- completedPhase IV
Statins to Ameliorate early onset Pre-eclampsia
Pre-eclampsia is a serious pregnancy condition causing high blood pressure. Currently, the only cure is giving birth, which often means babies arrive prematurely. This UK study investigates whether a daily statin pill (pravastatin) can safely lower harmful chemicals in the blood and help keep babies in the womb longer.
United Kingdom · England - recruiting
Does use of a new pre-eclampsia screening test reduce pre-eclampsia and preterm birth in the NHS?
This study looks at a new test to help prevent pre-eclampsia, a pregnancy condition with high blood pressure. It compares a new test to the current one used in the NHS to see if it reduces pre-eclampsia and premature births, aiming for better health outcomes for mums and babies.
United Kingdom · England - recruiting
Ergothioneine and pre-eclampsia study
This study looks into how diet, especially a nutrient called ergothioneine found in mushrooms, might be linked to pre-eclampsia in pregnant women. It aims to see if diet quality differs between women with and without this condition and how easy online diet tools are to use.
United Kingdom · England - recruiting
Pre-eclampsia prevention by timed birth at term 2 (PREVENT-2): a randomised trial
This study, PREVENT-2, looks at whether carefully timed delivery for pregnant women at higher risk of pre-eclampsia can reduce how often it happens and how serious it is. This could help both mothers and babies.
United Kingdom · England - active not recruitingNA
Physician Optimised Post-partum Hypertension Treatment Trial
This study looks at a new way for mums to manage high blood pressure after pregnancy when they go home. It uses a special blood pressure monitor and phone app, with support from doctors, to see if it helps keep blood pressure lower and improves heart and brain health.
United Kingdom - recruiting
Early Prediction of Preeclampsia Using arteriaL Stiffness in High-risk prEgnancies
This study is looking for better ways to spot pre-eclampsia early in high-risk pregnancies. Researchers are testing a quick, non-invasive method that measures the stiffness of blood vessels, alongside other checks, to help improve care for expectant mothers.
Canada - recruitingPHASE3
Chronic Hypertension and Acetyl Salicylic Acid in Pregnancy
This study looks at whether a daily low dose of aspirin (150mg) taken throughout pregnancy can help prevent serious health problems for mums and babies when the mother has high blood pressure. It aims to see if aspirin can reduce issues like pre-eclampsia and growth problems.
France - recruitingNA
Pilot Study of Microvesicles in Pre-eclamptic and Non-pre-eclamptic Women With Threatened Preterm Delivery
This study looks at tiny particles called microvesicles in the blood of pregnant women. We want to see if these particles are different in women with pre-eclampsia compared to those without it. This could help us understand pre-eclampsia better.
France - recruiting
Bioimpedence and Arterial Function Monitoring at Birth and in Infants
This study looks at how babies' hearts and arteries work and grow in their first year. We want to see if there are differences in babies born smaller than expected, and to test new ways of measuring heart health in newborn babies.
United Kingdom - not yet recruiting
Oxford Luteal Dysfunction and Placental Insufficiency Study
This study looks into pre-eclampsia, a serious high blood pressure condition in pregnancy. Researchers want to understand if early pregnancy hormone levels and ovary checks can predict which women might develop it, aiming to find ways to prevent it in the future.
United Kingdom - recruitingNA
Clinical Antenatal Randomised Study to CharactErise Key Roles of TetrahydroFOLate in HyperTensive Pregnancies
This study looks at how high blood pressure in pregnancy affects mothers and babies, focusing on a molecule called BH4. Researchers are testing if a folate supplement can improve blood vessel health for those with high blood pressure during pregnancy.
United Kingdom - recruiting
Placental Biology in Health and Disease
This study looks at tiny particles from the placenta called 'EVs' to understand pregnancy problems like pre-eclampsia and gestational diabetes. Researchers hope to find new ways to detect and treat these conditions early to help mums and babies.
United Kingdom