Diabetes Mellitus, Type 2 research hub
48 indexed studies · 30 currently recruiting
- recruitingPHASE3
EASi-PROTKT™ - A Study to Test Vicadrostat (BI 690517) Taken Together With Empagliflozin in People With Type 2 Diabetes, High Blood Pressure, and Cardiovascular Disease
This study looks at a new medicine, vicadrostat, for people with type 2 diabetes, high blood pressure, and heart disease. It aims to see if taking vicadrostat alongside empagliflozin can help reduce heart problems. Half the participants will get the study medicine, and half will get a dummy pill.
United States · Argentina · Australia - recruitingPHASE3
Zilebesiran in Patients With Hypertension Not Adequately Controlled and With Either Established Cardiovascular Disease or High Risk for Cardiovascular Disease
This study looks at a new medicine called zilebesiran for people with high blood pressure that isn't well controlled, especially if they also have heart problems or are at high risk of developing them. The aim is to see if zilebesiran can reduce serious heart-related events like heart attacks or strokes.
United States · Argentina · Australia - recruiting
Arterial Stiffness in Children and Young People With Hypertension and Chronic Kidney Disease
This study looks at why arteries in young people with kidney disease and high blood pressure can become stiff. We want to see if this is just due to blood pressure or other factors. Understanding this could help find ways to prevent heart and kidney problems later in life.
United Kingdom - recruitingNA
Real World Evaluation of Lifelight®: A Contactless Vital Signs Monitor for Self-monitoring Blood Pressure and Its Comparison to Standard of Care
This study compares a new contactless blood pressure monitor, Lifelight, with traditional cuffs for people with uncontrolled high blood pressure. It aims to see how well Lifelight works in real life and if it helps manage blood pressure.
United Kingdom - enrolling by invitationPHASE3
A Study Evaluating the Long-Term Efficacy and Safety of Ralinepag in Subjects With PAH Via an Open-Label Extension
This study looks at the long-term effects and safety of a drug called Ralinepag for people with a lung condition called pulmonary arterial hypertension (PAH). It's for those who have already tried Ralinepag in a previous study.
United States · Argentina · Australia - recruitingNA
Accuracy Testing of Validated and Non-validated Home BP Devices Sold on the Online Market.
This study checks if blood pressure monitors bought online, both approved and unapproved, give correct readings. Researchers compare them to a special 24-hour blood pressure test to see how accurate they are, aiming to help people with high blood pressure.
Canada - active not recruiting
Meta-Analyses of the Effect of Plant Protein Versus Animal Protein on Cardiometabolic Risk
This study looks at lots of past research to see if swapping animal protein for plant protein makes a difference to health conditions like diabetes, heart problems, and kidney issues. They want to understand if eating more plant-based protein, like from beans or nuts, can be better for our health.
Canada - active not recruiting
Impact of a Regional Program Agir Sur Sa SantE
This study looks at a new care plan called 'Agir Sur Sa SantÉ' (meaning 'Act on Your Health') in our local area. It aims to see how well this plan works for people with conditions like diabetes, obesity, and high blood pressure, focusing on improving their overall health.
Canada - active not recruitingPHASE3
A Master Protocol for Orforglipron (LY3502970) in Participants With Hypertension and Obesity or Overweight: (ATTAIN-Hypertension Screening)
This study is testing a new medicine, orforglipron, to see if it can help people manage high blood pressure when they also have obesity or are overweight. Researchers want to find out if it is safe and works well. Some people will get the medicine, and others will get a dummy pill.
United States · Argentina · China - recruiting
The European NAFLD Registry
This study aims to understand fatty liver disease (NAFLD) better. Researchers collect information and samples from patients across Europe to find new ways to detect and monitor the disease, especially how it progresses from fatty liver to more serious conditions like fibrosis.
Belgium · Finland · France - active not recruitingPHASE3
A Master Protocol Study of Orforglipron (LY3502970) in Participants With Hypertension and Obesity or Overweight (ATTAIN-Hypertension) GZL2
This study is looking at a new medicine called orforglipron for people with high blood pressure who are also overweight or living with obesity. It aims to see if the medicine can help reduce blood pressure and if it's safe to use. Half the participants will get the medicine, and the other half will get a dummy pill.
United States · Argentina · China - not yet recruitingNA
Personalised Pharmacometabolomic-guided Strategy Trial to Optimise Treatment for Hypertension
This study explores a 'smart approach' to choosing high blood pressure medication. By analysing blood tests and clinical information, doctors aim to find the best treatment for you, potentially reducing side effects and improving blood pressure control.
Germany · Netherlands · Spain - active not recruitingNA
WB-EMS Effects on Cardiometabolic Risk Factors
This study looks at how a type of exercise called whole-body electrical stimulation (WB-EMS) affects blood pressure and other health factors in men over 50. It wants to see if this quick, joint-friendly exercise can help people with slightly high blood pressure.
Germany - active not recruitingNA
The RADIANCE II Pivotal Study: A Study of the ReCor Medical Paradise System in Stage II Hypertension
This study is testing a new device called the Paradise System for people with high blood pressure that's not too severe. It aims to see if this system, which treats kidney nerves, can safely and effectively lower blood pressure when people are taking few or no medications.
United States · Belgium · France - recruitingNA
Renal Artery DenervatIon Using Radial accesS in Uncontrolled HyperTensioN
This study looks at a new way to treat high blood pressure that isn't controlled by medicines. It compares two methods of a procedure called renal denervation, which involves using a special device to calm the nerves in your kidneys. We want to see if a newer, less invasive approach is as safe and effective.
France · Germany · Switzerland - recruiting
Global SYMPLICITY Registry (GSR) DEFINE
This study looks at how safe and effective a treatment called renal denervation is for high blood pressure. It follows real patients in many hospitals over several years to understand its long-term benefits.
Germany · Switzerland - not yet recruitingNA
SCORE! Non-Physician Health Worker (NPHW) Implementation Protocol (SIP)
This study helps people in the SCORE! Cohort with high blood pressure, unhealthy cholesterol, or blood sugar issues. We're using trained health workers, not doctors, to support better health through lifestyle advice and check-ups over 12 months.
Canada - recruiting
The "Global Paradise System" Registry
This study looks at a treatment called renal denervation using the Paradise Ultrasound system for high blood pressure. It tracks how well it works and if it's safe over time in people who have already had the treatment. It also checks blood pressure readings at home and quality of life.
Austria · Belgium · France - recruiting
Optical Coherence Tomography And NEphropathy: The OCTANE Study
This study looks at changes in eye blood vessels in people with high blood pressure and kidney disease, compared to healthy individuals. It uses a simple eye scan (OCT) to see if these changes happen and if treatments help improve them.
United Kingdom - recruitingNA
Blood Pressure Following Isometric Exercise in Inactive Adults
This study looks at how a special type of exercise, called isometric exercise, affects blood pressure in adults who don't exercise much. It could help us understand if this exercise can lower blood pressure.
United Kingdom - not yet recruitingNA
Impact of Advanced Practical Nursing Intervention Versus Usual Care on Hypertension Control
This study in France looks at whether a new type of nurse, called an Advanced Practice Nurse (APN), can help people with high blood pressure control it better. Many people struggle to keep their blood pressure down, so researchers are checking if APNs can make a difference.
France - recruitingNA
Controlling and Lowering Blood Pressure With the MobiusHD™
This study looks at how well a device called MobiusHD™ works for people with high blood pressure that’s hard to treat. It checks if the device is safe and helps lower blood pressure after it’s been used in patients.
Germany · Netherlands · United Kingdom - active not recruitingNA
SPYRAL AFFIRM Global Study of RDN With the Symplicity Spyral RDN System in Subjects With Uncontrolled HTN
This study looks at a treatment called renal denervation (RDN) for high blood pressure. It uses a device called Symplicity Spyral to see how well it works and if it's safe in the long term, especially for people whose blood pressure is hard to control.
United States · Australia · Belgium - recruitingNA
Anti-hypertensive Therapy and Exercise Treatment to Improve Vascular Health in Patients With Hypertension.
This study looks at how blood pressure medication and personalised exercise affect high blood pressure. We're trying to find the best ways to improve blood vessel health, understand body changes, and make treatment decisions more personal for people with high blood pressure.
Germany - active not recruitingNA
Effects of a Probiotic in Hypertension
This study is looking at whether a special type of healthy bacteria, called a probiotic, can help lower blood pressure in people with mild high blood pressure. High blood pressure can lead to serious health problems, so finding new ways to manage it is important.
Germany - recruiting
Kidney Check: Diabetes, Blood Pressure & Kidney Health Checks & Care in Indigenous Communities.
This study offers free kidney health checks for Indigenous people aged 10-80 in rural areas of Canada. It aims to find kidney problems early, and those at risk of diabetes and high blood pressure, to improve care and create a lasting health system for these communities.
Canada - ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
A randomized, open-label, single dose, 2-way crossover bioequivalence study comparing apixaban 5 mg hard capsules (PG412 [Celon Pharma]) vs apixaban 5 mg film-coated tablets (Eliquis [Bristol-Myers Squibb]) under fasting conditions in healthy volunteers
This study compares two different versions of a medicine called apixaban (one is PG412, the other is Eliquis). Both help prevent blood clots. We want to see if the new version works in the body in the same way as the established one.
Poland - authorisedTherapeutic use (Phase IV)
Comparative study of eplerenone-based treatment strategy versus irbesartan-based blood pressure lowering in obese hypertensive patients (HEBRO Study)
This study compares two common strategies for lowering blood pressure in obese patients. It looks at whether treatments based on eplerenone or irbesartan are better at controlling blood pressure over 24 weeks. The aim is to find effective ways to manage high blood pressure in this group.
Greece - recruitingNA
BradycArdia paCemaKer With AV Interval Modulation for Blood prEssure treAtmenT
This study looks at whether a special feature in a Medtronic pacemaker can help lower high blood pressure. It compares having this feature on versus off in people who either need a pacemaker or already have one and also have high blood pressure.
United States · Australia · Belgium - recruitingPhase II
A study testing two medications, zibotentan and dapagliflozin, in people with high blood pressure
This study aims to see if two medicines, Zibotentan and Dapagliflozin, can help lower high blood pressure. Many people struggle to control their blood pressure, so researchers are testing this new combination to find better ways to help.
United Kingdom · England - recruiting
Under stress: Why women of black African-Caribbean heritage are at elevated risk of stroke
This study looks at why Black African and Caribbean women might be more likely to have a stroke, especially at a younger age. We're exploring how stress affects blood pressure and brain health in these women, and comparing it to White European women.
United Kingdom · England · Wales - recruiting
Cardiovascular Longitudinal ALSPAC Research Investigations Following Hypertensive Pregnancy in Young Adulthood
This study looks at young adults (30-40 years old) who were born to mothers with high blood pressure during pregnancy. Researchers want to understand why these individuals might have higher risks of heart and blood vessel problems later in life and how to prevent them.
United Kingdom - recruitingNA
The Man Van Project
The Man Van project offers mobile health checks at workplaces and communities for men, especially those from ethnic minority groups, to find health problems like prostate cancer early. The goal is to make healthcare easier to access and improve men's health outcomes.
United Kingdom - recruiting
Hypertension Explored in Long-term Postpartum Follow-up in Later Life
This study looks at why women who had high blood pressure during pregnancy might get heart and blood vessel problems later in life. Researchers want to understand these changes better to find new ways to help them.
United Kingdom - recruiting
Using health information and blood tests (metabolites) to personalise the treatment of high blood pressure
This study looks at how we can better choose high blood pressure medicines. It uses blood test results and health information to give doctors extra guidance. The aim is to find the best treatment for each person, reducing side effects and controlling blood pressure more effectively.
United Kingdom · England · Germany - recruitingNA
A Trial Within Cohort Feasibility Study Design Comparing Standard of Care Versus Weight Loss (Achieved Through Tirzepatide) for Obesity-related Hypertension in Young Adults
This study looks at how a new weight loss medicine, Tirzepatide, affects high blood pressure in young adults who are overweight or obese. We want to see if losing weight can help lower blood pressure more effectively than usual care.
United Kingdom - recruitingNA
Isometric Handgrip Training Frequency and Blood Pressure in People With Hypertension
This study looks at how often people with high blood pressure need to do a simple handgrip exercise. We want to see if doing it less often (two times a week instead of four) is still helpful for lowering blood pressure. This could make it easier for people to stick with exercise.
United Kingdom - ongoing, recruitingTherapeutic exploratory (Phase II)
Impact of Multiple Doses of BAY63-2521 on Safety, Tolerability, Pharmacokinetics and Pharmacodynamics in Patients With Interstitial Lung Disease (ILD) Associated Pulmonary Hypertension (PH)
This study is looking at a new medicine for people with high blood pressure in their lungs, caused by a lung condition. It wants to see if the medicine is safe, how the body handles it, and if it helps. It's an early-stage study.
Germany - not yet recruitingNA
Effect of Beetroot Juice on Cardiovascular and Autonomic Responses to Exercise in Adults With Type 2 Diabetes
This study looks at whether beetroot juice can help adults with Type 2 Diabetes recover better after exercise. It checks how exercise affects blood pressure and heart rate, as well as how helpful beetroot juice might be with these effects.
United Kingdom - recruiting
Evaluation of the Clinical Benefit of the Aktiia Blood Pressure Monitoring for Early Awareness of Hypertension and Prediction of Cardiovascular Risk
This study looks at how a new type of blood pressure monitor (Aktiia G1) can help people with high blood pressure. It aims to see if continuous monitoring, combined with lifestyle information, can improve how we manage high blood pressure and predict heart health risks.
Switzerland · United Kingdom - recruitingNA
Streamlined Denervation With spYral For an Optimized Treatment (SPYRAL SWYFT) in Subjects With Uncontrolled Hypertension
This study looks at a procedure called renal denervation to treat high blood pressure. It aims to see if a simpler way of doing the procedure is just as good, and possibly quicker, than older methods. This could offer a new option for people whose blood pressure is hard to control.
Australia · Belgium · Germany - ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
A study comparing the new drug PG413 produced by Celon Pharma SA with the drug Eliquis available on the market in healthy volunteers.
This study is testing a new medicine, PG413, to see how it compares to an existing medicine called Eliquis. Both medicines are used to prevent strokes and treat blood clots. This early study helps us understand how PG413 works in healthy people.
Poland - active not recruitingPHASE3
Open-Label Extension (OLE) Study to Assess Safety, Efficacy, and Tolerability of Lorundrostat in Subjects With Hypertension
This study looks at a new medicine called lorundrostat for high blood pressure. It checks how safe and effective it is over a longer period in people who have already taken part in a related study.
United States · Australia · Bulgaria - recruitingNA
Hypertension Management in Young Adults Personalised by Echocardiography and Clinical Outcome.
This study looks at how heart scans and clinic information can help doctors better manage high blood pressure in young adults (18-40). It aims to improve how we predict their risk of heart problems.
United Kingdom - ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
A single-dose, randomized, two-period, two-sequence, crossover comparative bioavailability study on formulations containing ramipril, amlodipine and indapamide in combination product versus Triatec® 10 mg capsules (Sanofi - Produtos Farmacêuticos, Lda., Portugal), containing ramipril, Norvasc® 10 mg, tablets (Upjohn EESV, the Netherlands), containing amlodipine and Natrilix® 2.5 mg film-coated tablets (Les Laboratoires Servier, France), containing indapamide co-administered together as reference in healthy male and female volunteers under fasting conditions.
This study is comparing how well a new combination medicine for high blood pressure works in healthy adults. It's looking at whether the new medicine is absorbed in the body in the same way as taking the individual ingredients separately.
Czechia - active not recruitingNA
A Study of the ReCor Medical Paradise System in Clinical Hypertension
This study looks at a new ultrasound system, called Paradise®, to treat high blood pressure. It compares this new treatment with a pretend procedure to see how safe and effective it is for people with different types of high blood pressure.
United States · Belgium · France - not yet recruitingNA
Effects of a Brown Seaweed Tart Cherry Blend in Mild-moderate Hypertension
This study is looking at whether a blend of brown seaweed and tart cherry can help people with slightly high blood pressure. These natural ingredients are thought to have good effects on the heart and blood vessels, and researchers want to see if they can reduce blood pressure without needing traditional medicines.
United Kingdom - recruiting
EMPOWER-1: A Multi-site Clinical Cohort Research Study to Reduce Health Inequality
This study aims to understand why common medicines don't work the same for everyone in the UK, especially for people from different backgrounds. It will look at many health conditions, hoping to improve how we treat them and make healthcare fairer for all.
United Kingdom