- recruitingNA
Safety of AI-Powered Virtual Assistant in Outpatient Management of Heart Failure
This study looks at whether a special computer program called SIRIO-HF, which is like a virtual assistant, can help people with a new diagnosis of heart failure manage their condition at home after leaving the hospital. We want to see if it's safe and helps reduce clinic visits.
United Kingdom - recruitingNA
Spot Analysis of Natriuresis to Guide up- or Down-titration of Diuretic Therapy in Ambulatory Patients With Chronic Heart Failure
This study looks at using simple urine tests to help doctors decide the best dose of water tablets (diuretics) for people with heart failure. The aim is to see if this method can help manage fluid build-up better and more safely.
Canada - recruiting
Lifestyle Behaviours of Women Newly Diagnosed With Heart Failure
This study looks at the daily activities, sleep, and overall well-being of women newly diagnosed with heart failure. We want to understand what helps or hinders them in staying active, as women have often been overlooked in heart failure research.
United Kingdom - not yet recruiting
Biomarkers for the Assessment of Congestion in Patients With Ambulatory and Hospitalised Heart Failure
This study is testing new blood and urine tests for people with heart failure. It hopes these new tests will better spot when fluid is building up in the body, which can help doctors treat patients sooner and potentially prevent hospital stays.
United Kingdom - recruiting
WeRoaM: Wearable Remote Monitoring in Heart Failure
This study looks at using wearable tech to help children with heart failure. It hopes to make it easier for families to get good care from home, especially if they live far from a hospital or face other challenges. We want to see if this tech is helpful and accurate.
Canada - recruitingPHASE3
A Study to Evaluate Finerenone on Clinical Efficacy and Safety in Patients With Heart Failure Who Are Intolerant or Not Eligible for Treatment With Steroidal Mineralocorticoid Receptor Antagonists
This study looks at a new medicine called Finerenone for people with heart failure. It compares Finerenone to a dummy pill (placebo) to see if it's safe and effective, especially for those who can't take other common heart failure medicines.
United States · Argentina · Brazil - recruiting
Detecting EARLY Heart Failure in Greater Manchester
This study aims to improve early detection of heart failure in Greater Manchester. Researchers are testing a new tool that identifies people at high risk before they show symptoms. The goal is to help doctors spot heart problems sooner, potentially allowing for earlier treatment and better health outcomes.
United Kingdom - not yet recruiting
Evaluation of Heart Failure Telemonitoring Eligibility Criteria
This study looks at people with heart failure who were part of a home monitoring programme in France. We want to see how they got on after they left the programme because they no longer met the health authority's criteria.
France - recruitingPHASE4
Acalabrutinib Monotherapy vs Investigator's Choice of Treatment in Patients With CL Leukaemia and Heart Failure
This study compares a drug called acalabrutinib with other standard treatments for people with chronic leukaemia and heart problems. It aims to see how safe and well acalabrutinib works in this group, particularly focusing on its effects on the heart.
United States · Czechia · Italy - recruitingNA
Reduction of Mitral Regurgitation With the SATURN Trans-Septal Transcatheter Mitral Valve Replacement (TMVR) System in Patients With Severe Symptomatic Mitral Regurgitation
This study looks at a new way to fix a leaky heart valve without open-heart surgery. It aims to see if a device called SATURN is safe and effective for people with severe leaky heart valves who can't have traditional surgery.
Georgia · Italy · Lithuania - recruitingPHASE2, PHASE3
Efficacy, Safety, and Pharmacokinetics of Vericiguat in Pediatric Participants With Heart Failure Due to Left Ventricular Systolic Dysfunction (MK-1242-036)
This study is looking at a new medicine called vericiguat for children and young people aged 29 days to 17 years with heart failure. We want to see if it can improve their heart health compared to a dummy medicine.
United States · Belgium · Brazil - recruiting
POWER Myocardial Fatigue Study: a Biomechanical Assessment of Contractility of Human Myocardium
This study aims to understand why hearts get tired in heart failure. Researchers will look at human heart tissue to learn how it works under different conditions and stress, hoping to find new ways to help hearts recover and reduce fatigue.
United Kingdom - recruiting
A Prospective, Observational, Single Centre Study to Assess the Feasibility of the Data Harvested by the Acorai Intracardiac Pressure Monitoring (ICPM) System in Predicting Prognosis in Patients Discharged From Hospital After Treatment for Acute Decompensated Heart Failure
This study is testing a new, easy-to-use device called the Acorai Heart Monitor. It hopes to measure heart pressures from outside your body, helping doctors understand heart failure better and predict how patients might do after leaving the hospital. This could make monitoring safer and simpler.
United Kingdom - enrolling by invitation
OPTimising a Screening Program to Detect Pacemaker-associated Heart Failure Using Artificial Intelligence
This study looks at new ways to find heart failure in people with pacemakers. Instead of lengthy heart scans, we're testing quick methods like hand-held ultrasound devices with AI and simple finger-prick blood tests. The goal is to make screening easier and find heart failure earlier so people can get treatment.
United Kingdom - recruitingNA
Medico-economic Evaluation of Therapeutic Adaptation Guided by the Soluble Suppression of Tumorigenicity 2 (sST-2) Biomarker in the Management of Patients With Acute Heart Failure
This study looks at whether monitoring a special blood test called sST2 can help improve the care of people with heart failure. We want to see if using this test helps reduce hospital stays and improves quality of life for patients.
France - recruiting
Predicting Readmissions Using Omics, Biostatistical Evaluate and Artificial Intelligence
This study aims to better predict when people with heart failure might need to go back to hospital. Researchers are using new technologies like AI and information from patients themselves to find patterns that could help doctors provide more precise care.
Canada - recruitingEARLY_PHASE1
Oral Carnitine in Heart Failure Patients
This study looks at whether taking a natural substance called L-Carnitine might help people with heart failure. Heart failure means your heart struggles to pump blood. L-Carnitine could help your heart get energy, potentially improving your symptoms and how you feel overall.
Canada - enrolling by invitationNA
Pacing in Heart Failure With Preserved LVEF
This study looks at how a special pacemaker might help people with heart failure. Researchers will try different settings on the pacemaker in 10 volunteers to see if it improves their hearts' function and symptoms.
United Kingdom - active not recruitingNA
ALT-FLOW II Trial of the Edwards APTURE Transcatheter Shunt System
This study looks at a new device for people with heart failure. It wants to see if the Edwards APTURE shunt system can help improve symptoms for those whose hearts pump well but still feel unwell, even with their usual medicines.
United States · Brazil · Canada - active not recruitingNA
ASCEND CSP IDE Study
This study is testing a new type of heart device lead for people with heart failure. It looks at how safe and effective the "CSP ICD Lead" is when used with special heart devices to help control irregular heartbeats and improve heart function.
United States · Australia · Canada - recruiting
Prediction of Heart-Failure with Machine Learning
This study looks at how data from an Apple Watch might help predict when heart failure patients could get worse or need to go back to the hospital. Researchers want to see if information like heart rate and activity collected by the watch can give doctors an early warning.
Germany - recruitingNA
Improving Care and Mental Well-Being for Adults With Heart Failure
This study looks at a new way to support people with heart failure by focusing on their mental health. It's called FRAME. The aim is to see if this support can be easily offered in different healthcare settings and to improve well-being for those with heart failure.
Canada - recruitingPHASE3
A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity
This study looks at a new medicine, NNC0487-0111, for people with heart failure and obesity. It compares the medicine to a dummy treatment (placebo) to see if it's safe and helps improve heart health.
United States · Argentina · Australia - enrolling by invitationNA
Alleviant ALLAY-HFrEF Study
This study is investigating a new treatment for heart failure called the Alleviant ALV1 System. It aims to see if creating a small opening between the heart's upper chambers can help people whose hearts aren't pumping blood effectively.
United States · Australia · Belgium - recruitingNA
The "Seamless" Patient:From Preoperative Preparation to Postoperative Rehabilitation
This study looks at how digital tools and better support before and after heart surgery can help patients. We want to see if these methods improve recovery and make patients feel more secure during their journey.
Germany - recruiting
Factors Influencing Participation in PRADO and Telemedicine Interventions in Heart Failure
This study looks at how well two support programs work for people with heart failure after leaving hospital. It's about helping patients get better care at home and using remote monitoring, and understanding what helps people use these services best.
France - active not recruiting
Multi-morbidity Screening in People With Type 2 Diabetes and Pre Diabetes
This study checks for other health issues often linked with Type 2 diabetes and pre-diabetes, like problems with your heart, liver, or sleep. It's testing a new, more thorough health check-up to find these problems earlier.
United Kingdom - recruiting
Prediction of Heart Failure and Cognitive Decline in Type 2 Diabetes
This study looks at people with Type 2 diabetes to find out who might be at risk of heart problems or memory and thinking difficulties. The goal is to create ways to prevent these issues before they become serious.
France - not yet recruiting
Clinical Information System Impact on Hospitalized Patients With Chronic Disease
This study looks at how a new computer system in hospitals, called Connect Care, affects patients with ongoing health problems like diabetes or heart disease. Researchers are checking if the system helps reduce hospital readmissions or deaths within 30 days of leaving the hospital.
Canada - recruiting
European Registry of Transcatheter Repair for Tricuspid Regurgitation
This study looks at how well new keyhole treatments for a heart problem called tricuspid regurgitation work. It follows patients who have these treatments to see how they recover and how long they live, helping doctors choose the best treatment for others.
Germany - active not recruitingNA
Pulmonary Artery Sensor System Pressure Monitoring to Improve Heart Failure (HF) Outcomes
This study looks at how a small sensor in your lung artery could help manage heart failure. The sensor measures pressure and helps doctors adjust your treatment to keep you healthier and out of hospital.
Germany - active not recruiting
MyoVasc Study on the Development and Progression of Heart Failure
This study looks at how heart failure develops and progresses. Researchers want to understand the different types of heart failure and how they affect blood vessels. This will help them find new ways to manage the condition.
Germany - active not recruitingNA
AMEND-CRT: Mechanical Dyssynchrony as Selection Criterion for CRT
This study looks at a new way to pick patients for a heart treatment called CRT. It aims to see if checking how the heart muscles move can help more people benefit and reduce unnecessary treatments, making it safer and more efficient.
Belgium · Brazil · France - recruiting
Mitochondrial Substrate Utilization in the Diabetic Human Heart
This study looks at how diabetes affects the heart's energy use, especially in people with heart failure. Researchers want to understand why diabetes leads to heart problems, hoping to find better ways to diagnose and treat them early.
Germany - enrolling by invitationNA
Alleviant ALLAY-HF Study
This study is for people with certain types of heart failure where their heart doesn't pump blood as well as it should. It's testing a new device, the Alleviant ALV1, which aims to improve how the heart works. Researchers want to see if it's safe and helps people feel better.
United States · Australia · Austria - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A Study to Learn How Different Amounts of the Study Medicine Called PF-07328948 are Tolerated and Act in the Body in Healthy Adults
This study is looking at a new medicine called PF-07328948 in healthy adults. We want to find out what doses are safe and how the medicine works in the body. It's an early stage study to understand the drug better, and is not for people with heart failure.
Belgium - active not recruitingNA
Neural Cardiac Therapy for Heart Failure Study (NECTAR-HF)
This study is looking into a new way to help people with heart failure by stimulating a nerve called the vagal nerve. It involves a small implanted device and aims to improve heart health and quality of life.
Belgium · Czechia · France - recruiting
Product Performance Report: Evaluate Long-term Reliability & Performance of Medtronic Marketed Cardiac Therapy Products
This study looks at how well Medtronic heart devices, like pacemakers and defibrillators, perform over a long time. It helps ensure these devices are reliable and safe for people with heart conditions such as irregular heartbeats or heart failure.
United States · Australia · Austria - ongoing, recruitingTherapeutic confirmatory (Phase III)
Hydralazine-ISDN in Patients With Chronic Heart Failure - Hydralazine Heart Failure Trial (H-HeFT) Metformin in Patients with Chronic Heart Failure and Diabetes or Insulin Resistance - Metformin Heart Failure Trial (Met-HeFT) A randomized, 2 x 2 factorial designed, double-blind, placebo controlled study (DANHEART).
This study looks at two different treatments, BiDil and Metformin, for people with long-term heart failure. Researchers want to see if these treatments can reduce serious events like hospital stays, heart transplants, or heart attacks, and improve overall health.
Denmark - active not recruitingNA
REDUCE LAP-HF TRIAL II
This study looks at a new tiny device, the IASD System II, for people with heart failure. It aims to see if this implant can improve symptoms and quality of life by helping the heart manage pressure better. Half the people get the implant, and half get a check-up without it.
United States · Australia · Austria - active not recruiting
Observation of Clinical Routine Care for Heart Failure Patients Implanted With BIOTRONIK CRT Devices
This study looks at how well a special device for heart failure, called a CRT, works for people in their everyday lives. It also checks for future heart problems and aims to make the device even better.
Australia · Austria · Belgium - ongoing, recruitingTherapeutic use (Phase IV)
DECISION; Digoxin Evaluation in Chronic heart failure: Investigational Study In Outpatients in the Netherlands
This study, called DECISION, is looking at digoxin, a common medicine, for people with heart failure in the Netherlands. It wants to see if digoxin helps reduce hospital visits for heart failure and prevent heart-related deaths in patients who are not in the hospital.
Netherlands - recruitingNA
The Effect of Obesity and Weight Loss in Heart Failure With Reduced Ejection Fraction.
This study explores if losing weight can improve the heart's health and quality of life for people with a specific type of heart failure. Participants will follow a supervised diet plan or continue their usual care.
Jersey · United Kingdom - recruitingPHASE2
A Research Study Comparing Different Doses of CDR132L With Placebo on the Structure and Function of the Heart in People With Heart Failure With Preserved Ejection Fraction and Left Ventricular Hypertrophy
This study investigates CDR132L, a new potential medicine, for people with heart failure. It compares different doses against a dummy treatment (placebo) to see how it affects heart structure and function. Participants will be in the study for about 60 weeks.
United States · Canada · Germany - active not recruitingNA
Triple Cardiovascular Disease Detection With an Artificial Intelligence-enabled Stethoscope
This study is testing a new AI-powered stethoscope to see if it can help doctors in local clinics find heart problems like heart failure earlier. The aim is to improve heart health and reduce emergency hospital visits for these conditions.
United Kingdom - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A study to Learn If Study Medicines Called Cyclosporine and Clarithromycin Affect How the Body Processes the Other Study Medicine Called PF-07328948 in Healthy Adults.
This study is looking at how two medicines, Cyclosporine and Clarithromycin, might change how your body handles a new medicine called PF-07328948. It's for healthy adults and aims to understand if these medicines interact with each other.
Belgium - recruiting
Heart Failure in Patients With Diabetes: Cells, Crosstalk and Consequences
This study looks at how diabetes and heart failure affect each other, focusing on body cells and communication between different tissues like fat and muscle. We'll compare people with and without these conditions to better understand their causes.
United Kingdom - recruitingNA
pErsonalised Nocebo Assessment of Beta-blockEr Symptoms in Heart Failure
This study looks into why some people with heart failure stop taking important beta-blocker medicines. We want to find out if their symptoms are real side effects or if worries about side effects play a role, helping more people stay on effective treatment.
United Kingdom - recruitingNA
Therapy to Maintain Remission in Dilated Cardiomyopathy
This study looks at whether people with a recovered heart condition can safely stop some of their medication without their heart problems returning. It focuses on two specific types of heart failure medicines.
United Kingdom - recruitingPHASE1
A Research Study on the Effects of NNC0537-1482 in Participants With Heart Failure
This study is testing a new medicine called NNC0537-1482 for people with heart failure. We're looking at its safety and how it works. Some will get the new medicine, others a dummy medicine. It lasts about two months, plus a check-up period.
United Kingdom