Diabetes Mellitus, Type 2 research hub
40 indexed studies · 28 currently recruiting
- active not recruitingPHASE3
Effect of Retatrutide Compared With Semaglutide in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Metformin With or Without SGLT2 Inhibitor (TRANSCEND-T2D-2)
This study compares two medicines, retatrutide and semaglutide, for adults with Type 2 Diabetes whose current treatment isn't enough. It will check how well they work and if they are safe, aiming to improve blood sugar control.
United States · Argentina · Canada - not yet recruitingPHASE3
A Study of Orforglipron (LY3502970) Compared With Dulaglutide in Pediatric Participants With Type 2 Diabetes
This study is looking at a new medicine called orforglipron for young people aged 10-17 with type 2 diabetes. It compares it with an existing medicine, dulaglutide, to see how well it works and if it's safe. The study lasts about 61 weeks.
United States · Belgium · Brazil - active not recruitingPHASE3
A Research Study to Look at How Semaglutide Compared to Placebo Affects Diabetic Eye Disease in People With Type 2 Diabetes
This study investigates how a medicine called semaglutide affects eye problems in people with type 2 diabetes over five years. Participants will get either semaglutide or a dummy medicine, injected once a week, along with their usual diabetes treatments.
United States · Brazil · Bulgaria - recruitingPHASE3
EASi-PROTKT™ - A Study to Test Vicadrostat (BI 690517) Taken Together With Empagliflozin in People With Type 2 Diabetes, High Blood Pressure, and Cardiovascular Disease
This study looks at a new medicine, vicadrostat, for people with type 2 diabetes, high blood pressure, and heart disease. It aims to see if taking vicadrostat alongside empagliflozin can help reduce heart problems. Half the participants will get the study medicine, and half will get a dummy pill.
United States · Argentina · Australia - recruiting
Heart Failure in Patients With Diabetes: Cells, Crosstalk and Consequences
This study looks at how diabetes and heart failure affect each other, focusing on body cells and communication between different tissues like fat and muscle. We'll compare people with and without these conditions to better understand their causes.
United Kingdom - not yet recruitingPHASE2
Digoxin and Senolysis in Heart Failure and Diabetes Mellitus
This study looks at how a common heart medicine, Digoxin, might help people with both heart failure and type 2 diabetes. We are exploring if Digoxin can improve how fat tissue works in these patients by clearing out certain old, 'tired' cells.
United Kingdom - active not recruitingNA
Identification of New Biomarkers of Insulin Resistance
This study looks for new ways to spot insulin resistance early, a step before type 2 diabetes. We'll check how a special protein called Rab3 changes with diet and exercise, and also look at gut health. This helps us understand and prevent type 2 diabetes.
United Kingdom - recruiting
Chronotype of Patients With Diabetes and Effect on Glycaemic Control
This study looks at how your natural sleep patterns, called chronotype, are linked to managing diabetes and your overall heart health. We want to understand how different sleep timings affect blood sugar levels and other health factors in people with type 1 and type 2 diabetes.
United Kingdom - active not recruitingPHASE2
A Research Study to Investigate the Effects of CagriSema Compared to Placebo in People With Type 2 Diabetes and Painful Diabetic Peripheral Neuropathy
This study looks at a new medicine called CagriSema for people with type 2 diabetes and pain from nerve damage. It compares CagriSema to a dummy medicine to see if it helps reduce pain and manage diabetes.
United States · Canada · Denmark - authorisedTherapeutic use (Phase IV)
NT-proBNP Selected PreventiOn of cardiac eveNts in a populaTion of dIabetic patients without A history of Cardiac disease; a prospective randomized trial
This study looks at how certain blood pressure and heart medications might help people with type 2 diabetes, who haven't had heart problems before, to avoid future heart issues. It focuses on a specific blood marker (NT-proBNP) to guide treatment.
Spain · Austria - recruiting
Prevalence and Determinants of Subclinical Cardiovascular Dysfunction in Adults With Type 2 Diabetes Mellitus
This study looks at how heart problems start in people with type 2 diabetes. We want to understand what causes these problems early on, before they cause symptoms. This could help us find new ways to treat or prevent heart disease in the future.
United Kingdom - enrolling by invitation
A Study to Follow Paediatric Participants With Growth Hormone Deficiency Treated With Somapacitan for Long Term Safety Information and Clinical Parameters
This study looks at the long-term safety and effects of a medicine called somapacitan in children with growth hormone deficiency. It involves children already taking this medicine and follows them over a long period to see how they get on.
United Kingdom - recruitingPHASE4
NT-proBNP Selected Prevention of Cardiac Events in Diabetic Patients
This study looks at how high doses of certain heart medicines (RAS-antagonists and beta-blockers) might help prevent heart problems in people with Type 2 diabetes who haven't had heart disease before. It also checks a blood marker called NT-proBNP.
Austria · Netherlands · New Zealand - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A study to test how insulin NNC0471-0119 works in the body in participants with type 2 diabetes when given by an insulin pump.
This study is looking at a new type of insulin, called NNC0471-0119, for people with type 2 diabetes. Researchers want to understand how it works in the body when given through an insulin pump. It's an early-stage study to gather basic information about the new insulin.
Germany - recruiting
A UK Registry for Metabolic and Bariatric Endoscopic Interventions
This UK study is collecting information on new, less invasive procedures using a camera on a thin tube (endoscope) to help people with obesity and type 2 diabetes lose weight. It aims to see how safe and effective these treatments are in real-life settings.
United Kingdom - recruitingPHASE2, PHASE3
A Randomised, Controlled Trial of a Low-energy Diet for Improving Functional Status in Heart Failure With PRESERVED Ejection Fraction Preserved Ejection Fraction
This study looks at how a special low-calorie diet might help people with a type of heart failure where the heart struggles to relax properly. It aims to see if diet can improve heart function, symptoms, and exercise ability.
United Kingdom - recruitingNA
A Study Looking to Improve Sleep and Reduce Sedentary Behaviour in Those Living With Type 2 Diabetes Mellitus
This study aims to help people with Type 2 diabetes who struggle with sleep and are not very active. It explores how a special talking therapy and advice on being more active can improve sleep and overall health in this group.
United Kingdom - active not recruitingNA
CGM Use in Adults With Type 2 Diabetes on Basal Insulin
This study looks at how a continuous glucose monitor (FreeStyle Libre 3) compares to regular finger-prick tests for managing type 2 diabetes. It aims to see if the monitor helps adults with type 2 diabetes better control their blood sugar over 16 weeks.
United Kingdom - not yet recruitingPHASE3
A Study to Evaluate Effect of AZD6234 in Adult Participants With Type 2 Diabetes Mellitus and Obesity or Overweight
This study is looking at a new medicine, AZD6234, for adults with Type 2 diabetes who are also overweight or have obesity. It aims to see how well it helps with weight loss and how safe it is compared to a dummy medicine.
United States · Argentina · Australia - active not recruiting
Impact of a Regional Program Agir Sur Sa SantE
This study looks at a new care plan called 'Agir Sur Sa SantÉ' (meaning 'Act on Your Health') in our local area. It aims to see how well this plan works for people with conditions like diabetes, obesity, and high blood pressure, focusing on improving their overall health.
Canada - recruitingNA
Clinical Utility of a Genomic Predictor Test on the Management of Cardiorenal Complications of Type 2 Diabetes
This study looks at how a genetic test predicting heart and kidney problems in people with type 2 diabetes affects treatment. It compares people who know their risk score with those who don't, to see if knowing this information helps them reach their health goals better.
Canada - recruiting
Bone Health After Bariatric Surgery in Patients With Type 2 Diabetes
This study looks at how weight-loss surgery (bariatric surgery), specifically sleeve gastrectomy, affects bone health in people with Type 2 diabetes. We want to see if this surgery makes bones stronger or weaker and compare them to people without diabetes or obesity.
Canada - recruitingNA
Rebalancing the Fat Content of the Heart and Muscles
This study looks at a new diabetes medicine called Semaglutide, combined with diet or exercise. We want to see how it affects the amount of fat in the heart and leg muscles of people with type 2 diabetes. It's about finding better ways to manage diabetes beyond just blood sugar.
United Kingdom - recruitingNA
Adipose Tissue Storage in the Rapid Remission of Hepatic and Cardiac Metabolic Dysfunction After Bariatric Surgery
This study looks at how weight loss surgery (bariatric surgery) helps improve type 2 diabetes by studying how the body's fat stores change. They want to see if these changes in fat are key to why diabetes gets better after surgery.
Canada - active not recruitingPHASE4
A Study of Cardiovascular Events iN Diabetes Plus
This study is for people with type 2 diabetes who haven't had a heart attack or stroke. It checks if a tablet called semaglutide can safely lower risks of heart problems, strokes, and death from heart issues over about 5 years, all done from home.
United Kingdom - recruiting
Who Will Benefit From Bariatric Surgery for Diabetes?
This study looks at why some people with type 2 diabetes benefit from weight-loss surgery (Roux-en-Y gastric bypass) more than others. Researchers want to understand if things like body fat, genes, and gut hormones play a role in putting type 2 diabetes into remission after surgery.
United Kingdom - recruitingNA
Driving with Neuropathy
This study looks at how training with visual feedback can help drivers with diabetes and nerve damage (neuropathy) to use their accelerator pedal safely. It aims to see if this training can reduce how much they press the pedal, making driving safer.
United Kingdom - recruitingNA
The Poor Responders Study
This study aims to understand why some people don't lose as much weight as expected after weight-loss surgery, despite having the same operation. Researchers want to identify factors that predict who will lose the most weight and who might struggle, before the surgery takes place.
United Kingdom - ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
A study comparing exposure of semaglutide and dapagliflozin dosed orally as mono-components versus in a fixed-dose combination
This study is looking at two medicines for type 2 diabetes, semaglutide and dapagliflozin. Researchers want to see how well the body uses these medicines when given separately, compared to when they are combined into one single tablet.
Germany - not yet recruiting
Functional Investigation of Endothelial Function and Regenerative Cell Exhaustion
This study looks at how type 2 diabetes affects special cells in your blood that help repair blood vessels. Researchers want to see if these repair cells work differently in people with type 2 diabetes compared to those without it, using a simple blood test.
Canada - recruitingNA
Home-based Heat Therapy for Type 2 Diabetes
This study is exploring if warm water soaks at home can help people with type 2 diabetes. Researchers want to see if regular heat treatment improves how the body handles sugar and fats, and if it helps blood vessels work better. It focuses on finding new, easy ways to support heart health.
Canada - recruitingPHASE1
Assessing Pharmacokinetics and Pharmacodynamics of Daily Enteric-coated Aspirin in Patients With StablE Diabetes II
This study looks at different low-dose aspirin treatments for people with type 2 diabetes. We want to find the best way to help aspirin work well to thin the blood and understand why it doesn't work for some people.
Canada - recruitingNA
Endoscopic Sutured Gastroplasty with Endomina® Device Versus Standard of Care in Patients with Type 2 Diabetes and Class I Obesity: a Multi-center, Randomized Controlled Trial
This study looks at a new stomach-reduction procedure for people with type 2 diabetes and obesity. It compares this procedure, called endoscopic gastroplasty using the Endomina device, with standard care to see if it helps put diabetes into remission.
France - recruiting
Prospective Study on Diabetes Mellitus and Its Complications in Newly Diagnosed Adult Patients
This study looks closely at adults newly diagnosed with diabetes to understand why and how the condition develops. It aims to identify different types of diabetes and track how it changes over time, comparing them to healthy individuals. This helps us learn more about managing diabetes.
Germany - active not recruitingPHASE3
A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Tirzepatide in People With Type 2 Diabetes Treated With Metformin, SGLT2 Inhibitor or Both
This study looks at a new medicine called CagriSema to see how well it lowers blood sugar and helps with weight loss in people with type 2 diabetes. It's compared to another medicine called tirzepatide. Participants will get one of the medicines by chance.
United States · Argentina · Australia - active not recruitingNA
The FreeStyle Libre Enabled Reduction of A1c Through Effective Eating and Exercise Study
This study helps people with Type 2 diabetes manage their blood sugar through healthy eating and exercise. Participants use smart devices to track progress and attend online classes. The goal is to create a helpful program for others with diabetes.
Canada - recruiting
Prediction of Heart Failure and Cognitive Decline in Type 2 Diabetes
This study looks at people with Type 2 diabetes to find out who might be at risk of heart problems or memory and thinking difficulties. The goal is to create ways to prevent these issues before they become serious.
France - enrolling by invitationNA
Combined Bariatric Surgery and Pancreas After Kidney Transplantation for Type II Diabetics
This study looks at combining stomach reduction surgery (sleeve gastrectomy) with a new pancreas and kidney for people with Type 2 diabetes. The goal is to help them stop insulin, control blood sugar, and protect their new kidney from diabetes-related damage.
Canada - recruitingNA
Evaluating a Digital Intervention for Alleviating Diabetes-specific Emotional Distress in Adults Living With T2DM
This study looks at how a digital helper called covivio might ease the emotional stress linked to type 2 diabetes. 250 adults in Germany will take part to see if it helps improve their mood and health.
Germany - recruiting
The Effect of Bariatric Surgery on Insulin Sensitivity and Energy Metabolism
This study looks at how weight-loss surgery affects blood sugar control and how the body uses energy in people with obesity and type 2 diabetes. We want to understand how this surgery improves health, especially for the liver.
Germany