Heart Failure with reduced ejection fraction. research hub
11 indexed studies · 10 currently recruiting
- recruitingTherapeutic use (Phase IV)
Pulmonary REsistance modification under treatment with Sacubitil/valsartaN in paTients with HeartFailure with reduced ejection fraction
This study looks at how a drug called Entresto affects blood pressure in the lungs and how easily blood flows through them, in people with a type of heart failure where the heart struggles to pump blood.
Poland - recruitingPhase III
Coenzyme Q10 for people with heart failure to improve their quality of life - the CORAL study
The CORAL study is investigating whether a daily supplement called Coenzyme Q10 (CoQ10) can improve quality of life for people with heart failure. Researchers want to see if taking this capsule three times a day helps boost energy, reduces tiredness, and makes everyday activities easier to manage.
United Kingdom · England - recruitingPhase III and phase IV (Integrated)
Initiation of angiotensin receptor-neprilysin inhibitor (ARNi) and sodium-glucose cotransporter-2 inhibitors (SGLT2i) in patients with heart failure with reduced ejection fraction (HFrEF): the INITIATE-HFrEF randomized open-label trial
This study is looking at new ways to treat heart failure where the heart struggles to pump blood effectively. It compares different combinations of existing medicines to see which approach works best and is safest for patients over a six-month period.
Portugal - recruitingPHASE3
Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction
This study looks at a new drug, omecamtiv mecarbil, for people with severe heart failure. It aims to see if the drug can help reduce hospital stays, the need for transplants, or the risk of death compared to a dummy pill.
United States · Canada · China - recruiting
The Sarcopenia Study
This study looks at muscle weakness, called sarcopenia, in people with heart failure. Researchers want to see if different types of heart failure affect how common sarcopenia is, comparing heart failure patients to healthy people and those with type 2 diabetes.
United Kingdom - recruiting
Prediction of Heart-Failure with Machine Learning
This study looks at how data from an Apple Watch might help predict when heart failure patients could get worse or need to go back to the hospital. Researchers want to see if information like heart rate and activity collected by the watch can give doctors an early warning.
Germany - recruitingNA
The Effect of Obesity and Weight Loss in Heart Failure With Reduced Ejection Fraction.
This study explores if losing weight can improve the heart's health and quality of life for people with a specific type of heart failure. Participants will follow a supervised diet plan or continue their usual care.
Jersey · United Kingdom - active not recruitingNA
Triple Cardiovascular Disease Detection With an Artificial Intelligence-enabled Stethoscope
This study is testing a new AI-powered stethoscope to see if it can help doctors in local clinics find heart problems like heart failure earlier. The aim is to improve heart health and reduce emergency hospital visits for these conditions.
United Kingdom - recruitingNA
Improving CRT Outcome With Non-Invasive Cardiac Mapping
This study looks at a new way to place a special device (CRT) for people with heart failure. It compares standard placement with a new method using a special mapping system to see if it improves how well the treatment works.
Netherlands · Portugal · Sweden - not yet recruiting
VITAL - the Heart Failure With Reduced Ejection Fraction Sub-study
This study looks at how we can better predict who will benefit from a heart device called a CRT. It uses special computer models, like a 'digital twin' of your heart, to help doctors decide if the device is right for you, avoiding unnecessary procedures.
United Kingdom - recruitingNA
Respiratory Sinus Arrhythmia (RSA) Pacing Post-CABG Surgery in Patients With HFrEF
This study tests a new pacemaker designed to restore a natural heart rhythm called Respiratory Sinus Arrhythmia (RSA) in heart failure patients after bypass surgery. Researchers want to know if it's safe and improves heart function compared to standard treatment.
United Kingdom