- recruiting
New bioMarkers tO straTIfy cOlorectal caNcer Referrals
This study looks at new blood tests for bowel cancer and polyps in people referred for urgent checks. It aims to see if these tests are better than current methods and what patients think about them.
United Kingdom - not yet recruitingPHASE2
5-fluorouracil Plus Panitumumab (Anti-EGFR) and Sotorasib (KRAS G12C Inhibitor) in First-line Treatment of Patients Non-eligible for a Doublet/Triplet Chemotherapy With Advanced Unresectab
This study looks at a new combination of medicines (5-FU, Panitumumab, and Sotorasib) for older or less healthy patients with advanced bowel cancer that has a specific genetic change (KRAS G12C mutation) and can't be removed by surgery. We want to see if this combination works well and is safe as a first treatment.
France · Germany · Italy - not yet recruitingNA
Rectus Sheath Catheters Following Midline Laparotomy
This study looks at a pain relief method using small tubes (catheters) after tummy surgery. It aims to see if giving pain medication directly to the nerves in the tummy muscles, alongside other pain relief, helps reduce pain more and improves recovery compared to a dummy treatment.
Germany - recruitingNA
Patients With Rectal Cancer: a "Wait-and-see" Approach
This study looks at treating rectal cancer with radiotherapy and chemotherapy. Instead of immediate surgery, patients are closely watched. If the cancer disappears after treatment, doctors might suggest waiting to see if surgery is still needed, aiming to avoid its side effects.
Canada - recruitingPHASE1, PHASE2
Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies
This study is testing a new medicine called S241656 for people with certain advanced cancers, including lung, bowel, and pancreatic cancers. It aims to find a safe and effective dose, either alone or with other treatments, for cancers with specific genetic changes.
United States · Denmark · Hong Kong - recruitingPHASE2
Clinical Trial Evaluating the Activity of Zanidatamab for the Treatment of Patients With Solid Tumors With an Alteration of the HER2 Gene.
This study is testing a new drug, zanidatamab, for different cancers like lung, sarcoma, head and neck, bowel, and womb cancer. It's for people whose cancer has a specific change in the HER2 gene and hasn't responded to previous treatments.
France