Colorectal Adenocarcinoma research hub
5 indexed studies · 4 currently recruiting
- authorisedPhase I and Phase II (Integrated)- First administration to humans
A phase I/IIa safety, dose finding and feasibility trial of CD30/CEA CART in patients with liver metastases from CEA positive colorectal adenocarcinoma
This study tests a new cell therapy called CAR-T for bowel cancer that has spread to the liver. Researchers want to find the safest dose and check for side effects. It is an early-stage trial to see if this treatment is safe and practical for patients in the future.
Germany - recruitingPHASE2
A Study to Evaluate the Efficacy of VVD-133214 in Combination With Pembrolizumab Compared With Pembrolizumab Alone in Participants With Advanced Cancer of the Colon or Rectum
This study looks at a new combination treatment for advanced bowel cancer that has spread. It combines a new drug, VVD-133214, with an existing immunotherapy, pembrolizumab. The aim is to see if this combination works better than pembrolizumab alone for certain types of bowel cancer.
United States · Argentina · Belgium - recruiting
Breath Research Narrow Validation for Gastrointestinal Cancer Detection
This study is developing a simple breath test to help find common gut cancers earlier, like those in the food pipe, stomach, pancreas, liver, and bowel. Finding cancer early means better treatment options. We're testing if breathing into a special device can quickly spot these cancers by detecting tiny molecules in your breath.
United Kingdom - recruitingNA
Measurement of MMP-14 Protein, a Potential New Marker for Colorectal Cancer Detection, in Plasma Vesicles Named Exosomes
This study looks for a protein called MMP-14 in blood to detect bowel cancer earlier. It hopes to reduce unnecessary colonoscopies for people with a positive stool test, making diagnosis simpler and less invasive through a new blood test.
France - recruitingPHASE1
Phase 1 Study of INBRX-109 in Subjects With Locally Advanced or Metastatic Solid Tumors Including Sarcomas
This early-stage study is testing a new drug, INBRX-109, for people with advanced solid tumours, including certain types of Ewing sarcoma and bowel cancer. Researchers want to see if it's safe and how well it works, both alone and with standard treatments. This is for patients who haven't responded to previous therapies.
United States · France · Italy