Respiratory Insufficiency research hub
7 indexed studies · 6 currently recruiting
- active not recruitingNA
NIV Mask and Headgear Evaluation
This study is testing new, custom-made masks and headgear for children and young people needing breathing support (NIV). It aims to provide a better fit than standard masks, improving comfort and how well the treatment works, especially for those with unique face shapes.
United Kingdom - recruitingNA
Platform of Randomized Adaptive Clinical Trials in Critical Illness
This study, called PRACTICAL, looks at new ways to help critically ill patients with severe breathing problems. It tests different treatments like breathing machine settings and other therapies to find the safest and most effective options for improving recovery and survival.
United States · Australia · Canada - recruitingNA
Home Versus Hospital Based NIV Care in MND
This study compares setting up breathing support (NIV) for Motor Neurone Disease patients at home versus in the hospital. It aims to see if home-based care is as safe and effective, making treatment more convenient while maintaining good patient outcomes for those with MND and breathing issues.
United Kingdom - recruitingNA
Partial Neuromuscular Blockade in Acute Hypoxemic Respiratory Failure
This study looks at a new way to help seriously ill patients breathe while on a ventilator. It explores using a special medicine (cisatracurium) to relax muscles just enough for safe, gentle breathing, aiming to avoid complications from full muscle relaxation.
Canada - recruiting
Respiratory Muscle Structure and Function in Mechanically Ventilated Patients and Long-term Outcomes
This study looks at how breathing muscles change during hospital ventilation and how this affects long-term recovery. It aims to understand how to help patients breathe on their own again and improve their quality of life after hospitalisation.
Canada - not yet recruitingPHASE4
Early Sedation With Dexmedetomidine vs. Placebo in Older Ventilated Critically Ill Patients
This study looks at whether a medicine called dexmedetomidine can help older critically ill patients breathe better when they’re on a ventilator. It compares this medicine to a dummy treatment to see if it helps them recover and survive for longer.
Canada - recruitingPHASE3
Doxapram Therapy in Preterm Infants (DOXA Trial)
This study looks at whether a medicine called doxapram can help premature babies who stop breathing (apnoea). It compares doxapram to a dummy medicine to see if it reduces problems like needing breathing machines, lung disease, and brain development issues.
Belgium · Canada · Netherlands