- not yet recruiting
Clinical Performance Study of Microbio InfectID-BSI for Detection of Bacteria and Yeast With Patient Blood Samples
This study is looking at a new test called InfectID-BSI. It uses a small amount of your blood to quickly check for serious infections caused by bacteria or yeast. We want to see if it works as well as, or better than, the current standard tests.
United States · Australia · United Kingdom - recruitingNA
The Effect of Vasopressor Therapy on Renal Perfusion in Septic Shock
This study looks at how different medicines, like vasopressin and angiotensin II, affect blood flow to the kidneys in very unwell patients with a serious infection called septic shock. We want to see if these medicines can help improve kidney function when it's failing.
United Kingdom - ongoing, recruitingTherapeutic confirmatory (Phase III)
Double blind randomized clinical trial comparing noradrenaline plus placebo versus noradrenaline plus terlipressin in septic shock.
This study is looking at a serious condition called septic shock. We want to see if adding a new medicine, terlipressin, to standard treatment (noradrenaline) can help reduce harm to organs and improve recovery time for patients in intensive care.
Spain - authorisedTherapeutic confirmatory (Phase III)
ADRESS : Efficacy of the Alpha 2 agonist dexmedetomidine for sympathetic Deactivation in REfractory Septic Shock: a randomized, controlled trial
This study looks at a medicine called dexmedetomidine for severe blood poisoning (septic shock). Researchers want to see if it helps reduce symptoms and improve survival compared to usual treatments. It's a key step to understand if this medicine can become a new option for patients.
France - recruiting
ARTICE® Real Data Collection & Observational Trial, Phase 4 Study
This study is gathering real-life health information about a treatment called ARTICE® for people with sepsis or septic shock in hospital. It aims to see how well ARTICE® works, if it helps reduce illness severity, and to understand who benefits most from it.
Germany - recruitingNA
Protocolized Reduction of Non-resuscitation Fluids Versus Usual Care in Septic Shock Patients
This study looks at whether giving less non-emergency fluids to adults with a serious infection called septic shock is better or worse than the usual way. It aims to see if limiting these fluids helps patients recover better.
Finland · Sweden · United Kingdom - enrolling by invitation
Impact of the Introduction of a Performance Improvement Program on the Initial Management of Sepsis and Septic Shock in Adults in the Emergency Department: a Before-and-after Study (IPA-SOS)
This study looks at how a special improvement programme at Brest University Hospital affects the care of adults with serious infections called sepsis or septic shock. Researchers want to see if the programme helps staff follow treatment guidelines better and improves how patients recover.
France - recruitingNA
Efficacy of Add-on Plasma Exchange As an Adjunctive Strategy Against Septic Shock
This study looks at a new treatment called therapeutic plasma exchange (TPE) for people with severe blood poisoning, called septic shock. Researchers want to see if TPE can help improve organ function and reduce the very high death rate from this condition.
Austria · Germany · Switzerland - not yet recruitingNA
Association Between Muscle L3 CT Scan Muscle Derived Parameters of Muscle Function Upon Intensive Care Unit Admission and 3 Months Mortality After ICU Discharge for Patients Admitted for Septic Shock. The SIMS Study
This study looks at whether a CT scan of muscles when someone is admitted to intensive care for severe infection (septic shock) can predict how well they will recover three months later. It helps us understand if muscle health plays a role in survival after critical illness.
France - active not recruitingPHASE3
Does High-dose Vitamin B3 Supplementation Prevent Major Adverse Kidney Events During Septic Shock?
This study is testing if a high dose of vitamin B3 (Nicotinamide) can help prevent kidney problems in very sick patients with an infection called septic shock. We want to see if it reduces serious kidney issues within 30 days.
France - recruiting
Evaluation of Parameters Collected From Routine Data for the Diagnosis of Sepsis and Septic Shock and Their Influence on Time to Diagnosis and Patient Outcome
This study looks back at hospital records to create a computer program to help spot health problems like sepsis earlier. It aims to improve how doctors diagnose and treat these serious conditions, potentially leading to better patient care and outcomes.
Germany - recruitingNA
Fever Control Using External Cooling in Mechanically Ventilated Patients With Septic Shock
This study looks at the best way to manage fever in very sick patients with septic shock who are on breathing machines. We're comparing letting the fever run its course versus using cooling methods to bring the body temperature down to normal. The main goal is to see which approach helps more people survive.
France - recruiting
Septic Shock-induced Immunosuppression
This study looks for better ways to spot and treat a serious problem called sepsis-induced immunosuppression. This happens when the body's infection-fighting system (immune system) becomes very weak after a severe infection, making people vulnerable to new infections.
France - recruitingNA
Evaluation of the Efficiency of Intermittent Enteral Nutrition on Multi-organ Failure From Patients With Mechanical Ventilation in Intensive Care Unit
This study looks at different ways to feed very sick patients in intensive care (ICU) who are on breathing machines. We want to see if feeding them in short bursts, like 'intermittent fasting', can help prevent organs from failing compared to feeding them continuously.
France - not yet recruitingPHASE3
Venous Excess Ultrasound for Personalized Resuscitation in Septic Shock
This study looks at using a special ultrasound (VEXUS) to manage fluids in patients with septic shock, a severe infection. It aims to see if this method is safe and can prevent kidney problems, preparing for a larger study.
Canada - ongoing, recruitingTherapeutic use (Phase IV)
Hemodynamic Phenotype-Based,Capillary Refill Time-Targeted Resuscitation In Early Septic Shock:ANDROMEDA-SHOCK-2
This study is looking at how best to treat people with severe blood poisoning (septic shock). It compares different intravenous fluids to see which helps patients recover better and quicker, focusing on how well their body's circulation is working.
Spain