- recruitingHuman Pharmacology (Phase I)- First administration to humans
A study to assess the safety and immunogenicity of a therapeutic hepatitis B virus vaccine, in healthy adults (RUBY).
Researchers are testing a new therapeutic vaccine for hepatitis B in healthy volunteers. This early-stage study, called RUBY, checks whether the vaccine is safe and how the immune system reacts. The goal is to help develop future treatments for people living with long-term hepatitis B infection.
Belgium - recruitingPhase I and Phase II (Integrated)- First administration to humans
Four-part, Randomized, Double-blind (Parts 1, 2A, 3 and 4), Multi-center, Placebo-controlled Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of GSK3965193 Monotherapy in Healthy Participants and in Participants Living with Chronic Hepatitis B Infection; and GSK3965193 in Combination with Bepirovirsen in Participants Living with Chronic Hepatitis B Infection
This study is testing a new medicine, GSK3965193, for people with chronic hepatitis B. We want to see if it's safe, how it works, and if it can help reduce the virus, especially when combined with another treatment called bepirovirsen.
France · Italy - active not recruitingPHASE2
A Study of Sequential Therapy With Daplusiran/Tomligisiran (DAP/TOM) Followed by Bepirovirsen in Participants Living With Chronic Hepatitis B (CHB)
This study is testing new medicines, daplusiran/tomligisiran (DAP/TOM) and bepirovirsen, for people with long-term Hepatitis B. It aims to find the best dose of DAP/TOM to use with bepirovirsen to improve treatment.
United States · Australia · Belgium - active not recruitingPHASE2
Long-term Follow-up Study to Evaluate Durability of Treatment Response in Previous Bepirovirsen Study Participants (B-Sure)
This study is checking if the benefits of bepirovirsen for Hepatitis B last over time. It's for people who previously took part in a bepirovirsen trial and showed good results. No new treatment is given in this follow-up study, just monitoring.
United States · Argentina · Australia - active not recruiting
HBRN: Immune Regulation and Costimulation in Natural History of Chronic Hepatitis B
This study looks at how your body's defence system, called the immune system, works in people with long-term hepatitis B. Researchers want to understand the balance between parts of the immune system that control the virus and those that fight it, to learn why some people get sicker than others.
United States · Canada - active not recruitingPHASE2
Study of Bepirovirsen in Participants Living With Human Immunodeficiency Virus and Chronic Hepatitis B Virus Infection (B-Focus)
This study is looking into a new medication called Bepirovirsen for people who have both HIV and long-term Hepatitis B. It will compare Bepirovirsen to a dummy treatment (placebo) to see if it's safe and effective in improving their health.
United States · Argentina · Brazil - enrolling by invitation
EuroSIDA - Clinical and Virological Outcome of European Patients Infected With HIV
The EuroSIDA study looks at how HIV affects people in Europe and how treatments work over time. It helps us understand health changes and the impact of new medicines for HIV and related conditions like hepatitis.
Argentina · Austria · Belarus