- recruitingPHASE1
Intravenous DNase I for the Treatment of Sepsis (IDEALSepsisI)
This study is looking at a new treatment called DNase I for people very sick with sepsis in intensive care. We want to see if it's safe, how much to give, and what effects it has on the body. This is an early-stage study to gather important information.
Canada - not yet recruiting
Mitochondrial Assessment in Critical Ill Patients in Intensive Care
This study looks at how critical illness affects tiny parts of our cells called mitochondria, which produce energy. We're trying to find a simple breath test to check their function in very sick patients on breathing machines in intensive care, which could help guide future treatments.
United Kingdom - recruiting
Intensive Care Decision-making, Survival and Dying Well
This study explores intensive care survivors' experiences to understand how their past treatment and wishes about end-of-life care would influence their decision to have intensive care again, considering different chances of survival and quality of life.
United Kingdom - recruiting
Early Severe Illness TrAnslational BioLogy InformaticS in Humans
This study, called ESTABLISH, looks at how the body reacts to severe illnesses like sepsis in the Intensive Care Unit (ICU). Researchers want to find better ways to diagnose these conditions early and discover new treatments to help patients recover.
Canada - recruiting
Intraabdominal Hypertension and Occurrence of Microaspiration in Cirrhotics Under Mechanical Ventilation
This study looks at how high pressure in the tummy area (intra-abdominal hypertension) might lead to tiny bits of stomach contents going into the lungs (microaspiration) in very sick patients with liver scarring (cirrhosis) who are on a breathing machine.
France - recruitingPHASE3
The VITDALIZE Study: Effect of High-dose Vitamin D3 on 28-day Mortality in Adult Critically Ill Patients
This study looks at whether high doses of vitamin D3 can help seriously ill adults in intensive care, especially those with very low vitamin D. Previous research hinted it might reduce deaths in this specific group, and this new study aims to confirm if it’s a safe and effective treatment.
Austria · Belgium · Germany - recruiting
MuScle WastIng and DysphaGia iN CriticAlly IlL Patients (SIGNAL)
This study looks at how muscle weakness in the mouth and throat affects swallowing in very unwell adults in intensive care. It aims to understand why this happens and find better ways to help them eat and drink safely.
United Kingdom - recruitingPhase IV
A platform trial to identify the best treatments for critically ill children admitted to paediatric intensive care
This study is looking for better ways to care for very sick children in intensive care. We are testing common treatments to see which ones work best and are safest, hoping to improve their recovery and future well-being.
United Kingdom · England · Northern Ireland - active not recruiting
Outcomes of Patients Who Survived Treatment on an Intensive Care Unit for COVID-19 in England and Wales
This study looks at the health of people in England and Wales one year after they left intensive care for COVID-19. Researchers will compare their health to people who were in intensive care for other reasons. The aim is to understand long-term health effects.
United Kingdom - not yet recruiting
Prevalence and Measurement of Delayed Gastric Emptying in Patients Receiving Extracorporeal Membrane Oxygenation
This study looks at how quickly food leaves the stomach in very sick patients, especially those on a life support machine called ECMO. It also aims to find the best and easiest ways to check stomach emptying at the bedside, to make sure patients get enough nutrition.
United Kingdom - recruitingPHASE4
Effect of Protocolized Magnesium Replacement on Mortality and Atrial Fibrillation in Critically Ill Patients
This study looks at how best to give magnesium to very ill patients in intensive care. Doctors currently give magnesium, but want to find out if aiming for slightly higher or lower levels helps patients survive better and avoids an irregular heartbeat.
Canada - recruitingNA
Continuous vs Bolus Protein (Protein Regimen Outcomes) in Critically Ill Children (Kids In Distress)
This study compares two ways of giving protein to very sick children aged 1-11 in intensive care: a steady drip or bigger, less frequent doses. We want to see which method helps them keep their weight and muscle better.
Canada - recruiting
Microvascular Monitoring in Circulatory Shock and Sepsis (MiMICSS)
This study looks at a new way to monitor critically ill patients in intensive care. It uses a device that shines a light on muscles and the brain to understand how blood flows in tiny vessels, hoping to improve care for conditions like sepsis.
Canada - recruiting
Metabolomics Study on Postoperative Intensive Care Acquired Muscle Weakness
This study looks at muscle weakness after surgery in intensive care. Researchers want to understand what changes in the body’s chemistry might cause this weakness or show who is at risk, by taking blood and muscle samples.
Austria · Germany - recruiting
Electroencephalography and Sleep Quality With Lormetazepam in the Intensive Care Unit
This study looks at how a medicine called lormetazepam affects brainwave patterns (EEG) in very unwell patients in intensive care. Researchers want to see if it improves sleep and how deeply sedated patients are.
Germany - recruiting
Immune Modulation by Exosomes in COVID-19
This study looks at how tiny messengers, called exosomes, from special cells might help reduce severe inflammation and organ damage in very sick COVID-19 patients. We're testing if these exosomes can calm the immune system in blood samples.
Germany - enrolling by invitation
Impact of the Introduction of a Performance Improvement Program on the Initial Management of Sepsis and Septic Shock in Adults in the Emergency Department: a Before-and-after Study (IPA-SOS)
This study looks at how a special improvement programme at Brest University Hospital affects the care of adults with serious infections called sepsis or septic shock. Researchers want to see if the programme helps staff follow treatment guidelines better and improves how patients recover.
France - recruiting
The Gut Microbiome - Source of Sepsis and Novel Target in Intensive Care Units?
This study looks at how serious illness and strong antibiotics affect the helpful germs in your gut. Researchers want to see if changes in these germs are linked to brain problems and infections in people in intensive care. They will collect samples and check brain function over time.
Germany - recruitingNA
Developing Strategies to Facilitate Consent of Legally Authorized Representatives to Clinical Trials
This study wants to learn how best to talk to family members (Legal Representatives) about joining research trials when their loved ones are very ill and can't speak for themselves. The goal is to make it easier for these families to understand and agree to clinical trials.
Germany - recruiting
Using sEMG of the Diaphragm to Assess Readiness for Extubation
This study looks at a new way to see if critically ill patients are ready to have their breathing tube removed. It uses a special sensor on the skin to check how well a muscle called the diaphragm is working, hoping to make this important step safer and more successful.
United Kingdom - recruiting
Setting up a Warehouse of Physiological Data and Biomedical Signals in Adult Intensive Care
This study collects vital sign data from adult intensive care patients using hospital monitors. It aims to create a database to help doctors better predict and detect organ failures and other problems early, potentially improving care and reducing hospital stays.
France