- active not recruitingPHASE1
Safety, PK/PD, and Immunogenicity Study of SC ALXN2030 in Healthy Participants
This study is looking into a new medication called ALXN2030. We want to check how safe it is and if it causes any side effects in healthy people. We're also seeing how the body handles the medicine. It's an early-stage study to gather important safety information.
United Kingdom - recruiting
Imaging Measures of Respiratory Health Registry
This study uses special MRI scans to understand lung health, both in people with breathing problems and healthy individuals. It helps scientists learn more about how lungs work and aims to find new ways to analyse these scans for better treatment in the future.
Canada - not yet recruitingNA
Metabolic Availability of Lysine From Barley in Young Adult Men
This study looks at how much of an important building block, called lysine, our bodies can get from barley. We're testing different cooking methods to see which ones help your body use more of barley's nutrients.
Canada - active not recruitingPHASE4
A Bronchoscopy Study to Assess the Effects of Inhaled Corticosteroids on Adult Healthy Volunteers
This study looks at how a common asthma medicine (fluticasone propionate) affects healthy lung cells. We want to understand these effects better to help in developing new treatments for severe asthma. Healthy adults will either receive the medicine or no treatment, and their lungs will be checked.
United Kingdom - not yet recruitingNA
Effects of Repetitive Transcranial Magnetic Stimulation on Two Cerebellar Targets
This study looks at how brain stimulation affects different areas of the brain that control movement and thinking. It uses a safe method called rTMS on healthy volunteers to learn how our brains work. This helps scientists develop new treatments for brain conditions.
France - recruiting
Quantifying 18kDa TSPO Expression in the Lung in Pulmonary Artery Hypertension (PAH)
This study aims to see if a special scan can detect changes in the lungs of people with Pulmonary Arterial Hypertension (PAH). By comparing these scans to healthy people, we hope to find a new way to check if treatments for PAH are working.
United Kingdom - recruitingNA
Eccentric Muscle Training, Stimulation, and Biomarkers in SCI
This study looks at a new way to help people with spinal cord injuries walk again. It combines gentle downhill treadmill walking with mild electrical stimulation. Researchers will check blood and spinal fluid to find the best time to start this training.
United States · Canada - active not recruitingNA
Determination of the Biological Activity of Enriched Serums on Healthy Volunteers After Consumption of the Kera-Diet® Ingredient
This study looks at how a special nutrient from a Kera-Diet supplement affects healthy cells in a lab. We want to see if the blood of healthy young men who take this supplement can help keep cells working well, especially when under stress.
France - recruitingNA
Interaction Between Dairy and Gut Hormone Response on Cognitive Performance in Children.
This study explores how different types of milk and yogurt affect how well children aged 9-14 think and learn. Researchers will compare full-fat, low-fat, and fat-free options, as well as skipping snacks, to see if dairy can improve brain function through gut hormones.
Canada - active not recruitingNA
Reconfirming the Safety and Performance of the Glyconics-DS System in Known Populations With and Without Diabetes
This study is checking a new way to test for diabetes using your fingernails. It uses a special light to look for sugar levels in your nails. Researchers want to make sure it's safe and works well for people with and without diabetes, comparing it to a standard blood test.
United Kingdom - recruitingNA
Effect of Sleep Extension in Prevention to Sleep Deprivation
This study looks at how not sleeping enough (sleep deprivation) affects how well people can run for a long time. It also checks if sleeping more than usual before an event (sleep extension) can help stop these negative effects, especially for people who do ultra-endurance sports.
France - recruitingPHASE3
BEATRIX: A Study to Learn About a Group B Streptococcus Vaccine in Healthy Pregnant Women and Their Babies
The BEATRIX study is looking at a vaccine for Group B Streptococcus (GBS) in pregnant women and their babies. It aims to understand if the vaccine is safe and how well it works to protect against GBS, a common bacteria that can sometimes cause serious infections.
United States · Argentina · Brazil - recruitingNA
Threonine Requirement in Adults >60 Years of Age
This study looks at how much threonine, an important nutrient from food, older adults need. Threonine helps protect your gut. Current recommendations are for younger adults, so this research aims to find the right amount for people over 60 to keep their gut healthy.
Canada - recruitingNA
Cycle Nation Communities: Increasing Cycling in Glasgow
This study in Glasgow checks if a 9-week cycling programme helps adults cycle more and improves their health, compared to a single cycling session. We're looking for adults who don't cycle much to take part.
United Kingdom - recruitingNA
The Effect of Short-term Supplementation of OliPhenolia® on Fat Oxidation
This study looks at whether a natural olive extract drink (OliPhenolia®) can help your body burn more fat during exercise. We're also checking if adding a caffeinated drink beforehand makes a difference for healthy, active people.
United Kingdom - recruiting
Contribution of the Kinematic Theory in the Early Differential Diagnosis of the Parkinson's Disease
This study looks for early signs of Parkinson's disease by studying hand movements, speech, and eye movements. Researchers want to see if these measurements can help tell the difference between people with Parkinson's, similar conditions, and healthy older adults aged 50-75.
Canada - recruitingNA
Does Abnormal Insulin Action in the Brain Underlie Cognitive and Metabolic Dysfunction in Schizophrenia
This study looks at whether problems with how the brain uses insulin might explain some thinking and memory issues, as well as common health problems like obesity and diabetes, in people with schizophrenia. Researchers will use a special scan after giving insulin through the nose to see how the brain reacts.
Canada - recruitingNA
Effects of Salbutamol in Athletes and Implications for Screening and Sports
This study looks at how a common asthma medicine (salbutamol) affects sports performance in healthy athletes. We want to see if it helps athletes who sometimes have trouble breathing during intense exercise, even if they don't have asthma. Understanding this could help with sports rules.
Canada - active not recruitingPHASE1
A Study in People With Overweight or Obesity to Compare How 2 Different Formulations of Survodutide Are Taken up by the Body
This study is looking at how two different forms of a new medicine, survodutide, are taken up by the body in healthy people who are overweight or have obesity. It aims to see if both forms work in a similar way.
United Kingdom - active not recruitingNA
Metabolic Availability of Methionine From Mung Beans in Healthy Adults
This study aims to understand how much useful protein, specifically an essential building block called methionine, our bodies can get from mung beans. Researchers will test different ways of cooking and combining mung beans to see how this affects their protein quality in healthy adult men.
Canada - recruitingNA
Bioavailability of Human Milk Oligosaccharides in Healthy Adults
This study looks at how the special sugars found in human milk, called HMOs, are used by healthy adults. We want to see if these sugars get into the bloodstream, as they might have benefits beyond digestion, like helping our immune system.
Germany - recruitingNA
Development of Electroencephalography (EEG) and Magnetoencephalography (MEG) Source Reconstruction With Fast Multipole Method
Researchers are looking at new ways to scan the brain more clearly and quickly. They want to see if combining special brain caps with new computer software can better show where brain activity happens during finger movements, nerve stimulation, and speech.
Germany - not yet recruiting
Measurement of Pro-resolving Inflammation Biomarkers in Saliva, Gingival Fluid, and Dental Pulp in Patients With Symptomatic Pulpitis and Healthy Controls
This study looks for early signs of tooth inflammation by checking spit, gum fluid, and tooth pulp. We want to see if these fluids can show how much a tooth is inflamed in people with toothache compared to healthy people. This could lead to easier ways to check tooth health.
France - active not recruitingPHASE1
A Study of SPY003-207 in Healthy Volunteers
This study is testing a new medicine, SPY003-207, for the first time in people. We want to see if it's safe, how much the body can handle, and how it moves through the body in healthy volunteers. Some people will get the medicine, others a dummy pill.
United States · Canada - recruiting
The Gut-Lung Axis and Respiratory Illness in Children
This study in Glasgow looks at how bugs in children's guts and lungs are linked, especially in kids with breathing or tummy problems. It wants to understand what a healthy link looks like and if these bugs change when children are unwell.
United Kingdom - recruiting
Muscle Mass, Quality, and the Menopause: Sex-specific Strategies to Mitigate Sarcopenia in Ageing Populations
This study looks at how menopause affects muscle and why women lose muscle faster than men as they age. Researchers will use special scans to see fat in muscles and speak to women about how exercise can help improve muscle strength and quality.
United Kingdom - not yet recruitingNA
Enhancing Health Literacy Through AI-Powered Chatbot: a Randomized Controlled Trial
This study looks at whether an AI chatbot can help Japanese caregivers understand more about HPV vaccination. It compares the chatbot to a leaflet to see which is better at helping them make decisions for their daughters aged 12-18.
United Kingdom - recruiting
Who Fares Best With Mindfulness Meditation
This study looks at how mindfulness meditation affects different people. It aims to find out who benefits most and who might experience problems. Researchers want to understand why mindfulness works for some and not for others, especially those with past trauma or negative thinking.
Belgium · United Kingdom - recruiting
Development of Novel MR Techniques Using Volunteer Participants
This study is developing new ways to use MRI scanners to get better and faster pictures of the body. We need healthy volunteers to help test these new scanning methods safely. It's about improving the technology, not about your health.
United Kingdom - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A TQT Study to Investigate the Effect of Enpatoran on Cardiac Repolarization in Healthy Participants
This study is looking at how a new medicine, called Enpatoran, affects the electrical activity of your heart. It's for healthy people aged 18 and over, and it's one of the first tests in humans to make sure the medicine is safe and doesn't cause heart problems.
Germany - recruiting
Development of a Non-invasive Screening Tool to Predict Metabolic Dysfunction-associated Steatotic Liver Disease
This study aims to develop a simple way to find liver disease commonly linked to weight and lifestyle, called MASLD (Fatty Liver Disease). We're looking at healthy volunteers and people with known MASLD to create a tool that can easily predict the condition without needing complicated tests.
United Kingdom - active not recruitingNA
Trimethylamine N-oxide Effects of a Pomegranate Supplement Simultaneously With Carnitine (TESSA)
This study looks at whether pomegranate extract can lower a substance called TMAO in healthy adults. TMAO is made when your body processes certain foods like meat and dairy, and high levels might be linked to heart disease. Researchers want to see if adding pomegranate can help reduce it.
United Kingdom - ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
A pivotal, randomized, open-label, two-treatment, two-sequence, four periods, crossover clinical trial to evaluate the bioequivalence of single doses of Test product Sacubitril/Valsartan, film-coated tablets 97 mg/103 mg (Manufacturer: JSC «Farmak», Ukraine) and Reference Entresto®, film-coated tablets 97 mg/103 mg (Novartis Europharm Limited, Ireland) in healthy subjects under fasted conditions
This study compares a new heart medicine from Ukraine with an existing one called Entresto. It aims to check if they work the same way in healthy people. Volunteers take both medicines, one after the other, to see how well their bodies absorb them when not eaten with food.
Poland - recruitingPHASE1
Single and Multiple Dose Pharmacokinetics (PK) of Aramchol From an Aramchol Meglumine Tablet
This study looks at a new medicine called Aramchol, in tablet form, for healthy adults. We want to see how the body absorbs and uses different doses of Aramchol and how much stays in the body over time. This helps us find the best way to give the medicine.
United Kingdom - recruitingNA
The Combined Effect of Dietary Nitrate and Caloric Restriction on Cognitive and Vascular Function.
This study looks at how beetroot juice and a special diet affect brain function and blood vessels in healthy older adults. Some will have a calorie-restricted diet, while others will maintain their weight. It's a pilot study to see if combining these approaches is helpful.
United Kingdom - not yet recruiting
Clinical and Radiographic Outcomes of the JointMedica Custom-Made Resurfacing Device
This study looks at a special custom-made hip cap for people with hip pain. It checks how well it works and if it's safe, especially how long it lasts and if it helps people move better and feel less pain. It gathers information from everyday patient experiences.
United Kingdom - recruiting
Genetic Variants and Regulation of Specialized Pro-resolving Mediator
This study looks at how tiny changes in our genes might affect how our bodies handle inflammation. We're trying to understand why some people get long-term inflammatory diseases like arthritis and heart conditions, hoping to find new ways to treat them.
United Kingdom - recruitingPHASE1
Digital Intervention for Psychedelic Preparation (DIPP): Comparing Meditation and Music-Based Programs
This study looks at how digital programs can prepare healthy people for a single 25mg psilocybin session. It compares a meditation program with a music program, checking if they are practical and how they affect the experience and well-being.
United Kingdom - recruitingNA
De-stressing the Brain: Can Eating Grapes During Periods of Mental Stress Protect Brain and Vascular Health in Young Adults
This study looks at whether eating grapes before stressful tasks can protect your brain and blood vessels. Researchers want to see if special compounds in grapes called flavonoids help young adults handle stress better, improving mood and thinking abilities.
United Kingdom - enrolling by invitation
Do Daily Disposable Soft Contact Lenses Require Frequent Checks After the Initial Fitting is Complete in Adults Under 40 With No Contraindications
This study looks at whether adults under 40 who wear daily disposable contact lenses really need lots of check-up appointments after their first fitting. Researchers want to find out the best number of visits. We're interested in healthy people new to lenses or who already wear them.
United Kingdom - not yet recruitingNA
Examining Lithium's Mechanism in Bipolar Disorder
This study looks at how lithium, a medicine for bipolar disorder, affects how healthy people react to light. We'll check how light affects your body and mind, and see how lithium changes this. This could help us understand how lithium works.
United Kingdom - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A PHASE 1 STUDY TO ASSESS THE EXCRETION BALANCE, PHARMACOKINETICS, AND METABOLISM OF 14CDC806 IN HEALTHY VOLUNTEERS
This study is looking at how a new drug, DC-806, moves through the body in healthy men. It aims to understand how much of the drug gets absorbed, how it's processed, and how it leaves the body, primarily through urine and faeces.
Netherlands - recruitingNA
Sex Hormones as Regulators of the Age- and Sex-dependent Benefits of Caloric Restriction
This study looks at how hormones, age, and sex affect weight loss from dieting. We want to understand why some people find it harder to lose weight and how diet affects women's health to help fight obesity.
United Kingdom - ongoing, recruitingHuman Pharmacology (Phase I)- Other
Physiologically based pharmacokinetic modelling of oral and intranasal formulations of zolmitriptan in healthy volunteers
This study is looking at how a specific migraine medicine, zolmitriptan, works in the body when taken as a tablet or a nose spray. It involves healthy adult volunteers to understand how the medicine is absorbed and processed.
Spain - recruitingNA
The Effects of the Bile Acid Supplement, 7-keto Lithocholic Acid, on Human Gut Microbiota and Risk Factors for Disease.
This study looks at how a natural supplement, 7-keto lithocholic acid (7-KLCA), might improve your gut health. We want to see if it helps good bacteria in your gut grow and if this could lead to better overall health.
United Kingdom - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A study to test how well different doses of BI 1815368 are tolerated by healthy men
This study is looking for healthy men aged 18 and over to test a new medicine chiamato BI 1815368. The main goal is to see how different doses are handled by the body and if they are safe. It's a very early stage of testing new medicines.
Belgium - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A phase I, open-label trial in two parallel parts to investigate mass balance, metabolism, and basic pharmacokinetics of BI 1810631 (C-14) administered as oral solution (part A) and to investigate absolute bioavailability of BI 1810631 administered as film-coated tablet together with an intravenous microtracer dose of BI 1810631 (C-14) (part B) in healthy male volunteers
This study looks at how a new medicine, BI 1810631, travels through the body and how much reaches the bloodstream. It helps us understand how the body processes the medicine when taken as a liquid or a tablet.
Netherlands - recruitingNA
Investigating the Clinical Utility of the Oxford Virtual Autism Assessment Tool (OVAAT)
This study is testing a new online tool, the Oxford Virtual Autism Assessment Tool (OVAAT), to see how well it can spot signs of autism in young people aged 13-18. Researchers want to know if it's as good as or better than existing assessments.
United Kingdom - recruiting
A Study Measuring Markers of Airway Inflammation in Breath Samples From People With Respiratory Diseases and Healthy Volunteers.
This study looks for early signs of lung cancer and other lung problems by testing breath. We're trying to find a simple, quick way to help doctors decide who needs more tests, especially for people with ongoing breathing issues.
United Kingdom - recruitingNA
Mapping the Impact of Gut Microbiota on Brain and Behavior Through the Lens of GABA
This study explores how gut bacteria, specifically those making GABA, might affect our brains and behavior. We're looking to see if taking a special probiotic can change GABA levels in the brain and improve how people perform on certain tasks.
United Kingdom