- recruitingPHASE1
An Open-label Study of AZD0120 in Adults With Multiple Sclerosis
This study is testing a new treatment called AZD0120 for adults with multiple sclerosis (MS). It's a first step to see how safe the treatment is and if people can tolerate it well. We're looking at different types of MS to find the right dose.
United States · Australia · Canada - active not recruitingPHASE1
A Study to Investigate the Safety, Tolerability, Pharmacokinetics, Immunogenicity, and Pharmacodynamics of a New Subcutaneous Formulation of Ocrelizumab in Participants With Multiple Sclerosis
This study is looking at a new way to give an existing medicine, ocrelizumab, as an injection under the skin for people with Multiple Sclerosis (MS). It aims to check if it's safe and how well people tolerate it, while also learning more about how the medicine works in the body.
United States · Brazil · Mexico - active not recruitingPHASE1
A Study to Evaluate the Safety, Tolerability, Efficacy, and Drug Levels of CC-97540 in Participants With Relapsing Forms of Multiple Sclerosis, Progressive Forms of Multiple Sclerosis or Refractory Myasthenia Gravis (MG) (Breakfree-2)
This study is looking at a new drug called CC-97540 for people with certain types of Multiple Sclerosis (MS) or a muscle weakness condition called Myasthenia Gravis (MG). We want to see if it's safe, how well people can handle it, and if it helps their condition.
United States · Belgium · France - active not recruitingPHASE3
Efficacy and Safety Study of Frexalimab (SAR441344) in Adults With Nonrelapsing Secondary Progressive Multiple Sclerosis
This study is testing a new drug called frexalimab for people with a type of multiple sclerosis (MS) called non-relapsing secondary progressive MS (nrSPMS). Researchers want to see if it can slow down MS progression and if it's safe. It's compared to a dummy drug (placebo).
United States · Argentina · Australia - active not recruitingPHASE3
A Study to Evaluate the Efficacy, Safety and Pharmacokinetics (PK) of a Higher Dose of Ocrelizumab in Adults With Primary Progressive Multiple Sclerosis (PPMS)
This study looks at a new, higher dose of ocrelizumab for people with primary progressive multiple sclerosis (PPMS). Researchers want to see if this dose is safe and works better than the current approved dose to slow down the disease.
United States · Argentina · Belgium - active not recruitingPHASE2
A Study of LY3541860 in Adult Participants With Relapsing Multiple Sclerosis
This study is testing a new drug, LY3541860, for adults with relapsing multiple sclerosis (MS). We want to see if it's safe and helps reduce MS flare-ups. The study will last about 9 months, with a 6-month follow-up.
United States · France · Italy - active not recruitingPHASE3
Efficacy and Safety Studies of Frexalimab (SAR441344) in Adults With Relapsing Forms of Multiple Sclerosis
This study is looking at a new medicine called frexalimab for people aged 18-55 with certain types of Multiple Sclerosis (MS). It compares frexalimab to an existing MS medicine, teriflunomide, to see how well it stops MS relapses and if it's safe.
United States · Argentina · Austria - active not recruitingPHASE3
A Rollover Study to Evaluate the Long-Term Safety and Efficacy of Ocrelizumab In Patients With Multiple Sclerosis
This study looks at the long-term safety and effectiveness of a medicine called ocrelizumab for people with Multiple Sclerosis (MS). It's for people already taking part in other ocrelizumab studies, to see how the treatment works over a longer time.
United States · Argentina · Australia - active not recruitingPHASE4
Concentration of Ofatumumab in the Breast Milk of Lactating Women With Relapsing Forms of Multiple Sclerosis
This study looks at how much ofatumumab, a medicine for multiple sclerosis, gets into breast milk. We want to see if it's safe for mothers with MS who are breastfeeding to take this medication. It involves collecting milk and blood samples from new mums.
United States · Germany · Italy - active not recruitingPHASE3
A Study to Evaluate the Efficacy, Safety and Pharmacokinetics (PK) of a Higher Dose of Ocrelizumab in Adults With Relapsing Multiple Sclerosis (RMS)
This study is testing a higher dose of a medicine called ocrelizumab for adults with a type of multiple sclerosis (MS) called relapsing MS. It compares the new dose to the standard dose to see if it's more effective and safe.
United States · Argentina · Australia - recruitingNA
EMG Biofeedback Training to Improve Balance in Individuals with Multiple Sclerosis
This study looks at a new training method called EMG Biofeedback, using sensors, to help people with multiple sclerosis improve their balance. It compares it to traditional exercises to see which works best and if the improvements last.
Canada - not yet recruitingNA
FIT-ATOMIC Exercise Feasibility Trial
This study looks at a 20-week home exercise programme for young people aged 11-25 with Multiple Sclerosis (MS). It aims to see if this type of exercise is a good way to help manage MS and improve their health, preparing for a larger study.
United States · Canada - active not recruiting
Validation and Standardization of Paramagnetic Rim Lesion (PRL) Identification in Multiple Sclerosis Across MAGNIMS Centers
This study looks at how consistently special brain scans (MRIs) are read across different hospitals for people with Multiple Sclerosis (MS). It aims to make sure everyone agrees on identifying specific 'rim lesions' in MS to help improve diagnosis and treatment plans for patients, using existing scan data only.
Austria · Czechia · Denmark - not yet recruiting
Early Prediction of Outcomes Following Optic Neuritis: Development and Acceptability of a Prognostic Tool
This study looks at how your genes and health information after optic neuritis might help predict if you'll develop multiple sclerosis (MS). It also checks your vision and quality of life.
United Kingdom - not yet recruitingPHASE1
Transcranial Magnetic Stimulation for Depression in Multiple Sclerosis
This study looks at a new way to treat depression and extreme tiredness (fatigue) in people with Multiple Sclerosis (MS). It uses magnetic pulses to gently stimulate the brain. Researchers want to see if it's safe and helps improve mood and energy levels.
Canada - recruiting
Measuring Silent Disease Progression in Multiple Sclerosis With a Multimodal Approach
This study looks at how multiple sclerosis (MS) progresses slowly, even without new attacks, in people on certain treatments. It uses regular check-ups, scans, blood tests, and optional smartphone/smartwatch data to understand these changes better.
Germany - recruitingNA
Remediation Program Via a "Serious Game" for the Cognitive Functions of Multiple Sclerosis Patients
This study is looking at a fun, computer-based 'serious game' to help people with multiple sclerosis (MS) improve their memory and how quickly they think. It aims to see if this game can be more helpful than usual care.
France - not yet recruitingNA
Evaluation of the NEUROSWING Orthosis on Walking Speed in a Population With Dorsal and/or Plantar Flexor Deficits, With a View to a Reimbursement Application
This study looks at a new ankle support, the NEUROSWING orthosis, to see if it helps people with walking difficulties caused by conditions like stroke or MS. Researchers will compare it to a standard carbon ankle support to see if it improves walking speed.
France - recruiting
Pregnancy Exposure Registry for Vumerity (Diroximel Fumarate)
This study looks at how babies born to mothers with multiple sclerosis (MS) are affected by a medication called Vumerity (diroximel fumarate) during pregnancy. It compares these babies to those whose mothers either didn't take MS medicines or took other similar treatments.
United States · Australia · Germany - recruiting
Detection of Spinal Cord Lesions Using the MP2RAGE Sequence in Inflammatory Diseases of the Neuraxis
This study looks at a new MRI scan (called MP2RAGE) to see if it's better at finding changes in the spinal cord for people with Multiple Sclerosis (MS). Finding these changes early can help doctors understand and manage MS better.
France - active not recruitingNA
Improving Cognitive Recovery in Multiple Sclerosis
This study looks at a new program, CIRCuiTS-MS, to help people with Multiple Sclerosis (MS) improve their thinking skills. It will check if the program is practical and helpful, paving the way for a larger trial to improve daily life for those with MS.
United Kingdom - recruitingNA
Study of Ovarian Reserve Concerning Patients With Multiple Sclerosis (MS), Compared to a Control Group
This study looks at the egg reserve in women with multiple sclerosis (MS) compared to healthy women. Researchers want to see if MS affects a woman's ability to have children, focusing on women aged 25-35.
France - authorisedTherapeutic use (Phase IV)
Effects of CLADribine tablets on the Immune Synapse, in Relapsing Multiple Sclerosis (RMS) patients_CLADIS.
This study looks at how a medicine called MAVENCLAD affects the body's defence system in people with a type of multiple sclerosis. Researchers want to see if it changes how immune cells communicate and how this affects their MS over one year.
Greece - recruiting
Cognitive Performance, Sleep Disturbances and Fatigue in Multiple Sclerosis
This study looks at how sleep problems and tiredness (fatigue) affect people with Multiple Sclerosis (MS). Researchers want to understand if poor sleep makes MS-related fatigue and thinking problems worse, and how different types of MS are affected. They are also using AI to help analyse sleep data.
Germany - recruitingNA
Deployment o the Multidisciplinary Prospective Cohort Imminent
This study aims to better understand long-term inflammatory diseases like lupus and severe asthma. Researchers will collect information and samples to find new ways to treat these conditions, reduce side effects, and improve daily life for patients. It's about finding better treatments for the future.
France - authorisedTherapeutic exploratory (Phase II)
A Phase 2a Study of SUN-627 to Evaluate Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Impact on Measures of Neuroinflammation in the Central Nervous System in Participants With Non-Active Progressive Multiple Sclerosis (SPMS/PPMS)
This study is looking at a new medicine called SUN-627 for people with certain types of Multiple Sclerosis (MS). Researchers want to see if it's safe, how the body uses it, and if it helps reduce inflammation in the brain over 16 weeks.
Finland - not yet recruiting
Screening for Cognitive Disorders in Multiple Sclerosis
This study looks at how MS affects memory and thinking skills. We will use simple tests to see if people with MS have these difficulties and how it impacts their daily lives. The aim is to better understand these challenges in adults with MS.
France - recruiting
Longitudinal Assessment of Iron Rims in MS Lesions
This study looks at how 'iron rims' around MS lesions on brain scans might affect the disease. We're also checking blood samples for genetic links. Some participants might get another special MRI scan to see how these iron rims change over time.
United Kingdom - active not recruitingPHASE3
Safety and Efficacy of Fingolimod in Pediatric Patients With Multiple Sclerosis
This study looks at how safe and effective two medicines, fingolimod and interferon beta-1a, are for young people aged 10-17 with multiple sclerosis (MS). It compares them to see which works best and is safest.
United States · Australia · Austria - recruiting
Lorraine Registry of Multiple Sclerosis
The Lorraine Registry of Multiple Sclerosis (RelSEP) is a long-term study collecting information from people in the Lorraine region of France who have recently been diagnosed with MS. It aims to understand how MS progresses and is treated over time, helping researchers learn more about the condition.
France - recruitingNA
The Role of Cytokines and Regulatory T Lymphocytes in Migraine Pathophysiology.
This study looks into why some people get migraines, especially those with other health conditions like autoimmune diseases. Researchers are examining how chemicals in the body, called cytokines, and special immune cells, called Treg cells, might be linked to migraine pain. They hope to better understand migraine causes.
France - authorisedTherapeutic exploratory (Phase II)
An autologous and antigen-specific cell-based therapy of vitamin D3-treated and myelin-derived peptide loaded tolerogenic dendritic cells in subjects with progressive forms of multiple sclerosis: a phase IIa, open-label, self-controlled, multi-center clinical trial.
This study is testing a new cell therapy called tolDC for people with progressive forms of Multiple Sclerosis (MS). It aims to see if tolDC can slow down how MS affects your body and if it's safe to use.
Belgium · Spain - recruitingNA
Montpellier PROspective Cohort in Relapsing Remitting Multiple Sclerosis Using Imaging and Serologic
This study looks at people in France with Relapsing Remitting Multiple Sclerosis (RRMS) to compare how two types of MS treatments (standard vs. high-strength) affect brain shrinkage over three years, using MRI scans and other tests.
France - completed
Changing physical activity and sedentary behaviour in people with MS to reduce fatigue: the iStep-MS study
This study, iStep-MS, looks at how a new activity program helps people with Multiple Sclerosis (MS) feel less tired. It hopes to find better ways for people with MS to be more active and sit less, improving their daily lives.
United Kingdom · England - recruitingNA
Artificial Intelligence-Assisted Magnetic Resonance Imaging for Quality, Efficiency and Equity in the National Health Service (NHS) Care of Multiple Sclerosis
This study looks at using special computer software (AI) with MRI scans to help doctors care for people with Multiple Sclerosis (MS) in the NHS. The goal is to improve how MS is monitored and how treatment decisions are made.
United Kingdom - not yet recruitingNA
Implementation of Online Mindfulness-Based Stress Reduction Tailored for People with Multiple Sclerosis
This study looks at an 8-week online course called Mindfulness-Based Stress Reduction (MBSR) for people with Multiple Sclerosis (MS). It aims to see if MBSR helps reduce stress, anxiety, and improve quality of life.
Canada - recruitingNA
Implementation of an App-based Walking Aid Skills Training Program
This study looks at a new app called 'ICanWALK' designed to help people who use walking aids like crutches or walkers. It aims to teach them how to use these aids safely and effectively, hoping to reduce falls and improve their confidence.
Canada - active not recruiting
Assessment of NfL and GFAP Levels, Atrophy of the Macula GCC by OCT and Whole Brain Atrophy by MRI to Predict Evolution of Neurological Disability in MS Patients
This study looks at new ways to predict how Multiple Sclerosis (MS) might progress. Researchers will use special scans and blood tests to see if these can help understand future changes in a person's disability, hoping to find better ways to track the disease.
France - active not recruitingPHASE3
LONG-TERM EFFECTIVENESS AND SAFETY EVALUATION OF OCRELIZUMAB
This study looks at the long-term effects and safety of a medicine called ocrelizumab for people with multiple sclerosis (MS). It aims to see how well it helps prevent disability over time, especially for daily activities and arm and hand use.
France - active not recruiting
OFSEP High Definition Cohort
This study aims to understand what causes Multiple Sclerosis (MS) to worsen and to create tools to predict how the disease might progress for individuals. It uses a large French MS registry to collect detailed information and help improve care.
France · Martinique - recruitingNA
From Genetics to Transcriptomics to Unravel the Mechanisms Behind a Poor Outcome in Multiple Sclerosis
This study aims to understand why Multiple Sclerosis (MS) affects people so differently. Researchers are looking at blood samples from people with MS and healthy volunteers to find clues in their genes and cells that might explain why some MS is more aggressive than others.
France - not yet recruitingNA
Remote Ischemic Conditioning in PPMS
This study looks at a new, gentle treatment called Remote Ischemic Conditioning (RIC) for Primary Progressive Multiple Sclerosis (PPMS). It's a simple, non-drug method that uses arm cuffs to see if it can help stop walking problems from getting worse. It's a first step to see if RIC might help people with MS.
Canada - enrolling by invitation
OCTive: A New Horizon in MS Digital Solution
This study is testing new digital tools to better understand how Multiple Sclerosis (MS) changes over time. It uses apps to check movement and special eye scans, hoping to offer a clearer, more personal view of MS progression for people in the UK.
United Kingdom - recruitingNA
Transcutaneous Tibial Neuro-stimulation to Improve Voiding Dysfunction in Multiple Sclerosis.
This study looks at a gentle electrical treatment called transcutaneous tibial neuro-stimulation (TTNS) to help people with Multiple Sclerosis (MS) who have trouble emptying their bladder. It compares the real treatment to a dummy one to see if it makes a difference.
France - active not recruitingPHASE2
Cannabis (THC vs. CBD) in Multiple Sclerosis
This study looks at how two parts of cannabis, THC and CBD, affect memory, thinking, and bladder problems in people with Multiple Sclerosis (MS). Participants will take either THC or CBD oil for 15 weeks.
Canada - recruiting
A Non-interventional Study Evaluating Clinical Utility and Implications on Improved Patient Management of Serum Neurofilament as a Prognostic Marker for Disease Activity in Patients With Relapsing Multiple Sclerosis
This study looks at how a blood test called serum neurofilament (sNfL) can help doctors manage multiple sclerosis (MS). It follows people with MS in Germany who are routinely tested and either continue their current treatment or switch to a new one called ofatumumab.
Germany - authorisedTherapeutic exploratory (Phase II)
TARGET-EBV in MS: A prospective randomized controlled parallel group phase 2b double blinded study to investigate if targeting Epstein Barr Virus with Tenofovir Alafenamide Fumarate compared to placebo as add-on treatment to anti-CD20 therapy reduces neuronal damage in multiple sclerosis
This study looks into whether a drug called Tenofovir Alafenamide, given alongside a standard MS treatment, can help reduce nerve damage in people with multiple sclerosis by targeting the Epstein-Barr virus. It compares the drug to a dummy pill.
Norway - active not recruiting
Central Vein Sign: a Diagnostic Biomarker in Multiple Sclerosis
This study looks at a new MRI technique called the Central Vein Sign (CVS) to see if it can help doctors diagnose Multiple Sclerosis (MS) more accurately and earlier. It aims to improve diagnosis for various types of MS presentations.
United States · Canada - enrolling by invitation
Kappa Free Light Chains (KFLC) in Multiple Sclerosis (MS) and Clinically Isolated Syndrome (CIS)
This study looks at how useful two tests, kappa free light chains (KFLC) and oligoclonal bands, are for diagnosing multiple sclerosis (MS) and clinically isolated syndrome (CIS) in spinal fluid. Researchers want to see if KFLC is as good as, better than, or worse than the current standard test.
Germany - recruiting
Development of a Novel Functional Eye-Tracking Software Application for Multiple Sclerosis
This study aims to create new software that uses eye movements to better understand and track Multiple Sclerosis (MS) and its effects on thinking and memory. It involves brief tasks and eye-tracking tests to help develop this new tool.
Canada