Metastatic Prostate Cancer research hub
18 indexed studies · 8 currently recruiting
- recruitingPHASE1
Study of ORIC-944 in Patients With Metastatic Prostate Cancer
This study is looking at a new medicine called ORIC-944 for men with advanced prostate cancer that has spread. It aims to find out if ORIC-944 is safe and if it helps shrink the cancer, both on its own and when given with other prostate cancer medicines.
United States · Australia · Spain - recruitingPHASE1, PHASE2
ACTinium in Castrate-RESistant Prostate Cancer After LUTEtium
This study is testing a new radioactive drug called Actinium (225Ac) rhPSMA-10.1 for men with advanced prostate cancer that has spread. It aims to find a safe dose and see how well it works, especially for those who've already had a similar treatment.
United Kingdom - active not recruiting
Plasma Analysis for Response Assessment and to DIrect the manaGement of Metastatic Prostate Cancer
This study looks at a new blood test using 'ptDNA' to help doctors choose the best treatments for men with advanced prostate cancer. It doesn't test new drugs, but aims to understand how existing treatments work for future patients.
United Kingdom - not yet recruitingPhase III
A large clinical trial testing different combinations of hormone treatments, with or without chemotherapy called docetaxel, in men with advanced prostate cancer whose prostate-specific antigen levels haven’t dropped enough after 6 months of treatment
This study, called INTENSIFY, looks at adding chemotherapy early to standard hormone treatment for men with advanced prostate cancer whose blood test (PSA) hasn't dropped enough. It aims to see if this helps them live longer.
United Kingdom - recruitingPHASE1
A Study Evaluating the Safety, Pharmacokinetics, and Activity of RO7656594 In Participants With Advanced or Metastatic Prostate Cancer
This study is testing a new drug, RO7656594, for men with advanced prostate cancer that has spread. It aims to see if the drug is safe, how it works in the body, and if it shows any early signs of helping people, helping doctors find the best dose.
United States · Australia · Canada - active not recruitingPHASE2
Additional Treatments to the Local Tumour for Metastatic Prostate Cancer: Assessment of Novel Treatment Algorithms
This study looks at new ways to treat prostate cancer that has spread. It compares adding treatments directly to the prostate and other affected areas with standard care, to see if it improves outcomes for men who have recently been diagnosed.
United Kingdom - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A Phase 1b Open-Label, Clinical Trial to Evaluate the Safety, Tolerability, and Pharmacokinetics of ARV-110 in Combination with Abiraterone in Patients with Metastatic Prostate Cancer
This study is looking at a new combination treatment, ARV-110 with abiraterone, for men with prostate cancer that has spread. It's an early-stage trial focused on checking if the treatment is safe and how the body handles it.
France - active not recruitingPHASE1, PHASE2
A Phase 1-2 Study of ST101 in Patients With Advanced Solid Tumors
This study is testing a new drug, ST101, for people with advanced cancers like breast cancer, melanoma, and glioblastoma. It aims to see if the drug is safe, how much to give, and if it could help shrink tumors. It's for adults whose cancer hasn't responded to other treatments.
United States · United Kingdom - active not recruitingNA
INTense ExeRcise for SurviVAL Among Men with Metastatic Prostate Cancer (INTERVAL - GAP4)
This study looks at how high-intensity exercise and support might help men with advanced prostate cancer live longer. It compares a special exercise program with doing self-guided activity to see which is more beneficial for overall health and survival.
United States · Australia · Canada - recruitingPHASE1, PHASE2
Study of AZD0516 as Monotherapy and in Combination in Participants With Metastatic Prostate Cancer
This study is testing a new drug, AZD0516, for men with prostate cancer that has spread. Researchers want to see if it's safe and how well it works, both alone and with another drug, AZD9574.
United States · Brazil · China - recruitingPHASE1, PHASE2
Phase Ib/II Platform Study of Multiple Anti-Cancer Agents in Participants With Metastatic Prostate Cancer
This study is looking at new ways to treat advanced prostate cancer that has spread. Researchers are testing different medicines to see how safe they are, if they have side effects, and how well they work in men whose cancer hasn't responded to previous treatments.
United States · Australia · Germany - recruitingPHASE1, PHASE2
Study of HLD-0915 in Patients With Metastatic Prostate Cancer
This study is testing a new drug, HLD-0915, for men with advanced prostate cancer that has stopped responding to standard treatments. It aims to see if the drug is safe and effective in slowing down the cancer's growth.
United States · United Kingdom - active not recruitingPHASE3
Study of Cabozantinib in Combination With Atezolizumab Versus Second NHT in Subjects With mCRPC
This study looks at a new combination of drugs, cabozantinib and atezolizumab, for men with prostate cancer that has spread and is no longer responding to hormone therapy. It compares this new combination with standard hormone treatments to see if it works better.
United States · Argentina · Australia - recruitingPHASE4
Evaluating Dose Timing (Morning vs Evening) of Endocrine-based Therapies in Metastatic Breast and Prostate Cancers
This study looks at whether taking cancer medicines in the morning or evening makes a difference for people with advanced breast or prostate cancer. It also checks if the study plan works well for a bigger future trial.
Canada - authorisedPhase I and Phase II (Integrated)- First administration to humans
A Phase I/II, Modular, Open-Label, Multi-Centre Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Preliminary Efficacy of AZD9750 as Monotherapy and in Combination with Other Anticancer Agents in Participants with Metastatic Prostate Cancer (ANDROMEDA)
This study is looking at a new drug, AZD9750, for men with prostate cancer that has spread. It checks if the drug is safe, how it works in the body, and if it helps shrink the cancer, both alone and with other treatments.
Netherlands · Spain - recruitingPHASE2
Duration of Androgen Receptor Pathway Inhibitor and ADT With Metastasis Directed Therapy in Oligometastatic Cancer of the Prostate (DIRECT)
This study looks at treating prostate cancer that has spread. We want to see if adding an extra tablet called enzalutamide to standard radiation and hormone therapy improves quality of life. It’s for men whose cancer has spread a little, but not too far, and they don’t want continuous hormone therapy.
Canada - active not recruitingPHASE1, PHASE2
Study of AZD5305 When Given in Combination With New Hormonal Agents in Patients With Metastatic Prostate Cancer
This study is looking at a new drug, AZD5305, combined with existing hormone therapies for men with prostate cancer that has spread. It aims to see if the combination is safe, how the body handles it, and if it helps treat the cancer.
United States · Australia · Italy - active not recruitingPHASE3
Prevention of Symptomatic Skeletal Events With Denosumab Administered Every 4 Weeks Versus Every 12 Weeks
This study is looking at whether a medicine called Denosumab can work just as well when given less often (every 12 weeks instead of every 4 weeks) for people with breast or prostate cancer that has spread to their bones. We want to see if we can reduce side effects and costs without losing its benefits.
Austria · Germany · Switzerland