Pulmonary hypertension research hub
24 indexed studies · 19 currently recruiting
- completed
Supervised Pulmonary Hypertension Exercise REhabilitation (SPHERe) trial
The SPHERe trial looks at whether an online, home-based exercise and support programme can help people living with pulmonary hypertension. Participants complete eight weeks of guided home exercise with specialist online support. Researchers want to see if this safely improves fitness, eases breathlessness, and boosts day-to-day quality of life.
United Kingdom · England · Scotland - active not recruitingPHASE2
Frespaciguat (MK-5475) INSIGNIA-PH-COPD: A Study of the Efficacy and Safety of Frespaciguat (an Inhaled sGC Stimulator) in Adults With PH-COPD
This study is testing a new inhaled medicine, frespaciguat, for people with lung disease (COPD) and high blood pressure in their lungs (pulmonary hypertension). Researchers want to see if it helps people walk further.
United States · Argentina · Australia - enrolling by invitationPHASE3
A Study Evaluating the Long-Term Efficacy and Safety of Ralinepag in Subjects With PAH Via an Open-Label Extension
This study looks at the long-term effects and safety of a drug called Ralinepag for people with a lung condition called pulmonary arterial hypertension (PAH). It's for those who have already tried Ralinepag in a previous study.
United States · Argentina · Australia - recruiting
Diaphragmatic Function as a Biomarker
This study looks at how your breathing muscles, especially your diaphragm, work if you have lung conditions like asthma or COPD. We want to understand if problems with these muscles are linked to feeling breathless and what that might mean for your health.
Germany - recruitingPHASE2
A Study of TX000045 in Patients With Pulmonary Hypertension Secondary to Heart Failure With Preserved Ejection Fraction (the APEX Study)
The APEX study is looking at a new medicine called TX000045 for people with high blood pressure in their lungs caused by a certain type of heart failure. It will compare two doses of the medicine against a dummy treatment to see if it helps.
United States · Armenia · Australia - recruiting
PVRI GoDeep Global Deep Phenotyping Meta-Registry for Pulmonary Hypertension
This study is gathering health information from many people around the world who have pulmonary hypertension (PH). It helps researchers understand PH better, looking at different groups of people and their health data to improve treatments for everyone.
Germany - recruitingPHASE3
Efficacy and Safety Study of Treprostinil Palmitil Inhalation Powder (TPIP) in Participants With Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD)
This study looks at a new inhaled medicine, called TPIP, for people with high blood pressure in the lungs due to scarring (PH-ILD). It wants to see if the medicine helps them walk further over 24 weeks compared to a dummy medicine.
United States · Argentina · Australia - recruiting
Giessen Pulmonary Hypertension Registry and Biobank
This study in Germany is looking at adults with high blood pressure in their lungs (pulmonary hypertension) to understand how they live long-term without needing a lung transplant. It aims to find out what factors help people stay healthy.
Germany - recruitingNA
Interoceptive Intervention for Pulmonary Hypertension
This study looks into a new way to help people with pulmonary hypertension (PH) feel better emotionally. It's called interoceptive intervention, which helps you understand your body's signals. We're testing if an online group program can improve well-being for PH patients.
United Kingdom - recruiting
Postcapillary Blood Gas Analysis in Wedge Position (Wedge-BGA)
This study looks at a new way to check blood samples during a heart test for pulmonary hypertension (high blood pressure in the lungs). By taking extra tiny blood samples, researchers hope to better understand this condition and find new ways to treat it.
Germany - recruitingNA
Development of Novel Physiological CMR Methods in Health and Disease
This study uses special MRI scans to understand how the heart works in healthy people and those with heart conditions. It looks at how the heart responds to small challenges, like a fluid boost, to find better ways to spot and treat heart problems.
United Kingdom - not yet recruitingNA
MedlyPeds Feasibility Study
This study looks at a new smartphone app called MedlyPeds, designed to help monitor children with heart conditions from home. It's testing how well it works and for which children it might be most helpful, gathering feedback to make it better.
Canada - not yet recruitingNA
Self-Help Booklets for Sleep in Adults With Pulmonary Hypertension
This study looks at whether special self-help booklets can improve sleep for adults in the UK who have a lung condition called pulmonary hypertension. These booklets are based on a proven sleep therapy and aim to help people sleep better and feel more rested.
United Kingdom - active not recruitingPHASE2
A Study of Mosliciguat in PH-ILD
This study looks at a new inhaled medicine, mosliciguat, for people with high blood pressure in their lungs caused by lung scarring (PH-ILD). It checks if the medicine is safe and if it helps improve their condition. Participants will be given either the new medicine or a dummy medicine.
United States · Argentina · Australia - recruiting
Digital Assessment of Real-World Walking Activity in Pulmonary Hypertension: A Prospective Multicenter Trial
This study looks at how walking activity in people with pulmonary hypertension changes over time. Scientists want to see if special sensors can accurately measure walking and if these measurements are linked to how the heart and lungs are working.
Germany - recruitingNA
Safety and PK-PD Study of Oral L-CIT in Preterm Infants With BPD±PH and NEC
This study looks at a natural substance called L-Citrulline to see if it's safe and helpful for premature babies with lung problems (like BPD and PH) or a serious gut condition (NEC). We want to understand how it works in their tiny bodies.
Canada - not yet recruiting
Pulmonary Arterial Hypertension and Associated Cardiovascular Disease Detection Using Artificial Intelligence
This study uses a special AI stethoscope to check for heart conditions like pulmonary hypertension during routine heart scans. By collecting new sound and electrical signals from the heart, researchers hope to make AI better at spotting these conditions early.
United Kingdom - active not recruitingPHASE2
A Study to Learn About the Study Medicine (Called PF-07868489) in People With Pulmonary Arterial Hypertension Who Have Previously Participated in a Clinical Study With PF-07868489
This study looks at a medicine called PF-07868489 for people with high blood pressure in their lungs (Pulmonary Arterial Hypertension). It's for those who have already tried this medicine in an earlier study, to see if it's safe and helps them over a longer time.
United States · Australia · Belgium - recruiting
Feasibility of Novel Clinical Trial Infrastructure, Design and Technology for Early Phase Studies in Patients With Pulmonary Hypertension (FIT-PH)
This study looks at new ways to monitor people with pulmonary hypertension (high blood pressure in the lungs). Researchers will use small pressure sensors and wearable activity trackers to see if these tools can help doctors better understand and manage the condition.
United Kingdom - recruiting
Clinical Registry for the Characterization of the 'Pulmonary Vascular Phenotype' in Patients With Chronic Obstructive Pulmonary Disease
This study looks at information from people in the UK with COPD who have had a special heart test. It aims to understand how COPD affects the blood vessels in the lungs, especially when people also have high blood pressure in their lungs, called pulmonary hypertension.
Austria · Switzerland · United Kingdom - recruiting
Accuracy of Smartwatches in Measuring Oxygen Levels in Patients With Pulmonary Hypertension: A Pilot Study
This study checks how well smartwatches measure oxygen levels in people with pulmonary hypertension. Researchers compare smartwatch readings with hospital equipment and blood tests, at rest, after exercise, and in low oxygen, all during a single hospital visit to see if smartwatches are accurate enough.
United Kingdom - recruiting
Developing the Probability Algorithm for Pulmonary Hypertension Echocardiography
This study looks at new ways to spot a condition called pulmonary hypertension, which is high blood pressure in the lung arteries. It uses heart scans (echocardiograms) and electrical heart readings (ECGs) to see if adding new measurements can help doctors find the condition earlier and more accurately.
United Kingdom - not yet recruiting
FIBRotic Interstitial Lung Disease With Nocturnal hypOXaemia and EXercise Induced desaTuRAtion
This study looks at how breathing during sleep or exercise affects people with lung fibrosis. We want to see if checking oxygen levels in these situations can help predict how their condition might change over time.
United Kingdom - active not recruiting
Improving Pulmonary Hypertension Screening by Echocardiography
This study looks at a new way to spot a type of high blood pressure in the lungs, called pulmonary hypertension, earlier. It uses a special heart scan to find people who might have this condition, even if current tests don't clearly show it.
United Kingdom