- recruitingTherapeutic use (Phase IV)
A randomized double-blind placebo-controlled trial investigating pain characteristics in response to diclofenac or placebo in symptomatic knee osteoarthritis.
This study looks at how well a common anti-inflammatory medicine called diclofenac eases knee pain in adults with osteoarthritis. Researchers are comparing diclofenac with a dummy pill (placebo) to better understand different types of knee pain and see who benefits most from this treatment.
Denmark - recruitingTherapeutic exploratory (Phase II)
A placebo-controlled, double-blinded, randomized, dose-finding trial using a combination of apocynin and paeonol (APPA) for the treatment of knee osteoarthritis
This study is testing a new combination medicine (APPA) for knee osteoarthritis. Researchers want to see if APPA can reduce knee pain better than a dummy treatment or a common painkiller like Panodil. They will mostly look at how much pain changes over 12 weeks.
Denmark - recruitingTherapeutic exploratory (Phase II)
A randomized, two-arm, placebo-controlled, participant and investigator-blinded study investigating the efficacy, safety and tolerability of DFV890 in patients with symptomatic knee osteoarthritis
This study is looking into a new medicine, DFV890, for people with knee osteoarthritis. It compares DFV890 to a dummy treatment (placebo) to see if it helps with pain and is safe to use.
Germany · Spain · Hungary - recruitingPhase I and Phase II (Integrated)- Other
A prospective, double-blinded, randomized, placebo-controlled phase 1/2a study to assess safety, tolerability, systemic exposure and preliminary efficacy of single intraarticular injections of three dose levels of SYN321 and placebo in patients with symptomatic knee osteoarthritis
This study is testing a new medicine, SYN321, for knee osteoarthritis. It's looking at how safe it is, how well people tolerate it, and if it helps with pain, compared to a dummy treatment. We hope to find out if it's a good option for future treatments.
Sweden - recruitingTherapeutic use (Phase IV)
The effects of 2-week long treatment with naproxen sodium (Nalgesin® Forte) on synovial fluid cytokine and naproxen concentration and clinical outcomes in patients with knee osteoarthritis – ZOOM-IN: A randomized, double-blind, placebo-controlled, parallel, multicenter clinical trial
This study is looking at how a pain relief medicine called naproxen (Nalgesin Forte) affects knee osteoarthritis over two weeks. Researchers are checking how it reduces inflammation and improves symptoms compared to a dummy pill (placebo).
Poland - authorisedTherapeutic exploratory (Phase II)
A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study Evaluating the Safety and Efficacy of PPV-06 Active Immunotherapy in Patients with Inflammatory Knee Osteoarthritis (KOA).
This study is testing a new treatment, PPV-06, for knee osteoarthritis. It aims to see if this treatment can reduce pain and improve movement compared to a dummy treatment, called a placebo, over 54 weeks.
Romania · Poland · France - recruitingTherapeutic confirmatory (Phase III)
A Randomized, Double-Blind, Multi-Center, Placebo-Controlled, Trial to Evaluate the Efficacy and Safety of Once Daily Diclofenac Gel AMZ001 3.06% in the Treatment of Pain and Symptoms of Knee Osteoarthritis
This study is testing a new gel (AMZ001) for knee osteoarthritis pain. Doctors want to see if it works better than a dummy gel and how safe it is. It's a key stage before the gel potentially becomes widely available.
Denmark · Czechia · Poland - recruitingTherapeutic exploratory (Phase II)
A randomized, placebo controlled, investigator and participant-blinded study, investigating safety, tolerability and efficacy of RHH646 in participants with knee osteoarthritis
This study is looking at a new medicine called RHH646 for people with knee osteoarthritis. Researchers want to see if it's safe, if people can tolerate it well, and if it helps by checking changes in knee cartilage over 52 weeks.
Denmark · Germany · Spain - recruiting
A randomised trial to understand the benefits of a new intervention designed to reduce muscle overactivity in people with knee osteoarthritis
This study looks at a new physiotherapy called Cognitive Muscular Therapy (CMT) for knee osteoarthritis. It helps people reduce muscle tightness and pain by learning new ways to use their knee muscles. We want to see if it helps those who haven't improved with usual physiotherapy.
United Kingdom · England - recruiting
Genicular embolisation for knee osteoarthritis
This study explores a new treatment called genicular artery embolisation (GAE) for ongoing knee pain from osteoarthritis. It aims to see if blocking small blood vessels in the knee can reduce pain for people who haven't found relief from other treatments but aren't ready for surgery.
United Kingdom · England · Scotland - recruitingHuman Pharmacology (Phase I)- Other
A Phase I Clinical Trial to Evaluate the Safety, Tolerability, and Pharmacokinetics of single ascending doses of 4P-004 versus placebo injected in the Target Knee Joint of Patients with grade 2 to 4 osteoarthritis on the Kellgren and Lawrence severity index.
This study is looking at a new medicine called 4P-004 for knee osteoarthritis. Scientists want to see if it's safe, how well the body handles it, and how it moves through the body after a single injection into the knee. This is an early-stage study.
Belgium - recruitingTherapeutic exploratory (Phase II)
A randomized, two-arm, placebo-controlled, participant, investigator and sponsor-blinded, proof-of-concept study investigating the efficacy, safety and tolerability of QUC398 in patients with symptomatic knee osteoarthritis
This study is testing a new medicine, QUC398, for people with knee osteoarthritis. We want to see if it helps reduce pain and is safe to use. Patients will receive either QUC398 or a dummy treatment, along with standard pain relief.
Denmark · Spain · France - recruitingPhase I and Phase II (Integrated)- Other
A Phase 1/2a Randomized, Double-Blind Placebo-controlled Study of Intra-articular Allocetra in Knee Osteoarthritis
This study is looking at a new treatment called Allocetra for knee osteoarthritis. We want to see how safe it is and if it helps reduce knee pain and improve daily activities for people with this condition.
Denmark - recruitingNA
FitJoints: Getting Fit for Hip and Knee Replacement
This study, called FitJoints, helps people waiting for hip or knee replacement surgery. It looks at how a special program of exercise, good food, and medicine checks before surgery can help them recover better, feel less pain, and improve their daily lives.
Canada - recruitingPHASE4
Using ROSA for Challenging The TKA Standard of Care
This study compares standard knee replacement surgery with a newer robotic-assisted method called ROSA for knee arthritis. It aims to see if the robotic help improves patient satisfaction, healing, and movement over one year.
Canada - recruiting
Movement Dynamics of Knee Osteoarthritis and Total Knee Replacement
This study looks at how people with knee arthritis walk and move, both before and after knee replacement surgery, compared to healthy people. We want to understand why some people still struggle with activity after surgery, hoping to find better ways to help them.
United Kingdom - active not recruitingNA
Combination of PRP and XLHA Prepared With RegenMatrix Medical Device To Treat Moderate to Severe Knee Osteoarthritis
This study looks at a new injection treatment for moderate to severe knee arthritis. It combines your body's healing cells (PRP) with a special gel (XLHA) to see if it reduces pain and improves life compared to existing treatments or a dummy injection.
France - recruitingPHASE2
A Trial to Investigate the Safety and Efficacy of Intra-articular 4P004 Injection in Subjects With Knee Synovitis and Osteoarthritis
This study is looking at a new injection called 4P004 for knee pain caused by arthritis and inflammation. It compares 4P004 to a dummy injection to see if it helps reduce pain and improve knee function in people aged 40-80.
United States · Canada · Denmark - active not recruitingNA
Sensor-based Physiotherapy Intervention With Virtual Reality
This study explores if a special virtual reality (VR) physiotherapy program can help people with knee pain from osteoarthritis. It compares home-based VR exercises to standard physiotherapy to see if the VR system is practical and helpful for patients.
United Kingdom - not yet recruitingPHASE3
Bone Marrow Aspirate Concentrate (BMAC) Treatment for Knee Osteoarthritis
This study is looking at a new treatment called Bone Marrow Aspirate Concentrate (BMAC) for knee arthritis. Researchers want to see if injecting BMAC into the knee helps reduce pain and improve function compared to standard care in people aged 40 and over.
Canada - recruitingNA
Genicular Artery Embolisation for Knee Osteoarthritis II
This study looks at a new treatment called Genicular Artery Embolisation (GAE) for knee osteoarthritis pain that hasn't improved with other treatments. It compares GAE to a dummy procedure to see if it helps reduce pain in your knee. Participants will be followed for up to 24 months.
United Kingdom - active not recruitingNA
Clinical Outcome After Total Knee Arthroplasty Using CR or PS Inlay
This study compares different types of knee replacement surgery for osteoarthritis. It looks at how well people can bend their knee and their overall wellbeing after having a new knee, over a period of up to ten years.
Germany - not yet recruitingNA
IMProving Outcomes With ACT After Knee Surgery
This study looks at a special type of therapy called Acceptance and Commitment Therapy (ACT) before knee replacement surgery. It aims to see if ACT can help people who are at higher risk of not doing as well after their surgery, especially if they feel down or worried.
United Kingdom - recruitingPHASE3
Effect of Genicular Arteries Embolization in Symptomatic Knee Osteoarthritis LipioJoint-2
This study, LipioJoint-2, looks at a new way to reduce knee pain called GAE (Genicular Arteries Embolization) using a special oil. It's for people aged 40-90 with painful knee osteoarthritis who haven't found relief from other treatments. The aim is to see if GAE truly helps with pain and movement.
France - active not recruitingNA
Robot-Assisted Partial Knee Replacement Versus Standard Total Knee Replacement
This study compares two types of knee replacement surgery for people with knee arthritis: a standard full knee replacement and a partial knee replacement helped by a robot. We want to see if using a robot for partial knee replacements can make them better and available to more people.
Canada - recruitingNA
Platelet-rich Plasma in Symptomatic Knee Osteoarthritis
This study is looking at whether injections of Platelet-Rich Plasma (PRP) can help reduce pain in people with moderate knee osteoarthritis. We're comparing PRP to a 'dummy' injection (placebo) to see if it makes a real difference.
France - recruitingNA
Knee Osteoarthritis and Thermal Spa Treatment
This study looks at how well spa treatment at Enghien-les-Bains helps people aged 50-80 with knee osteoarthritis. Researchers want to see if the spa therapy reduces pain and improves movement after six months, compared to standard care for this condition.
France - recruitingNA
Knee Osteoarthritis and Spa Therapy
This study looks at a special 18-day spa treatment program in France for people with knee osteoarthritis. We want to see if this program helps reduce pain and stiffness, makes it easier to move, and improves overall quality of life. The treatment involves mineral water baths and other therapies.
France - active not recruitingNA
Dietary Supplementation With Blueberry in OA
This study looks at how blueberry supplements might help people with knee osteoarthritis scheduled for knee replacement surgery. We want to see if blueberries can reduce joint inflammation, improve symptoms, and help with recovery after surgery, exploring their potential beyond just symptom relief.
United Kingdom - recruiting
Return to Golf After Orthopaedic Surgery
This study looks at how many golfers return to playing golf after having hip, knee, or shoulder replacement surgery. Researchers will follow their progress for a year to understand this process better.
United States · United Kingdom - active not recruitingNA
Uncemented Tritanium TKR vs Cemented Triathlon TKR
This study is looking at two types of knee replacement surgery to see if one protects bone density around the new knee better than the other. We want to find out if the way the new knee is attached (with or without cement) affects how strong your bone stays around it.
United Kingdom - recruitingNA
Development of an Outcome Score for Patients With Knee Osteoarthritis and Knee Joint Endoprosthesis Using an App
This study uses a smartphone app to better understand knee and hip replacement outcomes. It aims to develop a score that predicts patient satisfaction by combining app data with health questionnaires, helping doctors improve care.
Germany - not yet recruitingNA
Minimally Invasive Three-dimensional Knee Kinematic Assessment and Surgical Guidance Using Ultrasonic Rigid Registration
This study is testing a new tool to accurately measure knee movement and help surgeons during knee operations. It aims to improve how well knee surgery works by making sure the knee is lined up correctly and moves smoothly.
Canada - authorisedTherapeutic confirmatory (Phase III)
Randomized control trial comparison between intra-articular infiltrations of PRP, MFAT, and PRP-MFAT in the treatment of symptomatic knee osteoarthritis.
This study is looking into new ways to treat knee osteoarthritis. Researchers are comparing injections of different natural substances, like PRP and MFAT, to see which works best to reduce pain and improve movement in people with knee problems.
France - active not recruitingNA
GAE Using Embosphere Microspheres vs Corticosteroid Injections for Treatment of Symptomatic Knee OA (MOTION)
This study compares two treatments for knee pain caused by osteoarthritis: a new procedure (GAE using tiny spheres) and standard steroid injections. Researchers want to see which works best over two years for people with ongoing knee pain.
United States · Australia · Brazil - recruitingNA
Manual Arthroplasty Versus VELYS Robotic-Assisted Solution Functional Alignment Arthroplasty for Knee Osteoarthritis
This study compares standard knee replacement surgery with a new robotic-assisted method for knee arthritis. It aims to see if the robotic approach leads to better pain relief, function, and patient satisfaction, and if it's safer and more efficient.
United Kingdom - not yet recruitingNA
Gait in Fixed Or Rotating Cementless Total Knee Arthroplasties
This study compares two common knee replacement implants, Attune and Triathlon, which are designed to help people with painful knee arthritis. Researchers want to see if one implant helps patients walk better and feel more stable after surgery.
United Kingdom - active not recruiting
Observational Clinical Investigation of Arthrosamid in Knee Osteoarthritis
This study looks at how a treatment called Arthrosamid® works for people with knee osteoarthritis over five years. It's for adults already receiving this treatment, checking their progress with calls and occasional visits to understand its long-term effects.
Denmark · France · Germany - authorisedHuman Pharmacology (Phase I)- First administration to humans
First-in-human study to assess the safety and feasibility of intra-articular administration of allogeneic engineered gingival fibroblasts (aeGF) in participants with knee osteoarthritis.
This early-stage study is looking at a new treatment for knee osteoarthritis. Researchers want to see if injecting special cells (gingival fibroblasts) into the knee is safe and possible. This is the very first time this treatment is being tried in people.
Denmark - active not recruiting
Golf After Orthopaedic Surgery: A Longitudinal Follow-up (GOLF) Study
This study looks at how many golfers can return to their sport after hip, knee, or shoulder replacement surgery. It also checks when they can play again, how well they play, and their overall health and joint recovery.
United Kingdom - authorisedTherapeutic use (Phase IV)
Adductor canal and IPACK (infiltration between the popliteal artery and the capsule of the knee) blocks versus genicular nerves block for total knee arthroplasty: A randomized clinical trial
This study compares different pain relief methods after knee replacement surgery for osteoarthritis. It looks at how well various nerve blocks work to control pain, focusing on pain levels, how much pain medication is needed, and how quickly patients recover after the operation.
Spain - not yet recruiting
Exploring Factors Linked to Worsening Over Time in People With Early-stage Knee Osteoarthritis and Those With Prior Proven Acute Knee Injury.
This study looks at people with early knee arthritis or those who've had a serious knee injury. We want to find out why some people's knees get worse over time and others don't, by checking blood, knee fluid, or saliva, and asking about symptoms.
United Kingdom