- authorisedTherapeutic exploratory (Phase II)
A Double-blind, Placebo-controlled Study to Evaluate the Safety, Tolerability, and Potential Antiseizure Activity of Adjunctive OV329 Therapy in Adults with Drug-Resistant Focal Epilepsy
This study is testing a new medicine called OV329 for adults with focal epilepsy whose seizures are not controlled by usual treatments. Researchers want to see if adding OV329 to regular medicines is safe, well-tolerated, and helps reduce the number of seizures people experience.
Netherlands - recruitingPhase II and Phase III (Integrated)
A Double-Blind, Randomized, Multicenter, Trial Evaluating the Efficacy and Safety of PRAX-628 in Adults with Focal Seizures (POWER 1)
This study is testing a new medicine, PRAX-628, for adults with focal epilepsy. It compares PRAX-628 to a dummy pill to see if it reduces seizures and whether it's safe. It's a key step in understanding if this new treatment could help people with focal seizures.
Spain · Poland · Italy - active not recruitingPHASE2, PHASE3
Study to Determine if BHV-7000 is Effective and Safe in Adults With Refractory Focal Onset Epilepsy
This study is testing a new medicine called BHV-7000 to see if it can help adults with focal epilepsy that hasn't responded well to other treatments. Researchers want to find out if it's safe and effective in reducing seizures.
United States · Australia · Denmark - enrolling by invitationPHASE3
An Open-label Study of XEN1101 in Epilepsy
This study looks at a medicine called XEN1101 for people with certain types of epilepsy, including focal epilepsy and tonic-clonic seizures. It focuses on how safe and effective it is over a long time, up to six years, after they've been in a previous study.
United States · Argentina · Australia - active not recruitingPHASE2
A Study to Evaluate XEN1101 as Adjunctive Therapy in Focal Epilepsy
This study is testing a new medicine, XEN1101, for people aged 18-75 with focal epilepsy. It aims to see if the medicine can reduce seizures, how safe it is, and if people tolerate it well, when added to their current epilepsy treatments.
United States · Canada · Georgia - authorisedTherapeutic exploratory (Phase II)
Efficacy of probenecid on cluster seizures during dosage reduction of Anti Seizure Medication (ASM) in presurgical focal epilepsy video-EEG monitoring
This study looks at whether a medicine called probenecid can help people with focal epilepsy who are having 'cluster seizures' (several seizures close together). It aims to see if probenecid can reduce these seizures when patients are reducing their usual epilepsy medication in hospital to prepare for surgery.
France - recruitingNA
Thalamic Recordings in Children Undergoing SEEG
This study at Great Ormond Street Hospital looks at how epilepsy affects a part of the brain called the thalamus in children. We add extra brain sensors during routine epilepsy surgery assessments to understand how it works and explore new treatment ideas.
United Kingdom - enrolling by invitationPHASE2
Long-term Safety and Tolerability of BHV-7000
This study looks at the long-term safety of a new medicine, BHV-7000, for adults with focal epilepsy. It's for people who have already taken part in an earlier study for this particular drug. The main goal is to see if the medicine is safe and well-tolerated over a longer time.
United States · Argentina · Australia