- recruitingTherapeutic use (Phase IV)
Cerebral neuroinflammation during major depressive episode: multicentric comparative study (InflaDep)
This study looks into how inflammation in the brain might be linked to severe depression. Researchers are using special scans to compare brain inflammation in people with depression to those without. The goal is to better understand depression and find new ways to help treat it.
France - not yet recruitingNA
Prediction and Validation of Unipolar Depression With Psychosocial-somatic Markers in a Naturalistic Cohort Recruited in an Outpatient Setting
This five-year study aims to better understand depression by looking at different types of depression and how they might affect people over time. Participants will have blood samples taken to help identify these differences.
Germany - active not recruitingNA
Group Intervention for Interpersonal Skills
This study looks at two types of therapy for people with depression or anxiety. It compares standard talking therapy (CBT) with CBT plus a group session called Kiesler Circle Training. The aim is to see if adding the group helps more with social skills.
Germany - recruitingNA
Mechanisms of Transcutaneous Auricular Vagus Nerve Stimulation in Depression
This study looks into a new, gentle way to treat depression and bipolar disorder called transcutaneous auricular vagus nerve stimulation (tVNS). It aims to understand how tVNS works and if it can help people, without surgery. Researchers will compare tVNS to a dummy treatment.
Germany - enrolling by invitationNA
Development and Evaluation of a Digital Aftercare Program for Adolescents (12-17 Years) With Depressive Symptoms After Hospital Discharge (Mind-WIN Pilot Study) (Mind-WIN Pilot)
This study looks at a digital program called Mind-WIN for young people aged 12-17 with depression after leaving hospital. It checks if the program, which offers self-help or therapist support online, helps reduce depressive symptoms and improves their well-being.
Germany - recruiting
Evaluation of the Naturalistic User Experience of the Website "ich Bin Alles @Schule" (i Am Everything @school)
This study looks at how useful and easy to use a German website called "ich bin alles @Schule" is. It's for school staff to learn about depression and mental health in students. The aim is to see if the website helps and reaches the people it's meant for.
Germany - active not recruitingNA
Detection Algorithm for Recurrence or Relapse of Depression Thanks to a Smartwach
This study looks at how a special smartwatch and app called Dalia can help spot early signs of depression coming back. It tracks things like sleep and heart rate to see if these changes can warn people and their doctors sooner.
France - active not recruitingNA
Feasibility of Process-based Therapy in a Naturalistic Setting
This study is looking at a new way to help people with depression or anxiety. It's called 'Process-based Therapy' (PBT). We want to see if therapists can easily use this method in their everyday work and if it helps patients feel better.
Germany - recruiting
Assessment of Daily Stressors in Children With Depressive Symptoms for the Development of a Gamified Emotion Regulation App
This study is developing a fun app for children aged 8-12 with feelings of depression. The app aims to teach them coping skills. Researchers are first asking children and parents about daily worries and what support they find helpful, to make sure the app works best for them.
Germany - recruitingNA
7T Amygdala and Citalopram Study
This study looks at how a common antidepressant, citalopram, affects a brain area called the amygdala when people see emotional faces. It aims to understand how this medicine works on different parts of the amygdala.
United Kingdom - authorisedTherapeutic use (Phase IV)
A multicenter randomized, controlled, single-blind, adaptive phase IV clinical trial to evaluate the efficiency and effectiveness of a pre-emptive pharmacogenetic strategy for antidepressant selection in patients with depressive disorder: The PREDICT adaptive clinical trial.
This study looks at whether using a gene test can help doctors choose the best antidepressant for people with depression, especially when other treatments haven't worked well. It compares this approach to standard care.
Spain