- authorisedTherapeutic exploratory (Phase II)
A randomized, double-blind, placebo-controlled, multicenter Phase 2a/b study assessing the efficacy, safety and tolerability of DDY391 in participants with Sjögren's Disease
This clinical trial is testing a new medicine called DDY391 for adults with Sjögren's disease. Researchers want to see if it safely relieves common symptoms like dry eyes, dry mouth, joint pain, and exhaustion. Participants are randomly chosen to receive either DDY391 or a dummy treatment (placebo).
Portugal · Belgium · Denmark - authorisedTherapeutic exploratory (Phase II)
A randomized, parallel-group, open-label, Phase IIb pilot trial to evaluate the effectiveness in reducing systemic disease activity with methotrexate compared with hydroxychloroquine in adult male and female participants with moderate-to-severe primary Sjögren’s disease (MOSAIC STUDY)
The MOSAIC study looks at two medicines, methotrexate and hydroxychloroquine, to treat adults with moderate-to-severe primary Sjögren's disease. Researchers want to see which treatment works best to calm inflammation, ease dryness and joint pain, and improve everyday symptoms over about 74 weeks of treatment.
Italy - recruitingTherapeutic exploratory (Phase II)
ANISE-II; ANIfrolumab treatment for 24 weeks in patients with primary Sjögren’s syndrome – Efficacy and safety assessment in a randomized, double-blind, placebo-controlled phase-IIa proof-of-concept trial
This study is testing a new medicine called Saphnelo for Sjogren's disease. Researchers want to see if it helps reduce symptoms and if it's safe over 24 weeks. Patients will either receive Saphnelo or a dummy medicine.
Netherlands - recruitingTherapeutic exploratory (Phase II)
A Phase 2, Multicenter, Randomized, Double-blind, Placebo-controlled, Dose-ranging Study to Evaluate the Efficacy and Safety of Abiprubart in Participants with Sjögren’s Disease
This study is looking at a new medicine called Abiprubart for Sjögren’s disease. It's a key step to see how well it works and if it's safe. The trial involves different doses and uses a dummy medicine for comparison.
Germany · Hungary · Czechia