- active not recruitingNA
Post Market Clinical Follow-up (PMCF) Study of the A.L.P.S. Proximal Humerus Plating System
This study looks at a new surgical plate, the A.L.P.S. Proximal Humerus Plating System, used for broken upper arm bones. It aims to confirm the plate is safe and works well after it's been made available for use.
United States · Australia · Canada - active not recruitingPHASE2
Two-period Crossover Study to Demonstrate the Comparability of Pharmacokinetics of Subcutaneous Ianalumab Between 2mL Auto-injector/2mL PFS with1mL Pre-filled Syringe in Adult Participants With Autoimmune Disease
This study is testing a new way to give a drug called ianalumab for autoimmune diseases like lupus, Sjögren's, and rheumatoid arthritis. We are comparing different devices (pre-filled syringes and auto-injectors) to make sure they deliver the drug in the same way and are safe.
United States · Argentina · Canada - recruiting
ROLE of PLATELETS in the PATHOPHYSIOLOGY of SYSTEMIC LUPUS
This study looks at how tiny blood cells called platelets might be involved in conditions like lupus and arthritis. Researchers want to understand if platelets make these conditions worse and if targeting them could lead to new treatments. It could help us find better ways to diagnose and treat these illnesses.
France - recruitingNA
Neurofeedback for Nociplastic Pain in Rheumatoid Arthritis (NECTAR)
This study looks at a new way to help people with rheumatoid arthritis who still have pain even after their inflammation is treated. It uses a technique called neurofeedback to see if it can reduce this specific type of pain, as well as helping with tiredness and sleep problems.
United Kingdom - active not recruitingPHASE2
A Study to Evaluate the Efficacy, Safety, and Tolerability of IMVT-1402 in Adult Participants With Active, Difficult to Treat Rheumatoid Arthritis
This study is testing a new medicine, IMVT-1402, for adults with a type of rheumatoid arthritis that's been hard to treat. It checks if the medicine works and is safe compared to a dummy treatment.
United States · Argentina · Bulgaria - authorisedTherapeutic use (Phase IV)
DISCO-RA:DIScontinuation of COncomitant disease modifying anti-rheumatic drugs (DMARDs) in rheumatoid arthritis patients also using TNF inhibitors - a randomized long-term non-inferiority strategy trial
This study looks at whether people with rheumatoid arthritis who are doing well on a combination of medicines can safely stop one of their drugs (the DMARD) while continuing their TNF inhibitor. It aims to see if stopping the DMARD makes a difference to their condition over two years.
Netherlands - recruitingPHASE3
Efficacy of a Sequential Treatment Strategy in Rheumatoid Arthritis
This study looks at a new way to treat rheumatoid arthritis (RA) using two different medicines. It aims to see if starting with one medicine, then switching to another, works better for people whose current treatment isn't enough to control their RA.
France · Monaco - active not recruiting
Outcomes Study of the Trabecular Metal (TM) Reverse Shoulder System
This study looks at how well a new type of shoulder replacement, called the Trabecular Metal Reverse Shoulder System, works for people with severe shoulder problems. It aims to see how long it lasts, if it reduces pain, and improves movement.
United States · United Kingdom - active not recruitingNA
Zimmer Trabecular Metal Total Ankle PMCF
This study looks at how well a new type of ankle replacement, called the Zimmer Trabecular Metal Total Ankle, works in people with different kinds of arthritis. It checks how long the ankle replacement lasts, how much pain people have, and how well they can move after the surgery.
United States · Canada · Finland - recruitingPHASE1
A Study of CC-97540, CD-19-Targeted Nex-T CAR T Cells, in Participants With Severe, Refractory Autoimmune Diseases (Breakfree-1)
This study is testing a new cell therapy called CC-97540 for severe autoimmune diseases like lupus and rheumatoid arthritis. It aims to see if it's safe, how well it works, and how the body handles it, especially when other treatments haven't helped.
United States · Belgium · France - active not recruiting
G7 BiSpherical Acetabular Shell PMCF Study
This study looks at how well a new part for hip replacements, called the G7 BiSpherical Acetabular Shell, works for people with certain hip problems like arthritis. It checks if it reduces pain and improves movement after surgery.
France · Germany · Netherlands - recruitingPHASE2
A Study to Investigate Efficacy and Safety of AZD1163 in Participants With Rheumatoid Arthritis
This study is testing a new medicine, AZD1163, for people with rheumatoid arthritis (RA) who haven't found enough relief from other treatments. It aims to see if the new medicine is safe and helps reduce RA symptoms.
United States · Argentina · Brazil - recruitingNA
RhEumatoid Arthritis MEDIcation Adherence
This study looks at how working closely with pharmacists and doctors might help people with rheumatoid arthritis take their medicines more consistently. The goal is to see if this team approach improves their health compared to usual care.
France - ongoing, recruitingTherapeutic confirmatory (Phase III)
A randomised, double-blind, multicentre study comparing the efficacy, safety and immunogenicity of proposed Abatacept biosimilar (DRL_AB) with Orencia® administered by the intravenous route as an add-on to methotrexate in the treatment of patients with moderate to severe rheumatoid arthritis
This study is comparing a new version of a rheumatoid arthritis medicine, called DRL_AB, with an existing one, Orencia. It aims to see if the new medicine works as well, is safe, and causes a similar immune response in people with moderate to severe rheumatoid arthritis.
Czechia · Hungary · Poland - authorisedTherapeutic use (Phase IV)
Concentration guided dose reduction versus standard dosing in tocilizumab treated heumatoid arthritis patients:a randomised, international, multicenter, non-inferiority trial
This study compares two ways of giving tocilizumab for rheumatoid arthritis: adjusting the dose based on blood levels vs. standard dosing. We want to see if adjusting the dose works just as well and is safe, helping to find the best treatment plan for patients.
Netherlands - active not recruiting
BC Study of G7 Cup and Compatible Femoral Stems
This study looks at how well a new hip replacement cup, called the G7 Acetabular System, works for people needing hip surgery due to joint problems like arthritis. It helps ensure new implants are safe and effective.
United Kingdom - authorisedTherapeutic use (Phase IV)
A multicenter, randomized, open-label, blinded-assessor, phase 4 study in patients with early rheumatoid arthritis to compare active conventional therapy versus three biologic treatments, and two de-escalation strategies in patients who respond to treatment.
This study looks at different ways to treat early rheumatoid arthritis, comparing standard treatments with newer biologic medicines. It also explores if medicine doses can be lowered for people who are getting better, aiming to find the most effective and safe long-term approaches.
Iceland · Denmark · Norway - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A clinical study of MK-2420 in healthy men (MK-2420-003)
This study is looking into a new potential medicine, called MK-2420. It's being tested in healthy adult men to see how it works in the body and if it's safe. The goal is to find better ways to treat conditions like rheumatoid arthritis in the future.
Belgium - authorisedTherapeutic exploratory (Phase II)
A Phase 2, Randomized, Double-blind, Placebo-controlled Study to Investigate the Safety and Efficacy of ELV001 as Add-on Therapy in Patients with Active Rheumatoid Arthritis and Inadequate Response to Methotrexate and Tumor Necrosis Factor Inhibition (START SYNERGY)
This study is testing a new medicine, ELV001, for people with rheumatoid arthritis whose current treatments (methotrexate and another type of drug) aren't working well enough. We want to see if ELV001 is safe and helps reduce arthritis symptoms.
Czechia · Bulgaria · Hungary - ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
MK-2420 SAD Study
This early-stage study is looking at a new medicine called MK-2420 for rheumatoid arthritis. It's the first time this medicine is being given to people, to check how safe it is and how the body handles it. Only adult men can take part.
Belgium - recruitingPHASE1
A Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD5492 in Adult Participants With Systemic Lupus Erythematosus or Idiopathic Inflammatory Myopathies or Rheumatoid Arthritis.
This study looks at a new treatment called AZD5492 for lupus, myositis, and rheumatoid arthritis. It checks how safe it is, how well the body handles it, and how it works in adults.
United States · Canada · China - ongoing, recruitingHuman Pharmacology (Phase I)- Other
RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, MULTIPLE ASCENDING DOSE STUDY TO EVALUATE THE SAFETY, TOLERABILITY, PHARMACOKINETICS, AND PHARMACODYNAMICS OF IA-14069 IN HEALTHY SUBJECTS, WITH AN EXTENSION TO EXPLORE ANY DRUG-DRUG INTERACTION POTENTIAL WITH METHOTREXATE (PART 1), AND IN PATIENTS WITH RHEUMATOID ARTHRITIS, WITH PRELIMINARY ASSESSMENT OF EFFICACY IN PATIENTS (PART 2)
This study is testing a new medicine, IA-14069, for rheumatoid arthritis. It first checks if the medicine is safe and how it works in healthy people, then looks at its effects in people with rheumatoid arthritis.
Romania - active not recruiting
Zimmer POLAR Persona - TKA (EMEA Study)
This study looks at how well the Zimmer Persona knee replacement works for people with severe knee pain and disability. It tracks how long the implant lasts, its safety, and how much it improves patients' daily lives over several years.
Austria · France · Germany - active not recruiting
A Prospective, Clinical Investigation of the Vanguard 360 Revision Knee
This study looks at a new type of knee replacement system, called Vanguard 360, for people with knee problems like arthritis. It aims to see if this new system helps people move better, reduces pain, and lasts a long time after surgery.
United States · Belgium · Denmark - active not recruitingPHASE2
A Study of Efficacy and Safety of Rosnilimab in Subjects with Moderate to Severe Rheumatoid Arthritis (RENOIR)
This study is looking into a new medication called Rosnilimab for people with moderate to severe rheumatoid arthritis. We want to see if it's safe, and if it helps reduce symptoms, compared to a dummy treatment.
United States · Belgium · Canada - recruiting
Exactech Shoulder Post Market Clinical Follow-up Study
This study is looking at how well Exactech shoulder replacements work over a long time. It will follow people who have had this surgery to understand its safety and effectiveness for conditions like arthritis and rotator cuff tears, for at least 10 years.
United States · Canada · France - active not recruiting
Comprehensive Segmental Revision System
This study looks at how well a special shoulder and elbow replacement system works for people with joint problems, arthritis, or after surgery for cancer or injuries. It will track patients for at least 10 years to understand their long-term outcomes and improve future treatments.
Canada · Denmark · United Kingdom - active not recruiting
Sidus(TM) Post Market Clinical Follow-up (PMCF) Study
This study looks at how well a new shoulder replacement, called Sidus Stem-Free Shoulder, works in patients with shoulder pain due to conditions like arthritis. Doctors will check its safety and how long it lasts, as well as pain relief and shoulder movement, over a long period.
Austria · France · Germany - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A clinical study of MK-2420 in healthy people (MK-2420-002)
This study is testing a new medicine, MK-2420, in healthy adults. It's an early-stage study to understand how the medicine works in the body and if it's safe. While the medicine might eventually help people with rheumatoid arthritis, this study is about testing its basic effects.
Belgium - ongoing, recruitingTherapeutic confirmatory (Phase III)
A Prospective, Randomized, Double-blind, Parallel-group Study to Compare the Efficacy, Safety, Pharmacokinetics, and Immunogenicity of MB04 and EU-sourced Enbrel® in Patients with Moderate to Severe Rheumatoid Arthritis.
This study is comparing a new medication called MB04 with a standard medicine, Enbrel, for people with moderate to severe rheumatoid arthritis. We want to see if MB04 works just as well and is as safe as Enbrel. This will help us understand if it's a good treatment option.
Poland · Hungary · Bulgaria - ongoing, recruitingTherapeutic confirmatory (Phase III)
A MULTICENTER, PROSPECTIVE, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL OF SPIRONOLACTONE FOR THE TREATMENT OF ACTIVE RHEUMATOID ARTHRITIS (RA) - ALDORA
This study, called ALDORA, is looking at whether a common medicine called spironolactone could help people with rheumatoid arthritis (RA). It’s comparing spironolactone to a dummy pill to see if it reduces RA symptoms and improves heart health without causing too many side effects.
Germany · France - ongoing, recruitingTherapeutic exploratory (Phase II)
J3P-MC-FTAF: An Adaptive Phase 2a/2b, Randomized, Double-Blind, Placebo-Controlled Study of LY3871801 in Adult Participants With Moderately-to-Severely Active Rheumatoid Arthritis
This study is testing a new medicine, LY3871801, for adults with rheumatoid arthritis. It's a research study to see how well the medicine works and if it's safe compared to a dummy pill. We hope to find new ways to help people with this condition.
France · Czechia · Slovakia - ongoing, recruitingTherapeutic exploratory (Phase II)
J1A-MC-KDAF: A Phase 2b, Double-Blind, Placebo-Controlled Study to Evaluate Peresolimab in Adult Participants with Moderately-to-Severely Active Rheumatoid Arthritis
This study is testing a new medicine, peresolimab, for adults with moderate to severe rheumatoid arthritis. It aims to see if the medicine can reduce arthritis symptoms, like joint pain and swelling, better than a dummy treatment.
Hungary · Spain · Italy - authorisedTherapeutic use (Phase IV)
Filgotinib bridging in newly diagnosed rheumatoid arthritis patients (FAST RA trial); A pragmatic randomized controlled non-inferiority low intervention clinical trial
This study is testing different treatments for new rheumatoid arthritis to see which works best at getting people into remission quickly. It compares a steroid injection (Kenacort-A) with a newer tablet (Jyseleca) to find out how many people feel much better after three months.
Netherlands - authorisedHuman Pharmacology (Phase I)- First administration to humans
A First-in-Human, Open-label, Phase 1 Study to Evaluate Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Preliminary Efficacy of NBIM-1008 in Patients with Rheumatoid Arthritis
This early-stage study is testing a new medicine called NBIM-1008 for people with rheumatoid arthritis. We want to see if it's safe, how the body handles it, and if it might help with symptoms. This is the first time it’s being given to humans.
Poland · Romania - ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2a Multicenter, Randomized, Double Blind, Parallel-group, Proof of Concept Study Evaluating the Efficacy and Safety of Nipocalimab and Certolizumab Combination Therapy in Subjects with Active Rheumatoid Arthritis despite Prior Treatment with Advanced Therapies (bDMARD or tsDMARD)
This study is looking at a new combination of two medicines, nipocalimab and certolizumab (Cimzia), for adults with rheumatoid arthritis that hasn't improved with other strong treatments. We want to see if this combination helps reduce symptoms and is safe after 12 weeks.
Germany · Poland · Hungary - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A Phase 1b Study of Imvotamab in Moderate to Severe Rheumatoid Arthritis
This study is looking into a new treatment called Imvotamab for people with moderate to severe rheumatoid arthritis. It's an early-stage study to understand how safe the treatment is and if it has any effects on the body.
Poland - ongoing, recruitingTherapeutic exploratory (Phase II)
A randomized, double blind, placebo-controlled, dose response, phase II, multicentre trial to evaluate the efficacy and safety of oral AP1189 administered at the doses of 40, 70, or 100 mg for 12 weeks in combination with methotrexate, in DMARD-naïve participants with early rheumatoid arthritis and active inflammation.
This study is testing a new tablet, AP1189, for people recently diagnosed with rheumatoid arthritis who haven't tried other strong medicines yet. It aims to see how well different doses of AP1189 lower inflammation and improve symptoms when taken with another common arthritis medicine.
Bulgaria · Czechia · Poland - recruiting
7 Tesla MRI Brain Imaging to Decipher Filgotinib's Mode of Analgesic Action in Rheumatoid Arthritis
This study uses special brain scans to understand how a new medicine, filgotinib, helps ease pain in people with rheumatoid arthritis. Researchers want to see if it works by affecting the brain's pain signals or by reducing swelling in the joints.
United Kingdom - ongoing, recruitingTherapeutic use (Phase IV)
RCT part: CareRA2020: Effectiveness of a combination of Methotrexate and a step down glucocorticoid regimen (COBRA-Slim) for remission induction in patients with early Rheumatoid Arthritis (RA), with or without fast access to 24 weeks of Tumor Necrosis Factor (TNF) blockade in insufficient responders, a randomized, multicenter, pragmatic trial. LTE part: CareRA2020 LTE: a 3 year longitudinal observational, multicenter, follow-up of early RA patients after participation in the CareRA2020 RCT.
This study looks at how well a treatment for early rheumatoid arthritis (RA) works over a long time. It compares a standard approach with one that offers quicker access to a stronger medicine for those who aren't improving enough.
Belgium - ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2 Randomized, Double-blind, Placebo-controlled, Dose-ranging, Efficacy and Safety study of SAR441566 plus Methotrexate in Adults with Moderate to Severe Rheumatoid Arthritis
This study is testing a new medicine, SAR441566, for people with moderate to severe rheumatoid arthritis who are already taking methotrexate. It aims to see if the new medicine helps reduce arthritis symptoms and if it's safe to use. Patients will either get the new medicine or a dummy medicine.
Slovakia · Czechia · Germany - recruitingPHASE1
A Study of AZD0120 in Autoimmune Diseases
This study is looking at a new treatment called AZD0120 for certain long-term conditions like systemic sclerosis, inflammatory muscle diseases, and severe rheumatoid arthritis. It's an early-stage study to see how safe the treatment is and if people can tolerate it.
United States · Australia · Germany - ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
A placebo-controlled safety and tolerability study of intravenous (IV) and subcutaneous (SC) AZD1163 in healthy volunteers
This early-stage study is looking at a new medicine called AZD1163 for rheumatoid arthritis. Researchers want to see if it's safe and how well healthy people tolerate it when given through a vein or under the skin. It’s the first time this medicine is being tested in humans.
Germany - ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2a multi-center, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of Burfiralimab (hzVSF-v13) added to disease-modifying antirheumatic drugs in patient with moderate to severe Rheumatoid Arthritis
This study is testing a new medicine, Burfiralimab, for people with moderate to severe rheumatoid arthritis. We want to see if it helps reduce joint pain and swelling when added to their usual arthritis medicines. Participants will receive either the new medicine or a dummy treatment.
Spain · Austria · Czechia - active not recruitingPHASE3
Study to Assess Change in Disease Activity and Adverse Events of Oral Upadacitinib Compared to Subcutaneous Adalimumab in Adult Participants With Moderate to Severe Rheumatoid Arthritis
This study looks at two medicines, upadacitinib and adalimumab, for adults with moderate to severe Rheumatoid Arthritis (RA). It checks how safe and effective they are. Upadacitinib is a pill, and adalimumab is an injection. This helps us understand which treatment works best.
United States · Argentina · Belgium - authorisedHuman Pharmacology (Phase I)- Other
A Phase 1, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Pimozide after Multiple Dose Administration in Subjects with Rheumatoid Arthritis
This study is looking at a new medicine called Pimozide for rheumatoid arthritis. It aims to see if the medicine is safe, what side effects it might cause, and how it works in the body when given multiple times. This is a very early stage of research.
Bulgaria - ongoing, recruitingTherapeutic confirmatory (Phase III)
A Multicenter, Open-label, Long Term Extension Study to Assess the Safety and Efficacy of Filgotinib in Subjects with Rheumatoid Arthritis
This study is looking at the long-term safety and effectiveness of a medicine called Jyseleca for people with rheumatoid arthritis. Participants will take Jyseleca tablets, and doctors will monitor their health carefully over time.
Bulgaria · Hungary · Germany - recruiting
EMPOWER-1: A Multi-site Clinical Cohort Research Study to Reduce Health Inequality
This study aims to understand why common medicines don't work the same for everyone in the UK, especially for people from different backgrounds. It will look at many health conditions, hoping to improve how we treat them and make healthcare fairer for all.
United Kingdom - recruitingPhase II
Repair effects of leramistat in participants with rheumatoid arthritis
This study is looking at a new medicine called leramistat for people with rheumatoid arthritis. It wants to see what effects leramistat has on muscles. It's an early-stage study, meaning we're still learning if the medicine works and is safe.
United Kingdom · England - recruitingPHASE1
Study Evaluating Safety, Tolerability, PK/PD of Surovatamig in Adult RA or SLE Participants
This study is testing a new medicine, surovatamig, for rheumatoid arthritis (RA) and lupus (SLE). We want to see if it's safe, how it works in the body, and what dose is best. It's an early-stage study in adults.
United States · Australia · Belgium