- authorisedHuman Pharmacology (Phase I)- Other
PANVIRAL: Safety, Feasibility and Immunogenicity of Intra-Tumoral ORCA-010 Oncolytic Virus Administration in Metastatic Pancreatic Cancer – A Single-Center Phase 1 Trial
The PANVIRAL study is testing a new treatment called ORCA-010 for pancreatic cancer that has spread. ORCA-010 is a modified virus injected directly into tumours to kill cancer cells and trigger an immune response. This early-stage trial checks if the treatment is safe and practical for patients.
Netherlands - active not recruitingPHASE2
Basket Study of Entrectinib (RXDX-101) for the Treatment of Patients With Solid Tumors Harboring NTRK 1/2/3 (Trk A/B/C), ROS1, or ALK Gene Rearrangements (Fusions)
This study looks at a drug called entrectinib for different types of advanced cancer. It focuses on cancers with specific genetic changes (NTRK, ROS1, or ALK gene fusions). Researchers want to see if entrectinib can help treat these cancers.
United States · Australia · Belgium - recruitingPHASE3
Study of Daraxonrasib and Daraxonrasib + GnP as First-line Treatment in Patients With Metastatic Pancreatic Adenocarcinoma
This study is looking at a new drug, daraxonrasib, for people with pancreatic cancer that has spread. It compares daraxonrasib alone, or with standard chemotherapy (gemcitabine and nab-paclitaxel), against standard chemotherapy by itself. The aim is to see if the new treatments can help people live longer and stop the cancer from growing.
United States · Australia · Austria - completed
UK early detection initiative for pancreatic cancer
This UK research study looks at finding pancreatic cancer earlier in people aged 50 or older who were recently diagnosed with diabetes. Researchers are testing blood samples from 1,000 volunteers over two years to find early warning signs, hoping to create a simple screening test for the NHS in the future.
United Kingdom · England · Northern Ireland - recruitingPHASE3
Atebimetinib + GnP as a First Line Treatment in Patients With Metastatic Pancreatic Adenocarcinoma
This study is testing a new medicine, atebimetinib, alongside standard chemotherapy for pancreatic cancer that has spread. We want to see if this combination works better and is safe for patients who haven't had treatment before.
United States · Australia · Georgia - recruitingPHASE1
A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors
This study is testing a new drug, LY4052031, for people with advanced cancers like bladder, breast, and lung cancer. It aims to see if the drug is safe, what dose works best, and if it helps shrink tumors. It's an early-stage study to gather important information.
United States · Australia · China - recruitingPHASE3
Study of Daraxonrasib (RMC-6236) in Patients With Resected Pancreatic Ductal Adenocarcinoma (PDAC)
This study is for people who have had surgery for pancreatic cancer. We are testing a new drug, daraxonrasib, to see if it can stop the cancer from coming back, compared to just being watched. It's to help see if this new treatment works better.
United States · France · Germany - recruitingNA
Mainstreaming Genetics: Evaluation of a Digital Application to Scale and Spread Oncologist-initiated Genetic Testing
This study looks at a new digital tool called GA-Mainstream. It helps people with certain cancers like breast, ovarian, and colon cancer understand genetic testing better. The goal is to make sure patients feel informed and supported while getting tested for genes that can affect their cancer treatment.
Canada - recruitingPHASE3
Study of Zoldonrasib + Chemo of Investigator's Choice vs Placebo + Chemo of Investigator's Choice as First-line Treatment in Metastatic KRAS G12D-mutated Pancreatic Adenocarcinoma ( RASolute 305 )
This study is testing a new drug called zoldonrasib, combined with standard chemotherapy, for people with pancreatic cancer that has spread. It compares this combination to chemotherapy alone, to see if it helps people live longer or stops the cancer from growing for longer. It focuses on a specific type of cancer gene.
United States · United Kingdom - active not recruitingPHASE1, PHASE2
Study of Anti-CEACAM5 ADC M9140 in Participants With Advanced Solid Tumors (PROCEADE PanTumor)
This study looks at a new treatment called M9140 for different advanced cancers like stomach, lung, and pancreatic cancer. It aims to see if it's safe and effective for patients whose cancers have a specific marker called CEACAM5.
United States · Australia · Austria - not yet recruitingNA
Assessment of Adherence to Remotely Monitored Physical Activity Tracked on a Smartwatch, and Its Impact on Reducing Fatigue 3 Months After Adjuvant Chemotherapy for Cancer
This study looks at how well people with certain cancers stick to a special exercise program after chemotherapy. It uses smartwatches to track activity and checks if exercise helps reduce tiredness three months later.
France - active not recruitingPHASE2
Phase 2 Futibatinib in Combination With PD-1 Antibody Based Standard of Care in Solid Tumors
This study is testing a new drug, futibatinib, alongside standard cancer treatments for people with advanced oesophageal or pancreatic cancer. We want to see if this new combination helps fight the cancer and how safe it is.
United States · France · Germany - recruiting
Feasibility Study to Investigate Rectal Mucus in Aero-Digestive Tract Cancer.
This study looks at whether we can find signs of non-bowel cancers, like lung or pancreatic cancer, in a small sample of mucus taken from a person's bottom. We're testing a new, simple device to see if it can help detect these cancers earlier.
United Kingdom - recruiting
Cancer Loyalty Card Study 2 (CLOCS-2)
This study looks at shopping habits using loyalty card data from Tesco or Boots to see if certain purchases might hint at cancer earlier. It aims to help doctors diagnose pancreatic, bowel, oesophageal, stomach, liver, bladder, womb, vulval, and ovarian cancers sooner.
United Kingdom - recruitingPHASE2
APL-101 Study of Subjects With NSCLC With c-Met EXON 14 Skip Mutations and c-Met Dysregulation Advanced Solid Tumors
This study is testing a new oral medicine, APL-101, for people with advanced cancers. It focuses on lung cancer and other solid tumours where specific genetic changes linked to a protein called MET are found. Researchers want to see how well it works and if it's safe.
United States · Australia · Canada - recruitingEARLY_PHASE1
B-GLUCANCER2 : A Pilot Study Evaluating a New Method for Cancer Detection by Measuring the Activity of Different Glycosidase Enzymes in the Plasma of Patients With a Localized Cancer.
This study aims to find a new way to detect cancer early using a simple blood test. Researchers are looking for tiny clues called 'glycosidases' in blood plasma that might show if someone has breast, lung, or pancreatic cancer, and how well treatments are working.
France - recruitingNA
EUS-CPN With and Without Bupivacaine
This study looks at a procedure called EUS-CPN, used for pain linked to pancreatic cancer. It compares giving a painkiller called bupivacaine before the main treatment with not giving it, to see which is more effective and safer for managing pain.
Canada - not yet recruitingNA
Exercise to Boost Immunity in Advanced Cancer
This study in Sheffield looks at how exercise might help advanced mesothelioma or pancreatic cancer patients undergoing treatment. It wants to see if weekly exercise can boost their immune system and improve how well treatments work.
United Kingdom - recruitingPHASE2
Pembrolizumab With Olaparib as Combined Therapy in Metastatic Pancreatic Cancer
This study is testing a new combination of two drugs, pembrolizumab and olaparib, for people with pancreatic cancer that has spread. It focuses on patients whose cancer has specific genetic changes, hoping to find a more effective treatment.
Australia · United Kingdom - recruitingPHASE2
Durvalumab and Tremelimumab in Combination With Propranolol and Chemotherapy for Treatment of Advanced Hepatopancreabiliary Tumors (BLOCKED)
This study looks at combining special medicines called immunotherapy with propranolol, and sometimes chemotherapy, for advanced pancreatic, liver, or bile duct cancers. It aims to see how safe and effective this new treatment approach is for patients.
Canada - recruiting
American Hepato-Pancreato-Biliary Association (AHPBA) Pancreatic Irreversible Electroporation (IRE) Registry
This study is gathering information on a treatment called IRE for pancreatic cancer. It aims to help doctors understand the treatment better, improve care, and learn about any problems or benefits patients experience.
United States · Canada · Japan - active not recruitingNA
Alpha Radiation Emitters Device for the Treatment of Advanced Pancreatic Cancer
This study is testing a new radiation treatment called DaRT for advanced pancreatic cancer. It involves placing small devices directly into the tumour to deliver radiation. Doctors want to see if it's safe and effective for people whose cancer can't be removed by surgery.
Canada - active not recruitingPHASE3
Phase 3 Study of Daraxonrasib (RMC-6236) in Patients With Previously Treated Metastatic Pancreatic Ductal Adenocarcinoma (PDAC)
This study is looking for a new treatment for pancreatic cancer that has spread. It compares a new medicine called RMC-6236 with standard chemotherapy for people whose cancer has already been treated once before. The aim is to see if the new medicine is safer and works better.
United States · France · Germany - recruitingNA
Simulation-Free Celiac Plexus Pain Ablation Using Stereotactic Body Radiotherapy in Patients With Cancer-Related Celiac Pain
This study looks at a new, faster way to give radiation treatment for pain caused by cancer in the tummy area. It aims to see if treatment planning and delivery can happen in one visit, instead of over many days, using existing scans and special adjustments on the day of treatment.
Canada - active not recruitingPHASE1
Phase I Trial of Defactinib and VS-6766.
This study is testing two new drugs, Defactinib and VS-6766, for patients with advanced cancers like certain lung, ovarian, womb, and pancreatic cancers. It aims to find the safest dose and see how well the combination works.
United Kingdom - active not recruitingPHASE1, PHASE2
Study of AZD5305 as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Malignancies
This study is looking into a new drug, AZD5305, by itself or with other cancer treatments, for advanced solid cancers like ovarian, breast, and lung cancer. It aims to see if it's safe, tolerable, and effective.
United States · Australia · Canada - recruiting
A Pan-European Post-Authorisation Safety Study: Risk of Pancreatic Cancer Among Type 2 Diabetes Patients Who Initiated Exenatide as Compared With Those Who Initiated Other Non-Glucagon-Like Peptide 1 Receptor Agonists Based Glucose Lowering Drugs
This study looks at the possible link between a type 2 diabetes medicine called exenatide and pancreatic cancer. Researchers are comparing patients who started exenatide with those who started other diabetes medicines, using health records from several European countries.
Denmark · Finland · France - active not recruitingPHASE1, PHASE2
A Phase I/IIa Trial of HMBD-001 in Advanced HER3 Positive Solid Tumours
This study is testing a new drug, HMBD-001, for advanced cancers where a protein called HER3 is active. We want to find the best dose, understand side effects, and see if it helps stop cancer growth, sometimes with another drug called enzalutamide.
United Kingdom - recruitingPHASE1
A Study to Learn About the Study Medicine Called PF-08046876 in People With Advanced Solid Tumors
This study is looking at a new medicine called PF-08046876 for people with advanced cancers like bladder, lung, head & neck, oesophageal, or pancreatic cancer. It checks how safe the medicine is and how well it works. The medicine is given through a drip.
United States · Canada · China - recruiting
Volatile Organic Compound Assessment in Pancreatic Ductal Adenocarcinoma
Researchers are developing a breath test for pancreatic cancer. This test looks for tiny chemicals in your breath that might change when pancreatic cancer is present. The goal is to help doctors find pancreatic cancer earlier, especially in people with unclear symptoms, so treatment can start sooner.
United Kingdom - recruitingNA
Stereotactic Body Radiotherapy in Patients With Rare Oligometastatic Cancers (OligoRARE)
This study looks at adding special radiation to standard care for rare cancers that have spread a little. It wants to see if this addition helps people live longer compared to standard care alone.
Belgium · France · Germany - recruiting
Volatile Organic Compound Assessment in Pancreatic Ductal Adenocarcinoma (VAPOR2)
We're testing a new breath test to find pancreatic cancer earlier. This is important because pancreatic cancer can be hard to spot early. The test looks for special smells on your breath that might be linked to the cancer. Finding it sooner could mean more treatment choices and better health outcomes.
United Kingdom - recruiting
The MOMENTUM Study: The Multiple Outcome Evaluation of Radiation Therapy Using the MR-Linac Study
The MOMENTUM Study is tracking how a new type of advanced radiotherapy, called MR-Linac, works for people with different cancers. It aims to see if this treatment improves survival, controls cancer better, and enhances quality of life by using highly precise radiation guidance.
United States · Australia · Belgium - recruiting
REVOLUTION Surgery (REVOLUTION Surgery)
This study looks into why some cancer patients lose weight and muscle, a condition called cachexia. It aims to understand this problem better by gathering information from patients undergoing surgery for certain cancers and comparing it with people having surgery for non-cancer conditions.
United Kingdom - recruiting
In-Depth Characterisation of Biliary Strictures and Hepato-Pancreato-Biliary Focal Lesions for Development of New Technologies to Tackle Hepato-Pancreato-Biliary Cancers
This study aims to better understand cancers in the liver, bile ducts, and pancreas to find new ways to diagnose and treat them. Researchers are collecting samples to develop new technologies for earlier detection and more effective treatments for these challenging cancers.
United Kingdom - active not recruitingPHASE2
A Randomised Trial of ATRA in a Novel Drug Combination for Pancreatic Cancer
This study looks at a new combination of medicines for pancreatic cancer. It tests if adding a drug called ATRA to standard treatment (gemcitabine and nab-paclitaxel) helps patients with locally advanced pancreatic cancer not yet treated with other drugs. It's a randomised trial, meaning some get the new drug combo and some get the standard one.
United Kingdom - recruitingPHASE3
A Study to Evaluate the Effectiveness and Safety of Setidegrasib, Given With Either mFOLFIRINOX or NALIRIFOX Chemotherapies, in People With Pancreatic Cancer
This study is testing a new drug called setidegrasib for people in the UK with advanced pancreatic cancer. It's for those whose cancer has spread and has a specific gene change (KRAS G12D). The study wants to see if adding setidegrasib to standard chemotherapy helps people live longer and feel better.
United States · China · Japan