Primary Biliary Cholangitis research hub
7 indexed studies · 4 currently recruiting
- recruitingPHASE3
Seladelpar in Subjects With Primary Biliary Cholangitis (PBC) and Compensated Cirrhosis
This study is looking into a new medicine called Seladelpar for people with a liver condition called Primary Biliary Cholangitis (PBC) and mild liver scarring (cirrhosis). It aims to see how well Seladelpar works compared to a dummy pill to improve health outcomes.
United States · Argentina · Australia - recruiting
A Study Observing Everyday Effectiveness and Safety of the Drug Elafibranor in Participants With Primary Biliary Cholangitis Who Are Receiving Ongoing Treatment
This study looks at how a drug called elafibranor works for people with a rare liver disease called Primary Biliary Cholangitis (PBC) in everyday life. Researchers will check its effects, how safe it is, and how well people tolerate it over about five years.
United States · Australia · Austria - active not recruitingPHASE2
Study to Evaluate the Efficacy and Safety of K-808 (Pemafibrate) in Participants With Primary Biliary Cholangitis (PBC) With Inadequate Response to Ursodeoxycholic Acid (UDCA) and/or Obeticholic Acid (OCA) Treatment.
This study is testing a new medicine, K-808, for people with a liver condition called Primary Biliary Cholangitis (PBC). We want to see if K-808 is safe and helps improve the condition for those who haven't fully responded to current treatments.
United States · Canada · Japan - recruiting
LEOPARD Training and Validation Data Collection Study
This study aims to improve how we predict who needs a new liver transplant most urgently. Researchers are collecting health information from patients with severe liver diseases across Europe to create better tools, using artificial intelligence, to help decide who gets a liver transplant and when.
Austria · Belgium · France - recruitingPHASE2
A Study to Evaluate Efficacy and Safety of an Investigational Drug Named Volixibat in Patients With Itching Caused by Primary Biliary Cholangitis
This study is testing a new medicine, Volixibat, for people with Primary Biliary Cholangitis (PBC) who experience bothersome itching. We want to see if Volixibat can reduce itching and if it affects how PBC develops. It's a Phase 2 study, meaning we're still learning about its effects.
United States · Argentina · Belgium - ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2a, Double-Blind, Randomized, Active Controlled, Parallel Group Study Evaluating the Efficacy, Safety, and Tolerability of Bezafibrate Administered in Combination with Obeticholic Acid in Subjects with Primary Biliary Cholangitis
This study is looking at a new way to treat primary biliary cholangitis (PBC). It's testing a combination of two existing medicines, bezafibrate and Ocaliva, to see if they work better together to improve liver health and are safe for patients. Researchers will compare how patients feel and how their liver tests change.
Italy - active not recruitingPHASE3
A Study of Elafibranor in Adults With Primary Biliary Cholangitis and Inadequate Response or Intolerance to Ursodeoxycholic Acid.
This study investigates a new drug, elafibranor, for adults with Primary Biliary Cholangitis (PBC). It aims to see if elafibranor can improve liver health in people whose current treatment isn't working well or who can't tolerate it. It compares elafibranor to a dummy treatment.
United States · Czechia · France