- active not recruitingPHASE3
Belantamab Mafodotin Plus Pomalidomide and Dexamethasone (Pd) Versus Bortezomib Plus Pd in Relapsed/Refractory Multiple Myeloma
This study compares two drug combinations for people with multiple myeloma that has come back or not responded well to previous treatments. It aims to see if a new combination with belantamab mafodotin is better or safer than a standard treatment.
United States · Australia · Brazil - active not recruitingPHASE3
A Study Comparing Anitocabtagene Autoleucel to Standard of Care Therapy in Participants With Relapsed/ Refractory Multiple Myeloma
This study compares a new treatment called anitocabtagene autoleucel with standard care for people with multiple myeloma that has come back or not responded to previous treatments. It aims to see if the new treatment works better.
United States · Australia · Austria - ongoing, recruitingTherapeutic exploratory (Phase II)
ISKPD-IFM2018-03-Multicenter Open label Phase 2 study of Isatuximab plus Pomalidomide and Dexamethasone with Carfilzomib in Relapsed or Refractory Multiple Myeloma
This study is testing a new combination of medicines for people with multiple myeloma that has come back or hasn't responded to previous treatments. It aims to see how well these medicines work together to reduce the amount of cancer in the body.
France - recruitingPHASE1
A New Study Evaluating the Activity of Modular CAR T for mYeloma
This study looks at a new cell therapy called CAR T for multiple myeloma that has come back or isn't responding to treatment. We want to see if it's safe and how well it works. It uses specially changed white blood cells to fight the cancer.
United Kingdom - active not recruitingPHASE2
Pomalidomide in Relapsed and Refractory Multiple Myeloma (RRMM)
This study looks at adding a drug called cyclophosphamide to a combination of pomalidomide and dexamethasone for people with multiple myeloma that has come back or isn't responding to treatment. We want to see if adding it helps patients live longer without their disease getting worse.
United Kingdom - active not recruitingPHASE1
A Study of Talquetamab With Other Anticancer Therapies in Participants With Multiple Myeloma
This study is looking at a new medicine called talquetamab, combined with other treatments, for people with multiple myeloma. The main goal is to find safe doses and understand how well these combinations work together.
United States · Australia · Belgium - ongoing, recruitingTherapeutic exploratory (Phase II)
An open label, multicenter, phase II study of belantamab mafodotin in combination with VRd for the treatment of newly diagnosed transplant eligible multiple myeloma patients
This study is testing a new combination of treatments, including a medicine called belantamab mafodotin, for people recently diagnosed with multiple myeloma. It aims to see how safe the combined treatment is and how it affects blood tests and side effects, especially those affecting the eyes.
Spain - ongoing, recruitingTherapeutic confirmatory (Phase III)
Allogeneic stem cell transplantation vs. conventional therapy as salvage therapy for relapsed / progressive patients with multiple myeloma after a first-line therapy
This study compares a special stem cell treatment to standard care for people with multiple myeloma that has come back or worsened after their first treatment. It aims to see which approach helps people live longer and feel better over five years.
Germany - authorisedPhase I and Phase II (Integrated)- First administration to humans
BOB1-TCR therapy for treatment of relapsed or refractory B-cell malignancies - A Phase 1/2 clinical trial
This study is looking at a new type of treatment for certain blood cancers like leukaemia and lymphoma. It's called BOB1-TCR therapy. The first part checks if the treatment is safe and what dose to use, and the second part looks at how well it works.
Netherlands - ongoing, recruitingTherapeutic confirmatory (Phase III)
A randomized phase III non-inferiority trial assessing lenalidomide, bortezomib and dexamethasone induction therapy with either intravenous or subcutaneous isatuximab in transplant-eligible patients with newly diagnosed multiple myeloma (GMMG HD8/ DSMM XIX)
This study looks at new ways to treat multiple myeloma, a type of blood cancer. It compares giving a new medicine called isatuximab in two different ways (through a drip or an injection) alongside standard treatments. The aim is to see if an injection works as well as a drip.
Austria · Germany - recruitingPHASE3
Study Assessing Activity of Intravenous (IV) Etentamig Monotherapy Versus Standard Available Therapies in Adult Participants With Relapsed or Refractory Multiple Myeloma
This study is for adults with a type of blood cancer called multiple myeloma that has come back or isn't responding to treatment. It compares a new medicine, etentamig, with existing treatments to see how well they control the cancer.
United States · Australia · Austria - recruitingPHASE1, PHASE2
A Study to Assess Adverse Events and Change in Disease Activity of Oral Surzetoclax Alone or in Combination With Subcutaneous and/or Oral Antimyeloma Agents in Adult Participants With Multiple Myeloma (MM)
This study looks at a new drug, surzetoclax, for multiple myeloma that has come back or not responded to other treatments. It checks how safe it is and how well it works, sometimes alone and sometimes with other medicines. We're looking for adults with this type of myeloma.
United States · Australia · Belgium - recruitingPHASE2
Methods of T Cell Depletion Trial (MoTD)
This study compares different ways to prevent a complication called GvHD after stem cell transplants for various blood cancers. It's looking for the best treatment plan to help patients recover well, using common medicines like Thymoglobulin, Cyclophosphamide, Cyclosporine, Sirolimus, and Mycophenolate Mofetil.
United Kingdom - active not recruitingPHASE3
A Study to Compare Iberdomide Maintenance Versus Lenalidomide Maintenance Therapy Following Autologous Stem Cell Transplant in Participants With Newly Diagnosed Multiple Myeloma
This study compares two treatments, Iberdomide and Lenalidomide, after a stem cell transplant for multiple myeloma. It aims to find out which one works better at keeping the cancer under control following initial treatment.
United States · Argentina · Australia - authorisedTherapeutic exploratory (Phase II)
Daratumumab in combination with Carfilzomib, Pomalidomide and Dexamethasone (DCPD) in patients with multiple myeloma induced acute renal failure - "Time is Kidney in the Treatment of myeloma Cast nephropathy" The TIKTAC phase II trial (Pilot-study)
This study looks at a new combination of medicines (DCPD) for people with multiple myeloma whose kidneys are not working well. It aims to see if kidney function improves, or if people needing dialysis can stop needing it, after four cycles of treatment.
Austria - authorisedTherapeutic confirmatory (Phase III)
C1071015 - ELRANATAMAB POST TRIAL ACCESS: AN OPEN-LABEL, SINGLE-ARM STUDY FOR PARTICIPANTS WITH MULTIPLE MYELOMA CONTINUING FROM PFIZER-SPONSORED ELRANATAMAB CLINICAL STUDIES
This study is for people with multiple myeloma who are already taking the drug elranatamab as part of another Pfizer study. It helps them keep getting the treatment after their first study finishes. Doctors are watching for any side effects.
France · Spain · Germany - recruitingPHASE1
A Study to Assess Adverse Events of Intravenously (IV) Infused Etentamig (ABBV-383) in Adult Participants With Relapsed or Refractory Multiple Myeloma
This study looks at a new medicine called etentamig (ABBV-383) for multiple myeloma that has come back or isn't responding to other treatments. It aims to find out about any side effects and how it affects the disease in adults.
United States · Canada · Denmark - recruitingPHASE3
A Study Comparing JNJ-79635322 and an Anti-B-cell Maturation Antigen (BCMA)xCD3 Bispecific Antibody in Participants With Relapsed or Refractory Multiple Myeloma
This study is looking at a new treatment, JNJ-79635322, for multiple myeloma, a type of blood cancer. It compares this new treatment with an existing one (Teclistamab) to see which works better for people whose cancer has returned or hasn't responded to previous treatments.
United States · Australia · Canada - active not recruitingPHASE1
A Study Evaluating the Safety, Pharmacokinetics, and Activity of Cevostamab in Participants With Relapsed or Refractory Multiple Myeloma
This study looks at a new drug, Cevostamab, for people with multiple myeloma that has come back or not responded to previous treatments. It aims to check its safety, how it moves in the body, and if it helps when given alone or with other medicines.
United States · Australia · Canada - recruitingPHASE3
A Study of Teclistamab in Combination With Daratumumab and Lenalidomide (Tec-DR) and Talquetamab in Combination With Daratumumab and Lenalidomide (Tal-DR) in Participants With Newly Diagnosed Multiple Myeloma
This study is looking at new drug combinations for people recently diagnosed with a type of blood cancer called multiple myeloma. It compares two new treatments, Teclistamab or Talquetamab, each given with standard drugs, against the usual standard treatment, to see which works best.
United States · Australia · Austria - active not recruitingPHASE2
Study of Iopofosine I-131 (CLR 131) in Select B-Cell Malignancies (CLOVER-1) With Expansion in Waldenstrom
This study looks at a new drug, Iopofosine I-131, for people with certain B-cell cancers like Waldenstrom, myeloma, or lymphoma, who haven't responded well to other treatments. It aims to see how safe and effective this new approach is.
United States · Australia · Brazil - recruitingPHASE1, PHASE2
A Study to Evaluate Safety, Drug Levels and Effectiveness of CC-92480 (BMS-986348) in Combination With Other Treatments in Participants With Relapsed or Refractory Multiple Myeloma
This study looks at new drug combinations for multiple myeloma that has come back or isn't responding to usual treatment. It checks how safe they are, body reactions, and early signs of how well they might work.
United States · Canada · Norway - active not recruitingPHASE1
A Study Comparing Pre- and Post-Change Teclistamab in Participants With Relapsed or Refractory Multiple Myeloma
This study looks at a new way of making Teclistamab, a medicine for a blood cancer called multiple myeloma. We're checking if the new version works the same inside your body as the old one, to make sure it's safe and effective.
United States · Australia · Canada - active not recruitingPHASE3
A Study of Bortezomib, Lenalidomide and Dexamethasone (VRd) Followed by Cilta-cel, a CAR-T Therapy Directed Against BCMA Versus VRd Followed by Lenalidomide and Dexamethasone (Rd) Therapy in Participants With Newly Diagnosed Multiple Myeloma for Whom ASCT is Not Planned as Initial Therapy
This study looks at new treatments for multiple myeloma, a type of blood cancer. It compares a standard treatment plus a new cell therapy called cilta-cel, against the standard treatment alone, for people newly diagnosed who aren't having a stem cell transplant initially.
United States · Argentina · Australia - active not recruitingPHASE1, PHASE2
A Study to Determine Dose, Safety, Tolerability and Efficacy of CC-220 Monotherapy, and in Combination With Other Treatments in Subjects With Multiple Myeloma
This study is testing a new drug called CC-220, sometimes on its own and sometimes with other standard cancer medicines, for people with multiple myeloma. It aims to find the right dose, see how safe it is, and if it helps treat the disease.
United States · Australia · Canada - ongoing, recruitingTherapeutic exploratory (Phase II)
KRd consolidation in myeloma patients with a positive PET-CT after standard first line treatment. A phase II study
This study looks at a new treatment combination called KRd for people with multiple myeloma whose scans still show some active cancer after their first treatment. We want to see if KRd can help these patients achieve better results, specifically if their scans become completely clear.
Denmark · Norway - active not recruitingPHASE3
A Study to Compare the Efficacy and Safety of Idecabtagene Vicleucel With Lenalidomide Maintenance Therapy Versus Lenalidomide Maintenance Therapy Alone in Adult Participants With Newly Diagnosed Multiple Myeloma Who Have Suboptimal Response After Autologous Stem Cell Transplantation
This study compares a new cell therapy (ide-cel) plus standard maintenance medicine (lenalidomide) against lenalidomide alone for adults with newly diagnosed multiple myeloma. It's for those who haven't fully responded to their initial stem cell transplant.
United States · Australia · Austria - ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3 Study Comparing Daratumumab, VELCADE (bortezomib), Lenalidomide, and Dexamethasone (D-VRd) with VELCADE, Lenalidomide, and Dexamethasone (VRd) in Subjects with Untreated Multiple Myeloma and for Whom Hematopoietic Stem Cell Transplant is Not Planned as Initial Therapy
This study is looking at a new treatment combination for a type of blood cancer called multiple myeloma, for people who aren't having a stem cell transplant. It compares a new four-drug treatment with a standard three-drug treatment to see if the new one works better.
Spain · Netherlands · France - active not recruitingPHASE3
A Study Comparing Talquetamab in Combination With Daratumumab or in Combination With Daratumumab and Pomalidomide Versus Daratumumab in Combination With Pomalidomide and Dexamethasone in Participants With Multiple Myeloma That Returns After Treatment or is Resistant to Treatment
This study looks at new drug combinations for multiple myeloma that has come back or isn’t responding to treatment. It compares a drug called talquetamab, alone or with another drug called daratumumab, against a standard treatment of daratumumab, pomalidomide, and dexamethasone.
United States · Belgium · Brazil - recruitingPHASE3
MagnetisMM-32: A Study to Learn About the Study Medicine Called Elranatamab in People With Multiple Myeloma (MM) That Has Come Back After Taking Other Treatments (Including Prior Treatment With an Anti-CD38 Antibody and Lenalidomide)
This study is testing a new medicine called elranatamab for people with a type of blood cancer called multiple myeloma. It's for those whose cancer has returned after other treatments. We want to see if elranatamab works better than standard medicines.
United States · Argentina · Australia - active not recruitingPHASE3
A Study Designed to Evaluate the Safety and Efficacy of Venetoclax Plus Dexamethasone (VenDex) Compared With Pomalidomide Plus Dexamethasone (PomDex) in Participants With t(11;14)-Positive Relapsed or Refractory Multiple Myeloma.
This study compares two treatments, Venetoclax plus Dexamethasone, and Pomalidomide plus Dexamethasone, for people with a specific type of multiple myeloma (t(11;14)-positive) that has come back or not responded to previous treatments. It aims to see which treatment works best at preventing the disease from getting worse.
United States · Australia · Canada - active not recruiting
Clinical Decision-making, Prognosis, Quality of Life and Satisfaction in Relapsed/Refractory Multiple Myeloma
This study looks at how health-related quality of life, especially tiredness, affects people with multiple myeloma that has come back or isn't responding to treatment. Researchers want to see if a patient's own reports on their well-being can help predict how long they'll live, independent of other health factors.
Italy · United Kingdom - recruitingPHASE3
Phase 3 Study of Teclistamab in Combination With Lenalidomide and Teclistamab Alone Versus Lenalidomide Alone in Participants With Newly Diagnosed Multiple Myeloma as Maintenance Therapy Following Autologous Stem Cell Transplantation
This study looks at new treatments for multiple myeloma, a type of blood cancer. We're testing if teclistamab, alone or with lenalidomide, works better than lenalidomide alone after a stem cell transplant to stop the cancer from coming back.
United States · Argentina · Australia - ongoing, recruitingTherapeutic exploratory (Phase II)
Clinical Trial Using Humanized CART Directed Against BCMA (ARI0002h) in Patients With Relapsed/Refractory Multiple Myeloma to Proteasome Inhibitors, Immunomodulators and Anti-CD38 Antibody
This study is looking into a new treatment for multiple myeloma, a type of blood cancer. It's for adults whose cancer has come back or not responded to previous treatments. The trial aims to see how safe and effective this new cell therapy (called ARI0002h) is.
Spain - ongoing, recruitingTherapeutic exploratory (Phase II)
Continuing Treatment for Subjects Who Have Participated in a Prior Protocol Investigating Elotuzumab
This study looks at how long people with multiple myeloma, a type of blood cancer, continue taking elotuzumab or other treatments after being in an earlier study. It also checks for any side effects experienced.
Romania - active not recruiting
Prospective Research Assessment in Multiple Myeloma: An Observational Evaluation (PREAMBLE)
This study, PREAMBLE, looks at how well approved treatments for multiple myeloma work in everyday medical practice. It includes people newly diagnosed and those whose myeloma has returned or not responded to previous treatments, aiming to understand real-world effectiveness.
United States · Canada · France - recruiting
Examining the clinical effectiveness, feasibility and acceptability of intra-apheresis cycling for peripheral blood stem cell donations
This study looks into whether light exercise, like cycling, during stem cell donation can help people with myeloma. It aims to see if cycling helps collect more cells, making transplants more successful. It's a pilot study taking place in Birmingham.
United Kingdom - active not recruitingPHASE3
Study of Single Agent Belantamab Mafodotin Versus Pomalidomide Plus Low-dose Dexamethasone (Pom/Dex) in Participants With Relapsed/Refractory Multiple Myeloma (RRMM)
This study compares a new treatment, Belantamab Mafodotin, with a common combination treatment (Pomalidomide and Dexamethasone) for Multiple Myeloma that has returned or not responded well to past treatments. It aims to see which treatment works better and is safer.
United States · Australia · Belgium - recruitingPHASE3
A Study to Learn About the Effects of the Combination of Elranatamab, Daratumumab and Lenalidomide Compared With Daratumumab, Bortezomib, Lenalidomide, and Dexamethasone in Patients With Newly Diagnosed Multiple Myeloma Who Are Not Candidates for Transplant
This study compares two treatments for newly diagnosed multiple myeloma in adults who can't have a stem cell transplant. It aims to see if a combination including Elranatamab is better than another standard combination at controlling the cancer and improving patients' lives.
United States · Australia · Austria - recruitingPHASE3
A Study Comparing Talquetamab Plus Pomalidomide, Talquetamab Plus Teclistamab, and Elotuzumab, Pomalidomide, and Dexamethasone or Pomalidomide, Bortezomib, and Dexamethasone in Participants With Relapsed or Refractory Myeloma Who Have Received an Anti-CD38 Antibody and Lenalidomide
This study looks at new drug combinations for multiple myeloma that has come back or isn't responding to previous treatments. It compares different ways of combining talquetamab with other medicines to see which works best for people who have already tried certain common myeloma drugs.
United States · Argentina · Australia - active not recruitingPHASE3
A Study Comparing JNJ-68284528, a CAR-T Therapy Directed Against B-cell Maturation Antigen (BCMA), Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) or Daratumumab, Pomalidomide and Dexamethasone (DPd) in Participants With Relapsed and Lenalidomide-Refractory Multiple Myeloma
This study compares a new cell therapy (Cilta-cel) with standard treatments for multiple myeloma, a type of blood cancer. It's for people whose cancer has returned or isn't responding to their current medicine, especially lenalidomide, to see if the new treatment works better.
United States · Australia · Belgium - recruitingNA
Early Palliative Care for Patients With Multiple Myeloma and Aggressive Lymphoma
This study looks at adding early support care for people with multiple myeloma or aggressive lymphoma. It wants to see if this helps improve their well-being, mood, and how they feel about their care, compared to standard care alone.
Canada - recruitingPHASE1
A Study to Learn About the Effects of the Combination of Elranatamab (PF-06863135) and Iberdomide in Patients With Relapsed or Refractory Multiple Myeloma (MagnetisMM-30)
This study is looking at an experimental treatment for multiple myeloma that has come back or hasn't responded to other treatments. It combines two medicines, elranatamab and iberdomide, to see how safe and effective they are together in adults.
United States · Australia · Canada - active not recruitingPHASE2
Evaluation iNduction, Consolidation and Maintenance Treatment With Isatuximab , Carfilzomib, LEnalidomide and Dexamethasone
This study is looking at a new combination of four medicines (Isatuximab, Carfilzomib, Lenalidomide, and Dexamethasone) for people with newly diagnosed, high-risk multiple myeloma. It aims to see how safe and effective this treatment is.
Germany - recruitingPHASE1, PHASE2
Study to Assess Safety of HDP-101 in Patients With Relapsed Refractory Multiple Myeloma
This study is testing a new medicine called HDP-101 for people with a type of blood cancer called multiple myeloma that has come back or not responded to previous treatments. It aims to see if the medicine is safe and if it helps by slowing down or stopping the cancer.
United States · Germany · Hungary - active not recruitingPHASE2
A Study of JNJ-68284528, a Chimeric Antigen Receptor T Cell (CAR-T) Therapy Directed Against B-cell Maturation Antigen (BCMA) in Participants With Multiple Myeloma
This study looks at a new cell therapy called JNJ-68284528 for people with multiple myeloma. It aims to see how well it works in clearing up any remaining cancer cells after treatment.
United States · Belgium · France - active not recruitingPHASE3
An Extension Study of Venetoclax for Subjects Who Have Completed a Prior Venetoclax Clinical Trial
This study is for people who have already been taking a medicine called venetoclax for their cancer in another trial. It allows them to keep taking venetoclax if it's helping them and they're not having bad side effects, so doctors can learn more about its long-term safety.
United States · Australia · Austria - recruitingPHASE1, PHASE2
A Study to Assess Change in Disease Activity and Adverse Events (AE)s in Adult Participants With Multiple Myeloma Receiving Etentamig (ABBV-383) as an Intravenous (IV) Infusion Alone or in Combination With Oral, IV, Subcutaneous Daratumumab; Lenalidomide; Dexamethasone; Carfilzomib
This study is testing a new drug called Etentamig for adults with multiple myeloma, a type of blood cancer. Researchers want to see if it's safe and effective when given alone or with other common treatments to help manage the disease.
United States · Australia · Israel - active not recruiting
Selinexor (Nexpovio®) (SVd) in Patients With Relapsed or Refractory Multiple Myeloma
This study looks at how a medicine called selinexor (Nexpovio®) works for people in the UK with a blood cancer called multiple myeloma that has come back or not responded to previous treatments. It aims to understand how patients feel, how safe the treatment is, and how well it works in everyday healthcare.
Austria · Germany - active not recruitingPHASE3
A Study of Teclistamab in Combination With Daratumumab Subcutaneously (SC) (Tec-Dara) Versus Daratumumab SC, Pomalidomide, and Dexamethasone (DPd) or Daratumumab SC, Bortezomib, and Dexamethasone (DVd) in Participants With Relapsed or Refractory Multiple Myeloma
This study compares a new combination treatment, teclistamab with daratumumab (Tec-Dara), against standard treatments for multiple myeloma that has come back or isn't responding well. It aims to see if the new combination works better.
United States · Argentina · Belgium