- ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
Bioequivalence clinical trial of two formulations of dapagliflozin.
This study is looking at two versions of a diabetes medicine called dapagliflozin in healthy people. It wants to check if they act the same way in the body. This is a very early stage of testing.
Spain - recruitingPhase I
Phase I Study (QSC303441)
This early-stage study is looking for healthy volunteers aged 18-55. It's a 'Phase 1' trial, which usually tests new medicines for safety. Full details will be shared later, after the trial finishes.
United Kingdom · England - recruitingPhase I
Deferred registration: Quotient Sciences code: QSC303996
This is an early-stage study (Phase I) for healthy men aged 25 to 55. It's too early to share all the details, but they will be made public soon. This type of study mainly checks the safety of a new treatment.
United Kingdom · England - recruitingPHASE1, PHASE2
A Study to Evaluate BMS-986470 in Healthy Volunteers and Participants With Sickle Cell Disease
This study is testing a new medicine, BMS-986470, for people with sickle cell disease and healthy volunteers. Researchers want to see if it's safe, how it works in the body, and if it helps with sickle cell symptoms. It's an early-stage study.
United States · Canada · France - ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
Bioequivalence clinical trial of two formulations of bilastine.
This study is testing if two versions of a hay fever medicine called bilastine work the same way in healthy people. It's a very early stage of testing to make sure new medicines are just as good as existing ones.
Spain - recruitingPHASE1
A Study to Evaluate ALN-4285 in Adult Healthy Volunteers
This study is looking into a new medication called ALN-4285. It aims to see how safe it is and what happens to it in the body when given to healthy adults. Some participants will receive the medication, others a dummy treatment.
United Kingdom - recruitingPHASE1
A Study to Evaluate ALN-4915 in Adult Healthy Volunteers
This study is looking into a new medicine called ALN-4915. It's for healthy adults aged 18-65. The main aim is to check if the medicine is safe and how it affects the body.
United Kingdom - recruitingPhase I
Phase I trial, HS-25-802
This early-stage study is looking for healthy adults aged 18 to 55. Not much information is available about it yet, as the details will be shared later once the study finishes, as approved by the Health Research Authority.
United Kingdom · England - ongoing, recruitingHuman Pharmacology (Phase I)- Other
Randomized, crossover, two-period, comparative bioavailability study of two ibuprofen (arginate) formulations, administered as solutions in single oral dose of 400 mg to healthy subjects under fasting conditions.
This study is looking at two types of liquid ibuprofen arginate. We want to see how well they get into the body and if they work the same way. It's for healthy adults who haven't eaten, and they'll get a single dose of 400 mg.
Spain - not yet recruitingPhase I
Deferred registration - Phase I trial - Quotient Sciences code: QSC303633
This early-stage study is looking for healthy volunteers aged 18-55. It's a 'Phase 1' trial, which means it's one of the first times a new treatment is tried in people. We're waiting for more details, but it's important for understanding how new medicines work safely.
United Kingdom · England - ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
Randomised, crossover bioequivalence clinical trial of pregabalin 300 mg tablets versus pregabalin 300 mg hard capsules, after a single oral dose administration to healthy volunteers under fasting conditions.
This study compares two different forms of pregabalin 300mg – a tablet and a capsule – to see how similarly the body absorbs them. It's for healthy adults and helps ensure medicines work the same way. We're testing if they're interchangeable.
Spain - ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
Randomised, crossover bioequivalence clinical trial of rosuvastatin/ezetimibe 20 mg/ 10 mg film-coated tablets versus rosuvastatin/ezetimibe 20 mg/ 10 mg hard capsules, after a single oral dose administration to healthy volunteers under fasting conditions.
This study is comparing two versions of a combined heart medication in healthy volunteers. It checks if a new tablet form works the same way as an existing capsule form when taken once, on an empty stomach. The goal is to ensure both deliver the medication equally well.
Spain - completedPhase I
Phase I trial HMR code: 25-004
This early-stage study is looking for healthy women to help test a new treatment. We don't have all the details yet, but the aim is to see if the treatment is safe in people. More information will be shared after the study is finished.
United Kingdom · England - active not recruitingPHASE1, PHASE2
ELE-101 Safety & Tolerability Study in Healthy Participants and Patients With Depression
This study is looking at a new drug called ELE-101 for depression. It checks how safe it is and how it works in healthy people first, then in people with depression, to see if it could be a helpful new treatment.
United Kingdom - ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
Bioequivalence clinical trial of two formulations of loperamide.
This study is looking at how two different versions of a common medicine for tummy troubles, called loperamide, work in healthy people. We want to see if these two versions are absorbed in the body in the same way, to make sure they'll have the same effect.
Spain - ongoing, recruitingHuman Pharmacology (Phase I)- Other
Phase 1 clinical trial to evaluate the safety, tolerability and pharmacokinetics of multiple daily doses of IM-250 in healthy volunteers.
This study is testing a new medicine called IM-250 in healthy adult volunteers for the first time. We want to see if it's safe, how well people tolerate it, and what happens to the medicine in the body after taking multiple doses. It's an early-stage study.
Bulgaria - ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
Bioequivalence clinical trial of two formulations of dapagliflozin/metformin
This study is looking at two different versions of a common diabetes medicine, dapagliflozin/metformin. We want to see if they work the same way in healthy people. This helps make sure new medicines are just as good as existing ones.
Spain - ongoing, recruitingTherapeutic use (Phase IV)
YF_PROTECT: Prophylactic Treatment with Sofosbuvir for Yellow fever Exemption Circumstances and Travel
This study is looking at whether a medicine called Sofosbuvir could help people who can't have the Yellow Fever vaccine. It's testing if the medicine can stop the Yellow Fever virus from being detected in the body after vaccination, acting as a 'protective' treatment.
Netherlands - ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
Randomised, crossover bioequivalence clinical trial of apixabán 5 mg film coated tablets, after a single oral dose administration to healthy volunteers under fasting conditions.
This study is testing if a new version of the blood thinner apixaban works the same way as the original. Healthy adults take a single dose of both medicines to see how they behave in the body.
Spain - ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
Bioequivalence clinical trial of two formulations of dapagliflozin/metformin
This study is looking at how two different versions of a common medicine, dapagliflozin/metformin, are absorbed and used by the body. It involves healthy adults and aims to check if they work in the same way.
Spain - recruitingNA
Identifying Wearable Biomarkers to Monitor Dietary Intake
This study explores if wearable devices can accurately measure what people eat. Researchers will monitor healthy volunteers after high and low-calorie meals to see how their bodies react, hoping to create a better way to track diet than current methods.
United Kingdom - authorisedHuman Pharmacology (Phase I)- Other
Thorough QT/QTc study with GLPG3667, placebo, and active comparator in healthy subjects
This study is testing a new medicine, GLPG3667, in healthy people to see how it affects the heart's electrical activity. This is an early-stage study to check for any heart-related side effects before the medicine can be tested in people with the actual illness it’s designed to treat.
Netherlands - ongoing, recruitingTherapeutic use (Phase IV)
Effects of promethazine and altered gravity on bimanual coordination
This study looks at how a common anti-sickness medicine (promethazine) and changes in gravity might affect how well people use both hands together. We're inviting healthy adults to help us understand this better.
France - ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
Bioequivalence clinical trial of two formulations of ezetimibe/atorvastatin
This study is looking at how well two different versions of a medicine called ezetimibe/atorvastatin are absorbed by the body. This medicine is used to help lower cholesterol. We need healthy volunteers to take part and help us understand if the new version works the same as the established one.
Spain - ongoing, recruitingHuman Pharmacology (Phase I)- Other
Randomized, crossover, comparative bioavailability study of two Paracetamol-Ibuprofen 25-20 mg/ml oral suspension, administered in single dose to healthy subjects under fasting conditions.
This study is looking at two different liquid medicines that contain paracetamol and ibuprofen. We want to see how well and how quickly your body absorbs each medicine. It's for healthy adults and involves taking a single dose of each medicine on separate occasions.
Spain - ongoing, recruitingHuman Pharmacology (Phase I)- Other
Phase I clinical trial to evaluate the pharmacokinetics, safety and tolerability of repeated topical application of PARENTIDE in healthy volunteers
This study is testing a new cream called PARENTIDE on healthy people. We want to see how the cream is absorbed, if it's safe, and if people can tolerate it when used repeatedly. It's an early-stage study to understand the new treatment better.
Spain - ongoing, recruitingHuman Pharmacology (Phase I)- Other
RANDOMIZED, CROSSOVER, TWO-PERIOD, COMPARATIVE BIOAVAILABILITY STUDY OF TWO IBUPROFEN FORMULATIONS, AFTER A SINGLE ORAL DOSE OF 400 MG IN SOLUTION FORM TO HEALTHY SUBJECTS UNDER FASTING CONDITIONS
This study compares two different ibuprofen medicines to see how well they are absorbed by healthy people. Participants will take a single dose of ibuprofen on two separate occasions to help researchers understand which one gets into the body best.
Spain - recruitingPHASE1
A Brain Imaging Study to Assess the Binding of MSP-2020 to Serotonin 5-HT2A Receptors in Healthy Male Adults
This study looks at a new drug, MSP-2020, to understand how it works in the brain. We want to see how it connects with specific brain chemicals and how the body handles it. This research is for healthy men aged 23-55 and aims to help people with depression.
United Kingdom - ongoing, recruitingHuman Pharmacology (Phase I)- Other
Drug-Drug Interaction Study With BIA 28-6156 and Clarithromycin, Midazolam, and Dabigatran Etexilate in Healthy Participants
This study is looking at how a new drug, BIA 28-6156, reacts with three common medicines: clarithromycin (an antibiotic), midazolam (a sedative), and dabigatran etexilate (a blood thinner). We want to see if they affect each other when taken together, to make sure future patients can take them safely.
Belgium - ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
A DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED, PHASE I STUDY TO ASSESS THE SAFETY, TOLERABILITY, AND PHARMACOKINETICS OF SINGLE ANDMULTIPLE ASCENDING DOSES OF THN391 IN HEALTHY SUBJECTS
This early-stage study is looking for healthy volunteers to test a new medicine called THN391. We want to see if it's safe, how well the body handles it, and how it moves through the body after single and repeated doses. It's the first time this medicine will be given to people.
Netherlands - ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
Jim Beam Cumulative Irritation Patch Test
This study is looking at how skin reacts to a product called Jim Beam when applied repeatedly. It's a very early-stage trial, just testing on healthy volunteers to see if it causes any irritation. They're checking skin responses to make sure it's safe for people.
Germany - ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
A Study to Evaluate the Safety and Tolerability of JNJ-77730614 When Given as Single and Multiple Doses to Healthy Participants to Assess How Long JNJ 77730614 Stays in the Body (Pharmacokinetics) and How the Body Responds to it (Pharmacodynamics)
This study is looking at a new medicine called JNJ-77730614. We want to find out if it's safe for healthy people and how their bodies react to it. It's an early-stage study to learn more about the medicine. We'll check how long it stays in the body.
Belgium - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A study to investigate JNJ-80202135 (nipocalimab) delivered subcutaneously via prefilled syringe autoinjector and via normal syringe
This study is testing a new way to give a medicine called nipocalimab. It's looking at two different ways to inject it under the skin to see if they are safe and work well in healthy adults.
Belgium - not yet recruitingPHASE1
A Study to Compare How CHF10196 (Florensocatib) is Absorbed Into the Blood When Given Alone and With a Drug That Reduces Stomach Acid in Healthy Male Participants
This study is looking at how a new medicine, called Florensocatib (CHF10196), is taken up by the body. We want to see if taking it with a common stomach acid-reducing drug changes how much gets into the blood of healthy men. This helps us understand how medicines work together.
United Kingdom - ongoing, recruitingTherapeutic exploratory (Phase II)
A randomized, triple-blind, placebo-controlled study on the effect of rifaximin on psychobiological functions in healthy men.
This study is looking at how a medicine called Targaxan might affect how healthy men deal with stress. Researchers will check things like stress levels and gut health to understand its effects.
Belgium - authorisedHuman Pharmacology (Phase I)- Other
A randomized, open-label, two-period, two-sequence crossover trial to investigate the effect of food on the pharmacokinetics of Silexan 80 mg in healthy participants
This study is looking at how a medicine called Silexan 80mg is absorbed by the body when taken with food, compared to when it's taken without food. Healthy adults are taking part to help us understand this better.
France - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A Phase 1, Randomized, Double-Blind, Placebo and Positive-Controlled Crossover Study to Evaluate the Effect of Clinical and Supraclinical Doses of GEH200486 0.5 M Injection on the Thorough QT/QTc in Healthy Volunteers.
This study is looking at a new medicine called GEH200486. We want to see if different doses affect your heart, specifically its electrical rhythm. Healthy volunteers aged 18 and over will take part to help us understand this new treatment better and ensure it's safe.
Netherlands - ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
Bioequivalence study of GP-IMP-001 with regards to reference product
This study is looking at how a new drug called GP-IMP-001 is absorbed by the body compared to an existing drug. We need healthy male volunteers aged 18 and over to help us. It's an early-stage study to make sure the new drug works similarly.
Czechia - ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
Bioequivalence clinical trial of two formulations of vortioxetine.
This study is looking at two versions of a medicine called vortioxetine to see if they work the same way in the body. It’s for healthy adults and is an early-stage study to check how the medicine is absorbed.
Spain - ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
Randomised bioequivalence clinical trial of sacubitril/valsartan 49 mg/51 mg film-coated tablets, after a single oral dose administration to healthy volunteers under fasting conditions in crossover replicated design.
This study is testing if a new version of the heart medication called Entresto works the same way as the original. We're looking for healthy adults to take a single dose of both medications to see if they're absorbed in the body in the same amounts.
Spain - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A Study to Investigate Relative Bioavailability of Two Different Dosage Forms for Tozorakimab via Subcutaneous Administration in Healthy Volunteers
This study is looking at a new medicine called Tozorakimab. We want to see how two different ways of giving the medicine under the skin compare. It's for healthy adult volunteers to help us understand how the body uses the medicine.
Germany - ongoing, recruitingHuman Pharmacology (Phase I)- Other
Study of excretion of CORTICOSTEROIDS to improve their detection in Anti-doping controls.
This study looks at how the body gets rid of steroid medicines to help improve tests that check for their unfair use in sports. It needs healthy volunteers to understand how these medicines leave the body.
Spain - ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
Randomised, bioequivalence clinical trial of ezetimibe/atorvastatin 10 mg/40 mg tablets versus ezetimibe/atorvastatin 10 mg/40 mg film-coated tablets, after a single oral dose administration to healthy volunteers under fasting conditions in crossover replicated design
This study compared two versions of a combined heart medication (ezetimibe/atorvastatin) in healthy people. We wanted to see if they both delivered the medicine to the body in the same way, helping ensure new versions work just as well as existing ones.
Spain - authorisedTherapeutic use (Phase IV)
Studies to gain insight how the drugs PCSK9-inhibitors and statins affect cholesterol and bile acid metabolism
This study looks at how medicines like statins and PCSK9 inhibitors affect cholesterol and digestion in healthy men over 18. Doctors want to understand better how these drugs work to help treat high cholesterol.
Sweden - active not recruitingPHASE1, PHASE2
Safety and Immunogenicity of an Investigational Pentavalent Meningococcal ABCYW Vaccine Against Meningococcal Disease in Children, Toddlers, and Infants
This study is testing a new vaccine to protect children, toddlers, and babies against meningococcal disease. Researchers want to see if the new vaccine is safe and works well compared to existing vaccines, sometimes given alongside other routine childhood shots.
Brazil · Czechia · Denmark - ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
Phase 1 Safety and Tolerability Study of REGN9533 in Healthy Adults.
This study is looking for healthy adults to test a new medicine called REGN9533 for the very first time in people. The main goal is to check if it's safe to use and how well the body handles it. It's an early-stage study to gather important information.
Belgium - ongoing, recruitingTherapeutic exploratory (Phase II)
Comparison of multiple doses of intramuscular versus intranasal naloxone for reversal of opioid toxicity
This study looks at how well different ways of giving naloxone work to reverse the effects of strong painkillers (opioids) in healthy volunteers. Researchers are comparing injections to a nasal spray to see which is most effective and how many doses are needed.
Netherlands - completedPhase I
A clinical trial to assess three self-amplifying ribonucleic acid (saRNA) vaccines against Ebola, Marburg, and Lassa fever viruses
This study is testing new vaccines against serious viruses like Ebola. It's looking to see if these self-amplifying RNA vaccines are safe and how they affect the immune system in healthy adults. This is the first time these vaccines are being tested in people.
United Kingdom · England - ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
A study to assess the safety of ARGX-121 in Healthy Adult Participants
This study is looking into a new medication called ARGX-121 to see if it's safe for healthy adults. It's one of the very first times this medicine will be given to people. Researchers want to make sure it doesn't cause any serious problems.
Netherlands - recruitingNA
Artificial Intelligence Delivered Cardiac Magnetic Resonance - Prospective Validation
This study is testing if artificial intelligence (AI) can help take detailed heart scans (CMRIs) faster and just as well as human experts. It aims to make it easier to get these important heart checks.
United Kingdom