- completedPhase II
A trial of a clot-busting treatment in livers before transplantation
This study tests whether treating a donor liver with a clot-busting drug before surgery can prevent bile duct scarring. The medicine is added to a special machine holding the liver outside the body. Doctors want to see if this treatment is safe and reduces bleeding and complications after transplant.
United Kingdom · England - recruitingTherapeutic confirmatory (Phase III)
A Prospective, randomized, single blind, multicenter Phase III study on organ preservation with Custodiol-N solution compared with Custodiol solution in liver transplantation
This study compares two preservation fluids used to keep donor livers healthy before transplantation. Researchers want to see if an updated liquid, called Custodiol-N, protects the liver better than the standard liquid, Custodiol. Blood tests taken after surgery will show how well the new liver is working.
Spain - recruiting
Reducing blood clots in donated livers before transplantation
This study looks at whether a special treatment for donor livers can prevent problems after a liver transplant. We're testing if giving a 'clot-buster' medicine to the liver before transplant helps prevent scarring in the bile ducts, which can cause serious problems.
United Kingdom · England - recruiting
Establishing a Reference Framework for Outcomes After Machine-Preserved Liver Transplantation in Europe
This study looks at how well different methods of machine-preserving donor livers work for liver transplants in Europe. It aims to create new standards to show the best results we can expect with these modern techniques.
Austria · Belgium · France - recruitingPHASE4
Tacrolimus Associated Tremors in Liver Transplantation: Immediate-Release Versus Extended-Release Formulations
This study compares two forms of medicine called tacrolimus, given after a liver transplant. It aims to see which one causes fewer shaky hands (tremors), a common side effect, to help patients recover better.
Canada - recruitingNA
APCext : Effect of Temporary Porto-caval Shunt During Liver Transplantation on Function of Liver Graft From Extended Criteria Donor
This study looks at a special technique during liver transplants for when donor livers aren't perfect. We want to see if a temporary bypass, called a porto-caval shunt, helps protect the new liver and makes it work better by reducing stress during the operation.
France - recruitingNA
Quantiferon CMV to Identify Treatment Need for Asymptomatic CMV Infection After Solid Organ Transplant (QUANTIFOT)
This study looks at a blood test for organ transplant patients with Cytomegalovirus (CMV) infection. It aims to see if this test can help doctors decide who really needs antiviral medicine, to avoid unnecessary treatment and its side effects.
France - recruitingPHASE4
Evaluation of the Benefits of Administering Immunosuppressive Drugs as Single Daily Doses Over the First Year After Liver Transplantation (EASY)
This study looks at how people who have had liver transplants take their medicines. We want to see if taking a single daily dose of anti-rejection medicines works as well as taking them twice a day. This might make it easier for patients and improve their quality of life.
France - recruitingNA
Restrictive Fluid Management In Liver Transplantation (REFIL)
This study looks at different ways to manage fluids during liver transplants for adults with severe liver disease. Researchers want to see if a new fluid strategy, which aims for less fluid in the body, is safe and can reduce problems after surgery. This is a pilot study to check if a larger trial is possible.
Canada - recruitingNA
Assessment of a Quantra-guided Transfusion Algorithm in Liver Transplantation
This study looks at a new way to guide transfusions during liver transplants. It uses a special device called Quantra to help doctors give patients the right amount of blood products, aiming to reduce bleeding and overall transfusions compared to current methods.
France - recruitingNA
Immunometabolism of Machine Perfusion Strategies
This study looks at new ways to keep donated livers healthy for transplant, especially those from donors who have died from heart problems. It compares different machine-based methods to improve liver quality and understand how they work, aiming to increase the number of successful liver transplants.
United Kingdom - recruitingPHASE4
HOPE Against Cancer Recurrence in HCC
This study looks at a new way to prepare donor livers for transplant to help prevent cancer recurrence. It compares cooling livers with a special oxygen-rich fluid to the usual cooling method, hoping to reduce the chance of liver cancer coming back after transplant.
United States · Austria · Belgium