- active not recruiting
MiCLASP Post Market Clinical Follow-Up (PMCF) Study
This study looks at how well the Edwards PASCAL devices work to fix a leaky heart valve, called mitral regurgitation, and if they are safe after being used in patients. It aims to see if people feel better and if their quality of life improves.
Austria · Germany · Greece - active not recruitingNA
Prospective Treatment Algorithm Guiding Repair of Severe Ischemic Mitral Regurgitation
This study looks at how best to fix a leaky heart valve when it's caused by heart muscle damage. Doctors usually choose between repairing or replacing the valve. This research wants to see if following a specific guide to decide treatment leads to better results for patients after surgery.
Canada - active not recruitingNA
AHEAD: European Feasibility Study of the Cardiovalve Transfemoral Mitral Valve System
This study is testing a new device, the Cardiovalve, for people with severe leaky heart valves (mitral regurgitation). It aims to check if the device is safe and how well it reduces the leak, especially for those who can't have traditional surgery.
Germany · Greece · Italy - not yet recruiting
The EMBRACE Registry: European Post-Market Registry for Catheter Based Mitral Valve Replacement
This study is a registry tracking the new HighLife device for treating a leaky heart valve (mitral regurgitation) in people unsuitable for standard surgery. It's collecting real-world information on how well the device works after it's been approved for use.
Germany - recruiting
Multicenter Post-Market Observational Registry of the NeoChord Artificial Chordae Delivery System
This study looks at how well a device called the NeoChord Artificial Chordae System works for people with a heart condition called mitral valve disease. It tracks patients for five years after they've had the treatment, to see how they're doing in the long term.
Germany · Greece · Switzerland - recruiting
MitraClip® Registry
This study is gathering information on people in the UK who are having a heart procedure called MitraClip. It helps doctors understand how well this treatment works for a common heart problem called mitral regurgitation, where a heart valve leaks.
Germany - recruitingNA
Transcatheter Mitral Valve Replacement in Patients With Severe Symptomatic Mitral Regurgitation - APOLLO-EU Trial
This study is testing a new device, the Medtronic Intrepid™ system, for people with severe leaky heart valves (mitral regurgitation). It's for patients who can't have standard surgery or other treatments. The aim is to see if it's safe and helps improve their symptoms.
Denmark · France · Germany - recruitingNA
HighFLO Study - HighLife Trans-septal Mitral Valve Replacement (TSMVR) Feasibility Study of the Open Cell CLARITY Valve
This study is looking at a new heart valve called CLARITY for people with a leaky heart valve (mitral regurgitation). It aims to see if the new valve and its delivery system are safe and work well, especially for those who can't have traditional surgery.
Australia · Belgium · France - recruiting
A Multicenter Study on Atrioventricular Regurgitation in Transthyretin Amyloid Cardiomyopathy: Definition, Prevalence, and Prognostic Impact.
This study looks at a heart condition called ATTR amyloidosis and how it causes leakage in heart valves (mitral and tricuspid regurgitation). Researchers want to understand better how common and severe this leakage is, and how it affects patients, to improve diagnosis and care.
Austria · Germany · Italy - active not recruiting
MitraClip EXPAND G4 Study
This study is looking at a new version of the MitraClip device, called MitraClip G4. It's for people with a leaky heart valve, called mitral regurgitation. The aim is to check how safe and well this new device works in many patients over a long period.
United States · Canada · France - recruitingNA
Expanded Study of the HighLife 28mm Trans-septal Trans-catheter Mitral Valve in Patients With Moderate-severe or Severe Mitral Regurgitation and at High Surgical Risk
This study is testing a new heart valve called HighLife for people with a serious heart condition called mitral regurgitation who can't have traditional open-heart surgery. It aims to see if the new valve is safe and works well.
Australia · Belgium · France - recruiting
Annuloplasty Rings and Band Post-Market Clinical Follow-Up Study
This study looks at how well special rings and bands work to fix leaky heart valves (mitral and tricuspid regurgitation). It follows people who've had surgery with these Abbott devices for five years to make sure they're safe and effective.
United States · Estonia · France - recruitingNA
The ENCIRCLE Trial
This study is looking at a new device called the SAPIEN M3 System, including a special valve and its support. It's for people with a severe heart valve problem called mitral regurgitation who can't have other standard treatments. We want to see if it's safe and helps people feel better.
United States · Australia · Canada - recruiting
Tendyne European Experience Registry
This study looks at how well a new heart valve called the Tendyne Mitral Valve System works in real patients. It's for people with a leaky heart valve condition called mitral regurgitation who can't have traditional surgery.
Austria · Belgium · France - recruiting
CHoice of OptImal transCatheter trEatment for Mitral Insufficiency Registry
This study looks at how people with a leaky heart valve (mitral regurgitation) fare after a keyhole procedure called transcatheter mitral valve replacement (TMVR). It collects information from hospitals worldwide to understand the real-world results of this treatment.
United States · Australia · Austria