currently smoke. We want to understand how this medicine affects inflammation in the airways to see if it could be a helpful treatment.
Belgium · Germany · Netherlands - recruiting
Innate Immunity in COPD
This study investigates why people with COPD have ongoing lung inflammation and difficulty fighting off bacteria. Researchers are looking at how immune cells in the lungs and blood get their energy, hoping to find new ways to treat COPD.
United Kingdom - recruitingNA
Reducing Chronic Breathlessness in Adults by Following a Self-guided, Internet Based Supportive Intervention (SELF-BREATHE)
This study looks at how a self-guided online tool called SELF-BREATHE helps adults with long-term breathlessness. It aims to see if using this website improves their breathing and quality of life, and if it could be used more widely in the NHS.
United Kingdom - ongoing, recruitingHuman Pharmacology (Phase I)- Other
Open-label, non-randomised, single-dose, one sequence, two-period, cross-over study to investigate the effect of inhibition of P-glycoprotein and breast cancer resistance protein transporters by cyclosporine on the pharmacokinetics of CHF6001 in healthy volunteers.
This study looks at how a drug called CHF6001 works in the body and if another medicine, cyclosporine, changes it. We want to understand how these drugs interact so we can use them safely and effectively, especially for people with breathing problems like COPD.
Bulgaria - active not recruitingNA
Ryme Medical TLD Pilot Study
This study is looking at a new treatment called Targeted Lung Denervation (TLD) for people with a lung condition called COPD. It wants to see if the TLD treatment, using the Ryme Medical system, is safe and works well. This is a pilot study, meaning it's an early look at the treatment.
Australia · Austria · Denmark - recruitingPHASE3
Efficacy, Safety, and Tolerability Study of Lunsekimig Compared With Placebo in Adult Participants With Inadequately Controlled Chronic Obstructive Pulmonary Disease (COPD), Characterized by an Eosinophilic Phenotype
This study is testing a new medicine, lunsekimig, for people with COPD who still have symptoms even with current treatments. It aims to see if lunsekimig is safe and helps improve COPD, particularly for those with a specific type called an 'eosinophilic phenotype'.
United States · Argentina · Australia - recruitingPHASE4
Optimising Azithromycin Prevention Treatment in COPD to Reduce Exacerbations
This study looks at how best to use azithromycin to prevent flare-ups in people with COPD. It compares continuing the medicine, stopping it completely, or stopping it only during summer months, to see which approach works best for patients.
United Kingdom - ongoing, recruitingTherapeutic exploratory (Phase II)
Using live vaccines to induce beneficial innate immune training and reduce systemic inflammation in COPD patients (COPD-LIVE)
This study, called COPD-LIVE, is looking at whether common vaccines might help the body's natural defense system in people with long-term lung disease (COPD). It aims to see if specific vaccines can reduce inflammation and improve health over time.
Denmark - ongoing, recruitingTherapeutic use (Phase IV)
THE ANTES B+ STUDY: AN OPEN-LABEL, PRAGMATIC, RANDOMIZED, CONTROLLED TRIAL OF TRIPLE THERAPY VERSUS LABA-LAMA COMBINATION TO IMPROVE CLINICAL CONTROL IN HIGH-RISK GOLD B PATIENTS (B+)
This study looks at how well a new three-in-one inhaler, Trelegy, works compared to a standard two-in-one inhaler for people with severe COPD. We want to see if Trelegy helps patients keep their breathing problems better controlled over a year.
Spain - completedNot Specified
Evaluation of N-Tidal in primary care COPD diagnosis
The CORMORANT study is testing a new device called N-Tidal to see if it can help doctors diagnose a lung condition called COPD more easily and accurately in GP practices. This could lead to quicker treatment and better care for patients.
United Kingdom · England · Wales - active not recruiting
A Pragmatic Real-world Multicentre Observational Research Study to Explore the Clinical and Health Economic Impact of myCOPD
This study looks at how a digital app called myCOPD can help people in the UK with a long-term lung condition called COPD. It aims to see if the app helps people recover faster after hospital stays and manage their condition better, especially in areas where healthcare support is harder to access.
United Kingdom - ongoing, recruitingTherapeutic use (Phase IV)
Beta-blockeRs tO patieNts with CHronIc Obstructive puLmonary diseasE (BRONCHIOLE)
This study looks at how a specific blood pressure medicine, called a beta-blocker (Seloken), affects people with chronic obstructive pulmonary disease (COPD). It checks if the medicine improves health, prevents lung flare-ups, and reduces serious heart problems or strokes, using existing health records.
Sweden - recruiting
EMPOWER-1: A Multi-site Clinical Cohort Research Study to Reduce Health Inequality
This study aims to understand why common medicines don't work the same for everyone in the UK, especially for people from different backgrounds. It will look at many health conditions, hoping to improve how we treat them and make healthcare fairer for all.
United Kingdom