- recruitingHuman Pharmacology (Phase I)- First administration to humans
An Open-Label, Multicenter, Phase 1 Study Evaluating the Safety and Pharmacokinetics of ADU-1604 in Adults with Advanced Melanoma
This study is testing a new medicine, ADU-1604, for people with advanced melanoma, a type of skin cancer that has spread. It's the very first time this medicine is being given to humans, so researchers are checking how safe it is and how the body handles it.
France · Poland · Italy - recruitingHuman Pharmacology (Phase I)- First administration to humans
An open-label Phase 1 study of NEO-PTC-01 in patients with advanced or metastatic melanoma
This study is looking at a new medicine called NEO-PTC-01 for people with melanoma that has spread. It's an early-stage study to see if the medicine is safe and how it works in the body. It aims to help us understand if this new treatment could be useful for advanced melanoma.
Netherlands · Belgium · Spain - not yet recruitingPHASE3
iSCIB1+ in Combination With Ipilimumab and Nivolumab as First-Line Treatment for Advanced Unresectable Melanoma
This study looks at a new vaccine, iSCIB1+, for advanced skin cancer (melanoma). It wants to see if adding iSCIB1+ to standard immunotherapy (Nivolumab and Ipilimumab) helps people live longer and improves their health. Participants will get either the vaccine or a dummy treatment.
United States · United Kingdom - recruitingPHASE3
Study to Investigate Lifileucel Regimen Plus Pembrolizumab Compared With Pembrolizumab Alone in Participants With Untreated Advanced Melanoma.
This study compares a new combination treatment for advanced melanoma (lifileucel plus pembrolizumab) against pembrolizumab alone. It's for people who haven't had treatment for their advanced melanoma before. The aim is to see if the new combination is more effective and safe.
United States · Australia · Belgium - not yet recruiting
Power of Liquid Biopsy Tracking in Immunotherapy Treated Stage IV Melanoma
This study looks at new, simpler ways to check for melanoma returning in people who have had immunotherapy. We're testing blood and urine samples instead of frequent scans, and also looking at how the immune system responds, to find better follow-up care.
United Kingdom - active not recruitingPHASE2
A Study of Lifileucel (Tumor-infiltrating Lymphocytes) in Adults With Advanced Melanoma
This study is testing a new treatment called lifileucel for advanced melanoma, a type of skin cancer. It's for adults whose cancer has continued to grow despite previous treatments. The aim is to see if lifileucel can help control the cancer.
United States · Australia · Canada - active not recruitingPHASE1, PHASE2
Dose Escalation Study of a PD1-LAG3 Bispecific Antibody in Patients With Advanced and/or Metastatic Solid Tumors
This study is testing a new discovery drug called RO7247669 for advanced cancers. It aims to find the safest and most effective dose, and see if it can shrink certain tumours like melanoma, lung, and oesophageal cancer. The drug works by boosting the body's own immune system to fight cancer.
Denmark · Georgia · Israel - active not recruitingPHASE1, PHASE2
A Phase 1-2 Study of ST101 in Patients With Advanced Solid Tumors
This study is testing a new drug, ST101, for people with advanced cancers like breast cancer, melanoma, and glioblastoma. It aims to see if the drug is safe, how much to give, and if it could help shrink tumors. It's for adults whose cancer hasn't responded to other treatments.
United States · United Kingdom - active not recruitingPHASE3
IO102-IO103 in Combination With Pembrolizumab Versus Pembrolizumab Alone in Advanced Melanoma (IOB-013 / KN-D18)
This study looks at a new combination treatment for advanced melanoma, a type of skin cancer. It compares giving a new drug called IO102-IO103 alongside an existing drug, pembrolizumab, with giving pembrolizumab alone. The aim is to see if the combination helps patients live longer without their cancer getting worse.
United States · Australia · Belgium