Non-alcoholic Fatty Liver Disease research hub
15 indexed studies · 10 currently recruiting
- recruitingTherapeutic exploratory (Phase II)
17 β-Hydroxysteroid Dehydrogenase type 13 Minimization for the treatment of NASH (HORIZON): A Double-Blind, Placebo-Controlled Phase 2b Study to Evaluate the Efficacy and Safety of GSK4532990 in Adults with Nonalcoholic Steatohepatitis
This study is looking into a new medication for a liver condition called Non-Alcoholic Steatohepatitis (NASH). It aims to see if the medication can help improve liver scarring and reduce the illness, for people aged 18 and over.
Greece · Italy · Belgium - recruitingTherapeutic exploratory (Phase II)
Effect of orlistat on LIVER fat content in obese subjects with NAFLD and High concEntrAtion of pLasma proneurotensin THrough inhibition of neurotensin secretion and action
This study is looking at how a medicine called Orlistat affects fat in the liver for people with non-alcoholic fatty liver disease (NAFLD). It also checks if it helps with other health factors like weight and blood sugar over 6 months.
Sweden - recruiting
Fatty Liver Patient Registry
This study for people with fatty liver disease gathers health information to understand how the condition progresses and how well different treatments work. If you attend the Toronto General Hospital NAFLD clinic, your usual health information might be used, but no extra tests are needed.
Canada - recruiting
Metabolic Phenotyping and Follow-Up of Patients With and Without Diabetes After New Onset of STEMI
This study looks at how heart attacks affect people with and without diabetes. We want to understand more about metabolism, how bodies use energy, and their link to heart health to help improve treatments for people who've had a heart attack.
Germany - recruitingPHASE2
Soluble Fibre Supplementation in NAFLD
This study, called FIND, is looking at whether a special fibre supplement can help children aged 8-17 with fatty liver disease. Participants will take either the fibre or a dummy pill, and doctors will check their liver fat, diet, and do blood tests.
Canada - active not recruiting
Smart Watch Insights for Prevention of Exacerbations and Enhance Rehabilitation - Movement Study
This study uses smartwatches to understand how movement affects health for people with conditions like heart disease or diabetes. Researchers hope to find ways to predict health changes and improve wellbeing programmes using the information from the watches.
United Kingdom - recruiting
CHronic Hepatopathies Associated With ALcohol Consumption aNd metAbolic Syndrome
This study looks at how liver diseases are linked to alcohol or unhealthy eating habits. Researchers want to understand why some people develop liver cancer, even in early stages, by studying health factors, body scans, and liver samples.
France - recruiting
European Paediatric Non-Alcoholic Fatty Liver Disease Registry (EU-PNAFLD)
This study is gathering information about a liver condition called Non-Alcoholic Fatty Liver Disease (NAFLD) in children across Europe. Doctors and scientists are working together to understand it better, find new treatments, and see how it develops over time in young people.
Netherlands · United Kingdom - active not recruiting
MRI and Stable Isotope Tracer Studies for Detecting the Progression of Non-Alcoholic Steatohepatitis (NASH)
This study looks at how non-alcoholic fatty liver disease (NAFLD) gets worse. We use special scans and tests to understand changes in the body and how a substance called L-carnitine might help. This could lead to better ways to find and treat liver problems early.
United Kingdom - active not recruiting
Multi-morbidity Screening in People With Type 2 Diabetes and Pre Diabetes
This study checks for other health issues often linked with Type 2 diabetes and pre-diabetes, like problems with your heart, liver, or sleep. It's testing a new, more thorough health check-up to find these problems earlier.
United Kingdom - active not recruitingPHASE2
Phase 2b Study of GSK4532990 in Adults With NASH
This study is testing a new medicine, GSK4532990, for people with a serious liver condition called Non-Alcoholic Steatohepatitis (NASH). We want to see if this medicine can improve liver damage and inflammation compared to a dummy medicine.
United States · Argentina · Australia - recruiting
Integrated Diagnostics for Early Diagnosis of Liver Disease
This study aims to find better ways to spot liver disease early, especially scarring (fibrosis). Researchers are looking at blood tests, gut bacteria, and other information from patients in local clinics. They hope to create a new, improved test that's more accurate than current methods.
United Kingdom - active not recruitingPHASE2
A Clinical Study of Efinopegdutide in People With Compensated Cirrhosis Due to Steatohepatitis (MK-6024-017)
This study is looking into a new medicine called efinopegdutide for a liver condition called MASH. We want to see if it can help reduce liver fat, swelling, and scarring in people with MASH and mild scarring. It also checks how safe the medicine is.
United States · Australia · Canada - recruiting
Investigating Pathological Mechanisms in Non-alcoholic Fatty Liver Disease
This study aims to understand Non-Alcoholic Fatty Liver Disease (NAFLD) better. We're looking at different body samples to see how immune systems, gut bacteria, and metabolism are involved in NAFLD, especially in people having weight-loss surgery.
United Kingdom - recruitingPHASE4
Fibrosis Lessens After Metabolic Surgery
This study looks at how well weight-loss surgery compares to new medicines for treating liver disease. It focuses on a condition called MASH, which is linked to being overweight and can cause liver damage.
United States · Brazil · Canada