Major Depressive Disorder research hub
46 indexed studies · 34 currently recruiting
- recruitingTherapeutic confirmatory (Phase III)
Precision psychiatry: Anti-inflammatory medication in Immuno-metabolic depression
This clinical trial looks at whether an anti-inflammatory drug called celecoxib can help treat depression. Researchers want to see if reducing inflammation in the body improves low mood, tiredness, sleep, and appetite over 12 weeks. Participants will take either the study medicine or a dummy pill.
Netherlands - authorisedTherapeutic exploratory (Phase II)
The Role of Serotonin 4 Receptor Agonism in Regulating Mood and Cognition in Depression in women (RECAP-D)
This study looks at whether a medicine called prucalopride can help improve low mood and memory problems in women with depression. Researchers want to see if combining it with sertraline, a common antidepressant, works better than standard treatments or a dummy pill over an 8 to 12-week period.
Denmark - recruitingTherapeutic exploratory (Phase II)
KET01-IIT03: A Pilot, Open-label Phase II Trial of Adjunctive Treatment with Ketamine Hydrochloride Prolonged-Release Tablets (KET01) during the Initiation of Antidepressant Therapy in Major Depressive Disorder
This clinical study tests whether a new slow-release ketamine tablet, called KET01, can help people with severe depression feel better more quickly. Standard antidepressants usually take several weeks to work. Researchers want to see if taking KET01 alongside a new antidepressant relieves depression symptoms within the first week.
Sweden - authorisedTherapeutic use (Phase IV)
Unprescribing the Pill to Reassess Symptom and Cognitive Recovery in Depression (UNPRESCRIB-D)
This study looks at whether stopping the contraceptive pill helps women recover from depression. Researchers want to see if coming off the pill improves mood, memory, and concentration, and how it changes the way standard antidepressants, such as sertraline or duloxetine, work in the brain.
Denmark - authorisedTherapeutic exploratory (Phase II)
A Randomized, Delayed-Treatment Controlled, Phase 2 Pilot Study of Manualized MDMA-Assisted Therapy for Young Adults with Chronic Treatment-Resistant Major Depressive Disorder
This study tests whether midomafetamine (MDMA) combined with guided talking therapy can help adults with long-term depression that has not improved with standard treatments. Researchers want to see if this treatment is safe, practical to deliver, and effective at easing depression symptoms and improving daily functioning.
Norway - recruitingTherapeutic confirmatory (Phase III)
Long-term Study to Assess the Safety and Effectiveness of NMRA-335140 in Participants with Major Depressive Disorder
This clinical trial is testing a new investigational medicine called NMRA-335140 for adults living with major depression. Doctors want to see how safe the treatment is over a longer period and whether it helps improve low mood, anxiety, ability to feel pleasure, and overall quality of life.
Bulgaria · Czechia · Sweden - recruitingTherapeutic confirmatory (Phase III)
A Phase 3, Randomized, Double blind, Placebo controlled Study to Evaluate the Effects of Oral NMRA-335140 versus Placebo in Participants with Major Depressive Disorder
This study tests a new daily medicine called NMRA-335140 for adults with major depression. Researchers want to see if this tablet can help ease feelings of sadness and improve the ability to enjoy life over six weeks, comparing it against a dummy pill to ensure fair results.
Germany · Bulgaria · Czechia - recruitingHuman Pharmacology (Phase I)- Other
Monitoring the AD effects of ketamine in MDD patients
This study is looking at how a medicine called ketamine affects people with severe depression. Researchers want to understand its effects better to see if it could be a helpful treatment. It’s an early-stage study, meaning they are carefully checking how the body reacts to the medicine.
Netherlands - recruitingTherapeutic exploratory (Phase II)
A Phase II, 6-week, multi-centre, randomised, double-blind (participant and investigator), placebo-controlled, dose-finding trial to evaluate the efficacy, tolerability, and safety of different doses of oral BI 1569912 as adjunctive therapy in patients with major depressive disorder
This study is looking into a new medication for depression. It aims to see if different doses of this new drug, called BI 1569912, can help people with major depression feel better and if it's safe to use. Patients will take the new drug alongside their usual treatment.
Belgium · Bulgaria · Czechia - recruitingHuman Pharmacology (Phase I)- First administration to humans
Single Ascending Dose study of ENX-104
Researchers are studying a new medicine called ENX-104 for people with depression. This first study in humans will help find a safe dose and see how the body handles the medicine. It's an early step to see if ENX-104 could help treat depression in the future.
Netherlands - recruitingTherapeutic exploratory (Phase II)
A 14-week, multicentre, double-blind, randomised, placebo-controlled phase II study with an 8-week treatment period to assess the efficacy and tolerability of a fixed dose of BH-200 (250 mg BID) in outpatients with Major Depressive Disorder (MDD)
This study looks at a new medicine called BH-200 for adults with severe depression. It compares BH-200 to a dummy pill to see if it helps improve mood and daily life better, and if it's safe.
Spain · Estonia · Slovakia - recruitingTherapeutic confirmatory (Phase III)
An Open-label, Long-term, Safety and Efficacy Study of Aticaprant as Adjunctive Therapy in Adult and Elderly Participants With Major Depressive Disorder (MDD)
This study is testing a new medicine, JNJ-67953964, for adults with depression. It aims to see if it's safe and effective when added to their usual treatment over a long period. We'll monitor health, mood, and any side effects.
Sweden · Hungary · France - recruitingTherapeutic use (Phase IV)
Exploring the Pharmacomicrobiomics of Depression
This study looks at how a common antidepressant called venlafaxine affects the germs in your gut and how that relates to your depression symptoms and any side effects you might have. It hopes to understand how gut changes link to treatment results.
Netherlands - completedPhase II
Safety, blood levels and effects of N,N-dimethyltryptamine [DMT (SPL026)] in healthy participants and participants with major depressive disorder
This clinical trial looks at whether DMT, a natural psychedelic substance, can help treat major depression. Researchers want to see if giving DMT through an injection into a vein is safe, how the body processes it, and whether it eases depressive symptoms in adults alongside professional psychological support.
United Kingdom · England - recruitingNot Applicable
Home-based transcranial direct current stimulation for the treatment of major depressive disorder
This study looks at treating depression from home using a gentle electrical brain stimulation device called tDCS. It aims to see if tDCS, along with usual care, helps improve depression more than usual care alone for adults in England and Wales.
United Kingdom · England - not yet recruitingPHASE3
Sustained Mood Improvement With Laughing Gas Exposure
This study looks into whether laughing gas (nitrous oxide) can help improve mood in people with severe depression that hasn't responded to other treatments. It compares laughing gas to oxygen over four weeks.
Canada - recruitingPHASE4
Optimized Predictive Treatment In Medications for Unipolar Major Depression (OPTIMUM-D)
This study, OPTIMUM-D, looks at whether we can better predict which depression treatment works best for you. It uses information like brain scans and other body markers to help decide if a common antidepressant, escitalopram, works better with or without brexpiprazole, another medication for depression.
Canada - recruitingNA
Deep TMS for Comorbid Depression and Cognitive Impairment in Older Adults
This study looks at a special type of brain stimulation, called Deep TMS, for people over 60 with both depression and early Alzheimer's or memory problems. It's for those whose depression hasn't improved with usual treatments. We want to see if it's safe and helps with mood.
Canada - recruitingNA
Effectiveness of an Integrated Care Pathway for Depression: Cluster Randomized Controlled Trial
This study looks at a new way to help teenagers aged 13-18 with depression in local clinics. It compares a special care plan called CARIBOU-2 with usual care to see which is better at reducing depression symptoms and improving daily life.
Canada - not yet recruitingNA
Prediction and Validation of Unipolar Depression With Psychosocial-somatic Markers in a Naturalistic Cohort Recruited in an Outpatient Setting
This five-year study aims to better understand depression by looking at different types of depression and how they might affect people over time. Participants will have blood samples taken to help identify these differences.
Germany - recruitingPHASE2
Pharmacologic Treatment Augmentation in Chronic Depression
This study looks into new ways to treat severe, long-lasting depression when other treatments haven't worked. It tests ketamine and a type of therapy called CBASP, sometimes together, to see if they can help improve symptoms.
Germany - recruitingNA
Group Intervention for Romantic Relationships in Young Adults With Severe Mental Illness
This study helps adults with severe mental illness improve their romantic and social skills. It's a group program called "Better Together" that aims to reduce loneliness and build confidence for healthy relationships, supported by mental health experts.
France - recruiting
Basal Plasma Lithium Levels and Suicidal Events
This study looks at how natural lithium levels in the body might be linked to suicidal thoughts and actions in people with depression. It compares those with and without a history of suicidal events to understand how lithium could help prevent them.
France - recruitingPHASE4
Personalized Indications for CBT and Antidepressants in Treating Depression
This study looks at how to find the best treatment for depression, either talking therapy (like CBT) or antidepressants, for each person. Researchers want to see if specific factors, such as childhood experiences or certain body markers, can help decide which treatment works best. It aims for more effective, personalised care.
Canada - recruitingPHASE3
The Effect of a Six Week Intensified Pharmacological Treatment for Major Depressive Disorder Compared to Treatment as Usual in Subjects Who Had a First-time Treatment Failure on Their First-line Treatment.
This study looks into new ways to treat severe depression when first treatments haven't worked well. It compares an intensive use of esketamine (a type of ketamine) with usual care, aiming to find better and faster relief for people struggling with depression.
Austria · Germany · Greece - recruitingNA
Evaluation of the Impact of the EDIT-B® Blood Test on the Health Status of Patients Presenting a Major Depressive Episode. Clinical Utility and Medico-Economic Aspects
This study looks at a new blood test, EDIT-B®, to help doctors tell the difference between two types of depression: major depression and bipolar disorder. This is important because the treatments are different, and getting the right diagnosis sooner can improve health and prevent serious problems.
France - recruitingNA
Integrated Suicide & Trauma Therapy for Suicide Risk
This study looks at a new therapy, ISTT, for people who have considered suicide and experienced childhood trauma. It aims to help them learn coping skills and deal with past trauma to reduce suicide risk.
Canada - recruitingNA
EEG Microstates Across At-Risk Mental States
This study looks at brain activity in young people (15-30) with or at risk of certain mental health conditions like depression, psychosis, and autism. It uses special scans and tests to understand how brain patterns might be linked to these conditions and overall well-being.
France - recruitingNA
Temporal Interference and Depression
This study is testing a new, gentle brain stimulation for severe depression. It aims to see if this treatment, called Temporal Interference (TI) stimulation, is safe, manageable, and helps improve symptoms without strong side effects. Participants will receive TI or a dummy treatment while watching emotional films.
Canada - authorisedTherapeutic exploratory (Phase II)
Antidepressant effects of psilocybin in the absence of serotoninergic psychedelic experience: a dimensional functional neuroimaging approach
This study is looking into a new medication called pimavanserin for major depression. It aims to see if this drug can help improve depression by looking at brain activity, even if participants don't feel the 'psychedelic' effects typically associated with some other treatments.
Spain - recruitingPHASE3
Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
This study is looking at a new medicine called NBI-1065845 for people with depression. It's for those already taking antidepressants but still struggling. The main goal is to check its long-term safety and if people can take it alongside their usual treatment.
United States · Belgium · Bulgaria - recruitingNA
Patient-oriented Randomized Pragmatic Feasibility Trial with RTMS in Depression and Anxiety
This study looks at a brain stimulation treatment called TMS for depression and anxiety, specifically in people whose previous treatments haven't worked. We want to see if different types of TMS treatment are helpful and how best to run a bigger study in the future.
Canada - recruitingPHASE2
Measuring Psychomotor Response to L-DOPA Challenge As a Biomarker for Outcomes in Late-Life Depression: a Pilot Feasibility Trial
This study looks at treating severe depression in older adults using a drug called L-DOPA. It explores how L-DOPA affects thinking speed, memory, and mood, and whether it’s a practical treatment option for this type of depression.
Canada - active not recruitingNA
Home-Based CR and tDCS to Enhance Cognition in Persons With Mild Cognitive Impairment and Late Life Depression
This study looks into new ways to help older adults experiencing memory problems or depression. It combines brain exercises and a gentle brain stimulation at home to see if it can improve memory and thinking skills, aiming to prevent conditions like Alzheimer's.
Canada - active not recruitingNA
MST for Parkinson's Disease
This study is testing a new treatment called Magnetic Seizure Therapy (MST) for depression in people with Parkinson's disease. It wants to see if MST is a practical and safe option before it's compared to other treatments in the future. The trial is happening in Canada and involves 20 patients.
Canada - active not recruitingNA
Neural Mechanisms of Intermittent Theta Burst Stimulation in the Core Depression Network
This study looks at how a new, quick brain stimulation called iTBS helps people with depression. Researchers use special scans (PET and MRI) to understand how this treatment changes brain activity, comparing it to a dummy treatment over several weeks.
Canada - recruitingNA
Risk and Resiliency Factors in the RCMP: A Prospective Investigation
This study looks at mental health in Canadian police (RCMP) recruits. It aims to understand what helps or harms their mental well-being when facing stressful situations, with the goal of improving support for them and other emergency workers.
Canada - recruitingNA
Comorbid Obesity and Depression With an Anti-inflammatory Medication
This study looks into using a medicine called minocycline for people who have both obesity and depression. It's for those with signs of body inflammation. The aim is to see if this treatment can help improve depression symptoms by reducing inflammation.
United Kingdom - active not recruitingNA
Repetitive Versus Deep Transcranial Magnetic Stimulation for Major Depression
This study is comparing two types of brain stimulation, rTMS and dTMS, for major depression that hasn't improved with other treatments. It aims to see which method works better to reduce depression symptoms.
Canada - recruitingPHASE2
Trial of Mirtazapine for Depression in IBD
This study is testing if it's practical to run a larger trial for people with both depression and a bowel condition. We'll see if a depression tablet called mirtazapine helps, compared to a dummy pill. It's a first step to understand if this treatment could be useful.
United Kingdom - authorisedTherapeutic use (Phase IV)
Thiopental Induction Dose during Electroconvulsive therapy for depression (TIDE) - a randomized controlled trial of the effect of anesthetic dose during electroconvulsive therapy for major depression
This study looks at how different amounts of the medicine thiopental, used for sleep during electroconvulsive therapy (ECT), affect treatment for severe depression. Researchers want to see if a lower dose works better than a higher dose for improving mood.
Sweden - active not recruitingPHASE1, PHASE2
ELE-101 Safety & Tolerability Study in Healthy Participants and Patients With Depression
This study is looking at a new drug called ELE-101 for depression. It checks how safe it is and how it works in healthy people first, then in people with depression, to see if it could be a helpful new treatment.
United Kingdom - recruitingPHASE2
A Phase 2a Study to Evaluate the Safety and Tolerability of GM-2505 in Patients With MDD
This study is testing a new medicine, GM-2505, for moderate to severe depression. It's looking at how safe it is and if it helps people feel better. We're inviting adults aged 18-65 with depression to take part.
United Kingdom - authorisedTherapeutic confirmatory (Phase III)
A Phase III Long-Term Extension Trial with Optional Additional Doses of CYB003 to Assess the Safety and Long-term Efficacy in Participants with Major Depressive Disorder (EXTEND)
This study looks at a new medicine called CYB003 for people with depression. It's for those who have already shown improvement in previous studies. The main goal is to see if the medicine helps prevent depression from coming back over a long time and to check its safety.
Greece · Poland · Ireland - recruitingPHASE3
NBI-1065845-MDD3026: Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
This study is looking into a new medication called NBI-1065845 for people with depression who haven't fully responded to their current antidepressants. It will compare the new medication to a dummy pill (placebo) to see if it helps improve symptoms when added to existing treatment.
United States · Belgium · Canada - enrolling by invitationPHASE3
Phase III Long-term Extension Trial to Assess Safety and Efficacy of CYB003 in MDD (EXTEND)
This study is for people who have already taken part in the APPROACH or EMBRACE trials for depression and received the study medicine, CYB003. It aims to check how safe CYB003 is and how well it works over a longer time for major depression.
United States · Australia · Greece