Heart failure with preserved ejection fraction research hub
17 indexed studies · 16 currently recruiting
- recruitingHuman Pharmacology (Phase I)- First administration to humans
A clinical trial of MK-1824 in healthy participants (MK-1824-001)
This early-stage clinical trial tests a new medicine called MK-1824 in healthy adult men. As a Phase 1 study, it is the first time the medicine is given to humans. Researchers want to check its safety, side effects, and how it behaves inside the body before testing it in patients.
Belgium - recruitingPHASE3
Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity
This study looks at a new medicine, Maridebart cafraglutide, for people with heart failure and obesity. It aims to see if the medicine can reduce heart-related problems like hospital stays, improve symptoms, and help people live longer, alongside their usual heart failure care.
United States · Argentina · Australia - recruitingTherapeutic use (Phase IV)
Sacubitril-Valsartan in Heart Failure with Preserved Ejection Fraction and Secondary Mitral Valve Regurgitation (PRAISE-MR)
This study looks at how a medicine called Entresto might help people with a common type of heart failure and a leaky heart valve. Researchers want to see if Entresto improves heart function and symptoms over 6 months.
Belgium - recruitingTherapeutic use (Phase IV)
Impact of trimetazidine on endothelial function and biomarkers correlating with the prognosis of heart failure with preserved ejection fraction
This study is looking at a medicine called Trimeductan MR for people with a type of heart failure where the heart still pumps blood well. It wants to see if the medicine can reduce hospital stays for heart failure or prevent death, and how it affects heart health.
Poland - recruitingTherapeutic use (Phase IV)
The effect of empagliflozin on peripheral microvascular dysfunction in heart failure with preserved ejection fraction
This study for people with a type of heart failure called 'heart failure with preserved ejection fraction' is looking at how a medicine called empagliflozin affects tiny blood vessels in the skin. We want to see if it improves blood flow.
Netherlands - recruitingHuman Pharmacology (Phase I)- Other
A Study to Learn How Different Amounts of the Study Medicine Called PF-07293893 are Tolerated and Act in the Body of Healthy Adults.
This study is looking at a new medicine called PF-07293893 in healthy adults. Researchers want to understand how different amounts of the medicine are handled by the body and if it's safe. It's an early-stage study to learn more about this potential treatment for heart failure.
Belgium - not yet recruitingNA
Training in HFpEF-PH
This study looks at a special exercise program for people with heart failure (HFpEF) and high blood pressure in their lungs (pulmonary hypertension). We want to see if it's safe, helps them exercise more easily, and improves their overall health and heart function.
Germany · Lithuania - recruitingNA
Atrioventricular Node Ablation and Conduction System Pacing in Patients With Well Controlled Permanent Atrial Fibrillation (AF), Heart Failure and Preserved Ejection Fraction: Heart Rate Regularization Versus Medical Rate Control
This study looks at a new way to treat people with permanent atrial fibrillation and a type of heart failure called HFpEF. It compares a procedure called AV node ablation with a pacemaker to standard medication, aiming to see if it reduces serious heart-related events.
Belgium · France - recruitingPHASE2
A Study of TX000045 in Patients With Pulmonary Hypertension Secondary to Heart Failure With Preserved Ejection Fraction (the APEX Study)
The APEX study is looking at a new medicine called TX000045 for people with high blood pressure in their lungs caused by a certain type of heart failure. It will compare two doses of the medicine against a dummy treatment to see if it helps.
United States · Armenia · Australia - recruitingNA
Managing Congestion in Heart Failure: A Mechanistic Study in Patients With HFpEF
This study (MAGIC-HF) investigates how daily remote monitoring of heart pressure and body water helps manage fluid buildup in people with a type of heart failure called HFpEF. It uses a small implanted sensor and a smart scale to give doctors better information, aiming to reduce hospital stays and improve health.
Germany - recruitingNA
The Effect of Obesity and Weight Loss in Heart Failure With Preserved Ejection Fraction
This study investigates if losing weight can help people with a specific type of heart failure called HFpEF. It aims to see if diet-led weight loss improves heart function, exercise ability, and quality of life in overweight or obese patients.
United Kingdom - recruiting
The Sarcopenia Study
This study looks at muscle weakness, called sarcopenia, in people with heart failure. Researchers want to see if different types of heart failure affect how common sarcopenia is, comparing heart failure patients to healthy people and those with type 2 diabetes.
United Kingdom - authorisedTherapeutic use (Phase IV)
Effects of sodium-glucose cotransporter 2 inhibition on the mechanisms of heart failure with preserved ejection fraction
This study is looking at how a common heart failure medicine called Forxiga works in people who have a specific type of heart failure. It aims to understand the drug's effects on the heart's pumping ability and structure, helping us learn more about how it helps patients.
Spain - recruiting
Biomarkers in Patients With Suspected HFpEF
This study looks for better ways to spot heart failure, especially in people with obesity or low levels of a common blood test. Researchers hope to find new blood markers to help doctors diagnose heart failure more accurately and earlier.
United Kingdom - recruiting
Cardiomyopathies and Heart Muscle Diseases: Cardiac Imaging in the Evaluation of Myocardial Fibrosis Transition
This study is looking at heart scarring, called fibrosis, in different heart muscle conditions. We're using a special scan with a new dye to better understand this scarring and how it changes over time. The aim is to find new ways to diagnose and treat these heart problems.
United Kingdom - recruiting
Manganese-enhanced Magnetic Resonance Imaging (MEMRI) in Heart Failure With Preserved Ejection Fraction
This study looks at why people with a type of heart failure called HFpEF, especially those with Type 2 Diabetes, get so unwell. Using special MRI scans and dyes, researchers want to see how their hearts handle calcium and energy, comparing them to healthy volunteers.
United Kingdom - recruitingPHASE2, PHASE3
A Randomised, Controlled Trial of a Low-energy Diet for Improving Functional Status in Heart Failure With PRESERVED Ejection Fraction Preserved Ejection Fraction
This study looks at how a special low-calorie diet might help people with a type of heart failure where the heart struggles to relax properly. It aims to see if diet can improve heart function, symptoms, and exercise ability.
United Kingdom