Systemic Lupus Erythematosus research hub
50 indexed studies · 13 currently recruiting
- recruitingPHASE1
A Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD5492 in Adult Participants With Systemic Lupus Erythematosus or Idiopathic Inflammatory Myopathies or Rheumatoid Arthritis.
This study looks at a new treatment called AZD5492 for lupus, myositis, and rheumatoid arthritis. It checks how safe it is, how well the body handles it, and how it works in adults.
United States · Canada · China - ongoing, recruitingHuman Pharmacology (Phase I)- Other
RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, MULTIPLE ASCENDING DOSE STUDY TO EVALUATE THE SAFETY, TOLERABILITY, PHARMACOKINETICS, AND PHARMACODYNAMICS OF IA-14069 IN HEALTHY SUBJECTS, WITH AN EXTENSION TO EXPLORE ANY DRUG-DRUG INTERACTION POTENTIAL WITH METHOTREXATE (PART 1), AND IN PATIENTS WITH RHEUMATOID ARTHRITIS, WITH PRELIMINARY ASSESSMENT OF EFFICACY IN PATIENTS (PART 2)
This study is testing a new medicine, IA-14069, for rheumatoid arthritis. It first checks if the medicine is safe and how it works in healthy people, then looks at its effects in people with rheumatoid arthritis.
Romania - active not recruiting
Zimmer POLAR Persona - TKA (EMEA Study)
This study looks at how well the Zimmer Persona knee replacement works for people with severe knee pain and disability. It tracks how long the implant lasts, its safety, and how much it improves patients' daily lives over several years.
Austria · France · Germany - active not recruiting
A Prospective, Clinical Investigation of the Vanguard 360 Revision Knee
This study looks at a new type of knee replacement system, called Vanguard 360, for people with knee problems like arthritis. It aims to see if this new system helps people move better, reduces pain, and lasts a long time after surgery.
United States · Belgium · Denmark - recruiting
Exactech Shoulder Post Market Clinical Follow-up Study
This study is looking at how well Exactech shoulder replacements work over a long time. It will follow people who have had this surgery to understand its safety and effectiveness for conditions like arthritis and rotator cuff tears, for at least 10 years.
United States · Canada · France - active not recruiting
Comprehensive Segmental Revision System
This study looks at how well a special shoulder and elbow replacement system works for people with joint problems, arthritis, or after surgery for cancer or injuries. It will track patients for at least 10 years to understand their long-term outcomes and improve future treatments.
Canada · Denmark · United Kingdom - active not recruitingPHASE2
A Study of Efficacy and Safety of Rosnilimab in Subjects with Moderate to Severe Rheumatoid Arthritis (RENOIR)
This study is looking into a new medication called Rosnilimab for people with moderate to severe rheumatoid arthritis. We want to see if it's safe, and if it helps reduce symptoms, compared to a dummy treatment.
United States · Belgium · Canada - active not recruiting
Sidus(TM) Post Market Clinical Follow-up (PMCF) Study
This study looks at how well a new shoulder replacement, called Sidus Stem-Free Shoulder, works in patients with shoulder pain due to conditions like arthritis. Doctors will check its safety and how long it lasts, as well as pain relief and shoulder movement, over a long period.
Austria · France · Germany - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A clinical study of MK-2420 in healthy people (MK-2420-002)
This study is testing a new medicine, MK-2420, in healthy adults. It's an early-stage study to understand how the medicine works in the body and if it's safe. While the medicine might eventually help people with rheumatoid arthritis, this study is about testing its basic effects.
Belgium - ongoing, recruitingTherapeutic confirmatory (Phase III)
A Prospective, Randomized, Double-blind, Parallel-group Study to Compare the Efficacy, Safety, Pharmacokinetics, and Immunogenicity of MB04 and EU-sourced Enbrel® in Patients with Moderate to Severe Rheumatoid Arthritis.
This study is comparing a new medication called MB04 with a standard medicine, Enbrel, for people with moderate to severe rheumatoid arthritis. We want to see if MB04 works just as well and is as safe as Enbrel. This will help us understand if it's a good treatment option.
Poland · Hungary · Bulgaria - ongoing, recruitingTherapeutic confirmatory (Phase III)
A MULTICENTER, PROSPECTIVE, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL OF SPIRONOLACTONE FOR THE TREATMENT OF ACTIVE RHEUMATOID ARTHRITIS (RA) - ALDORA
This study, called ALDORA, is looking at whether a common medicine called spironolactone could help people with rheumatoid arthritis (RA). It’s comparing spironolactone to a dummy pill to see if it reduces RA symptoms and improves heart health without causing too many side effects.
Germany · France - ongoing, recruitingTherapeutic exploratory (Phase II)
J3P-MC-FTAF: An Adaptive Phase 2a/2b, Randomized, Double-Blind, Placebo-Controlled Study of LY3871801 in Adult Participants With Moderately-to-Severely Active Rheumatoid Arthritis
This study is testing a new medicine, LY3871801, for adults with rheumatoid arthritis. It's a research study to see how well the medicine works and if it's safe compared to a dummy pill. We hope to find new ways to help people with this condition.
France · Czechia · Slovakia - authorisedTherapeutic use (Phase IV)
Filgotinib bridging in newly diagnosed rheumatoid arthritis patients (FAST RA trial); A pragmatic randomized controlled non-inferiority low intervention clinical trial
This study is testing different treatments for new rheumatoid arthritis to see which works best at getting people into remission quickly. It compares a steroid injection (Kenacort-A) with a newer tablet (Jyseleca) to find out how many people feel much better after three months.
Netherlands - ongoing, recruitingTherapeutic exploratory (Phase II)
J1A-MC-KDAF: A Phase 2b, Double-Blind, Placebo-Controlled Study to Evaluate Peresolimab in Adult Participants with Moderately-to-Severely Active Rheumatoid Arthritis
This study is testing a new medicine, peresolimab, for adults with moderate to severe rheumatoid arthritis. It aims to see if the medicine can reduce arthritis symptoms, like joint pain and swelling, better than a dummy treatment.
Hungary · Spain · Italy - authorisedHuman Pharmacology (Phase I)- First administration to humans
A First-in-Human, Open-label, Phase 1 Study to Evaluate Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Preliminary Efficacy of NBIM-1008 in Patients with Rheumatoid Arthritis
This early-stage study is testing a new medicine called NBIM-1008 for people with rheumatoid arthritis. We want to see if it's safe, how the body handles it, and if it might help with symptoms. This is the first time it’s being given to humans.
Poland · Romania - ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2a Multicenter, Randomized, Double Blind, Parallel-group, Proof of Concept Study Evaluating the Efficacy and Safety of Nipocalimab and Certolizumab Combination Therapy in Subjects with Active Rheumatoid Arthritis despite Prior Treatment with Advanced Therapies (bDMARD or tsDMARD)
This study is looking at a new combination of two medicines, nipocalimab and certolizumab (Cimzia), for adults with rheumatoid arthritis that hasn't improved with other strong treatments. We want to see if this combination helps reduce symptoms and is safe after 12 weeks.
Germany · Poland · Hungary - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A Phase 1b Study of Imvotamab in Moderate to Severe Rheumatoid Arthritis
This study is looking into a new treatment called Imvotamab for people with moderate to severe rheumatoid arthritis. It's an early-stage study to understand how safe the treatment is and if it has any effects on the body.
Poland - ongoing, recruitingTherapeutic exploratory (Phase II)
A randomized, double blind, placebo-controlled, dose response, phase II, multicentre trial to evaluate the efficacy and safety of oral AP1189 administered at the doses of 40, 70, or 100 mg for 12 weeks in combination with methotrexate, in DMARD-naïve participants with early rheumatoid arthritis and active inflammation.
This study is testing a new tablet, AP1189, for people recently diagnosed with rheumatoid arthritis who haven't tried other strong medicines yet. It aims to see how well different doses of AP1189 lower inflammation and improve symptoms when taken with another common arthritis medicine.
Bulgaria · Czechia · Poland - recruiting
7 Tesla MRI Brain Imaging to Decipher Filgotinib's Mode of Analgesic Action in Rheumatoid Arthritis
This study uses special brain scans to understand how a new medicine, filgotinib, helps ease pain in people with rheumatoid arthritis. Researchers want to see if it works by affecting the brain's pain signals or by reducing swelling in the joints.
United Kingdom - ongoing, recruitingTherapeutic use (Phase IV)
RCT part: CareRA2020: Effectiveness of a combination of Methotrexate and a step down glucocorticoid regimen (COBRA-Slim) for remission induction in patients with early Rheumatoid Arthritis (RA), with or without fast access to 24 weeks of Tumor Necrosis Factor (TNF) blockade in insufficient responders, a randomized, multicenter, pragmatic trial. LTE part: CareRA2020 LTE: a 3 year longitudinal observational, multicenter, follow-up of early RA patients after participation in the CareRA2020 RCT.
This study looks at how well a treatment for early rheumatoid arthritis (RA) works over a long time. It compares a standard approach with one that offers quicker access to a stronger medicine for those who aren't improving enough.
Belgium - ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2 Randomized, Double-blind, Placebo-controlled, Dose-ranging, Efficacy and Safety study of SAR441566 plus Methotrexate in Adults with Moderate to Severe Rheumatoid Arthritis
This study is testing a new medicine, SAR441566, for people with moderate to severe rheumatoid arthritis who are already taking methotrexate. It aims to see if the new medicine helps reduce arthritis symptoms and if it's safe to use. Patients will either get the new medicine or a dummy medicine.
Slovakia · Czechia · Germany - recruitingPHASE1
A Study of AZD0120 in Autoimmune Diseases
This study is looking at a new treatment called AZD0120 for certain long-term conditions like systemic sclerosis, inflammatory muscle diseases, and severe rheumatoid arthritis. It's an early-stage study to see how safe the treatment is and if people can tolerate it.
United States · Australia · Germany - ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
A placebo-controlled safety and tolerability study of intravenous (IV) and subcutaneous (SC) AZD1163 in healthy volunteers
This early-stage study is looking at a new medicine called AZD1163 for rheumatoid arthritis. Researchers want to see if it's safe and how well healthy people tolerate it when given through a vein or under the skin. It’s the first time this medicine is being tested in humans.
Germany - ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2a multi-center, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of Burfiralimab (hzVSF-v13) added to disease-modifying antirheumatic drugs in patient with moderate to severe Rheumatoid Arthritis
This study is testing a new medicine, Burfiralimab, for people with moderate to severe rheumatoid arthritis. We want to see if it helps reduce joint pain and swelling when added to their usual arthritis medicines. Participants will receive either the new medicine or a dummy treatment.
Spain · Austria · Czechia - active not recruitingPHASE3
Study to Assess Change in Disease Activity and Adverse Events of Oral Upadacitinib Compared to Subcutaneous Adalimumab in Adult Participants With Moderate to Severe Rheumatoid Arthritis
This study looks at two medicines, upadacitinib and adalimumab, for adults with moderate to severe Rheumatoid Arthritis (RA). It checks how safe and effective they are. Upadacitinib is a pill, and adalimumab is an injection. This helps us understand which treatment works best.
United States · Argentina · Belgium - authorisedHuman Pharmacology (Phase I)- Other
A Phase 1, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Pimozide after Multiple Dose Administration in Subjects with Rheumatoid Arthritis
This study is looking at a new medicine called Pimozide for rheumatoid arthritis. It aims to see if the medicine is safe, what side effects it might cause, and how it works in the body when given multiple times. This is a very early stage of research.
Bulgaria - ongoing, recruitingTherapeutic confirmatory (Phase III)
A Multicenter, Open-label, Long Term Extension Study to Assess the Safety and Efficacy of Filgotinib in Subjects with Rheumatoid Arthritis
This study is looking at the long-term safety and effectiveness of a medicine called Jyseleca for people with rheumatoid arthritis. Participants will take Jyseleca tablets, and doctors will monitor their health carefully over time.
Bulgaria · Hungary · Germany - recruiting
EMPOWER-1: A Multi-site Clinical Cohort Research Study to Reduce Health Inequality
This study aims to understand why common medicines don't work the same for everyone in the UK, especially for people from different backgrounds. It will look at many health conditions, hoping to improve how we treat them and make healthcare fairer for all.
United Kingdom - recruitingPhase II
Repair effects of leramistat in participants with rheumatoid arthritis
This study is looking at a new medicine called leramistat for people with rheumatoid arthritis. It wants to see what effects leramistat has on muscles. It's an early-stage study, meaning we're still learning if the medicine works and is safe.
United Kingdom · England - recruitingPHASE1
Study Evaluating Safety, Tolerability, PK/PD of Surovatamig in Adult RA or SLE Participants
This study is testing a new medicine, surovatamig, for rheumatoid arthritis (RA) and lupus (SLE). We want to see if it's safe, how it works in the body, and what dose is best. It's an early-stage study in adults.
United States · Australia · Belgium - active not recruitingPHASE4
Effect of Proactive Therapeutic Drug Monitoring on Maintenance of Sustained Disease Control in Adults With Rheumatoid Arthritis on a Subcutaneous TNF Inhibitor: The Rheumatoid Arthritis Therapeutic DRUg Monitoring Trial (RA-DRUM)
This study looks at how best to manage rheumatoid arthritis for people taking a common treatment called adalimumab. Researchers will check drug levels in the blood to see if this helps keep the condition under control better than usual care and prevents flare-ups.
Austria · Italy · Norway - recruitingPHASE2
A Study to Assess the Efficacy and Safety of RO7790121 in Participants With Moderate to Severe Rheumatoid Arthritis Who Have Not Responded to or Who Cannot Tolerate Tumor Necrosis Factor (TNF) and/or Janus Kinase (JAK Inhibitors)
This study is looking into a new medication called Afimkibart for adults with moderate to severe rheumatoid arthritis. It's for those who haven't found enough relief from or can't take other common treatments. The aim is to see how well it works and if it's safe.
United States · Argentina · Belgium - recruitingPHASE2
A Study to Investigate Efficacy and Safety of AZD1163 in Participants With Rheumatoid Arthritis
This study is testing a new medicine, AZD1163, for people with rheumatoid arthritis (RA) who haven't found enough relief from other treatments. It aims to see if the new medicine is safe and helps reduce RA symptoms.
United States · Argentina · Brazil - ongoing, recruitingPhase II and Phase III (Integrated)
Thiamine against chronic rheumatoid arthritis fatigue
This study looks at whether a high dose of vitamin B1 (thiamine) can help reduce tiredness in people with rheumatoid arthritis. We want to see if fatigue levels change after four weeks of treatment.
Denmark - authorisedTherapeutic use (Phase IV)
Non-inferiority study of TOCILIZUMAB in dose-banding versus dose-weight in rheumatoid arthritis with low activity or clinical remission
This study looks at a different way to give RoActemra (tocilizumab) for rheumatoid arthritis. We want to see if giving a standard dose based on how well you're doing, rather than your weight, works just as well for patients with low disease activity or who are in remission.
France - authorisedHuman Pharmacology (Phase I)- Other
Phase 1b study to assess the safety and tolerability of SR-878 in patients with rheumatoid arthritis
This study is testing a new medicine, SR-878, for people with rheumatoid arthritis. It's a very early study to check if the medicine is safe and if people can tolerate it well. Researchers want to see how the body reacts to this new treatment.
Romania - active not recruitingPHASE1, PHASE2
Comparison of B-cell Depletion by Rituximab and Anti-CD 19 CAR-T Therapy in Patients With Rheumatoid Arthritis
This study compares a new cell therapy (KYV101) with an existing medicine (Rituximab) for severe rheumatoid arthritis that hasn't responded to other treatments. It checks how safe and effective they are at reducing disease activity and certain antibodies.
Germany - active not recruiting
A Study to Evaluate the Safety of Remsima® SC in the Treatment of RA, AS, PsA and Ps
This study looks at how safe a medicine called Remsima® SC is for people with certain long-term conditions like rheumatoid arthritis, a type of spinal arthritis, psoriatic arthritis, and psoriasis. It aims to see if there are any unwelcome side effects.
France - not yet recruiting
Ultrasonic COmparison of Salivary Glands in Autoimmune Diseases (COUGAR)
This study looks at how ultrasound scans of spit glands can help understand conditions like Sjögren's, lupus, and rheumatoid arthritis. Researchers want to see if these scans can tell the difference between these diseases and how they affect people with dry mouth.
France - recruitingPHASE1
An Ascending Dose Study of PIT565 in Participants With Rheumatoid Arthritis
This study is testing a new medicine, PIT565, for people with rheumatoid arthritis. We want to see if it's safe, how well the body handles it, and if it could help. It's an early stage study, focusing on finding the right dose.
Argentina · Bulgaria · China - active not recruitingNA
Cemented TrendHip® - Multicenter PMCF Study on Total Indications
This study is checking how well a specific type of hip replacement part, called the TrendHip® stem, works and if it's safe. It's for people who've had or are having a hip replacement using this part, to see how they're doing over time.
Germany - active not recruiting
Deciphering Rheumatoid Arthritis-associated Interstitial Lung Disease Pathogenesis 2
This study looks into why some people with rheumatoid arthritis (RA) also get a lung condition called interstitial lung disease (ILD). Researchers want to understand the causes and how ILD progresses in RA patients to improve care.
France - recruiting
Characterisation of Intestinal Microbiota of Patients With Spondyloarthritis or Rheumatoid Arthritis
This study looks at the gut bacteria in people with spondyloarthritis or rheumatoid arthritis to see if it's different from healthy people. Researchers want to understand if specific gut bacteria are linked to these conditions and could help find new ways to detect or treat them.
France - active not recruiting
Comprehensive Nano - Post Market Clinical Follow-Up Study
This study looks at how well a shoulder replacement system, called Comprehensive Nano, works for people with shoulder pain from conditions like arthritis. Doctors will check on patients who have had this surgery to see how they recover and how the new shoulder helps them.
Austria · Canada · South Korea - not yet recruitingPHASE4
Tdose Binding and Tocilizumab
This study looks at different ways to give a medicine called tocilizumab for rheumatoid arthritis. We want to see if a standard dose works as well as a dose based on a person's weight, for patients whose arthritis is already well-controlled.
France - active not recruitingNA
The Medacta International GMK Sphere Post-Marketing Surveillance Study
This study is checking how well a new knee replacement, called the GMK Sphere, works for people with arthritis. Doctors will follow patients after their surgery to see how they recover and if the new knee joint helps them get back to their daily lives.
Belgium · United Kingdom - ongoing, recruitingTherapeutic confirmatory (Phase III)
A Randomized, Placebo-Controlled, Double-Blind, Parallel Group, Phase 3 Study to Evaluate the Efficacy and Safety of Subcutaneous CT-P13 in Patients with Moderately to Severely Active Rheumatoid Arthritis
This study is looking at a new medicine called CT-P13 for adults with moderate to severe rheumatoid arthritis. Researchers want to see if it helps reduce symptoms and is safe to use. Some people will get the new medicine, and others will get a dummy medicine to compare.
Poland - active not recruiting
The CCP Study: Coordinated Programme to Prevent Arthritis - Can We Identify Arthritis at a Pre-clinical Stage ?
This study looks for early signs of arthritis, especially rheumatoid arthritis, before people even have noticeable symptoms. By closely watching people who might be at risk, researchers hope to learn how to identify the condition earlier and potentially treat it sooner.
United Kingdom - recruiting
Evaluation of the PHENO4U Data Platform in Patients Undergoing Total Knee Arthroplasty
This study looks at how a new digital platform, Pheno4U, helps patients who have had total knee replacement surgery. It collects information about their recovery and how well their knee works.
Germany · United Kingdom - active not recruiting
Prospective Observational Study of Filgotinib in Subjects With Rheumatoid Arthritis
This study looks at how a medicine called filgotinib works for people with rheumatoid arthritis in everyday life. Researchers want to see if it makes a difference to symptoms, side effects, and how patients feel, simply by observing those already taking the medication.
Belgium · Germany · Italy