Hypertrophic cardiomyopathy research hub
14 indexed studies · 8 currently recruiting
- completedPhase II
The efficacy and mechanism of trientine in patients with hypertrophic cardiomyopathy
This UK clinical trial investigates whether a medicine called trientine can reduce heart muscle thickening in people with hypertrophic cardiomyopathy (HCM). HCM makes it harder for the heart to pump blood. Researchers want to see if trientine improves symptoms, exercise capacity, and overall heart function over one year of treatment.
United Kingdom · England - authorisedTherapeutic exploratory (Phase II)
Learning From Early Aficamten In HCM (LEAF-HCM)
The LEAF-HCM trial tests a new medicine called aficamten (MYQORZO) for adults with hypertrophic cardiomyopathy, a condition where the heart muscle thickens. Researchers want to see if taking this daily tablet for 54 weeks improves blood flow, relieves heart strain, and safely reduces symptoms compared to a dummy tablet.
Netherlands - recruitingTherapeutic confirmatory (Phase III)
The use of empagliflozin in patients with hypertrophic cardiomyopathy
This study looks at whether a daily tablet called empagliflozin can help people with hypertrophic cardiomyopathy. Researchers want to see if the medication improves exercise capacity and daily quality of life over one year, compared to an inactive dummy tablet (placebo).
Poland - recruitingTherapeutic confirmatory (Phase III)
A Long-term Safety Extension Study of Mavacamten (MYK-461) in Adults with Hypertrophic Cardiomyopathy Who Have Completed the MAVERICKHCM (MYK-461-006) or EXPLORER-HCM (MYK-461-005) Trials (MAVA-LTE)
This study looks at the long-term safety of a medicine called mavacamten for adults with a heart condition called hypertrophic cardiomyopathy. It follows people who have already taken part in previous studies of this medicine.
Spain · Netherlands · Denmark - recruiting
French Hypertrophic Cardiomyopathy Observatory
This study aims to understand hypertrophic cardiomyopathy (HCM) better in France. Researchers will collect information from patients about their diagnosis, treatment, and health over several years to help improve care for this heart condition.
France - active not recruitingNA
Prospective Evaluation Of Exercise-Induced Cardiac Conduction Instability In Predicting Ventricular Fibrillation Events In Hypertrophic Cardiomyopathy
This study looks for a better way to identify people with a heart condition called hypertrophic cardiomyopathy (HCM) who are at risk of dangerous heart rhythms. It tests a new method involving an electrical vest and exercise against current approaches to see which is more accurate.
United Kingdom - active not recruiting
HCMR - Novel Markers of Prognosis in Hypertrophic Cardiomyopathy
This study looks at new ways to understand hypertrophic cardiomyopathy (HCM), a heart condition, to better predict who might be at higher risk of serious problems like sudden cardiac arrest or heart failure. Researchers hope to find better tests to guide treatments.
United States · Canada · Germany - recruiting
Evaluation of HEArt invoLvement in Patients With FABRY Disease
This study looks at people with Fabry disease to understand how their hearts are affected. Researchers want to find out what causes heart rhythm problems, sudden heart failure, and early death, to help improve care for these patients.
Germany - enrolling by invitation
Hypertrophic Cardiomyopathy Registry, Biobank and Imaging Data Repository
This study aims to better understand hypertrophic cardiomyopathy (HCM), a heart condition, by collecting health information, genetic samples, and heart scans from people with HCM or those at risk. The goal is to improve diagnosis, predict who might get sick, and find better treatments.
Canada - active not recruiting
A Retrospective Cohort Study of Mavacamten Patient Support Program in Canada
This study looks back at information from Canadian adults with a heart condition called hypertrophic cardiomyopathy who used the medicine mavacamten. It helps us understand more about these patients and how they used the medicine through a special support programme.
Canada - active not recruitingNA
Electromechanically Optimised Right Ventricular Pacing In Hypertrophic Cardiomyopathy (EMORI-HCM)
This study looks at how adjusting pacemakers, particularly in people with thickened heart muscle (Hypertrophic Cardiomyopathy), can help the heart pump more easily. We’re studying if changing pacemaker settings can reduce symptoms like breathlessness and chest pain, and improve quality of life.
United Kingdom - not yet recruitingNA
Coronary Sinus Reducer Objective Impact on SymptoMs, Ischaemia and miCrovascular Resistance in Non-obstructive Hypertrophic CardioMyopathy
This study looks at a new device for people with a heart condition called hypertrophic cardiomyopathy (HCM). In HCM, the heart muscle becomes thick. This device, called a coronary sinus reducer, aims to improve blood flow to the heart and reduce symptoms like chest pain. Half of the participants will get the device, and half will have a dummy procedure to see if it works.
United Kingdom - recruiting
The SMARTER Cardiomyopathy Study
This study looks into heart muscle diseases called cardiomyopathies. Researchers want to understand what causes them and why they affect people differently. They will collect blood samples and health information to learn more, hoping to find better ways to diagnose and treat these conditions.
United Kingdom - recruiting
Cardiomyopathies and Heart Muscle Diseases: Cardiac Imaging in the Evaluation of Myocardial Fibrosis Transition
This study is looking at heart scarring, called fibrosis, in different heart muscle conditions. We're using a special scan with a new dye to better understand this scarring and how it changes over time. The aim is to find new ways to diagnose and treat these heart problems.
United Kingdom