Locally Advanced or Metastatic Solid Tumors research hub
11 indexed studies · 7 currently recruiting
- authorisedHuman Pharmacology (Phase I)- First administration to humans
A dose escalation and expansion study of XB010 as a single agent and combination therapy in subjects with locally advanced or metastatic solid tumors
This early-stage clinical trial is testing a new drug called XB010 in adults with advanced solid tumours. Researchers want to find out if the treatment is safe, discover the best dose, and see how well it works either on its own or alongside other cancer medicines.
Italy · Netherlands · France - authorisedHuman Pharmacology (Phase I)- First administration to humans
A PHASE I, OPEN-LABEL, MULTICENTER, DOSE ESCALATION AND COHORT EXPANSION STUDY OF MINT91 IN COMBINATION WITH OTHER ANTI-CANCER DRUGS IN PATIENTS WITH LOCALLY ADVANCED OR METASTATIC SOLID TUMORS
This early-stage clinical trial tests a new cancer drug called MINT91. Researchers want to find a safe dose and see how it works alongside other cancer treatments. The study is for adult women with advanced solid tumours that have grown locally or spread elsewhere in the body.
France - recruitingHuman Pharmacology (Phase I)- Other
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Anti-Tumor Activity of Inavolisib in Combination with Paclitaxel in Patients with Locally Advanced or Metastatic Solid Tumors
This study is looking at a new medicine called Inavolisib, given with Paclitaxel, for people with advanced solid cancers. It aims to see if the treatment is safe, how the body handles it, and if it can help shrink tumours.
Denmark · Spain · France - recruitingHuman Pharmacology (Phase I)- First administration to humans
A Phase 1 Study of TAS0612 in Patients with Locally Advanced or Metastatic Solid Tumors
This study is looking for people with advanced solid cancers that have spread. It's testing a new medicine called TAS0612 for the very first time in humans. The main goal is to see if the medicine is safe and what dose can be given, rather than to treat the cancer directly.
Belgium · Spain · France - recruitingHuman Pharmacology (Phase I)- First administration to humans
A study evaluating the safety, tolerability, pharmacokinetics, and activity of RO7566802 given alone and in combination with atezolizumab in patients with locally advanced or metastatic solid tumor malignancies
This study is looking at a new medicine, RO7566802, both by itself and with another drug called atezolizumab. It's for adults with advanced or spreading solid cancers. The main goals are to check if it's safe, how the body handles it, and if it shows signs of helping.
Spain · Czechia - recruitingHuman Pharmacology (Phase I)- First administration to humans
A Study to Investigate the Safety and Effectiveness of RO7759065 in Combination with Atezolizumab in Participants with Locally Advanced or Metastatic Cancer
This study is looking at a new medicine, RO7759065, combined with an existing cancer drug, atezolizumab. It's for adults with advanced cancer that has spread. Researchers want to see if this combination is safe and how well it works to treat different types of solid tumours.
Italy · Spain · France - completedPhase I
A Phase Ia/Ib study of STA551 as a single agent and in combination with atezolizumab in patients with solid tumors
This early-stage clinical trial looks at a new experimental immunotherapy drug called STA551. It is being tested on its own and alongside an approved cancer drug, atezolizumab. The trial aims to find safe doses and see if it can help adults with advanced solid tumours who have run out of standard treatments.
United Kingdom · England · Japan - recruitingHuman Pharmacology (Phase I)- First administration to humans
A Study to Evaluate the Safety, Pharmacokinetics, and Activity of RO7496353 in Combination with a Checkpoint Inhibitor with or without Standard-of-Care Chemotherapy in Patients with Locally Advanced or Metastatic Solid Tumors
This study is testing a new medicine, RO7496353, in people with advanced solid tumours. It's looking at how safe it is and how it works, both alone and with other common treatments like chemotherapy and immunotherapy.
Italy · Spain - recruitingHuman Pharmacology (Phase I)- First administration to humans
An Open-label Dose-Escalation Study to Evaluate XmAb24306 as a Single Agent and in Combination with Atezolizumab in Patients with Locally Advanced or Metastatic Solid Tumors
This study is testing a new medicine called XmAb24306, both on its own and with another drug, atezolizumab. It's for adults with advanced or metastatic solid tumors. Scientists are looking at how safe it is and what dose works best.
Netherlands · Belgium · Spain - recruitingPHASE1
Study of XB010 in Subjects With Solid Tumors
This study is testing a new medicine called XB010, both on its own and with another drug (pembrolizumab), for people with certain advanced solid cancers. It aims to see how safe it is, how well the body handles it, and if it helps shrink tumours when other treatments haven't worked.
United States · United Kingdom - authorisedPhase I and Phase II (Integrated)- First administration to humans
A Phase 1/2, Multicenter, Open-label, Dose-escalation, and Dose-expansion Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamic, and Antitumor Activity of CR-001 in Adult Participants with Locally Advanced or Metastatic Solid Tumors.
This study is testing a new medicine, CR-001, for adults with certain advanced or spreading cancers. It aims to find a safe and effective dose, understand how the body uses the medicine, and see if it can shrink tumors or slow their growth.
Spain · Ireland · Italy