- recruitingTherapeutic use (Phase IV)
“Randomized, double-blind clinical trial to assess the efficacy of tranexamic acid in reducing blood loss in patients with hip fracture”.
This study looks at whether a medicine called tranexamic acid can reduce blood loss in adults having surgery for a broken hip. Researchers want to see if the treatment lowers the need for blood transfusions and helps patients recover safely both in hospital and over the following year.
Spain - recruitingTherapeutic use (Phase IV)
Zoledronate Early to Hip Fractures Patients – safe and effective? A Randomized controlled double-blinded treatment strategy trial on Zoledronate in hip fracture patients: The ZEBRA trial
The ZEBRA trial is testing whether giving a bone-strengthening medicine called zoledronate soon after a hip fracture is safe and effective. Researchers want to see if early treatment helps bones heal better, improves walking and recovery, and stops future fractures, without causing unwanted side effects during your hospital stay.
Norway - recruitingTherapeutic use (Phase IV)
Hemodynamic safety of isobaric levobupivacaine versus isobaric bupivacaine for subarachnoid anesthesia in patients over 65 years old undergoing hip fracture surgery
This study compares two common numbing medicines used for spinal anaesthesia in people aged 65 and over having hip fracture surgery. Doctors want to see whether levobupivacaine or bupivacaine is better at keeping blood pressure and heart rate stable during and after the operation.
Spain - recruitingTherapeutic use (Phase IV)
Oral laxatives after hip fracture surgery: A randomised controlled trial
Having surgery for a broken hip often causes constipation due to painkillers and bed rest. This study compares common laxatives, including macrogol and bisacodyl, to see which works best to get bowels moving within three days, helping patients recover comfortably without needing extra emergency treatments.
Denmark - recruitingTherapeutic use (Phase IV)
Comparative analysis of the effectiveness and security of the blockade Erectus Spinae Plane Lumbar (ESP-L) versus the absence of locoregional block in hip surgery
This study is looking at how well a pain-relief injection in the back (called an ESP block) works for people having hip surgery. They want to see if it reduces pain better than no injection, and if it's safe. It's for adults having operations on their hip or upper leg bone.
Spain - completedNot Applicable
WHiTE13-DECI: An investigation of people 60 years and over with a broken hip to determine whether they are less likely to have delirium after hip surgery if we treat them with infliximab during the operation
This UK study tests whether a medicine called infliximab can stop sudden confusion (delirium) after hip surgery. Adults aged 60 and over having an operation for a broken hip receive either infliximab or a dummy medicine. Researchers then check their memory, recovery, and well-being over the following 12 months.
United Kingdom - recruiting
WHiTE16-DELPHIC: An investigation of people 60 years and over with a broken hip to determine whether they are less likely to have delirium after hip surgery if we treat them with corticosteroids during the operation
This study looks at whether a common drug called dexamethasone can stop confusion (delirium) in people over 60 who have hip surgery after breaking a hip. Half get the drug, half get usual care. We'll compare their recovery to see if it helps.
United Kingdom - recruitingNA
Remote Ischaemic Conditioning for Post-surgical Complications in Hip Fracture (RIC-FRACTURE)
This study looks at a gentle treatment called Remote Ischaemic Conditioning (RIC) for people with hip fractures. RIC uses a blood pressure cuff to briefly restrict blood flow in an arm or leg, aiming to improve healing and reduce problems after surgery. We want to see if it's safe and practical.
United Kingdom - not yet recruiting
Improving Shared DECISion-making in oldEr Hip Fracture Patients Living With Frailty
This study aims to create a tool to help older people with hip fractures and frailty make important decisions about their treatment. It will use NHS data and interviews to understand what matters most to patients, helping them choose the best care path.
United Kingdom