- active not recruitingPHASE3
Quizartinib or Placebo Plus Chemotherapy in Newly Diagnosed Patients With FLT3-ITD Negative AML
This study is looking at a new drug, quizartinib, combined with standard chemotherapy for adults recently diagnosed with a specific type of leukaemia called AML. We want to see if this combination improves treatment outcomes compared to chemotherapy alone.
United States · Australia · Austria - recruitingPHASE1, PHASE2
Safety and Efficacy of Ponatinib for Treatment of Pediatric Recurrent or Refractory Leukemias, Lymphomas or Solid Tumors
This study is looking at a medicine called ponatinib for children aged 1 to 17 with certain types of cancer, like leukemia and lymphoma. We want to see how safe it is and how well it works when other treatments haven't helped or aren't suitable.
Belgium · France · Italy - recruiting
GMALL Registry and Collection of Biomaterial: Prospective Data Collection Regarding Diagnosis, Treatment and Outcome of Adult Acute Lymphoblastic Leukemia (ALL) Patients and Related Diseases Associated With a Prospective Collection of Biomaterial
This study is gathering information on adults in the UK with acute lymphoblastic leukaemia (ALL) or similar blood cancers. Doctors want to learn more about how these cancers are diagnosed and treated, and how patients recover. It helps improve future care for people with these conditions, whether or not they're on a specific trial.
Austria · Germany - active not recruitingNA
Biological Characterisation of High Risk CHildhood Cancer in Children, Adolescents and Young Adults (MICCHADO)
This study looks at DNA and immune system features in childhood, teenage, and young adult cancers like neuroblastoma and leukaemia. We aim to better understand these high-risk cancers from diagnosis through treatment to find new ways to help. Participants give blood, bone marrow, or spinal fluid samples.
France - active not recruitingPHASE1
A Feasibility and Safety Study of Dual Specificity CD19 and CD22 CAR-T Cell Immunotherapy for CD19+CD22+ Leukemia
This study looks at a new treatment for certain types of leukaemia and lymphoma that have come back or not responded to usual treatments. It uses specially modified cells from the patient to target and fight cancer cells more effectively.
United States · Canada - recruiting
Cohort of Patients With Chronic Myelomonocytic Leukemia
Researchers are collecting blood samples from adults with a type of blood cancer called chronic myelomonocytic leukemia (CMML). This study aims to understand CMML better by looking at samples taken during diagnosis and treatment, helping improve future care for patients.
France - recruitingNA
Study of the Impact of Frequency of Changing PICCline Dressings in Patients With Acute Leukemia
This study looks at how often changing dressings on special tubes (PICC lines) in people with leukaemia affects infections. Researchers want to see if changing the dressing more often can lower the risk of serious infections that can be dangerous for patients.
France - active not recruiting
Identification and Evaluation of Patients at Risk of Developing Cardiotoxicity After Receiving Chemotherapy for Breast Cancer, Lymphoma or Leukemia
This study looks at how chemotherapy for breast cancer, lymphoma, or leukaemia can sometimes affect the heart. Researchers want to find out who might be at risk and why, by checking heart health before, during, and after treatment.
Canada - active not recruitingPHASE3
Lactobacillus Plantarum in Preventing Acute Graft Versus Host Disease in Children Undergoing Donor Stem Cell Transplant
This study looks at whether a good bacteria (Lactobacillus plantarum) can help prevent a serious problem called graft versus host disease in children and young adults having a stem cell transplant. Patients will either get the good bacteria or a dummy treatment.
United States · Canada - recruitingNA
MoleculAr Profiling for Pediatric and Young Adult Cancer Treatment Stratification 2
This study, MAPPYACTS 2, helps doctors in France find the best treatments for children and young adults with cancer that has come back or isn't responding. It uses special tests to look closely at cancer cells to suggest personalised treatment options.
France - recruiting
Solving Riddles Through Sequencing
This study looks at new ways to diagnose tough cases of blood cancers like leukaemia. Doctors want to see if advanced genetic testing can help provide clearer, more accurate diagnoses for people whose conditions are hard to understand using standard tests.
Germany - active not recruitingPHASE1, PHASE2
Safety and Dose Finding Study of Neratinib in Children and Young Adults With Cancer That Has Returned or Not Responded to Treatment
This study is testing a new drug called neratinib for children and young adults with cancer that has come back or not responded to other treatments. The main goals are to find a safe dose and understand its effects on the cancer and patients.
United States · Canada