- recruitingHuman Pharmacology (Phase I)- Other
Study to Learn How Safe EV25 is and the Amount of EV25 in the Body Over a Period of Time, When Given as a Single Dose to Adult Healthy People [CCI]
This clinical trial is testing a new medicine called EV25, designed to treat or prevent influenza (the flu). Researchers want to see how safe it is and how the body handles a single dose. The study is currently looking for healthy adult volunteers aged 18 and older to take part.
Belgium - recruitingHuman Pharmacology (Phase I)- First administration to humans
First-in-human Phase 1 Study to Assess the Safety, Tolerability, and Immunogenicity of the Adjuvanted Universal Influenza Vaccine “fH1/DSP-0546LP” in Healthy Adults
This study is testing a new 'universal flu vaccine' called fH1/DSP-0546LP in healthy adults for the first time. Researchers want to see if it's safe, how well people tolerate it, and if it helps the body build protection against the flu.
Belgium - recruitingTherapeutic use (Phase IV)
Optimizing the time of day of influenza vaccine administration in adults aged 60-85 years: A randomized controlled trial
This study is looking at the best time of day for people aged 60-85 to have their flu jab. We want to see if getting the vaccine at a certain time helps your body create more protection against the flu virus.
Netherlands - recruitingTherapeutic confirmatory (Phase III)
A Phase 3, Randomized, Observer-blind, Active-controlled, Case-driven Study to Investigate the Safety, Efficacy, and Immunogenicity of mRNA-1010 Candidate Seasonal Influenza Vaccine Compared with a Licensed Inactivated Seasonal Influenza Vaccine in Adults ≥50 Years of Age
This study is testing a new mRNA flu vaccine for adults aged 50 and over. Researchers want to see how safe and effective it is compared to a standard flu jab. It aims to protect against the flu and understand how the body reacts to the new vaccine.
Germany · Bulgaria · Estonia - recruitingTherapeutic exploratory (Phase II)
Phase 2a, single center, randomized, double-blind, study to evaluate the immunogenicity and safety of one single administration of OVX836 influenza vaccine at two dose levels (180µg or 480μg) given intramuscularly (IM), either as a booster or a primary vaccination in healthy adults previously administered with OVX836, Influvac Tetra® or placebo in the OVX836-002 (EudraCT number: 2019-002939-28) and OVX836-003 (EudraCT number: 2021-002535-39) studies
This study is testing a new flu vaccine called OVX836 in healthy adults. We want to see how safe it is and how well it helps your body fight off the flu at two different dose levels. It’s for people who have had this vaccine or a standard flu jab before.
Belgium - recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
The pivotal bioequivalence study comparing the test product to the reference product, which belongs to the group of medicines used in treatment and prevention of Influenza.
This study is testing a new version of a common flu medicine to see if it works the same way as the original. It's a Phase I trial, meaning it's an early stage of testing involving healthy adults, not people who are ill. The goal is to make sure the new medicine is just as effective.
Czechia - recruitingTherapeutic use (Phase IV)
(The Lion Trial) LAIV induced Immune respOnse in the Nasopharynx
This study, called 'The Lion Trial,' is looking at how the Fluenz nasal spray flu vaccine works. Researchers want to understand if the vaccine virus is found in the nose after vaccination and how the body’s immune system reacts to it.
Netherlands - recruitingHuman Pharmacology (Phase I)- Other
A randomized, Phase 1b, single-center, observer-blind, active-controlled study to evaluate the safety, immunogenicity, and immunological mechanisms of one single administration of TETRALITE influenza vaccine at two dose levels of LiteVax Adjuvant, in healthy participants aged 60 years and older and in healthy participants aged 18 to 50 years.
This study is testing a new flu vaccine called TETRALITE in two different strengths, combined with an ingredient called LiteVax. It's looking at how safe it is and how well it helps the body fight off the flu in healthy people aged 18 and over.
Belgium - recruitingHuman Pharmacology (Phase I)- First administration to humans
A randomized first-in-human, Phase 1, single-center, observer-blind, active-controlled 3-arm study to evaluate the safety, tolerability, and immunogenicity of one single administration of TETRALITE, a novel adjuvanted influenza vaccine, in healthy participants aged 18 to 50 years
This study is testing a new flu vaccine called TETRALITE in healthy adults. Researchers want to see if it's safe, how well people tolerate it, and how strongly it helps the body fight off the flu compared to an existing flu vaccine.
Belgium - completedPhase II
A clinical trial of the safety of the live, attenuated influenza vaccine nasal spray in children aged 12 - 23 months
This study looks at a nasal flu vaccine for children aged 12 to 23 months. Flu can be serious for young children. We want to see if the nasal spray is safe for this age group, especially regarding breathing problems. Every child gets both the vaccine and a dummy spray.
United Kingdom - recruitingPHASE3
A Study to Evaluate the Safety and Efficacy of MK-1406/CD388 for Prevention of Influenza (MK-1406-005/CD388.SQ.3.06)
This study is testing a new medicine, CD388, to see if it can prevent flu in people aged 12 and over who are more likely to get seriously ill from the flu. It compares CD388 to a dummy treatment (placebo) to check how well it works and if it's safe.
United States · Argentina · Australia - not yet recruitingPHASE2
Phase 2a Study of the Efficacy and Safety of TRX-100 in a Human Influenza A Challenge Model
This study is looking into a new medicine, TRX-100, to see if it can help prevent flu (influenza A). We want to find out if it's safe and effective in healthy adults by giving them the medicine and then a small amount of the flu virus.
United Kingdom - recruitingPHASE1, PHASE2
Phase 1/2 Study of a Plant-Based Seasonal Recombinant Trivalent VLP Influenza Vaccine
This study is testing a new plant-based flu vaccine that uses different parts of the flu virus to see if it's safe and works well. It's for adults 18 and older, and we want to find the best dose.
Canada - recruitingNA
GEneRating Mucosal Immunity After INfluenzA Infection and Vaccination in Lung and Lymphoid TissuE
This study looks at how our bodies fight flu after vaccination and infection. We want to understand immune responses in healthy adults (18-55) by comparing a nasal spray flu vaccine with being given the actual flu virus.
United Kingdom - recruiting
Pediatric and Ambulatory Research in Infectious Diseases
This study is setting up a network of children's doctors in France to better track common infections like colds and tummy bugs. They are using special training and computer tools to gather information and learn more about these illnesses in children under 16.
France - active not recruitingNA
Taxifolin/Ergothioneine and Immune Biomarkers in Healthy Volunteers (TaxEr)
This study looks at how natural substances, Taxifolin and Ergothioneine, found in foods like apples and mushrooms, might affect our immune system. We want to see if these substances can help improve how our body fights off illness, especially as we get older, by reducing stress on our cells.
United Kingdom - active not recruitingPHASE3
A Study of mRNA-1018-H5 Pandemic Influenza Vaccine in Healthy Adults
This study is testing a new mRNA vaccine (mRNA-1018-H5) for pandemic influenza in healthy adults. Researchers want to see how well it helps the body fight off the flu and if it's safe and causes any side effects. Participants will receive either the vaccine or a dummy shot.
United States · United Kingdom