Severe Hypertriglyceridemia research hub
8 indexed studies · 4 currently recruiting
- recruitingPHASE3
Study of Plozasiran in Adults With Severe Hypertriglyceridemia at Risk of Acute Pancreatitis
This study is testing a new medicine, plozasiran, for people with very high triglycerides who have had pancreatitis. It will check if the medicine is safe and helps reduce the risk of future pancreatitis attacks. Participants will get either the study medicine or a dummy medicine.
United States · Argentina · Austria - recruitingTherapeutic confirmatory (Phase III)
ISIS 678354-CS5: A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study of ISIS 678354 Administered Subcutaneously to Patients with Severe Hypertriglyceridemia.
This study is testing a new medicine, ISIS 678354, for people with very high levels of a type of fat in their blood called triglycerides. It aims to see if the medicine can lower these levels compared to a dummy medicine.
Finland · Germany · Poland - active not recruitingPHASE3
CORE-OLE: A Study of Olezarsen (ISIS 678354) Administered Subcutaneously to Participants With Severe Hypertriglyceridemia (SHTG)
This study is looking at a new medicine called Olezarsen for people with very high triglyceride levels. It's an ongoing study for those who have already started the treatment in previous trials, checking its long-term safety and how well it's tolerated.
United States · Argentina · Australia - recruitingTherapeutic confirmatory (Phase III)
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Pegozafermin in Subjects with Severe Hypertriglyceridemia (SHTG)
This study is testing a new medicine, Pegozafermin, for people with very high triglyceride levels. We want to see if it lowers these levels and if it's safe to use. Half the participants will get the new medicine and half will get a dummy medicine.
Spain · Poland · Hungary - active not recruitingPHASE3
Study of Plozasiran (ARO-APOC3) in Adults With Severe Hypertriglyceridemia
This study is testing a new injection, Plozasiran, for adults with very high triglycerides. It will check if the treatment is safe and effective compared to a dummy injection over 12 months. Afterwards, participants might continue in an optional extension.
United States · Argentina · Australia - active not recruitingPHASE3
Study of Plozasiran in Adults With Severe Hypertriglyceridemia
This study is looking into a new injection treatment, plozasiran, for adults with very high triglyceride levels. It will check if the treatment is safe and if it works to lower these levels. Participants will receive either the new drug or a dummy injection.
United States · Argentina · Brazil - recruitingPHASE2
A Study of Solbinsiran (LY3561774) in Participants With Severe Hypertriglyceridemia
This study is testing a new medicine, Solbinsiran, for people with very high levels of a type of fat called triglycerides. It aims to see if the medicine can safely lower these fat levels compared to a dummy treatment.
United States · Canada · China - active not recruitingPHASE3
To Evaluate the Efficacy and Safety of Pegozafermin in Subjects With Severe Hypertriglyceridemia
This study looks at a new drug called Pegozafermin for people with very high triglyceride levels, a type of fat in the blood. Researchers want to see if this drug can safely lower these levels over 26 weeks compared to a dummy drug.
United States · Argentina · Austria