- not yet recruiting
Testing the clinical effectiveness of Social Recovery Therapy for people with psychosis and social disability
This study tests a new therapy called Social Recovery Therapy (SRT) for people with psychosis who find it hard to get involved in daily activities. It compares SRT with usual care to see if it helps people live more active and fulfilling lives.
United Kingdom · England - recruiting
Using video feedback to strengthen interactions between parents with psychosis and their young children
This study looks at using video feedback to help parents with psychosis bond with their young children. It aims to see if this approach is helpful and practical before doing a larger study. Participants will either get video feedback or their usual care.
United Kingdom · England - not yet recruitingNA
A Case Series of Culturally-adapted CBTp for Black People in the UK
This study looks at a special type of talking therapy for Black people in the UK who experience psychosis. It checks if this therapy, which is adjusted for different cultures, is practical, comfortable, and safe for them.
United Kingdom - recruiting
Psychodynamic Interpersonal Therapy for psychosis (PITp): a feasibility randomised controlled trial
This study looks into a talking therapy called PITp for people experiencing psychosis. It wants to see if this therapy, alongside usual NHS care, is a good idea for a larger study. Adults in Greater Manchester with psychosis can take part.
United Kingdom · England - recruitingNA
Early Psychosis: Investigating Cognition
This study explores brain chemistry changes in people who have recently experienced psychosis. It investigates how brain chemicals like glutamate might affect memory and attention, and if a mild electrical brain stimulation could offer a new, personalised treatment approach.
United Kingdom - completed
The feasibility of cognitive behavioural therapy for depression and anxiety adapted for psychosis risk in primary care
This study looks at a new way to help people with depression and anxiety who also have unusual experiences like hearing or seeing things. It tries out a talking therapy in NHS services to see if it helps them sooner, before these experiences become more upsetting.
United Kingdom · England - recruitingPHASE3
A Study to Evaluate Safety and Efficacy of KarXT + KarX-EC as a Treatment for Psychosis Associated With Alzheimer's Disease (ADEPT-5)
This study is looking at a new treatment called KarXT + KarX-EC for psychosis, which can affect people with Alzheimer's disease. Researchers want to see if this treatment is safe and helps reduce psychotic symptoms like hallucinations or delusions in individuals aged 55 to 90.
United States · Australia · Canada - recruitingNA
Piloting of an Intervention to Reduce Problematic Alcohol Use in Early Phase Psychosis Patients
This study looks at a talking therapy called Cognitive Enhancement Therapy (CET) for young people with early psychosis who also drink too much alcohol. It hopes to reduce alcohol use and improve recovery.
Canada - active not recruitingNA
Cognitive Remediation for Social Cognition in Schizophrenia and Related Disorders
This study looks at a new online programme called RC2S+ for people with schizophrenia and similar conditions. It aims to see if using this programme distantly is practical and helpful for improving social thinking skills.
Canada - recruiting
Semantic and Syntactic Computerized Analysis of Free Speech
This study looks at how changes in speech might predict if someone at high risk will develop serious mental health conditions like schizophrenia. Researchers are using computer programs to analyse speech patterns to find early warning signs.
France - active not recruitingPHASE2
IVIG and Rituximab in Antibody-associated Psychosis - SINAPPS2
This study looks at whether special treatments called immunotherapy can help people with a type of psychosis linked to the body's immune system. Researchers want to see if these treatments, intravenous immunoglobulin (IVIG) and rituximab, are safe and effective for this condition.
United Kingdom - not yet recruitingNA
The Mouth Matters in Mental Health Trial -2
This study looks at how a 'link worker' can help people with severe mental health issues attend dental appointments. It aims to see if this support improves their dental attendance and overall oral health, and if it's a good value for money for the NHS.
United Kingdom - recruitingNA
Multimodal Intervention to Support Hospital-to-Community Transition in Bipolar Disorder
This study helps young people with bipolar disorder move from hospital to home. It offers group learning, support from others who understand, and guidance for their local doctors. The aim is to see if this special plan can help people stay well and out of hospital.
Canada - not yet recruitingNA
Developing a Virtual Reality-assisted Intervention for Emotion Regulation Difficulties in Psychosis
This study looks at using virtual reality (VR) to help people with psychosis manage their feelings better. It combines talking therapy with VR practice to assist people in handling emotions when they need to, making it easier to live their daily lives.
United Kingdom - not yet recruitingNA
The Personalized Psychological Treatment for Psychosis
This study is testing a new, more tailored type of talking therapy called Personalized Metacognitive Training (P-MCT) for people with psychosis that involves delusions. We want to see if this personalized approach works better than the standard therapy to help people feel and cope better.
Chile · France · Germany - active not recruitingNA
Family-Focused Therapy for Individuals at High Clinical Risk for Psychosis: A Confirmatory Efficacy Trial
This study looks at a special family therapy for young people (aged 13-25) at high risk of developing psychosis. It compares this therapy with standard care to see how well it helps families understand symptoms, improve communication, and cope better.
United States · Canada - recruiting
E-Detection Tool for Emerging Mental Disorders
This study is developing an online tool to help spot early signs of psychosis in young people aged 12-35. It uses questionnaires and short online activities to identify those who might be developing this condition, aiming for earlier support and better outcomes.
United Kingdom - recruitingNA
Investigating the Effect of a Single-dose of Levetiracetam on Brain Function, Chemistry and Cognitive Performance in Psychosis Risk
This study explores if a medicine called levetiracetam can improve brain function and thinking in young adults at risk of psychosis. Researchers will use special brain scans to see how the medicine affects the brain.
United Kingdom - recruiting
Behavioural Development, Long-term Outcomes and Opportunities to Optimize Youth Mental Health Trajectories
This study, called BLOOM, looks at how young people's mental health develops between ages 9 and 25. It aims to understand early signs of mental health conditions like depression and ADHD, to help find ways to support young people before problems become serious.
Canada - active not recruiting
AMP SCZ® Observational Study: PREDICT-DPACC
This study aims to better understand and predict who might develop psychosis, a serious mental health condition. Researchers are looking for young people (12-30) who are at high risk but haven't had a full psychotic episode yet. The goal is to find ways to help people sooner.
United States · Australia · Canada - not yet recruitingNA
Testing the Efficacy of the Cannabis Clinic for Patients With Psychosis (CCP) Intervention for Cannabis Use Reduction/Cessation in Patients With First Episode Psychosis (FEP)
This study looks at a special programme to help people with psychosis reduce or stop using cannabis. Cannabis can make psychosis worse, so this programme offers support through talking therapies and group sessions to improve care for these patients.
United Kingdom - not yet recruitingPHASE3
Stratification and Treatment in Early Psychosis Study - ENHANCE
This study looks at adding CBD oil to usual treatment for young people (16-40) experiencing their first episode of psychosis, who haven't fully improved yet. We want to see if CBD helps and is safe, compared to a dummy treatment.
Austria · Germany · Greece - recruiting
HYEEG Discourse in Psychosis: A Neurobehavioural Study
This study looks at how people with psychosis, especially schizophrenia, communicate and interact socially. Researchers want to understand why some struggle with social connections and how their brain activity and body language play a role, hoping to improve support for them.
Canada - recruitingNA
Effects of Action-Based Cognitive Remediation on Substance Misuse in Early Phase Psychosis
This study looks at a new type of therapy called ABCR for young people (aged 16-30) with early psychosis who also use alcohol or cannabis. It wants to see if ABCR can help reduce their substance use and improve their overall well-being.
Canada - recruitingNA
Outcomes From Remediation and Behavioural Intervention Techniques
This study looks at how well different talking therapies, like CBT for psychosis and brain training, work for people with conditions like schizophrenia. Researchers want to find out who benefits most from each therapy, or a combination, to help improve daily life.
Canada - recruiting
Immune Mechanisms of Antipsychotic Treatment Response
This study looks at how your body's defence system, called the immune system, might affect psychosis and how well treatments work. They collect blood and spinal fluid to find better ways to diagnose and treat psychosis.
United Kingdom - not yet recruitingPHASE3
Stratification and Treatment in Early Psychosis Study -ASSIST
This study looks at whether adding a medicine called CBD to standard clozapine treatment helps people with tough-to-treat psychosis feel better. It also checks if CBD is safe. Participants will get either CBD or a dummy pill and continue their usual care.
Germany · Greece · Israel