- completed
Cognitive Muscular Therapy - developing a training programme for physiotherapists
Researchers at the University of Salford are testing a new approach called Cognitive Muscular Therapy for persistent low back pain. This study explores how thoughts affect muscle tension. The goal is to develop a training programme for NHS physiotherapists so they can help patients relax tense muscles and reduce back pain.
United Kingdom · England - recruitingTherapeutic exploratory (Phase II)
Intervertebral Disc REgeneration mediated by Autologous Mesenchymal stem/stromal cells intradiscal injection: a phase IIB randomized clinical trial
This study looks into a new way to treat ongoing lower back pain. It uses a patient's own stem cells injected into the back discs to see if it lessens pain and improves daily function over 12 months.
Italy - completed
FORENSIC-UK: Fusion versus Best Conservative Care
This study looks at whether an operation called spinal fusion helps people with ongoing severe lower back pain better than other non-surgical treatments. It also checks if the operation is good value for the NHS.
United Kingdom · England · Northern Ireland - recruiting
Quebec Low Back Pain Study: Core Dataset
This study looks into why some people's back pain lasts a long time and others get better. Researchers will follow adults with new or long-lasting low back pain in Quebec for two years, using an online platform to gather information about their pain and daily life.
Canada - authorisedTherapeutic confirmatory (Phase III)
A Randomized, Multicenter, Double-Blind, Parallel-Group, Placebo and Active-Controlled Phase III Therapeutic Superiority Trial Comparing the Efficacy and Tolerability of a Fixed-Dose Combination of Diclofenac potassium + Thiocolchicoside to Diclofenac potassium (Cataflam®) in Patients with Acute Severe Low Back Pain.
This study is looking at a new combination of two common pain medications, diclofenac potassium and thiocolchicoside, to see if it's better than diclofenac alone for severe back pain. Researchers are also checking for side effects.
Cyprus · Greece - active not recruitingNA
Effects of Isolated Lumbar Extension Resistance Training Alone and in Combination with General Exercise and Manual Therapy
This study looks at how a special back exercise machine, alone or with other treatments, helps people with long-term back pain. It checks if the exercise improves back muscles, reduces pain, and boosts quality of life.
Germany - recruitingNA
The Effects of EXOPULSE Mollii Suit on Low Back Pain
This study looks at how a special suit, called the EXOPULSE Mollii Suit, might help people with ongoing lower back pain. It aims to see if the suit can reduce pain and improve daily life by stimulating many muscles at once.
France - recruitingNA
Motivating Core-muscle Exercises With Wearable Sensors, Haptics and Interactive Gaming
This study looks at a special smartbelt and app for people with long-term back pain. It checks if using this system during exercise helps reduce pain and improve daily life more than usual care alone.
United Kingdom - active not recruitingNA
The Costs and Effectiveness of Cognitive Functional Therapy for People with Persistent Low Back Pain in Coventry.
This study looks at a special type of therapy called Cognitive Functional Therapy (CFT) for long-term back pain in Coventry. It wants to see if CFT helps people who also face health inequalities or have other health problems, checking how well it works and its costs.
United Kingdom - recruitingNA
Efficacy on Anxiety of the Digital Music Application Versus Equimolar Mixture of Oxygen and Nitrous Oxide in Patients Receiving CT-guided Lumbar Infiltration
This study looks at using a digital music app to help people with back pain feel less anxious during CT scans. It compares music to a gas mix (nitrous oxide and oxygen) currently used, hoping music works just as well but is easier and more comfortable.
France - active not recruiting
Personalisation of Prosthetic Care for Lower- Limb Amputees
This study looks at why some people with a lower-leg amputation get back pain. Researchers want to understand how walking styles, muscle use, and feelings like depression affect back pain. The aim is to help create better care plans for amputees.
United Kingdom - active not recruitingPHASE4
Multifidus PET Scan Study
This study looks at how a special device for ongoing low back pain affects the brain and back muscles. It uses a type of scan (PET scan) to see changes, hoping to understand why this treatment helps people feel better, move more easily, and improve their quality of life.
United Kingdom - authorisedTherapeutic confirmatory (Phase III)
ZAMBA: Zoledronic Acid for Modic Back Pain. A randomized, double blind, placebo-controlled, multicenter trial
This study, called ZAMBA, is looking at whether a medicine called zoledronic acid can help people with ongoing back pain. It compares this medicine to a dummy treatment (placebo) to see if it improves daily activities and pain levels over one year.
Norway