- completedPhase I
Deferred registration - Quotient Sciences code: QSC303694
This is an early Phase 1 research study looking for healthy men aged 18 to 65. Its purpose is to check the safety of a new medicine and see how the body handles it. Detailed information about the study medicine is temporarily private while early testing gets under way.
United Kingdom · England - recruitingPhase I
Deferred registration: HMR code: 25-008
This is an early-stage Phase 1 clinical trial looking for healthy adult volunteers aged 18 to 55. It aims to test a new treatment for safety. Full scientific details are currently withheld under standard UK research rules, but more information will be published as the study moves forward.
United Kingdom · England - completedPhase I
Phase I trial: MM-120-101
This is an early Phase 1 clinical trial called MM-120-101 looking for healthy volunteers. The UK Health Research Authority has agreed that full trial details can stay confidential for now. All details and results will be made fully public within 30 months after the trial finishes.
United Kingdom · England - completedPhase I
Deferred Registration: Quotient Sciences Code: QSC303709
This is an early-stage Phase 1 clinical trial run by Quotient Sciences in the UK. The study is testing the safety of a potential new medicine in healthy male volunteers aged 30 to 65. Specific details about the medicine are temporarily confidential and will be published once initial testing finishes.
United Kingdom · England - completedPhase I
Deferred Registration: Quotient Sciences Code: QSC303955
This is an early-stage Phase 1 clinical trial for healthy adults aged 18 to 55. It tests the safety of a new medicine. Detailed information about the drug is currently kept confidential under official UK research rules, but it will be made public once this initial stage finishes.
United Kingdom · England - recruitingPhase I
Deferred Registration - Quotient Sciences Code: QSC303945
This is an early-stage Phase 1 clinical trial looking for healthy men aged 30 to 65. It is run by Quotient Sciences to test the safety of a new medicine. The exact drug details are currently kept private under standard UK trial rules and will be published later.
United Kingdom · England - recruitingPhase I
Deferred registration - Quotient Sciences Code: QSC304026
This is an early-stage Phase 1 clinical trial looking for healthy male volunteers aged 30 to 65. Run by Quotient Sciences, the trial checks the safety of a potential new treatment. Full study details are temporarily withheld under standard registry rules and will be published once this deferral period ends.
United Kingdom · England - recruitingNot Applicable
Safety and tolerability of a skin sensor for glucose and lactate
Researchers in Liverpool are testing a new wearable skin sensor. It uses tiny needles to measure sugar (glucose) and lactate levels. This trial tests whether the sensor is safe, comfortable, and accurate in healthy adults aged 18 to 45. It could help doctors monitor unwell hospital patients in the future.
United Kingdom · England - recruitingHuman Pharmacology (Phase I)- Other
A Phase I, open-label, non-randomized study to assess the absorption, distribution, metabolism and excretion (ADME) and pharmacokinetics of LTP001 following a single oral dose of [14C]LTP001 in healthy male participants
This early-stage study looks at how a new medicine, called LTP001, moves through the human body. Healthy adult men will take a single dose containing a safe, tiny tracking marker. Researchers will collect blood and urine samples to see how the body absorbs, breaks down, and removes the drug.
Netherlands - recruitingTherapeutic exploratory (Phase II)
Morphine effects on stress response and social interaction – an exploratory randomized controlled experimental medicine study
This study looks at how morphine affects the brain and body during social stress. Researchers want to see if this pain-relief medicine can reduce the emotional sting of being left out. Healthy adult volunteers will receive either a dose of morphine or a dummy saltwater drip before having a brain scan.
Sweden - recruitingHuman Pharmacology (Phase I)- Other
Study of exposure to substances prohibited by the World Anti-Doping Agency in healthy volunteers (ESPAMA_3). Proof of concept
This early-stage research study looks at how the human body processes substances that are banned in sports. Researchers want to see how these substances break down. This will help anti-doping laboratories develop better, more accurate drug tests to keep sports fair and protect athletes from false test results.
Spain - recruitingTherapeutic use (Phase IV)
Ergogenic effects of pseudoephedrine on edurance performance in relation to the determination of threshold values in urine and capillary and venous blood
This study looks at whether pseudoephedrine, a common cold and decongestant medicine, boosts cycling performance in healthy adults. Researchers want to see how different doses affect speed, stamina, and heart rate during a 90-minute cycle test, and how the medicine shows up in blood and urine samples.
Belgium - recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
Bio-equivalence of Rosuvastatin 10 mg
This clinical trial is testing a 10 mg rosuvastatin tablet in healthy adults. Researchers want to check whether a new version of this cholesterol-lowering medicine enters the bloodstream in the same way as the original version. This helps ensure that more affordable, generic options remain safe and effective.
Netherlands - recruitingHuman Pharmacology (Phase I)- First administration to humans
Phase I study to evaluate safety and immunogenicity of V-212 in healthy adult volunteers.
This clinical trial is testing an experimental vaccine called V-212 in healthy adults aged 18 and older. Researchers want to find out if the vaccine is safe, see what side effects it might cause, and check how well it stimulates the body's natural immune system defences.
Belgium - recruitingHuman Pharmacology (Phase I)- Other
Mass Balance Study of [14C] ABBV-932 in Healthy Male Volunteers
This study is testing a new medicine called ABBV-932 in healthy adult men. Researchers want to see how the human body takes in, processes, and gets rid of the drug. A tiny, safe amount of a tracking tag is used to follow the medicine as it passes through the body.
Netherlands - recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
Bioequivalence clinical trial of two formulations of empagliflozin/metformin
This study tests two different versions of a combination tablet containing empagliflozin and metformin. Researchers want to confirm that both tablets release the same amount of medicine into the bloodstream at the same speed. It involves healthy adult volunteers to ensure the new version works just like the original.
Spain - authorisedHuman Pharmacology (Phase I)- Other
Randomized, crossover, comparative bioavailability study of two tadalafil formulations (oral suspension and film-coated tablets) after a single oral dose of 20 mg under fed conditions in healthy male volunteers.
This clinical trial compares a new liquid version of tadalafil with the standard tablet. Researchers want to see how the body absorbs both forms after a meal. The study is open to healthy adult men aged 18 and over to help create an option for people who struggle swallowing pills.
Spain - recruitingHuman Pharmacology (Phase I)- Other
Study of exposure to substances prohibited by the World Anti-Doping Agency in healthy volunteers (ESPAMA_4). Proof of concept
This early-stage research study looks at how substances banned in competitive sports behave in the human body. Researchers are studying healthy male volunteers aged 18 and over. The goal is to improve anti-doping tests, helping sports authorities detect cheating and keep athletic competitions fair and safe for everyone.
Spain - recruitingHuman Pharmacology (Phase I)- Other
A study to investigate the pharmacokinetics and safety of a single dose of duvakitug in healthy adult participants
This early-stage clinical trial looks at a new experimental medicine called duvakitug. Researchers want to find out how safe a single dose is and how it moves through the body in healthy adult volunteers. The findings will help scientists decide if duvakitug can be developed into a future treatment.
Germany - recruitingHuman Pharmacology (Phase I)- Other
Pilot, randomized, crossover, comparative bioavailability study of two tadalafil formulations (oral suspension and film-coated tablets) after a single oral dose of 20 mg under fasting conditions in healthy male volunteers.
This study tests a new liquid version of tadalafil, a medicine commonly used for erectile difficulties. Researchers want to see if the body absorbs this liquid just as well as the standard tablet. Healthy men aged 18 and older will take single doses on an empty stomach to compare them.
Spain - recruitingHuman Pharmacology (Phase I)- Other
A trial to learn how well different doses of andexanet alfa work and how they affect blood clotting throughout the body in healthy adults who have taken an FXa inhibitor
This study tests different doses of a medicine called andexanet alfa in healthy adults. Researchers want to see how quickly and safely it reverses the effects of blood-thinning medicines (FXa inhibitors). This helps doctors learn how to stop serious bleeding in emergencies for patients taking these blood thinners.
Germany - recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
Bioequivalence clinical trial of two formulations of canagliflozin
This study tests two different versions of a medicine called canagliflozin in healthy adults. Researchers want to check if both tablets release the drug into the body in the exact same way. This helps make sure a new or generic version is just as safe and effective as the original.
Spain - authorisedHuman Pharmacology (Phase I)- Bioequivalence Study
Bioequivalence study of Vitamin D3 Pharma Patent 20,000 IU and the Vigantol 20,000 IU oral drops solutions and assessment of bioavailability in healthy volunteers
This clinical trial compares two liquid brands of high-dose vitamin D3 drops. Researchers want to see if the human body absorbs a newer brand in the exact same way as an established brand. The study is open to healthy adult volunteers aged 18 and over.
Hungary - recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
Bioequivalence clinical trial of two formulations of edoxaban.
This study is looking at two versions of a medicine called edoxaban in healthy volunteers. It wants to see if both versions act the same way in the body. This helps ensure new medicines work just as well as existing ones.
Spain - recruitingHuman Pharmacology (Phase I)- Other
A study to compare the pharmacokinetics of salbutamol administered via metered dose inhalers containing propellants HFA-152a (test) or HFA-134a (reference) in healthy participants aged 18 to 55 inclusive.
This study is looking at two types of asthma inhalers to see how a medicine called salbutamol is absorbed by the body. We need healthy people aged 18 to 55 to help us understand if a new version of the inhaler medicine works similarly to the current one.
Netherlands - recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
A Randomized, Double-blind, Controlled, Parallel-group, Single Dose, Three arm Study to Compare the Pharmacokinetic Similarity of MAB-22 Versus Prolia® Sourced from the European Union and United States in Healthy Male Participants
This study is looking at a new version of a medicine for bone conditions, called MAB-22. We want to see if it works the same way in the body as an existing medicine, Prolia®. Healthy men will take a single dose of one of these medicines.
Hungary · Netherlands - recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
A study to learn how zilucoplan moves throughout the body over time when given in 2 different ways in healthy adults
This study looks at a new medicine called zilucoplan in healthy adults. Researchers want to see how the medicine moves through the body over time when given in two different ways. It's an early-stage study to understand the medicine better.
Netherlands - recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
Bioequivalence clinical trial of two formulations of linagliptin
This study is looking at how two different versions of a medicine called linagliptin work in the body. We need healthy volunteers to help us understand if the new version is just as good as an existing one. This is an early-stage study to check the medicine's effects.
Spain - recruitingHuman Pharmacology (Phase I)- First administration to humans
Investigation of Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single Subcutaneous Injections of NNC0582-0001 in Healthy Adults
This study is looking at a new medicine called NNC0582-0001, given as a single injection under the skin. It aims to check if it's safe and how the body handles it in healthy adults. This is the very first time this medicine is being tested in people.
Austria - recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
Bioequivalence clinical trial of two formulations of dapagliflozin.
This study is looking at two versions of a diabetes medicine called dapagliflozin in healthy people. It wants to check if they act the same way in the body. This is a very early stage of testing.
Spain - recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
Bioequivalence clinical trial of two formulations of bilastine.
This study is testing if two versions of a hay fever medicine called bilastine work the same way in healthy people. It's a very early stage of testing to make sure new medicines are just as good as existing ones.
Spain - recruitingTherapeutic use (Phase IV)
YF_PROTECT: Prophylactic Treatment with Sofosbuvir for Yellow fever Exemption Circumstances and Travel
This study is looking at whether a medicine called Sofosbuvir could help people who can't have the Yellow Fever vaccine. It's testing if the medicine can stop the Yellow Fever virus from being detected in the body after vaccination, acting as a 'protective' treatment.
Netherlands - recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
Bioequivalence clinical trial of two formulations of linagliptin/metformin
This study is checking if two different versions of a medicine for type 2 diabetes, containing linagliptin and metformin, work in the same way in healthy people. It's a first step to make sure any new version is just as good as the original.
Spain - recruitingHuman Pharmacology (Phase I)- Other
Randomized, crossover, two-period, comparative bioavailability study of two ibuprofen (arginate) formulations, administered as solutions in single oral dose of 400 mg to healthy subjects under fasting conditions.
This study is looking at two types of liquid ibuprofen arginate. We want to see how well they get into the body and if they work the same way. It's for healthy adults who haven't eaten, and they'll get a single dose of 400 mg.
Spain - recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
Bioequivalence clinical trial of two formulations of linagliptin/metformin.
Researchers are comparing two versions of a blood sugar lowering medicine. This study is for healthy volunteers to see if the body uses these two versions in the same way. It helps ensure new medicines work as expected.
Spain - recruitingHuman Pharmacology (Phase I)- First administration to humans
A DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED, PHASE I STUDY TO ASSESS THE SAFETY, TOLERABILITY, AND PHARMACOKINETICS OF SINGLE ANDMULTIPLE ASCENDING DOSES OF THN391 IN HEALTHY SUBJECTS
This early-stage study is looking for healthy volunteers to test a new medicine called THN391. We want to see if it's safe, how well the body handles it, and how it moves through the body after single and repeated doses. It's the first time this medicine will be given to people.
Netherlands - recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
Bioequivalence clinical trial of two formulations of loperamide.
This study is looking at how two different versions of a common medicine for tummy troubles, called loperamide, are absorbed by the body. We need healthy volunteers to help us understand if they work in the same way. It's an early-stage study to check the medicine's behaviour.
Spain - recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
KF2024#1 trial: Esketamine interaction study
This study is looking at how a new drug called esketamine works in healthy people. It's a very early stage of research to understand how the body uses and gets rid of the medicine, and if it's the same as another known version of the drug.
Finland - recruitingTherapeutic exploratory (Phase II)
A randomized, triple-blind, placebo-controlled study on the effect of rifaximin on psychobiological functions in healthy men.
This study is looking at how a medicine called Targaxan might affect how healthy men deal with stress. Researchers will check things like stress levels and gut health to understand its effects.
Belgium - recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
Bioequivalence study of GP-IMP-001 with regards to reference product
This study is looking at how a new drug called GP-IMP-001 is absorbed by the body compared to an existing drug. We need healthy male volunteers aged 18 and over to help us. It's an early-stage study to make sure the new drug works similarly.
Czechia - recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
Bioequivalence clinical trial of two formulations of vortioxetine.
This study is looking at two versions of a medicine called vortioxetine to see if they work the same way in the body. It’s for healthy adults and is an early-stage study to check how the medicine is absorbed.
Spain - recruitingHuman Pharmacology (Phase I)- First administration to humans
Phase 1 Safety and Tolerability Study of REGN9533 in Healthy Adults.
This study is looking for healthy adults to test a new medicine called REGN9533 for the very first time in people. The main goal is to check if it's safe to use and how well the body handles it. It's an early-stage study to gather important information.
Belgium - recruitingHuman Pharmacology (Phase I)- Other
Randomized, crossover, comparative bioavailability study of two Paracetamol-Ibuprofen 25-20 mg/ml oral suspension, administered in single dose to healthy subjects under fasting conditions.
This study is looking at two different liquid medicines that contain paracetamol and ibuprofen. We want to see how well and how quickly your body absorbs each medicine. It's for healthy adults and involves taking a single dose of each medicine on separate occasions.
Spain - recruitingHuman Pharmacology (Phase I)- Other
Randomized, open-label clinical trial (Phase 1) to evaluate safety, tolerability, pharmacokinetics and food effects of a single dose of IM-250 in healthy volunteers
This early-stage study is looking for healthy volunteers to test a new medicine called IM-250. We want to see if it's safe, how well the body handles it, and if food changes how it works. This is the first time it will be given to people.
Bulgaria - recruitingHuman Pharmacology (Phase I)- Other
A study investigating the safety, absorption, and elimination of RO7795068, a new compound that may potentially be used in the treatment of obesity
This study is looking into a new medicine, RO7795068, which might help treat obesity. We want to understand how safe it is and how the body takes it in and gets rid of it. We're inviting healthy volunteers to take part.
Netherlands - recruitingHuman Pharmacology (Phase I)- Other
Drug-Drug Interaction Study With BIA 28-6156 and Clarithromycin, Midazolam, and Dabigatran Etexilate in Healthy Participants
This study is looking at how a new drug, BIA 28-6156, reacts with three common medicines: clarithromycin (an antibiotic), midazolam (a sedative), and dabigatran etexilate (a blood thinner). We want to see if they affect each other when taken together, to make sure future patients can take them safely.
Belgium - recruitingHuman Pharmacology (Phase I)- Other
Phase I clinical trial to evaluate the pharmacokinetics, safety and tolerability of repeated topical application of PARENTIDE in healthy volunteers
This study is testing a new cream called PARENTIDE on healthy people. We want to see how the cream is absorbed, if it's safe, and if people can tolerate it when used repeatedly. It's an early-stage study to understand the new treatment better.
Spain - recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
Bioequivalence clinical trial of two formulations of ezetimibe/atorvastatin
This study is looking at how well two different versions of a medicine called ezetimibe/atorvastatin are absorbed by the body. This medicine is used to help lower cholesterol. We need healthy volunteers to take part and help us understand if the new version works the same as the established one.
Spain - recruitingHuman Pharmacology (Phase I)- Other
RANDOMIZED, CROSSOVER, TWO-PERIOD, COMPARATIVE BIOAVAILABILITY STUDY OF TWO IBUPROFEN FORMULATIONS, AFTER A SINGLE ORAL DOSE OF 400 MG IN SOLUTION FORM TO HEALTHY SUBJECTS UNDER FASTING CONDITIONS
This study compares two different ibuprofen medicines to see how well they are absorbed by healthy people. Participants will take a single dose of ibuprofen on two separate occasions to help researchers understand which one gets into the body best.
Spain - recruitingHuman Pharmacology (Phase I)- Other
A Study on Oral and Intranasal Forms in Healthy Volunteers using Pharmacokinetic Modeling
This study is looking at how two different ways of taking a medicine – by mouth and through the nose – work in healthy people. It's an early-stage study to understand how the body handles the medicine.
Spain