- ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
Bioequivalence clinical trial of two formulations of ezetimibe/atorvastatin
This study is looking at how well two different versions of a medicine called ezetimibe/atorvastatin are absorbed by the body. This medicine is used to help lower cholesterol. We need healthy volunteers to take part and help us understand if the new version works the same as the established one.
Spain - ongoing, recruitingHuman Pharmacology (Phase I)- Other
Phase I clinical trial to evaluate the pharmacokinetics, safety and tolerability of repeated topical application of PARENTIDE in healthy volunteers
This study is testing a new cream called PARENTIDE on healthy people. We want to see how the cream is absorbed, if it's safe, and if people can tolerate it when used repeatedly. It's an early-stage study to understand the new treatment better.
Spain - ongoing, recruitingHuman Pharmacology (Phase I)- Other
RANDOMIZED, CROSSOVER, TWO-PERIOD, COMPARATIVE BIOAVAILABILITY STUDY OF TWO IBUPROFEN FORMULATIONS, AFTER A SINGLE ORAL DOSE OF 400 MG IN SOLUTION FORM TO HEALTHY SUBJECTS UNDER FASTING CONDITIONS
This study compares two different ibuprofen medicines to see how well they are absorbed by healthy people. Participants will take a single dose of ibuprofen on two separate occasions to help researchers understand which one gets into the body best.
Spain - recruitingPHASE1
A Brain Imaging Study to Assess the Binding of MSP-2020 to Serotonin 5-HT2A Receptors in Healthy Male Adults
This study looks at a new drug, MSP-2020, to understand how it works in the brain. We want to see how it connects with specific brain chemicals and how the body handles it. This research is for healthy men aged 23-55 and aims to help people with depression.
United Kingdom - ongoing, recruitingHuman Pharmacology (Phase I)- Other
Drug-Drug Interaction Study With BIA 28-6156 and Clarithromycin, Midazolam, and Dabigatran Etexilate in Healthy Participants
This study is looking at how a new drug, BIA 28-6156, reacts with three common medicines: clarithromycin (an antibiotic), midazolam (a sedative), and dabigatran etexilate (a blood thinner). We want to see if they affect each other when taken together, to make sure future patients can take them safely.
Belgium - ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
A Study to Evaluate the Safety and Tolerability of JNJ-77730614 When Given as Single and Multiple Doses to Healthy Participants to Assess How Long JNJ 77730614 Stays in the Body (Pharmacokinetics) and How the Body Responds to it (Pharmacodynamics)
This study is looking at a new medicine called JNJ-77730614. We want to find out if it's safe for healthy people and how their bodies react to it. It's an early-stage study to learn more about the medicine. We'll check how long it stays in the body.
Belgium - ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
A DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED, PHASE I STUDY TO ASSESS THE SAFETY, TOLERABILITY, AND PHARMACOKINETICS OF SINGLE ANDMULTIPLE ASCENDING DOSES OF THN391 IN HEALTHY SUBJECTS
This early-stage study is looking for healthy volunteers to test a new medicine called THN391. We want to see if it's safe, how well the body handles it, and how it moves through the body after single and repeated doses. It's the first time this medicine will be given to people.
Netherlands - ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
Jim Beam Cumulative Irritation Patch Test
This study is looking at how skin reacts to a product called Jim Beam when applied repeatedly. It's a very early-stage trial, just testing on healthy volunteers to see if it causes any irritation. They're checking skin responses to make sure it's safe for people.
Germany - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A study to investigate JNJ-80202135 (nipocalimab) delivered subcutaneously via prefilled syringe autoinjector and via normal syringe
This study is testing a new way to give a medicine called nipocalimab. It's looking at two different ways to inject it under the skin to see if they are safe and work well in healthy adults.
Belgium - not yet recruitingPHASE1
A Study to Compare How CHF10196 (Florensocatib) is Absorbed Into the Blood When Given Alone and With a Drug That Reduces Stomach Acid in Healthy Male Participants
This study is looking at how a new medicine, called Florensocatib (CHF10196), is taken up by the body. We want to see if taking it with a common stomach acid-reducing drug changes how much gets into the blood of healthy men. This helps us understand how medicines work together.
United Kingdom - ongoing, recruitingTherapeutic exploratory (Phase II)
A randomized, triple-blind, placebo-controlled study on the effect of rifaximin on psychobiological functions in healthy men.
This study is looking at how a medicine called Targaxan might affect how healthy men deal with stress. Researchers will check things like stress levels and gut health to understand its effects.
Belgium - authorisedHuman Pharmacology (Phase I)- Other
A randomized, open-label, two-period, two-sequence crossover trial to investigate the effect of food on the pharmacokinetics of Silexan 80 mg in healthy participants
This study is looking at how a medicine called Silexan 80mg is absorbed by the body when taken with food, compared to when it's taken without food. Healthy adults are taking part to help us understand this better.
France - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A Phase 1, Randomized, Double-Blind, Placebo and Positive-Controlled Crossover Study to Evaluate the Effect of Clinical and Supraclinical Doses of GEH200486 0.5 M Injection on the Thorough QT/QTc in Healthy Volunteers.
This study is looking at a new medicine called GEH200486. We want to see if different doses affect your heart, specifically its electrical rhythm. Healthy volunteers aged 18 and over will take part to help us understand this new treatment better and ensure it's safe.
Netherlands - ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
Bioequivalence study of GP-IMP-001 with regards to reference product
This study is looking at how a new drug called GP-IMP-001 is absorbed by the body compared to an existing drug. We need healthy male volunteers aged 18 and over to help us. It's an early-stage study to make sure the new drug works similarly.
Czechia - ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
Bioequivalence clinical trial of two formulations of vortioxetine.
This study is looking at two versions of a medicine called vortioxetine to see if they work the same way in the body. It’s for healthy adults and is an early-stage study to check how the medicine is absorbed.
Spain - ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
Randomised bioequivalence clinical trial of sacubitril/valsartan 49 mg/51 mg film-coated tablets, after a single oral dose administration to healthy volunteers under fasting conditions in crossover replicated design.
This study is testing if a new version of the heart medication called Entresto works the same way as the original. We're looking for healthy adults to take a single dose of both medications to see if they're absorbed in the body in the same amounts.
Spain - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A Study to Investigate Relative Bioavailability of Two Different Dosage Forms for Tozorakimab via Subcutaneous Administration in Healthy Volunteers
This study is looking at a new medicine called Tozorakimab. We want to see how two different ways of giving the medicine under the skin compare. It's for healthy adult volunteers to help us understand how the body uses the medicine.
Germany - ongoing, recruitingHuman Pharmacology (Phase I)- Other
Study of excretion of CORTICOSTEROIDS to improve their detection in Anti-doping controls.
This study looks at how the body gets rid of steroid medicines to help improve tests that check for their unfair use in sports. It needs healthy volunteers to understand how these medicines leave the body.
Spain - ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
Randomised, bioequivalence clinical trial of ezetimibe/atorvastatin 10 mg/40 mg tablets versus ezetimibe/atorvastatin 10 mg/40 mg film-coated tablets, after a single oral dose administration to healthy volunteers under fasting conditions in crossover replicated design
This study compared two versions of a combined heart medication (ezetimibe/atorvastatin) in healthy people. We wanted to see if they both delivered the medicine to the body in the same way, helping ensure new versions work just as well as existing ones.
Spain - authorisedTherapeutic use (Phase IV)
Studies to gain insight how the drugs PCSK9-inhibitors and statins affect cholesterol and bile acid metabolism
This study looks at how medicines like statins and PCSK9 inhibitors affect cholesterol and digestion in healthy men over 18. Doctors want to understand better how these drugs work to help treat high cholesterol.
Sweden - active not recruitingPHASE1, PHASE2
Safety and Immunogenicity of an Investigational Pentavalent Meningococcal ABCYW Vaccine Against Meningococcal Disease in Children, Toddlers, and Infants
This study is testing a new vaccine to protect children, toddlers, and babies against meningococcal disease. Researchers want to see if the new vaccine is safe and works well compared to existing vaccines, sometimes given alongside other routine childhood shots.
Brazil · Czechia · Denmark - ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
Phase 1 Safety and Tolerability Study of REGN9533 in Healthy Adults.
This study is looking for healthy adults to test a new medicine called REGN9533 for the very first time in people. The main goal is to check if it's safe to use and how well the body handles it. It's an early-stage study to gather important information.
Belgium - ongoing, recruitingTherapeutic exploratory (Phase II)
Comparison of multiple doses of intramuscular versus intranasal naloxone for reversal of opioid toxicity
This study looks at how well different ways of giving naloxone work to reverse the effects of strong painkillers (opioids) in healthy volunteers. Researchers are comparing injections to a nasal spray to see which is most effective and how many doses are needed.
Netherlands - completedPhase I
A clinical trial to assess three self-amplifying ribonucleic acid (saRNA) vaccines against Ebola, Marburg, and Lassa fever viruses
This study is testing new vaccines against serious viruses like Ebola. It's looking to see if these self-amplifying RNA vaccines are safe and how they affect the immune system in healthy adults. This is the first time these vaccines are being tested in people.
United Kingdom · England - ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
A study to assess the safety of ARGX-121 in Healthy Adult Participants
This study is looking into a new medication called ARGX-121 to see if it's safe for healthy adults. It's one of the very first times this medicine will be given to people. Researchers want to make sure it doesn't cause any serious problems.
Netherlands - recruitingNA
Artificial Intelligence Delivered Cardiac Magnetic Resonance - Prospective Validation
This study is testing if artificial intelligence (AI) can help take detailed heart scans (CMRIs) faster and just as well as human experts. It aims to make it easier to get these important heart checks.
United Kingdom - recruitingPHASE1, PHASE2
A Study to Evaluate BMS-986470 in Healthy Volunteers and Participants With Sickle Cell Disease
This study is testing a new medicine, BMS-986470, for people with sickle cell disease and healthy volunteers. Researchers want to see if it's safe, how it works in the body, and if it helps with sickle cell symptoms. It's an early-stage study.
United States · Canada · France - recruitingPHASE1
A Study to Evaluate Novel KarX and KarT Prototypes Versus the KarXT and KarX-EC Reference Following Single Doses, Explore the Effect of Food After Multiple Doses of Selected Prototypes, and Evaluate Alternative Formulations of KarX and KarXT Following Single and Multiple Ascending Doses
This study is testing new versions of a medicine called KarXT and KarX-EC in healthy adults. Researchers want to see how these new versions work after a single dose and if food changes how they act after several doses. It's about finding out how medicines are absorbed by the body.
United Kingdom - ongoing, recruitingHuman Pharmacology (Phase I)- Other
Study of exposure to substances prohibited by the World Anti-Doping Agency in healthy volunteers. Proof of concept.
This study is looking at how healthy people react to certain substances that are banned in sports. It's a very early stage study to understand more about these substances in the body.
Spain - ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
Randomised bioequivalence clinical trial of sacubitril/valsartan 97 mg/103 mg film-coated tablets, after a single oral dose administration to healthy volunteers under fasting conditions in crossover replicated design.
This study is comparing two versions of a heart failure medicine called sacubitril/valsartan. We're looking at how well a new generic version works compared to the original Entresto, specifically how quickly and how much of the medicine gets into the body of healthy volunteers when taken on an empty stomach.
Spain - ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
A randomised, open-label, reference-replicated crossover trial to investigate the bioequivalence of two formulations of Silexan 80 mg in healthy volunteers
This study is looking at two versions of an 80mg Silexan capsule for healthy adults. It's to check if the new version works the same way in the body as the original, making sure it's just as good and safe.
France - ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
Randomised, crossover bioequivalence clinical trial of hydrochlorothiazide 25 mg tablets, after a single oral dose administration to healthy volunteers under fasting conditions.
This study is looking at how two different versions of a 25mg hydrochlorothiazide tablet work in healthy people. We want to check if both tablets deliver the same amount of medicine to the body in the same way, helping to ensure they are equally effective.
Spain - recruitingPHASE1
Pharmacokinetics of GH001 Delivered Via a Proprietary Aerosol Delivery Device in Healthy Subjects
This study is looking at a new way to deliver a medicine called GH001 through an inhaler. We want to see how the body handles the medicine and if it's safe for healthy people. It's a first step to understand this new treatment.
United Kingdom - not yet recruitingPHASE1
Progesterone and Muscle Protein Synthesis in Premenopausal Women (MP4-MPS)
This study looks at how the hormone progesterone affects muscle growth in healthy young women. Researchers want to see if progesterone changes how muscles respond to exercise compared to a dummy pill. It involves taking pills, exercising one leg, and giving blood and small muscle samples.
Canada - recruitingNA
Evaluation of the Biomechanics of Crowding and the Energetic Cost of Endurance Runners Unilateral Transtibial Amputees.
This study looks at how running blades work for people with one leg amputation. We want to understand how different blades affect running, energy use, and injury risk, especially for long-distance running. The aim is to help amputee runners perform better and stay safe.
France - recruitingNA
Evaluation of Adding Nitrate Into Foods for Regulating Nitric Oxide Bioavailability in Healthy Individuals
This study looks at whether adding a natural ingredient called nitrate to common foods like biscuits and porridge can help improve heart health and lower blood pressure in healthy people. Researchers want to see if these nitrate-enriched foods work as well as existing supplements.
United Kingdom - completedPhase I
Phase I trial: CA47303
This early-stage study, called CA47303, is looking for healthy women aged 18 to 45. It's designed to understand how a new investigational treatment works in the body and if it's safe. Details about the treatment will be made public later.
United Kingdom · Northern Ireland - active not recruitingPHASE3
Study of a 21-valent Pneumococcal Conjugate Vaccine in Healthy Infants From Approximately 2 Months of Age
This study is testing a new vaccine (PCV21) for healthy babies aged 2 to 4 months. It aims to see if it's safe and helps babies make germ-fighting antibodies against pneumococcal disease, comparing it to an existing vaccine alongside their routine immunisations.
Belgium · Czechia · Estonia - ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
A Phase 1 relative bioavailability study in 14 healthy adult participants investigating the Arvisol® tablets to see whether its pharmacokinetic properties are similar to the reference drug which is a marketed oral soliton cannabidiol, named Epidiolex® CBD oral solution.
This study is looking at a new tablet form of a medicine called Arvisol®. We want to see if it works in the body in the same way as an existing liquid medicine, Epidiolex®, which contains CBD. It's for healthy adults.
Hungary - ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
Bioequivalence clinical trial of two formulations of loperamide.
This study is looking at how two different versions of a common medicine for tummy troubles, called loperamide, are absorbed by the body. We need healthy volunteers to help us understand if they work in the same way. It's an early-stage study to check the medicine's behaviour.
Spain - completedPhase I
An open-label mass balance study of [14C]EIK1001 in healthy male subjects
This study is looking into how the body handles a new cancer drug, EIK1001. We need healthy men to take a single dose to see how the body breaks it down and gets rid of it. This helps doctors create more effective cancer treatments for the future.
United Kingdom · England - authorisedHuman Pharmacology (Phase I)- Other
A PHASE 1, OPEN-LABEL STUDY TO ASSESS THE ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION, INCLUDING THE MASS BALANCE, OF A SINGLE ORAL DOSE OF [14C]-VAFIDEMSTAT IN HEALTHY MALE PARTICIPANTS
This early-stage study is looking at a new medicine called Vafidemstat in healthy men. Researchers want to understand how the body takes in, uses, and gets rid of this medicine after one dose. It helps them learn important basic information about how the drug works.
Netherlands - recruitingPHASE1, PHASE2
Study Evaluating ABCL635 for Vasomotor Symptoms of Menopause
This study is looking into a new medication called ABCL635 for hot flashes and night sweats caused by menopause. It aims to see if it's safe, how it works in the body, and if it helps with these symptoms in both healthy people and women experiencing moderate to severe symptoms.
Canada - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A trial to learn how much [11C]savolitinib enters the brains of healthy participants
This study looks at how a new medicine, called [11C]savolitinib, gets into the brains of healthy adults. It's a very early stage of research to understand how the medicine works in the body.
Sweden - completedPhase I
Phase I trial HMR code: 25-001
This early-stage study is looking for healthy volunteers. It's a 'Phase 1' trial, which usually means researchers are testing a new treatment or medicine for the first time in people. More details about the study will be shared later.
United Kingdom · England - completedPhase I
A study to compare how the body takes in and gets rid of sefaxersen when given by an injection device or a regular syringe in healthy adults
This study looks at a new way to give sefaxersen, a drug being developed for a kidney condition. It compares an injection device to a standard syringe in healthy adults to see if both methods deliver the drug equally well and if the device makes it easier to use.
United Kingdom · England - completedPhase I
Phase 1 trial HMR code: 25-006
This early-stage study, called HMR 25-006, is looking for healthy female volunteers. The main goal is to test a new treatment for the first time in people. More detailed information about the study will be shared later, within 30 months after it has finished.
United Kingdom · England - ongoing, recruitingTherapeutic use (Phase IV)
Hypoxic ventilatory response (HVR): Effect of Esketamine
This study looks at how a medicine called esketamine affects breathing when there's not much oxygen. It's for healthy volunteers and will help us understand the drug's effects on the body, including any side effects and how much stays in the blood.
Netherlands - ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
Randomised, crossover bioequivalence clinical trial of ezetimibe/atorvastatin 10 mg/80 mg tablets versus ezetimibe/atorvastatin 10 mg/80 mg film-coated tablets, after a single oral dose administration to healthy volunteers under fasting conditions
This study is comparing two versions of a combined heart medication (ezetimibe and atorvastatin) to see if they work the same way in the body. We're looking for healthy volunteers to help us understand if a new version of the tablet is just as effective as the existing one.
Spain - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A study to evaluate how the body absorbs, breaks down and removes drug as well as safety and tolerability when two drugs are administered together as an injection under the skin to healthy participants.
This study is looking at two new medicines given together as a jab under the skin. We want to see how your body handles them and if they cause any side effects in healthy people. This helps us understand how the drugs work safely.
Belgium