Obstructive sleep apnea with an incomplete clinical response to oral appliance therapy. research hub

SYNERGY OSA - EFFICACY, SAFETY and TOLERABILITY OF COMBINED THERAPY WITH A SOMNOMED ORAL APPLIANCE AND THE CARBONIC ANHYDRASE INHIBITOR SULTHIAME IN PATIENTS WITH OBSTRUCTIVE SLEEP APNEA. A Randomized, Double-Blind, Placebo Controlled, Proof-of-Concept Trial

This study tests whether adding a tablet called sulthiame to a standard dental sleep splint helps treat obstructive sleep apnoea. Researchers want to see if this combined treatment reduces nighttime breathing pauses and improves daytime energy better than a dummy tablet in adults whose splint is not fully working.