- recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
Bioequivalence clinical trial of two formulations of dapagliflozin/metformin
This early-stage study compares two different tablet versions of dapagliflozin and metformin in healthy adults aged 18 and over. Researchers want to confirm that both formulations release the medicines into the bloodstream at the same rate and amount, ensuring they work equally well in the body.
Spain - authorisedHuman Pharmacology (Phase I)- Other
Detection of rEPO using Dried Blood Spot (DBS)
This study tests whether a simple finger-prick blood test can detect a substance called rEPO. Dried blood spot testing uses tiny drops of blood dried on paper cards. Researchers want to see if this quick, easy method works accurately in healthy adult volunteers aged 18 and older.
Spain - authorisedHuman Pharmacology (Phase I)- Other
Pharmacokinetics, safety and tolerability of tramadol after multiple-dose
This early-stage study looks at how the body processes repeated doses of tramadol, a common painkiller. Healthy adult volunteers will take the medicine over a set period. Researchers will check how it moves through the bloodstream and monitor for any side effects to help ensure it is safe.
Spain - recruitingPHASE1, PHASE2
A Study of RO7830698 in Healthy Participants and Participants With Chronic Obstructive Pulmonary Disease
This study tests a new potential medicine called RO7830698. Researchers want to find out how safe it is and how it behaves in the body. The trial involves both healthy volunteers and people with chronic obstructive pulmonary disease (COPD). It compares the new medicine against a dummy treatment called a placebo.
United Kingdom - recruitingNA
Satiety, Microbiome, Appetite Regulation, and Tracking Energy Across Targeted Snacks: Acute Postprandial Study
This study looks at how different snack bars affect hunger, energy levels, and eating habits in healthy adults. Participants will try two types of snack bars over a few days, filling out short surveys to see how they feel afterwards. It's a remote study, meaning you can take part from home.
United Kingdom - recruitingHuman Pharmacology (Phase I)- Other
A study to investigate the effect of capivasertib on the pharmacokinetics of oral dextromethorphan (CYP2D6) in healthy participants
This study looks at how a medicine called capivasertib affects how the body breaks down another medicine, dextromethorphan. It involves healthy adult volunteers. The findings will help doctors understand if capivasertib changes the way other everyday medicines work, helping to keep future patients safe from unwanted drug interactions.
Germany - recruitingPHASE1
A Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of DNL921 in Healthy Participants and Participants With Alzheimer's Disease
This study is looking at a new potential medicine, DNL921, for Alzheimer's disease. Researchers want to see if it's safe, how the body handles it, and how it affects the body. They're testing it in healthy people and those with early Alzheimer's.
United Kingdom - recruitingHuman Pharmacology (Phase I)- First administration to humans
A study to learn if UCB3101 is safe and how it moves through the body of healthy participants
This study is looking at a new medicine called UCB3101 for the very first time in people. We want to find out if it's safe and how it works in the body. Volunteers who are healthy adults are needed to help us learn more about this potential new drug.
Belgium - recruitingTherapeutic exploratory (Phase II)
Effect of Modafinil on military observational performance and residual capacity of the Dutch Air Assault Brigade: a field trial
This study looked at how a medicine called modafinil affected the mental sharpness and performance of healthy soldiers. Researchers wanted to see if it helped them stay alert and perform better during their duties.
Netherlands - recruitingHuman Pharmacology (Phase I)- Other
AN OPEN-LABEL, RANDOMIZED STUDY TO EVALUATE THE RELATIVE BIOAVAILABILITY OF A NEW TABLET FORMULATION OF MINZASOLMIN AND THE POTENTIAL EFFECT OF FOOD ON THE PHARMACOKINETICS OF MINZASOLMIN IN HEALTHY PARTICIPANTS
This study looks at a new tablet version of a drug called Minzasolmin. We want to see how well the body absorbs it compared to an older form, and if food changes how it works. This is an early study in healthy people.
Germany - completedPhase I
Study to assess the pharmacokinetics, tolerability, and food effect of PTC923 in healthy subjects
Researchers in the UK are testing a new medicine called PTC923 in healthy volunteers aged 18 to 55. The medicine is being developed to treat phenylketonuria (PKU), a rare brain condition. This study checks how the body handles the drug and whether food changes how well it works.
United Kingdom · England - completedPhase I
A study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of BCX10013 in healthy participants
This study is testing a new medicine, BCX10013, for the very first time in healthy people. It aims to see if it's safe, how the body handles it, and how it affects a part of the immune system. This could help treat future patients.
United Kingdom · England · Netherlands - recruitingPHASE1
Comparing the Extent to Which Romosozumab (AMG 785) is Made Available in the Body When Administered as a Single SC Injection or as 2 SC Injections
This study is looking at how a new medicine, Romosozumab, gets into the body. We want to see if one injection works the same as two smaller injections. It's for healthy people aged 18-60 to help us understand the best way to give this medicine.
United States · United Kingdom - recruitingPHASE1
A Study to Investigate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AZD1043 in Healthy Adult Participants Living With Overweight and/or Obesity.
This study is looking into a new medication called AZD1043 for people who are overweight or have obesity. Researchers want to understand if it's safe, how the body handles it, and how it affects the body.
United States · United Kingdom - recruiting
GEL & MEDication Dysphagia
This study looks at how people with certain health conditions find it hard to swallow medicines. It tests if special gels or thicker foods can help them swallow pills more safely and easily. This could help prevent problems and make taking medicine better for those with swallowing difficulties.
Germany - active not recruitingPHASE1
A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of UCB5285 in Healthy Study Participants
This study is looking into a new medicine called UCB5285. We want to see if it's safe and how the body handles it in healthy people, including those of Japanese background. It's an early-stage study to understand the medicine better.
United Kingdom - recruitingPHASE1
Impact of PEG Bowel Preparation on Gut Microbiome Composition Recovery
This study looks at how a common bowel cleansing drink, PEGLyte, affects the helpful germs (microbiome) in your gut. It aims to understand these changes and how quickly your gut returns to normal after taking the drink.
Canada - recruitingNA
Non-invasive Ultrasonic Auricular Vagus Nerve Stimulation
This study looks at a new, gentle way to stimulate a special nerve called the Vagus nerve using sound waves instead of electricity. It aims to see how this affects healthy people's bodies and minds, hoping to find new ways to help with conditions like anxiety or depression in the future.
United Kingdom - recruitingNA
Evaluation of the Role of miR-1 in the Pathogenesis and as a Biomarker in Muscular Dystrophies and Congenital Myopathies
This study looks at a tiny molecule called miR-1 in blood to see if it can help doctors understand and track muscle diseases like Duchenne muscular dystrophy. We want to find out if changes in miR-1 levels show how the disease is progressing.
France - recruitingPHASE1
A Study to Investigate the Safety and Pharmacokinetics of Single- and Multiple-ascending Doses of AZD4916 in Healthy Volunteers
This study is looking at a new medicine called AZD4916 in healthy adults. Researchers want to check if it's safe and how it moves through the body after taking different doses, both once and multiple times.
United States · United Kingdom - recruitingNA
tVNS and Approach-Avoidance Behavior in Anhedonia and Anxiety
This study looks at how anxiety and anhedonia (loss of pleasure) affect how people react to rewards and threats. It also checks if a gentle electrical stimulation (tVNS) to a nerve in your neck can help. It involves online tasks, brain scans, and virtual reality games.
Germany - recruitingPHASE4
Rate of Tranexamic Acid Administration on Blood Pressure (RateTXA) Study.
This study looks at how fast we give tranexamic acid (a drug to stop bleeding) to pregnant women having a C-section affects their blood pressure. We're comparing giving it over 1 minute versus 10 minutes to see if the speed makes a difference.
Canada - active not recruitingPHASE1
A Study to Assess the Relative Bioavailability of Different Subcutaneous Formulations ofAZD6234
This study looks at how a new medicine, AZD6234, gets into the body when given in different ways. It aims to find the best way to give the medicine and check for any side effects in healthy people.
United Kingdom - recruitingNA
The Effect of Ketone Monoesters on Skeletal Muscle Protein Synthesis and Whole-body Protein Metabolism.
This study looks at how a special drink called a ketone monoester, taken with protein, affects muscle growth and repair in healthy young adults. We want to see if it can help muscles get stronger and recover better.
United Kingdom - active not recruitingPHASE1
A Study to Investigate Andexanet Dosing and the Interaction Between Andexanet and Subsequent Enoxaparin in Healthy Participants
This study is testing a new medicine called Andexanet. It's for healthy people aged 18 to 55. We want to see how Andexanet works with common blood thinners like Rivaroxaban and Apixaban, and if it affects another blood thinner called Enoxaparin. This helps doctors understand how to use Andexanet safely.
Germany · United Kingdom - active not recruitingPHASE2
A Study of Annual Doses of MK-1406/CD388 in Healthy Adults (MK-1406-006/CD388.SQ.2.07)
This study looks at the new drug CD388 in healthy adults. It checks if taking it once a year for two years is safe and how your body reacts to it, especially if you had a good experience with it before. Researchers also want to see if your body makes substances that fight the drug.
United States · United Kingdom - active not recruitingPHASE1
A Study of Absorption, Distribution, Metabolism and Excretion (ADME) of [14C]AZD4144
This study in Nottingham is looking for healthy men aged 30-65. It aims to understand how a new medicine moves through the body, how it's broken down, and if it causes any side effects. We'll track it using a tiny amount of carbon-14.
United Kingdom - enrolling by invitation
Do Daily Disposable Soft Contact Lenses Require Frequent Checks After the Initial Fitting is Complete in Adults Under 40 With No Contraindications
This study looks at whether adults under 40 who wear daily disposable contact lenses really need lots of check-up appointments after their first fitting. Researchers want to find out the best number of visits. We're interested in healthy people new to lenses or who already wear them.
United Kingdom - recruitingPHASE1, PHASE2
Study of TGM-312-SC01 in Healthy Participants and Adults With MASH
This study is testing a new medicine, TGM-312-SC01, for liver condition called MASH. We want to see if it's safe, what dose works best, and how it affects the body in both healthy people and those with MASH.
United Kingdom - not yet recruitingPHASE1
Safety, Tolerability, PK, and PD of TGM-148 in Healthy Participants
This study is looking into a new treatment called TGM-148. We want to check if it's safe and how the body handles it in healthy adults aged 18-45. Volunteers will receive either TGM-148 or a dummy treatment (placebo). This is a very early stage of testing new medicines.
United Kingdom - active not recruitingNA
Probiotics in Wellbeing
This study looks at whether a daily probiotic supplement can improve general wellbeing and reduce inflammation in healthy adults. It will compare a probiotic capsule with a dummy capsule over 12 weeks to see if it helps the gut, immune system, and brain communicate better, potentially boosting mood and memory.
United Kingdom - recruitingNA
Satiety, Microbiome, Appetite Regulation, and Tracking Energy Across Targeted Snacks: Chronic Study
This study is looking at how a special high-fibre snack bar affects hunger and gut health over 4 weeks. You'd eat two snack bars daily and provide samples and complete surveys from home. It aims to see if this bar helps you feel fuller and improves your gut compared to a regular snack bar.
United Kingdom - recruitingPHASE1
A Drug-drug Interaction Study to Assess the Effect of Phenytoin and Itraconazole on the Pharmacokinetics of Pelabresib in Healthy Participants
This study looks at how a new medicine, pelabresib, interacts with two common drugs, phenytoin and itraconazole, in healthy people. We want to understand how these drugs affect pelabresib's levels in the body and check for safety.
United Kingdom