Head & Neck Squamous Cell Carcinoma research hub
26 indexed studies · 12 currently recruiting
- recruiting
Diagnostic Performance Of 4D Dynamic LAFOV FDG-PET Acquisition for Differentiation of Residual Disease and Post-radiation Inflammation in Head Neck SCC Treated by Radiotherapy.
This study aims to improve how we check for cancer after radiotherapy for head and neck cancer. It uses a special scan called a PET scan to tell the difference between remaining cancer and irritation from treatment, helping doctors provide the best care.
France - recruitingPHASE1, PHASE2
Afatinib in Patients With Fanconi Anemia (FA) and Advanced Head and Neck Squamous Cell Carcinoma (HNSCC)
This study is testing a drug called Afatinib for people with Head and Neck cancer who also have Fanconi Anemia. We want to see if it's safe and helps control the cancer. This is an early-stage study to learn more about this drug in this specific group of patients.
Germany · Spain - active not recruitingPHASE3
Trial of Laryngeal Preservation Comparing Induced CT Followed by RT vs CT Concomitant to RT
This study looks at treating a certain type of throat cancer with chemotherapy and radiotherapy to try and save the voice box. We're comparing two ways of giving chemotherapy to see which works better to keep the voice box working for longer.
France - active not recruitingPHASE1, PHASE2
Phase 1/2 Study Evaluating MCLA-129, a Human Anti-EGFR, Anti-c-MET Bispecific Antibody, in Advanced NSCLC and Other Solid Tumors, Alone and in Combination
This study is looking into a new drug, MCLA-129, for some advanced cancers like lung or stomach cancer. It will see how safe and effective it is, both by itself and with other treatments. It's for people who haven't responded to previous treatments.
United States · Belgium · France - recruitingPHASE1
A Study of NX-1607 in Adults With Advanced Malignancies
This study is looking into a new treatment called NX-1607 for various advanced cancers, including ovarian, stomach, and lung cancer. It aims to see how safe the treatment is and if it can help fight the cancer, sometimes combined with another drug called Paclitaxel.
United States · United Kingdom - active not recruitingPHASE2, PHASE3
Study of Zanzalintinib (XL092) + Pembrolizumab vs Pembrolizumab in Subjects With PD-L1 Positive Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma
This study is for people with head and neck cancer that has come back or spread and can't be cured by usual treatments. It compares a new drug, zanzalintinib, combined with pembrolizumab, against pembrolizumab alone, to see if the new combination works better.
United States · Argentina · Australia - recruitingPHASE1
A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors
This study is testing a new drug, LY4052031, for people with advanced cancers like bladder, breast, and lung cancer. It aims to see if the drug is safe, what dose works best, and if it helps shrink tumors. It's an early-stage study to gather important information.
United States · Australia · China - recruiting
Liquid Biopsy for Early DiagNosis of Squamous Cell Carcinoma of the HeAd and NeCk rEgion
This study is looking into a new, simple blood test called a "liquid biopsy" to help find head and neck cancer earlier. By checking tiny bits of DNA in your blood, doctors hope to speed up diagnosis, helping people get treatment sooner and potentially improving their chances of recovery.
United Kingdom - not yet recruitingPHASE2
Surgery and Reducing Ionizing Radiation of the Unknown Primary
This study looks at new ways to treat head and neck cancer when the original spot isn't found, especially cancers linked to HPV. It explores whether less radiation or surgery alone can be just as effective while reducing side effects.
Australia · Canada - active not recruitingPHASE2
Pembrolizumab and Lenvatinib After Definitive Chemoradiation of Locally Advanced HNSCC
This study is testing if a combination of two drugs, pembrolizumab and lenvatinib, works better than pembrolizumab alone for people with a type of head and neck cancer. This is given after initial treatment.
Germany - recruitingPHASE2
Immunotherapy and Carbon Ion Radiotherapy In Solid Cancers With Stable Disease
This study looks at combining two treatments — immunotherapy and a special type of radiotherapy called carbon ion therapy — for certain cancers that haven't worsened with current immunotherapy. It aims to see if this combination is safe and effective.
Germany · Italy - active not recruitingPHASE2
Stereotactic Radiotherapy Combined With Chemotherapy or Not for Treatment of Oligometastases in HNSCC
This study looks at treating head and neck cancer that has spread a little, comparing powerful X-ray treatment (stereotactic radiotherapy) alone or with chemotherapy. We're checking how people feel, their quality of life, and if there are fewer side effects.
France - active not recruiting
Real-time Detection of ctDNA and/or HPV DNA in High-risk Locally-advanced Head and Neck Squamous Cell Carcinoma
This study looks at new ways to detect head and neck cancer coming back after treatment. We're testing a special blood test that can find tiny bits of cancer DNA in patients with advanced head and neck cancer, to see if it can help us understand and treat the disease better.
Canada - active not recruitingPHASE2
Evorpacept (ALX148) in Combination With Pembrolizumab and Chemotherapy in Patients With Advanced Head and Neck Squamous Cell Carcinoma (ASPEN-04)
This study looks at a new drug, evorpacept, combined with pembrolizumab and chemotherapy for advanced head and neck cancer. It aims to see if this new combination is effective for patients who haven't had treatment for their advanced disease.
United States · Australia · Belgium - recruitingPHASE3
A Phase 3 Study to Evaluate Petosemtamab Compared With Investigator's Choice Monotherapy in Previously Treated Head and Neck Squamous Cell Carcinoma Patients (LiGeR-HN2)
This study is looking at a new treatment called petosemtamab for advanced head and neck cancer. It compares this new drug with standard treatments chosen by doctors, for patients whose cancer has come back or spread after previous therapies.
United States · Argentina · Australia - ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
A Study of PF-08046031 in Adults With Advanced Melanoma and Other Solid Tumors
This study is testing a new medicine, PF-08046031, for adults with advanced melanoma (a type of skin cancer) and other solid cancers like lung, head and neck, and oesophageal cancer. This is an early-stage study to see if the medicine is safe and how it works in the body.
Germany · Sweden · France - recruitingNA
Thermotherapy in Addition to SOC Palliative Radiotherapy
This study looks at adding a gentle heat treatment (thermotherapy) to standard radiotherapy for certain advanced or recurrent head, neck, skin, or breast cancers. It aims to see if this combination is safe and helps shrink tumours more effectively for patients in the UK.
United Kingdom - recruitingPHASE1, PHASE2
A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors
This study is looking at a new drug called MCLA-158 for advanced cancers like bowel and head and neck cancer. It aims to find the safest dose and see how well it works alone or with other treatments. It's for patients whose cancer has spread or come back.
United States · Belgium · France - active not recruitingPHASE1
A Study to Test Whether Treatment With BI 770371 in Combination With Pembrolizumab With or Without Cetuximab Helps People With Head and Neck Cancer Compared With Pembrolizumab Alone
This study is for adults with head and neck cancer that has spread or returned. It tests if combining new medicines like BI 770371, pembrolizumab, and cetuximab can shrink tumors better than pembrolizumab alone. It aims to see if these combinations help the immune system fight cancer.
United States · Australia · Brazil - authorisedTherapeutic exploratory (Phase II)
A phase II study of ficerafusp alfa (BCA 101) in combination with nivolumab in platinum refractory head and neck squamous cell carcinoma patients who progressed within 6 months after multimodal treatment for locally advanced disease ( BICARA)
This study is testing a new combination treatment, Ficerafusp Alfa and Nivolumab, for a type of head and neck cancer. It's for patients whose cancer has come back or worsened after previous treatments. Researchers want to see how well this new treatment shrinks the cancer.
France - ongoing, recruitingTherapeutic exploratory (Phase II)
A Randomized, Phase 2, Open-Label, Multi-Arm Study of Tislelizumab in Combination With Investigational Agents as First-Line Treatment in Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma
This study is testing new combinations of medicines to treat a type of head and neck cancer that has come back or spread. Doctors are looking at how well these new treatments shrink the cancer and if they are safe.
France · Italy · Spain - recruitingPHASE3
A Phase 3 Study to Evaluate Petosemtamab Plus Pembrolizumab vs Pembrolizumab in First-line Treatment of Head and Neck Cancer (LiGeR - HN1)
This study compares a new treatment combining petosemtamab and pembrolizumab with pembrolizumab alone for advanced head and neck cancer. It aims to see if the combination works better and is safe for patients whose cancer has come back or spread.
United States · Argentina · Australia - active not recruitingPHASE2
Evorpacept (ALX148) in Combination With Pembrolizumab in Patients With Advanced Head and Neck Squamous Cell Carcinoma (ASPEN-03)
This study looks at a new drug, evorpacept, combined with an existing one, pembrolizumab, for advanced head and neck cancer. It aims to see if this combination works better than pembrolizumab alone for patients who haven't had treatment for advanced stages of their cancer. It's a Phase 2 trial, meaning it's still in earlier stages of testing.
United States · Australia · Belgium - active not recruitingPHASE2
Study of Novel Treatment Combination Therapies in Participants With Head and Neck Squamous Cell Carcinoma Regardless of PD-L1 Expression Status; Substudy-01
This study is testing new combinations of treatments for head and neck cancer that has come back or spread. It compares two new drugs plus chemotherapy against one new drug plus chemotherapy. The aim is to find safer and more effective ways to treat this type of cancer.
United States · Australia · China - active not recruitingPHASE2
A Study of Tislelizumab in Combination With Investigational Agents in Participants With Head and Neck Squamous Cell Carcinoma
This study is looking at a new treatment called tislelizumab, sometimes combined with other medicines, for head and neck cancer that has come back or spread. The aim is to see if it can shrink tumours and if it's safe for patients.
United States · Australia · Canada - recruitingPHASE1
A Phase 1, Dose-escalation Study of [225Ac]-FPI-2068 in Adult Patients With Advanced Solid Tumours
This study is testing a new medicine for people with advanced cancers that haven't responded to other treatments. It aims to see how safe the medicine is, how it moves through the body, and what dose works best.
United States · Canada