- recruitingPhase III
To test artificial intelligence (AI)-assisted magnetic resonance imaging (MRI) in detecting disease activity in Multiple Sclerosis, and to determine whether AI impacts MRI review, treatment decisions, costs, and follow-up care
This study looks at using clever computer programs (AI) to help doctors interpret MRI scans for people with Multiple Sclerosis (MS). It aims to see if this technology, called icobrain ms, can better spot MS activity, guide treatment, and improve care in the NHS.
United Kingdom · England - active not recruitingNA
OPM- MEG in Non-immune And iMmune-medIated Neurological Disease
This study uses new brain scanning technology to understand how brain conditions caused by the immune system affect children aged 2-15. It aims to improve diagnosis, treatment, and long-term care for illnesses like autoimmune encephalitis and multiple sclerosis, comparing them with other brain diseases.
United Kingdom - completedNot Applicable
REFUEL-MS: Clinical and Cost-Effectiveness RCT
This study looks into an app called REFUEL-MS to help people with Multiple Sclerosis (MS) manage fatigue. The app offers exercises and coping strategies. We want to see if it reduces tiredness more than usual care and if it's safe.
United Kingdom · England · Scotland - authorisedTherapeutic confirmatory (Phase III)
A Randomized Open Label Trial Exploring the Soluble and Imaging Biomarker Dynamic Responses to Tolebrutinib Compared to Rituximab Treatment in Patients with Multiple Sclerosis (MS)
This study compares two treatments, Tolebrutinib and Rituximab, for Multiple Sclerosis (MS). Researchers are looking at how these medicines affect certain markers in the body, especially in the fluid around the brain and spine, to see which one works best at protecting nerves.
Sweden - active not recruiting
A Novel Wearable Digital Biomarker for Detecting Changes in Multiple Sclerosis (MS) Condition
This study is testing smart insoles and a phone app that could help monitor Multiple Sclerosis (MS) symptoms daily. It focuses on walking changes, a key issue for many with MS, to see if this technology can help track the condition more accurately from home.
United States · Canada · United Kingdom - recruitingNA
Comparing Transanal Irrigation With Navina Smart vs. Standard Bowel Care in Patients With Multiple Sclerosis
This study compares two ways to manage bowel problems caused by multiple sclerosis (MS): a new device called Navina Smart and standard care. It’s for adults with MS who haven't tried this specific device before, to see if the new method works better.
Denmark · France · Italy - enrolling by invitation
Multiple Sclerosis: FutureMS-2 - an Observational Cohort and Scottish Precision Medicine Study
FutureMS-2 is a study following people with MS in Scotland to understand how the condition changes over many years. It builds on an earlier study, aiming to answer important questions about how MS affects individuals and how best to manage it.
United Kingdom - not yet recruitingNA
Optimising Access to Vocational Rehabilitation for People With Multiple Sclerosis
This study looks at how MS charities can help people with MS stay in their jobs. It tests a special support program to see if it's practical and helpful, especially for those who might not get help elsewhere.
United Kingdom - active not recruitingPHASE4
Concentration of Ofatumumab in the Breast Milk of Lactating Women With Relapsing Forms of Multiple Sclerosis
This study looks at how much ofatumumab, a medicine for multiple sclerosis, gets into breast milk. We want to see if it's safe for mothers with MS who are breastfeeding to take this medication. It involves collecting milk and blood samples from new mums.
United States · Germany · Italy - recruitingNA
Artificial Intelligence-Assisted Magnetic Resonance Imaging for Quality, Efficiency and Equity in the National Health Service (NHS) Care of Multiple Sclerosis
This study looks at using special computer software (AI) with MRI scans to help doctors care for people with Multiple Sclerosis (MS) in the NHS. The goal is to improve how MS is monitored and how treatment decisions are made.
United Kingdom - ongoing, recruitingTherapeutic exploratory (Phase II)
Tenofovir Alafenamide Fumarate and Epstein-Barr virus activity in people with MS – The TAF-MS study
This study, called TAF-MS, is looking into how a medicine called Tenofovir Alafenamide Fumarate (TAF) affects the Epstein-Barr virus (EBV) in people with Multiple Sclerosis (MS). Researchers want to see if this treatment can help reduce EBV activity, which may be linked to MS.
Norway - recruitingPHASE2
Natalizumab for the Treatment of People With Inflammatory Demyelination Suggestive of Multiple Sclerosis, or Definite Multiple Sclerosis, at First Presentation (AttackMS)
This study investigates whether starting a highly effective MS treatment, Natalizumab (Tyruko®), very soon after someone first shows symptoms can help repair nerve damage. It focuses on people with early signs of MS or a definite diagnosis.
United Kingdom - recruitingNA
Hesperidin RCT in MS
This study looks into whether a natural plant extract called hesperidin, found in citrus fruits, can help people with Multiple Sclerosis (MS) feel less tired and improve their thinking. Half the participants will get hesperidin, and the other half a dummy pill.
United Kingdom - authorisedTherapeutic exploratory (Phase II)
Prospective, randomized, double-blind, placebo-controlled, single-center comparative trial evaluating oral hydroxychloroquine 200 mg BID for reducing microglial activation in the brain of patients with progressive multiple sclerosis (MS)
This study is testing if a drug called hydroxychloroquine can help slow down multiple sclerosis (MS) in people with progressive forms of the disease. Researchers want to see if it reduces brain inflammation using special scans and also check if it improves walking, thinking, and daily life.
Finland - recruitingPHASE4
Individualised Cryoneurolysis to Treat Pain in the Context of Spasticity in the Upper and Lower Extremities
This study compares two treatments, cryoneurolysis (freezing nerves) and botulinum toxin (Botox), for pain caused by spasticity. It aims to see which treatment works best for people with conditions like stroke, MS, or spinal cord injury, by looking at pain, movement, and daily activities.
United Kingdom - ongoing, recruitingHuman Pharmacology (Phase I)- Other
Safety Study to Compare the Gastrointestinal Tolerability of Oral Tegomil Fumarate and Dimethyl Fumarate (Tecfidera®) in Healthy Volunteers.
This study is looking at a new medicine called Tegomil Fumarate. It's compared to an existing medicine, Tecfidera®, to see which is easier on the stomach and gut. This is a very early study in healthy people, not people with a specific illness.
Portugal - ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2 double blind, randomized, placebo controlled study evaluating the effect of SAR443820 on serum neurofilament levels in participants with multiple sclerosis, followed by an open-label long-term extension period
This study looks at a new drug, SAR443820, for multiple sclerosis (MS). Researchers want to see if it lowers a marker in the blood called neurofilament, which can show nerve damage. It's a Phase 2 trial, meaning it's still in earlier stages of testing.
Spain · Belgium · Germany - active not recruitingPHASE3
Efficacy and Safety Studies of Frexalimab (SAR441344) in Adults With Relapsing Forms of Multiple Sclerosis
This study is looking at a new medicine called frexalimab for people aged 18-55 with certain types of Multiple Sclerosis (MS). It compares frexalimab to an existing MS medicine, teriflunomide, to see how well it stops MS relapses and if it's safe.
United States · Argentina · Austria - active not recruitingPHASE3
A Study to Evaluate the Efficacy, Safety and Pharmacokinetics (PK) of a Higher Dose of Ocrelizumab in Adults With Primary Progressive Multiple Sclerosis (PPMS)
This study looks at a new, higher dose of ocrelizumab for people with primary progressive multiple sclerosis (PPMS). Researchers want to see if this dose is safe and works better than the current approved dose to slow down the disease.
United States · Argentina · Belgium - recruitingPHASE2
A Study to Investigate Multiple Sclerosis Relapse Prevention With mRNA-1195 Compared With Placebo in Participants Aged 18 to ≤55 Years
This study is looking into a new medicine called mRNA-1195 to see if it can help stop relapses in people with Multiple Sclerosis (MS). It compares mRNA-1195 with a dummy treatment (placebo) to check its safety and how the body reacts to it.
United States · Australia · United Kingdom - enrolling by invitation
Metabolic Imaging of Neurological Disease
This study uses new scanning technology to look at how the brain uses sugar in people with Multiple Sclerosis (MS) or after a stroke, compared to healthy volunteers. It aims to understand brain changes and takes place at the University of Oxford.
United Kingdom - active not recruiting
Covid-19 Vaccine Immune Response in Multiple Sclerosis
This study looks at how well COVID-19 vaccines work in people with Multiple Sclerosis (MS). It compares their immune response to people without MS, by checking how many protective antibodies they make after vaccination.
United Kingdom - recruitingPHASE1
A Study to Evaluate the Safety, Tolerability, Efficacy, and Drug Levels of CC-97540 in Participants With Relapsing Forms of Multiple Sclerosis, Progressive Forms of Multiple Sclerosis or Refractory Myasthenia Gravis (MG) (Breakfree-2)
This study is looking at a new drug called CC-97540 for people with certain types of Multiple Sclerosis (MS) or a muscle weakness condition called Myasthenia Gravis (MG). We want to see if it's safe, how well people can handle it, and if it helps their condition.
United States · Belgium · France - recruitingPHASE1
A Study to Investigate the Safety, Tolerability, Pharmacokinetics, Immunogenicity, and Pharmacodynamics of a New Subcutaneous Formulation of Ocrelizumab in Participants With Multiple Sclerosis
This study is looking at a new way to give an existing medicine, ocrelizumab, as an injection under the skin for people with Multiple Sclerosis (MS). It aims to check if it's safe and how well people tolerate it, while also learning more about how the medicine works in the body.
United States · Brazil · Mexico - active not recruitingPHASE3
A Rollover Study to Evaluate the Long-Term Safety and Efficacy of Ocrelizumab In Patients With Multiple Sclerosis
This study looks at the long-term safety and effectiveness of a medicine called ocrelizumab for people with Multiple Sclerosis (MS). It's for people already taking part in other ocrelizumab studies, to see how the treatment works over a longer time.
United States · Argentina · Australia - active not recruitingPHASE3
Efficacy and Safety Study of Frexalimab (SAR441344) in Adults With Nonrelapsing Secondary Progressive Multiple Sclerosis
This study is testing a new drug called frexalimab for people with a type of multiple sclerosis (MS) called non-relapsing secondary progressive MS (nrSPMS). Researchers want to see if it can slow down MS progression and if it's safe. It's compared to a dummy drug (placebo).
United States · Argentina · Australia - recruitingNA
EMG Biofeedback Training to Improve Balance in Individuals with Multiple Sclerosis
This study looks at a new training method called EMG Biofeedback, using sensors, to help people with multiple sclerosis improve their balance. It compares it to traditional exercises to see which works best and if the improvements last.
Canada - not yet recruitingNA
FIT-ATOMIC Exercise Feasibility Trial
This study looks at a 20-week home exercise programme for young people aged 11-25 with Multiple Sclerosis (MS). It aims to see if this type of exercise is a good way to help manage MS and improve their health, preparing for a larger study.
United States · Canada - not yet recruitingPHASE1
Transcranial Magnetic Stimulation for Depression in Multiple Sclerosis
This study looks at a new way to treat depression and extreme tiredness (fatigue) in people with Multiple Sclerosis (MS). It uses magnetic pulses to gently stimulate the brain. Researchers want to see if it's safe and helps improve mood and energy levels.
Canada - recruiting
Measuring Silent Disease Progression in Multiple Sclerosis With a Multimodal Approach
This study looks at how multiple sclerosis (MS) progresses slowly, even without new attacks, in people on certain treatments. It uses regular check-ups, scans, blood tests, and optional smartphone/smartwatch data to understand these changes better.
Germany - recruitingNA
Remediation Program Via a "Serious Game" for the Cognitive Functions of Multiple Sclerosis Patients
This study is looking at a fun, computer-based 'serious game' to help people with multiple sclerosis (MS) improve their memory and how quickly they think. It aims to see if this game can be more helpful than usual care.
France - not yet recruitingNA
Evaluation of the NEUROSWING Orthosis on Walking Speed in a Population With Dorsal and/or Plantar Flexor Deficits, With a View to a Reimbursement Application
This study looks at a new ankle support, the NEUROSWING orthosis, to see if it helps people with walking difficulties caused by conditions like stroke or MS. Researchers will compare it to a standard carbon ankle support to see if it improves walking speed.
France - recruiting
Pregnancy Exposure Registry for Vumerity (Diroximel Fumarate)
This study looks at how babies born to mothers with multiple sclerosis (MS) are affected by a medication called Vumerity (diroximel fumarate) during pregnancy. It compares these babies to those whose mothers either didn't take MS medicines or took other similar treatments.
United States · Australia · Germany - recruiting
Detection of Spinal Cord Lesions Using the MP2RAGE Sequence in Inflammatory Diseases of the Neuraxis
This study looks at a new MRI scan (called MP2RAGE) to see if it's better at finding changes in the spinal cord for people with Multiple Sclerosis (MS). Finding these changes early can help doctors understand and manage MS better.
France - active not recruitingNA
Improving Cognitive Recovery in Multiple Sclerosis
This study looks at a new program, CIRCuiTS-MS, to help people with Multiple Sclerosis (MS) improve their thinking skills. It will check if the program is practical and helpful, paving the way for a larger trial to improve daily life for those with MS.
United Kingdom - recruitingNA
Study of Ovarian Reserve Concerning Patients With Multiple Sclerosis (MS), Compared to a Control Group
This study looks at the egg reserve in women with multiple sclerosis (MS) compared to healthy women. Researchers want to see if MS affects a woman's ability to have children, focusing on women aged 25-35.
France - recruiting
Cognitive Performance, Sleep Disturbances and Fatigue in Multiple Sclerosis
This study looks at how sleep problems and tiredness (fatigue) affect people with Multiple Sclerosis (MS). Researchers want to understand if poor sleep makes MS-related fatigue and thinking problems worse, and how different types of MS are affected. They are also using AI to help analyse sleep data.
Germany - recruitingNA
Deployment o the Multidisciplinary Prospective Cohort Imminent
This study aims to better understand long-term inflammatory diseases like lupus and severe asthma. Researchers will collect information and samples to find new ways to treat these conditions, reduce side effects, and improve daily life for patients. It's about finding better treatments for the future.
France - authorisedTherapeutic exploratory (Phase II)
A Phase 2a Study of SUN-627 to Evaluate Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Impact on Measures of Neuroinflammation in the Central Nervous System in Participants With Non-Active Progressive Multiple Sclerosis (SPMS/PPMS)
This study is looking at a new medicine called SUN-627 for people with certain types of Multiple Sclerosis (MS). Researchers want to see if it's safe, how the body uses it, and if it helps reduce inflammation in the brain over 16 weeks.
Finland - not yet recruiting
Screening for Cognitive Disorders in Multiple Sclerosis
This study looks at how MS affects memory and thinking skills. We will use simple tests to see if people with MS have these difficulties and how it impacts their daily lives. The aim is to better understand these challenges in adults with MS.
France - authorisedTherapeutic use (Phase IV)
Effects of CLADribine tablets on the Immune Synapse, in Relapsing Multiple Sclerosis (RMS) patients_CLADIS.
This study looks at how a medicine called MAVENCLAD affects the body's defence system in people with a type of multiple sclerosis. Researchers want to see if it changes how immune cells communicate and how this affects their MS over one year.
Greece - active not recruitingPHASE3
Safety and Efficacy of Fingolimod in Pediatric Patients With Multiple Sclerosis
This study looks at how safe and effective two medicines, fingolimod and interferon beta-1a, are for young people aged 10-17 with multiple sclerosis (MS). It compares them to see which works best and is safest.
United States · Australia · Austria - recruiting
Lorraine Registry of Multiple Sclerosis
The Lorraine Registry of Multiple Sclerosis (RelSEP) is a long-term study collecting information from people in the Lorraine region of France who have recently been diagnosed with MS. It aims to understand how MS progresses and is treated over time, helping researchers learn more about the condition.
France - recruitingNA
The Role of Cytokines and Regulatory T Lymphocytes in Migraine Pathophysiology.
This study looks into why some people get migraines, especially those with other health conditions like autoimmune diseases. Researchers are examining how chemicals in the body, called cytokines, and special immune cells, called Treg cells, might be linked to migraine pain. They hope to better understand migraine causes.
France - recruiting
Longitudinal Assessment of Iron Rims in MS Lesions
This study looks at how 'iron rims' around MS lesions on brain scans might affect the disease. We're also checking blood samples for genetic links. Some participants might get another special MRI scan to see how these iron rims change over time.
United Kingdom - authorisedTherapeutic exploratory (Phase II)
An autologous and antigen-specific cell-based therapy of vitamin D3-treated and myelin-derived peptide loaded tolerogenic dendritic cells in subjects with progressive forms of multiple sclerosis: a phase IIa, open-label, self-controlled, multi-center clinical trial.
This study is testing a new cell therapy called tolDC for people with progressive forms of Multiple Sclerosis (MS). It aims to see if tolDC can slow down how MS affects your body and if it's safe to use.
Belgium · Spain - completed
Changing physical activity and sedentary behaviour in people with MS to reduce fatigue: the iStep-MS study
This study, iStep-MS, looks at how a new activity program helps people with Multiple Sclerosis (MS) feel less tired. It hopes to find better ways for people with MS to be more active and sit less, improving their daily lives.
United Kingdom · England - recruitingNA
Montpellier PROspective Cohort in Relapsing Remitting Multiple Sclerosis Using Imaging and Serologic
This study looks at people in France with Relapsing Remitting Multiple Sclerosis (RRMS) to compare how two types of MS treatments (standard vs. high-strength) affect brain shrinkage over three years, using MRI scans and other tests.
France - active not recruitingPHASE2
A Study of LY3541860 in Adult Participants With Relapsing Multiple Sclerosis
This study is testing a new drug, LY3541860, for adults with relapsing multiple sclerosis (MS). We want to see if it's safe and helps reduce MS flare-ups. The study will last about 9 months, with a 6-month follow-up.
United States · France · Italy - recruitingNA
Implementation of an App-based Walking Aid Skills Training Program
This study looks at a new app called 'ICanWALK' designed to help people who use walking aids like crutches or walkers. It aims to teach them how to use these aids safely and effectively, hoping to reduce falls and improve their confidence.
Canada