- recruitingNA
Bronchoscopic RElease of Air Trapped in Hyperinflated Emphysematous Lung - Study 3
This study looks at a new treatment called Apreo BREATHE for people with severe emphysema, a type of COPD. It tests if inserting small devices into airways can help release trapped air and improve breathing, alongside usual care.
United States · Austria · Germany - recruitingNA
My Lung Health Coach-A Virtual COPD Self-management Support Program Integrated Into the Electronic Patient Record
This study looks at a 12-week online coaching program called 'My Lung Health Coach' for people with COPD. It helps you manage your condition with tips on things like breathing, exercise, and medicines. We also check out a special app that works with the program.
Canada - recruitingNA
The Effects of Oscillatory Positive Expiratory Pressure (OPEP) Therapy in Patients With COPD
This study looks at whether a special breathing device called OPEP can help people with COPD breathe better and cough less. Participants will use the device at home for four weeks, and researchers will compare their breathing and cough symptoms before and after.
Canada - recruiting
Diaphragmatic Function as a Biomarker
This study looks at how your breathing muscles, especially your diaphragm, work if you have lung conditions like asthma or COPD. We want to understand if problems with these muscles are linked to feeling breathless and what that might mean for your health.
Germany - active not recruiting
COPD Case Finding In Nottingham and District: C-FIND COPD A Pilot Study
This study in Nottingham checks for a lung condition called COPD in people already having a lung health scan. It uses breathing tests and aims to find COPD early, as spotting it late means more lung damage. Participants will also get health advice.
United Kingdom - recruiting
Effects of Pulmonary Diseases and Their Treatment on Cardiac Function
This study looks at how long-term lung diseases like COPD, asthma, or lung scarring affect the heart, especially the left side. Researchers will use special scans to see if treatments for lung problems also help the heart, aiming for better care.
Germany - recruitingPHASE1, PHASE2
Impact of Long-acting Bronchodilator- -Corticoid Inhaled Therapy on Ventilation, Lung Function and Breathlessness
This study looks at how a specific inhaler (Trixeo Aerosphere) helps people with COPD breathe easier. It's a new medicine being tested to understand how it improves breathing and reduces shortness of breath.
France - recruitingNA
A Trial of the Implantable Artificial Bronchus 50 Flex in Patients With Severe Emphysema
This study is testing a new implant called the IAB 50 Flex for people in the UK with severe emphysema, a type of serious lung disease. Doctors want to see if this implant can help them breathe better and improve their quality of life.
France · Netherlands - recruitingNA
The REDUCE EU Study - Endobronchial Thermal Liquid Ablation (ETLA) for the Treatment of Emphysema
This study looks at a new way to treat severe emphysema called ETLA. It aims to see if this treatment is safe and effective by shrinking parts of the lung that are over-inflated, helping people breathe better and improve their quality of life.
Austria · Germany · Netherlands - active not recruitingNA
Symptoms and Functions in Patients With COPD and Chronic Bronchitis Switching From CIG to THS
This study looks at how people with lung disease (COPD) who smoke feel and function when they switch from regular cigarettes to heated tobacco products (THS). It aims to see if switching can improve symptoms like cough and breathlessness, and help their lungs work better.
United States · Bulgaria · Czechia - recruiting
AYLo - AutoimmunitY and Loss of y
This study looks at how changes in your `Y` chromosome, which only men have, might be linked to certain long-term conditions like arthritis and similar diseases. Researchers want to understand if these changes affect how your immune system works and the progression of these conditions.
Germany - recruitingPHASE2
Effects of Blocking TSLP on Airway Inflammation and the Epithelial Immune-response to Exacerbation Triggers in Patients With COPD
This study is looking at a new medicine called tezepelumab for people with COPD. It aims to see if this medicine can help reduce inflammation in the airways and prevent flare-ups of their condition.
Denmark · United Kingdom - recruiting
The Use of Entropy to Assess Sleep Disordered Breathing in Chronic Respiratory Disease
This study looks at breathing problems during sleep in people with long-term lung conditions like asthma or COPD. Researchers are using a new way to analyse sleep study data to better understand how these conditions affect sleep and breathing.
United Kingdom - active not recruitingNA
Aiding COPD and CHF Ultrasound-guided Management Through ENhanced Point Of Care UltraSound
This study looks at whether using a special ultrasound and software called PRESUNA can help people with COPD or heart failure manage their health better at home. It compares this new approach to the usual care provided by a home hospital team.
Canada - recruitingNA
Sputum-guided Treatment With Comprehensive Care Management in COPD - A Randomized-controlled Trial
This study looks at new ways to help people with COPD have fewer flare-ups. It combines personal health support and care suited to your body with regular care to see if this helps reduce hospital visits.
Canada - active not recruitingNA
Quebec Lung Cancer Screening PLUS Trial
This study looks at whether giving educational information to patients, doctors, and pharmacists can help people with undiagnosed or untreated lung and heart conditions get the right medications. It's part of an existing lung cancer screening program in Quebec.
Canada - not yet recruiting
Investigation of the Effects of Oxidized Antigens on the T-Cell Response and the Epigenetic Reprogramming of Neutrophils in Lung Diseases - OXIGENE -
The OXIGENE study looks at blood from people with lung conditions like asthma or pneumonia. It aims to understand how their immune system works during illness and if certain immune cells change over time. This could help develop better ways to diagnose and treat lung diseases in the future.
Germany - recruitingPHASE3
Supported Rescue Packs Post-discharge in Chronic Obstructive Pulmonary Disease
This study looks at a new way to help people with COPD stay out of hospital after a flare-up. It tests if a 'supported rescue pack' plan, including medicine, a self-management guide, and phone support, works better than usual care to reduce hospital readmissions.
United Kingdom - enrolling by invitation
The Feasibility of Electrical Impedance Tomography to Guide Non-invasive Respiratory Interventions in Chronic Respiratory Disease
This study explores how a new technology called Electrical Impedance Tomography (EIT) can help doctors set up breathing machines better. EIT gives real-time pictures of the lungs, aiming to make these machines more effective and comfortable for people with serious breathing problems.
United Kingdom - recruitingPHASE3
Long-term Safety and Tolerability of Tozorakimab in Patients With COPD and History of Exacerbations
This study, called ROMEO, is testing the long-term safety of a new medicine for people with a lung condition called COPD. It's for people who have had flare-ups of their COPD in the past and have already taken part in an earlier study for this medicine.
France - active not recruitingPHASE4
RELVAR Effects on Parasternal Muscle Activity, Diaphragm, and Ventilation in Severe COPD
This study looks at how a common COPD inhaler, called Relvar, affects breathing muscles and overall breathing in people with severe long-term lung disease. Researchers want to understand if this medicine helps these muscles work better.
Canada - recruiting
Clinimetric Properties of Muscle Mass and Stiffness Measurements of the Quadriceps in Patients With COPD
This study looks at new ways to measure leg muscles in people with COPD. We want to see how good simple measurements, like thigh circumference and a special scan, are at tracking muscle health, especially for those starting a rehabilitation programme.
France - recruitingNA
myAirvo 3 (High Flow Nasal Therapy; HFNT) for COPD Patients in the Home
This study looks at a device called myAirvo 3, which provides `high-flow` oxygen through your nose, for people with severe COPD. It aims to see if using it at home can reduce flare-ups, improve quality of life, and keep you out of hospital.
United States · Canada - recruitingNA
Structured Review: To Optimise Management and Prevent Harm in COPD
This study aims to help people with COPD who have frequent flare-ups. We want to improve their treatment, check for other health problems, and reduce how often they need steroid tablets, which have side effects. It’s a thorough health check to help you feel better.
United Kingdom - authorisedTherapeutic use (Phase IV)
Erdosteine effect on oxidative stress, inflammatory response and immune modulation in patients with COPD. A single center, open label, double arm, controlled, 4-week, explorative, ex vivo study.
This study looks at how a drug called erdosteine affects the body's defence systems and inflammation in people with COPD. Researchers will compare those taking erdosteine plus usual care to those on usual care alone over four weeks.
Italy - recruitingNA
Balance Training Following Pulmonary Rehabilitation on Balance in People With Chronic Obstructive Pulmonary Disease (COPD)
This study is looking at a new balance training programme, called Sport4Steadiness, for people with COPD. It wants to see if the programme is helpful and easy to use, and if the study can be run smoothly. The aim is to help people with COPD improve their balance and potentially reduce falls.
United Kingdom - not yet recruitingNA
Effectiveness of Pollution Monitoring in Clinical Exercise Rehabilitation
This study looks at whether real-time air pollution warnings can help people with heart and lung conditions exercise outdoors more safely. Participants will use an app that gives exercise tips and, for some, also shows local air quality to help them choose better times or places to walk.
United Kingdom - recruiting
Study of Inflammatory and Physiological Profiles of Healthy and Diseased Lung
This study looks at how lung diseases like asthma and COPD affect the body. Researchers want to understand these conditions better by studying samples from healthy people and those with lung problems to find better ways to help patients.
United Kingdom - not yet recruiting
Development of the Drug and Alcohol Respiratory Health Test
This study is creating a simple test to check lung health in adults who use certain substances. Many people with substance use disorder have breathing problems that often go unnoticed. This new test aims to find these issues early so people can get the right help.
United Kingdom - active not recruitingNA
Evaluation of the Safety and Efficacy of TLD in Patients with COPD
This study is looking at a new treatment called Targeted Lung Denervation (TLD) for people with a lung condition called COPD. It aims to see if TLD is safe and works better than standard care to reduce flare-ups of COPD symptoms.
United States · Austria · France - recruiting
The Clear Conversations Project
This project, called 'Clear Conversations', helps healthcare staff improve how they talk to patients. The aim is for patients with conditions like COPD or those managing their weight to better understand their health info, feel more in control, and get better results.
United Kingdom - not yet recruiting
The AcCREDiT 2 Study
The AcCREDiT 2 study looks at how to quickly identify infections in people with breathing problems, like pneumonia or flare-ups of conditions like COPD. It aims to improve how we test for these infections and make sure patients get the right treatment faster.
United Kingdom - active not recruitingPHASE2
A Study to Evaluate Solrikitug in Participants With COPD (ZION)
This study is testing a new medicine, Solrikitug, for people with a lung condition called COPD. Researchers want to see if different doses are safe and how they affect the body and COPD symptoms compared to a dummy medicine.
United States · Australia · New Zealand