Chronic obstructive pulmonary disease (COPD) research hub
30 indexed studies · 6 currently recruiting
- recruiting
A trial of a virtual ward programme for patients with acute exacerbations of chronic obstructive pulmonary disease (COPD)
This study looks at a new 'virtual ward' program for people with a lung condition called COPD. Instead of hospital, patients get care at home using digital tools. We want to see if it's safe, effective, and helps free up hospital beds.
United Kingdom · England - recruitingPhase IV
Testing if the BCG vaccine alters exacerbations in people with chronic obstructive pulmonary disease
This study is testing if the BCG vaccine, typically used for tuberculosis, can reduce chest infections (exacerbations) in people with chronic obstructive pulmonary disease (COPD). It aims to see if the vaccine helps the immune system fight off infections better.
United Kingdom - recruitingPhase II
Maintaining the integrity of muscle during hospitalisation in older persons with severe acute exacerbation of chronic obstructive pulmonary disease (MINT-COPD)
This study looks at a new medicine, RJx-01, for people with COPD who are in hospital. It aims to see if it's safe and helps muscles and quality of life after a flare-up. It's for people aged 45 and over.
United Kingdom · England - ongoing, recruitingTherapeutic confirmatory (Phase III)
A 52-week, randomized, double-blind, double-dummy, placebo- and active- controlled (Roflumilast, Daliresp® 500μg), parallel group, study to evaluate the efficacy and safety of two doses of CHF6001 DPI add-on to maintenance triple therapy in subjects with Chronic Obstructive Pulmonary Disease (COPD) and chronic bronchitis
This study looks at new inhaled medications for people with a type of lung disease called COPD. It aims to see if these new medicines can help reduce flare-ups, improve breathing, and make everyday life better.
Spain · Estonia · Austria - authorisedTherapeutic use (Phase IV)
COPD-2VAX: Enhancing Protection Against Respiratory Infections Through AS01-Mediated Innate Immune Activation in High-Risk Patients
This study looks at how new vaccines for lung conditions and common infections work in people with COPD. It aims to see if these vaccines can help their body's defenses (immune system) fight off respiratory illnesses better.
Denmark - recruiting
Clinical Registry for the Characterization of the 'Pulmonary Vascular Phenotype' in Patients With Chronic Obstructive Pulmonary Disease
This study looks at information from people in the UK with COPD who have had a special heart test. It aims to understand how COPD affects the blood vessels in the lungs, especially when people also have high blood pressure in their lungs, called pulmonary hypertension.
Austria · Switzerland · United Kingdom - recruiting
Feasibility of brief training to support pulmonary rehabilitation referral and attendance in chronic obstructive pulmonary disease
This study looks at new ways to help people with a lung condition called COPD access a helpful exercise programme (pulmonary rehab). We're testing a short training program for healthcare staff to improve how they talk about and refer patients to this rehab.
United Kingdom · England - active not recruitingPHASE3
A Study to Evaluate Astegolimab in Participants With Chronic Obstructive Pulmonary Disease
This study looks at a new drug, astegolimab, for people with COPD who have flare-ups often. It compares the new drug to a dummy treatment (placebo) to see if it's safe and helps improve their breathing and reduce flare-ups.
United States · Argentina · Australia - recruitingNA
Make Every Step Count: Personalised Music Feedback to Walking for People Living With COPD
This study looks at a new smartphone app, BeatClearWalker, for people with COPD who are doing walking exercises as part of their pulmonary rehabilitation. It uses music to help them keep to the right pace, aiming to make exercise easier and more enjoyable.
United Kingdom - ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase III, Multicentre, Randomized, Double-blind, Chronic-dosing, Parallel-group, Placebo-controlled Study to Evaluate the Efficacy and Safety of Two Dose Regimens of Tozorakimab in Participants with Symptomatic Chronic Obstructive Pulmonary Disease (COPD) with a History of COPD Exacerbations (Oberon)
This study is looking at a new medicine called Tozorakimab for people with COPD. It aims to see if it can reduce severe flare-ups and if it's safe. Participants will be compared to those taking a dummy medicine.
Czechia · Denmark · Bulgaria - ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase IIb, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Evaluate the Efficacy and Safety of Astegolimab in Patients with Chronic Obstructive Pulmonary Disease
This study is testing a new medicine, astegolimab, for people with lung disease called COPD. It wants to see if this medicine can reduce flare-ups (exacerbations) and improve how people feel and breathe. They are also looking at how safe it is.
France · Romania · Denmark - recruitingPHASE2
A Study to Investigate the Effect of AZD6793 in Participants With Moderate to Very Severe Chronic Obstructive Pulmonary Disease
This study is testing a new medicine, AZD6793, for people with moderate to very severe COPD. It will compare different doses of the medicine against a dummy pill to see if it helps and is safe.
United States · Argentina · Australia - recruitingPhase III
A trial to assess if aspirin with omega-3 and colchicine are medicines that can help recovery from a COPD exacerbation.
This study looks at whether adding aspirin, omega-3, and colchicine to usual care can help people with COPD recover better from flare-ups. We want to see if these common medicines can make a difference and reduce problems after a flare-up.
United Kingdom · England - ongoing, recruitingTherapeutic use (Phase IV)
Triple therapy effectiveness in COPD patients with characteristics of asthma: A pragmatic primary care trial - The TRACkER trial
This study looks at whether a three-in-one inhaler (triple therapy) works better than two-in-one inhalers for people with COPD who also have asthma-like symptoms. It aims to see if triple therapy improves their overall health and well-being more.
Netherlands - recruitingPHASE3
A Study to Investigate the Efficacy and Safety of Tezepelumab in Adult Participants With Moderate to Very Severe COPD (D5241C00006)
This study is testing a new medicine, tezepelumab, for adults with moderate to very severe COPD. It wants to see if the medicine helps improve their breathing and overall health, and if it's safe to use.
United States · Brazil · Canada - active not recruitingPHASE3
Long-term Efficacy and Safety of Tozorakimab in Participants With Chronic Obstructive Pulmonary Disease With a History of Exacerbations (PROSPERO).
This study is for people with COPD who have been in previous trials (OBERON or TITANIA). It looks at the long-term effects of a medicine called Tozorakimab, comparing it to a dummy treatment, to see if it's safe and helps reduce flare-ups.
United States · Argentina · Australia - ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase III, Multicentre, Randomised, Double-blind, Chronic-dosing, Parallel-group, Placebo-controlled Extension Study to Evaluate the Long-term Efficacy and Safety of Tozorakimab in Participants with Chronic Obstructive Pulmonary Disease (COPD) with a History of Exacerbations (PROSPERO)
This study is testing a new medicine called Tozorakimab for people with severe COPD. It aims to see if Tozorakimab can reduce flare-ups and is safe to use long-term, compared to a dummy medicine.
Sweden · Romania · Spain - ongoing, recruitingTherapeutic confirmatory (Phase III)
A PHASE III, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, MULTICENTER STUDY TO EVALUATE THE EFFICACY AND SAFETY OF ASTEGOLIMAB IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE
This study is testing a new medicine, astegolimab, for people with a lung condition called COPD. It wants to see if this medicine can help reduce flare-ups (exacerbations) of COPD and if it's safe to use. You might get the new medicine or a dummy medicine.
Hungary · Greece · Spain - ongoing, recruitingHuman Pharmacology (Phase I)- Other
An open-label, healthy subject, two-part study to assess the effect of verapamil on systemic exposure of EP395 (Part A), and to assess the effect of EP395 on systemic exposure of midazolam and digoxin (Part B)
This study is looking at how two medicines, EP395 and verapamil, affect each other in healthy people. It also checks how EP395 affects other common medicines like midazolam and digoxin. The aim is to understand how these drugs behave in the body.
Sweden - recruiting
Study to Evaluate Long-term Effectiveness and Safety, Patient Characteristics and Subjective Patient-reported Outcomes of Dupilumab in Patients With Chronic Obstructive Pulmonary Disease (COPD) Under Real-world Conditions
This study looks at how a new medicine, dupilumab, works for people with a lung condition called COPD in their everyday lives. Researchers will observe over two years how it affects their health, quality of life, and safety.
Germany - recruiting
Breathlessness Perceptions Within Respiratory Diseases
This study looks at why people with lung conditions feel breathless. We will check how breathing, feelings, and everyday activities affect breathlessness. The goal is to understand breathlessness better to find new ways to help people feel more comfortable and healthy.
United Kingdom - active not recruitingPHASE3
Efficacy and Safety of Tozorakimab in Symptomatic Chronic Obstructive Pulmonary Disease With a History of Exacerbations
This study is looking into a new medication called tozorakimab for people with severe COPD who have frequent flare-ups. It aims to see if this treatment can reduce these flare-ups and improve symptoms. Patients will receive either the new medicine or a dummy treatment.
United States · Argentina · Belgium - ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase III, Multicentre, Randomised, Double-blind, Chronic-dosing, Parallel-group, Placebo-controlled Study to Evaluate the Efficacy and Safety of Tozorakimab in Participants with Symptomatic Chronic Obstructive Pulmonary Disease (COPD) with a History of COPD Exacerbations (MIRANDA)
This study is testing a new medicine, tozorakimab, for people with lung disease called COPD. It wants to see if this medicine can help reduce flare-ups of COPD. Some people will get the new medicine, and others will get a dummy medicine, alongside their usual care.
Greece · Denmark · Netherlands - recruitingNot Applicable
Testing whether home sensors can predict flare-ups in chronic lung disease
This study is testing a system with smartwatches and home monitors to help spot flare-ups in people with a lung condition called COPD. It aims to see if these tools can help people manage their condition better by noticing problems earlier.
United Kingdom · England - active not recruiting
Chronicling the COPD Patient Journey and Change in COPD Symptoms, Quality of Life and Exacerbations Following Initiation of Budenoside/Glycopyrronium/Formoterol [BGF]
This study looks at how a specific inhaler (Budenoside/Glycopyrronium/Formoterol) affects people with COPD in everyday life. For six months, it tracks changes in their symptoms, quality of life, and flare-ups after they start using this medication.
Canada - ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase III, Multicentre, Randomized, Double-blind, Chronic-dosing, Parallel-group, Placebo-controlled Study to Evaluate the Efficacy and Safety of Two Dose Regimens of Tozorakimab in Participants with Symptomatic Chronic Obstructive Pulmonary Disease (COPD) with a History of COPD Exacerbations (TITANIA)
This study is testing a new medicine, Tozorakimab, for people with severe COPD who often have flare-ups. We want to see if it reduces these flare-ups and is safe to use. Some people will get the new medicine, others a dummy medicine (placebo).
Poland · Germany · Italy - ongoing, recruitingTherapeutic use (Phase IV)
COPD - Eosinophil-guided Reduction of Inhaled Corticosteroids (COPERNICOS)
This study looks at how well different types of azithromycin (an antibiotic) work for people with a lung condition called COPD. We want to see if these medicines can reduce how often people are hospitalised or pass away within a year.
Denmark - ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase III, 52-week, Multinational, Multicenter, Randomized, Double-blind, 2-arm Parallel Group Study Comparing Efficacy, Safety and Tolerability of the Fixed Dose Triple Combination of Beclomethasone Dipropionate Plus Formoterol Fumarate Plus Glycopyrronium Bromide (CHF 5993) With the Fixed Dose Dual Combination of Beclomethasone Dipropionate Plus Formoterol Fumarate (CHF 1535), Both Administered Via pMDI in Subjects With Chronic Obstructive Pulmonary Disease (COPD)
This study is testing a new combination inhaler for people with a lung condition called COPD. It compares a new three-in-one inhaler to an existing two-in-one inhaler over one year to see which works better and is safer for breathing and overall health.
Hungary · Poland · Czechia - authorisedHuman Pharmacology (Phase I)- First administration to humans
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Immunogenicity, Pharmacodynamics and Clinical Activity of BBT002 in Healthy Volunteers and Patients with Chronic Obstructive Pulmonary Disease (COPD) or Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) and Comorbid Asthma
This study is testing a new medicine, BBT002, for people with long-term lung conditions like COPD and asthma, or a nose condition called CRSwNP. Researchers want to see if it's safe, how the body handles it, and if it helps these conditions.
Poland - recruiting
Understanding how COPD flare-ups change the body's recovery process
This study looks at how COPD flare-ups affect your body's recovery. Researchers want to understand why people don't fully recover and how frequent flare-ups worsen health, so they can find better ways to help.
United Kingdom · England