- authorisedHuman Pharmacology (Phase I)- Other
A Phase I Study using Oncolytic AdenoVirus Immunotherapy with Repeat Administrations in Recurrent GliOblastoma (VIRAGO)
The VIRAGO study is an early-stage clinical trial for adults whose glioblastoma (a type of brain tumour) has returned. It tests a specially altered virus designed to attack tumour cells and alert the immune system. The main goal is to check whether repeated doses of this treatment are safe.
Netherlands - recruitingPhase I and Phase II (Integrated)- Other
A phase I/II multicenter trial evaluating the association of hypofractionated stereotactic radiation therapy and the anti-PD-L1 Durvalumab (Medi4736) for patients with recurrent glioblastoma
This study looks at combining a new type of radiation therapy with a drug called Durvalumab (Imfinzi) for people with a brain tumour called glioblastoma that has come back. It aims to see if this treatment is safe and if it helps people live longer.
France - recruitingEARLY_PHASE1
Pilot Trial for Treatment of Recurrent Glioblastoma
This early trial aims to test new, personalised treatments for people with an aggressive type of brain tumour called glioblastoma that has come back. It will check if these treatments are safe and if this type of study can be done on a larger scale.
Canada - recruitingPHASE3
Sonocloud-9 in Association With Carboplatin Versus Standard-of-Care Chemotherapies (CCNU or TMZ) in Recurrent GBM
This study is looking at a new way to treat glioblastoma brain tumours that have come back. It combines a special ultrasound device called SonoCloud-9 with an anti-cancer drug, carboplatin, to see if it works better than standard treatments.
United States · Austria · Belgium - authorisedHuman Pharmacology (Phase I)- Other
A study to investigate how a single dose of the drug melflufen reaches brain tumor tissue, and how it affects the tumour, in patients who are already scheduled for surgery for a returning glioblastoma
This study looks at a new drug, melflufen, for people with glioblastoma that has come back. Doctors want to see how the drug gets into brain tumours and what it does to them, right before surgery.
Norway - recruitingPHASE1, PHASE2
Study of an AAV Mediated Dual-Payload Gene Therapy in Patients With High Grade Glioma
This study is testing a new gene therapy, TGX-007, for an aggressive type of brain tumour called glioblastoma. It aims to find the safest dose and see how well it works. TGX-007 helps the body fight the cancer by working with a common antiviral medicine, valaciclovir.
United States · United Kingdom - active not recruitingPHASE1, PHASE2
A Phase 1-2 Study of ST101 in Patients With Advanced Solid Tumors
This study is testing a new drug, ST101, for people with advanced cancers like breast cancer, melanoma, and glioblastoma. It aims to see if the drug is safe, how much to give, and if it could help shrink tumors. It's for adults whose cancer hasn't responded to other treatments.
United States · United Kingdom