- recruitingNA
Therapy to Maintain Remission in Dilated Cardiomyopathy
This study looks at whether people with a recovered heart condition can safely stop some of their medication without their heart problems returning. It focuses on two specific types of heart failure medicines.
United Kingdom - recruiting
Coronary Flow During Rapid Heart Rates
This study looks at how the heart's blood supply copes during very fast heartbeats, like those in Ventricular Tachycardia (VT). Researchers want to understand why some people tolerate VT better than others, especially if they have heart artery disease. The goal is to improve treatments and potentially reduce the need for devices like ICDs.
United Kingdom - recruitingPHASE1
A Research Study on the Effects of NNC0537-1482 in Participants With Heart Failure
This study is testing a new medicine called NNC0537-1482 for people with heart failure. We're looking at its safety and how it works. Some will get the new medicine, others a dummy medicine. It lasts about two months, plus a check-up period.
United Kingdom - recruitingPHASE3
Phase III Study Investigating Heart Failure and Cardiovascular Death With Baxdrostat in Combination With Dapagliflozin
This study looks at how two medicines, Baxdrostat and dapagliflozin, might help people with heart failure. We're testing if this combination can reduce hospital stays for heart failure or prevent death from heart problems in people with type 2 diabetes and high blood pressure.
United States · Argentina · Australia - recruitingNA
Rate or Rhythm Control in CRT: the RHYTHMIC Study
This study looks at two ways to control an irregular heart rhythm called Atrial Fibrillation (AF) in people with heart failure who have a special pacemaker (CRT). It compares AF ablation (a procedure to correct the rhythm) with AV node ablation (a procedure to slow the heart rate).
United Kingdom - recruitingNA
Heart Failure Carer Support Programme: Implementation Testing in the UK.
This study looks at how a new support programme, HELP, can assist unpaid carers of people with heart failure. It aims to find the best way to deliver HELP across the UK and see its impact on both carers and patients.
United Kingdom - ongoing, recruitingTherapeutic use (Phase IV)
Effects of Digoxin in Modern Heart Failure Treatment
This study looks at how well the medicine Digoxin works for people with heart failure. It checks how much oxygen your body uses during exercise and how well your heart pumps, to understand its effects in modern treatments.
Portugal - ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2 Proof-of-Concept clinical trial to quantify myocardial manganese uptake rate by cardiovascular magnetic resonance imaging following mangafodipir trisodium administration in healthy volunteers and heart failure patients with preserved ejection fraction caused by hypertrophic cardiomyopathy or cardiac amyloidosis.
This study looks at how a special scan can show how much manganese goes into the heart, comparing healthy people with those who have heart failure due to specific conditions. The aim is to see if this method can help us understand these heart problems better.
Norway - active not recruiting
Outcomes of Patients Who Survived Treatment on an Intensive Care Unit for COVID-19 in England and Wales
This study looks at the health of people in England and Wales one year after they left intensive care for COVID-19. Researchers will compare their health to people who were in intensive care for other reasons. The aim is to understand long-term health effects.
United Kingdom - recruitingPHASE3
A Research Study Looking Into How Ziltivekimab Works Compared to Placebo in Participants With Heart Failure and Inflammation
This study is looking into a new medicine called ziltivekimab for people with heart failure and inflammation. It compares ziltivekimab to a dummy medicine (placebo) to see if it can help. The treatment you receive is chosen by chance, and the study will last up to 1 year and 4 months.
United States · Argentina · Australia - not yet recruiting
A Study on Remote Health Support for Patients With Heart Failure.
This study looks at using remote support for people in the UK with heart failure. It checks if using a digital questionnaire to monitor symptoms and support needs at home is practical, helpful, and easy to use. This isn't about new medicines, but about improving everyday care.
Germany · Italy · Lithuania - recruiting
Utilising AI Analysis of Sounds To prEdict heaRt failurE decOmpensation
This study is looking into a new way to spot early signs of worsening heart failure using AI to listen to changes in sounds like your voice and breathing. This could help doctors treat you sooner and potentially reduce hospital visits.
United Kingdom - recruitingPHASE4
The STOP-MED CTRCD Trial
This study looks at whether it's safe for cancer survivors to stop heart failure medicines if their heart has recovered well. It's for people whose hearts were affected by cancer treatment but are now working normally again.
United States · Australia · Canada - active not recruitingPHASE3
A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With Heart Failure and Inflammation
This study looks at a new medicine called ziltivekimab for people with heart failure and inflammation. It aims to see if monthly injections of ziltivekimab can help, compared to a dummy medicine, over a few years.
United States · Argentina · Australia - recruitingPHASE3
Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction
This study looks at a new drug, omecamtiv mecarbil, for people with severe heart failure. It aims to see if the drug can help reduce hospital stays, the need for transplants, or the risk of death compared to a dummy pill.
United States · Canada · China - recruiting
Biomarkers in Patients With Suspected HFpEF
This study looks for better ways to spot heart failure, especially in people with obesity or low levels of a common blood test. Researchers hope to find new blood markers to help doctors diagnose heart failure more accurately and earlier.
United Kingdom - active not recruiting
Personalized Therapy Study - HFRS (TriageHF) Post Approval Study
This study looks at how a special feature called TriageHF on Medtronic heart devices helps people with heart failure. Researchers will watch how these devices are used in everyday care to see how well they work after being released for general use.
United States · France · Greece - recruitingNA
Physiological Versus Right Ventricular Outcome Trial Evaluated for Bradycardia Treatment Upgrades
This study looks at whether changing from an older type of pacemaker to a newer, more natural one can improve symptoms and quality of life for people whose hearts have become weaker. We want to see if better pacing makes a difference.
United Kingdom - ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
A research study on the effects of NNC0537-1482 in healthy individuals when injected under the skin.
This study is looking at a new medicine, NNC0537-1482, for heart failure. It's the first time it’s being given to people. Healthy adults will receive an injection under their skin to see how safe it is and how it works in the body.
Netherlands - active not recruitingNA
First in Human Clinical Investigation of the FIRE1 System in Heart Failure Patients (FUTURE-HF)
This study is testing a new device, the FIRE1 System, for people with heart failure. It will involve up to 50 patients to see if the device can be safely put into the body and if it works as intended. We want to understand how it could help manage heart failure.
Czechia · Georgia · Ireland - recruitingPHASE3
A Study to Determine the Efficacy and Safety of Finerenone on Morbidity and Mortality Among Hospitalized Heart Failure Patients
This study is testing a new drug called finerenone for people hospitalised with heart failure. We want to see if it's safe and effective for patients whose hearts can still pump blood fairly well, to improve their health and quality of life.
United States · Argentina · Australia - not yet recruiting
Detecting the Undetected: Heart Failure Screening at the Lymphoedema Point of Care
This study looks for undiagnosed heart failure in people with leg swelling (lymphoedema). It uses a quick test at the clinic to find heart problems early, aiming to prevent serious complications and improve care without extra trips to the GP.
United Kingdom - recruitingPHASE2
A Research Study Comparing CDR132L With Placebo on the Structure and Function of the Heart in People With Heart Failure With Reduced/Mildly Reduced Ejection Fraction and Left Ventricular Hypertrophy
This study is testing a new medicine, CDR132L, for people with heart failure. It aims to see how the medicine affects the heart's structure and function. Some people will get the new medicine, others a dummy pill, to compare the results over about 60 weeks.
Australia · Czechia · Germany - active not recruitingNA
Targeted Assessment in High-Risk paTients With dIAbetes to ideNtify Undiagnosed Heart Failure
This study looks at a new way to find hidden heart failure in people with diabetes who are at higher risk. We're testing if checking a specific blood marker helps doctors discover heart problems earlier, so people can get the right care sooner.
United Kingdom - recruiting
Preparatory Work for a Trial of Adjuncts to Diuretic Treatment in Patients Hospitalised With Heart Failure: Addressing Uncertainties and Building Consensus
This study is preparing for a future trial about new treatments for heart failure. Researchers are asking doctors, nurses, and heart failure patients and their carers to help design the best way to test these treatments.
United Kingdom - recruitingPHASE2
Sotagliflozin in Patients With Heart Failure Symptoms and Type 1 Diabetes
This study looks at whether a tablet called sotagliflozin can help people with type 1 diabetes and heart failure feel better. We're testing if it improves their quality of life and is safe, compared to a dummy pill.
United Kingdom - recruiting
IRONHEART: Intravenous Iron in Non-ischaemic Heart Failure
This study looks at how giving iron through a drip (intravenous iron) affects people with a specific type of heart failure and iron deficiency. It aims to see if it improves heart function and overall well-being.
United Kingdom - recruitingPHASE3
A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity
This study looks at a new medicine, NNC0487-0111, for people with heart failure and obesity. It compares the medicine to a dummy treatment (placebo) to see if it's safe and helps improve heart health.
United States · Argentina · Australia - recruitingNA
Hybrid Ablation of Atrial Fibrillation in Heart Failure
This study looks at a new way to treat persistent atrial fibrillation (a type of irregular heartbeat) in people who also have heart failure. It compares a combined treatment (hybrid ablation) with the usual treatment to see which works best at keeping a steady heart rhythm.
United Kingdom - not yet recruiting
Left Bundle Branch Area Pacing 3D Guidance System
This study is developing a smart computer system to improve how pacemakers are fitted for people with certain heart conditions. It aims to help doctors place the pacemaker lead more accurately, potentially leading to better results for patients.
United Kingdom - active not recruitingNA
Evaluate the Safety and Performance of the AccuCinch® Ventricular Repair System - The CorCinch-EU Study
This study is testing a new device, the AccuCinch® system, for people with severe heart failure. It aims to see how safe and effective it is at improving heart function and symptoms, especially for those whose heart is enlarged and not pumping well.
Belarus · Belgium · Czechia - ongoing, recruitingTherapeutic exploratory (Phase II)
C3651011 - A PHASE 2, DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED, 4-ARM STUDY TO INVESTIGATE SYMPTOMS, FUNCTION, HEALTH-RELATED QUALITY OF LIFE AND SAFETY WITH REPEATED SUBCUTANEOUS ADMINISTRATION OF PONSEGROMAB VERSUS PLACEBO IN ADULT PARTICIPANTS WITH HEART FAILURE
This study is testing a new medicine, ponsegromab, for people with heart failure. We want to see if it improves symptoms like breathlessness and tiredness, how well people can do daily activities, and their overall quality of life, compared to a dummy medicine.
Germany · Poland · Hungary - recruitingPHASE3
A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Heart Failure
This study looks into a new treatment for adults with heart failure. It combines two medicines, vicadrostat and empagliflozin, to see if they can improve heart health in people with a specific type of heart failure. Participants take tablets daily and are closely monitored.
United States · Argentina · Australia - recruitingNA
RCT of Implantable Defibrillators in Patients With Non Ischemic Cardiomyopathy, Scar and Severe Systolic Heart Failure
This study looks at whether implanting a small device, called an ICD, helps people with a specific type of heart failure live longer. It compares patients who get the device with those who don't, to see if it improves their health over several years.
United Kingdom - recruitingNA
Atrial Fibrillation Ablation Versus Atrioventricular Nodal Ablation with Conduction System Pacing in Heart Failure
This study compares two treatments for people with long-term atrial fibrillation and heart failure: one uses a pacemaker and a procedure to block faulty signals, the other uses a procedure to reset the heart's rhythm. It aims to see which is better at improving health.
Austria · Belgium · Bulgaria - authorisedTherapeutic use (Phase IV)
Discontinuation or Continuation of SGLT-2 Inhibitors Before Cardiac Surgery: Impact on Postoperative Cardiovascular Outcomes – DISCO Study
This study looks at whether continuing or stopping certain heart failure medications (SGLT-2 inhibitors) before heart surgery affects how well patients recover. It aims to improve outcomes for people with heart failure having surgery.
France - not yet recruiting
Coronary Artery Disease in Hearts Donated for Transplantation
This study looks at donor hearts that can't be used for transplant because doctors think they have blocked arteries. We will use a special X-ray test to see if these hearts are actually healthy enough to be used. The goal is to help more people get heart transplants.
United Kingdom - recruitingPHASE2
A Study to Learn About the Study Medicine Called PF-07328948 in Adults With Heart Failure (BRANCH-HF)
This study is testing a new medicine, PF-07328948, for adults with heart failure. We want to see if it's safe and helps improve symptoms when taken alongside existing treatments. Volunteers will take the medicine or a dummy pill for 36 weeks.
United States · Brazil · Bulgaria - recruitingPHASE2
Study to Evaluate Safety, Tolerability and Drug Levels of BMS-986435/MYK-224 in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF)
This study is looking into a new medication called BMS-986435/MYK-224 for people with a type of heart failure called HFpEF. Researchers want to see if it's safe, how well people tolerate it, and how much of the medicine stays in the body.
United States · Argentina · Canada - active not recruiting
Epidemiology of Complications After Solid Organ Transplantation - EpCOT Study
This study looks at health problems, especially cancer, after organ transplants in the UK. Researchers are combining existing patient information to better understand why cancer happens and how it affects people after a transplant, to help improve care.
United Kingdom - recruitingNA
Smartphone Twelve-Lead ECG Utility In ST-Elevation Myocardial Infarction II
This study is testing a new smartphone device called AliveCor 12-lead ECG. It aims to see if this device can accurately detect heart attacks (STEMI and NSTEMI) in people with chest pain, just as well as the standard ECG machines used in hospitals.
United States · United Kingdom - recruiting
EMPOWER-1: A Multi-site Clinical Cohort Research Study to Reduce Health Inequality
This study aims to understand why common medicines don't work the same for everyone in the UK, especially for people from different backgrounds. It will look at many health conditions, hoping to improve how we treat them and make healthcare fairer for all.
United Kingdom - recruitingPHASE3
A Study to Test Whether Vicadrostat (BI 690517) in Combination With Empagliflozin Helps People With Heart Failure and a Weak Pumping Function of the Left Side of the Heart
This study investigates if a new drug, vicadrostat, combined with empagliflozin, can help adults with heart failure and a weakened heart pump. Participants will take study medications for up to 3.5 years, alongside their usual care.
United States · Argentina · Belgium - recruiting
Product Performance Report: Evaluate Long-term Reliability & Performance of Medtronic Marketed Cardiac Therapy Products
This study looks at how well Medtronic heart devices, like pacemakers and defibrillators, perform over a long time. It helps ensure these devices are reliable and safe for people with heart conditions such as irregular heartbeats or heart failure.
United States · Australia · Austria - recruitingPHASE2, PHASE3
Efficacy, Safety, and Pharmacokinetics of Vericiguat in Pediatric Participants With Heart Failure Due to Left Ventricular Systolic Dysfunction (MK-1242-036)
This study is looking at a new medicine called vericiguat for children and young people aged 29 days to 17 years with heart failure. We want to see if it can improve their heart health compared to a dummy medicine.
United States · Belgium · Brazil - active not recruitingNA
REDUCE LAP-HF RANDOMIZED TRIAL I
This study looks at a new small device for people with heart failure. It aims to see if this device can lower high pressure in the heart's upper left chamber, which could help reduce symptoms.
United States · Australia · Belgium - ongoing, recruitingPhase I and Phase II (Integrated)- Other
Safety and Tolerability of AC01 in patients with heart failure
This study is looking at a new medicine called AC01 for people with heart failure. It's an early-stage trial checking if the medicine is safe and if people can take it without too many problems. Both men and women aged 18 and over can take part.
Sweden · Italy · Netherlands - active not recruitingNA
Effects of Telemonitoring on the Outcome of Heart Failure Patients After an Incidence of Acute Decompensation
This study is looking at how a smartphone app called Medly can help people with heart failure manage their condition after leaving hospital. It aims to see if Medly improves their self-care, quality of life, and helps prevent them from needing to be readmitted to hospital soon after discharge.
Canada - recruitingNA
Breast cancEr, FITness and ExeRcise for Heart Health: The BE-FITTER Study
This study looks at how exercise or yoga helps older women who've had breast cancer and chemotherapy. It checks if these activities can improve heart and muscle health and make daily tasks easier.
Canada - recruitingNA
Surgical Ablation of AF Efficacy Trial
This study looks at whether a surgical procedure to treat an irregular heartbeat (atrial fibrillation) during heart surgery can help prevent future heart problems, especially heart failure. It compares adding this procedure to not adding it, in people already having heart surgery.
Canada