suspected or proven infection, critical illness research hub

A single-centre, partially blind, randomised, parallel-group, two-arms, superiority study to compare the efficacy and safety of extended (3 h) and intermittent infusion (0.5 h) of β-lactams (cefepime, ceftriaxone, meropenem, piperacillin/tazobactam) in critically ill paediatric patients (PEBBLE)

This study looks at how best to give antibiotics (like cefepime or meropenem) to very sick children with infections. Researchers compare giving these medicines slowly over a longer time versus quickly over a short time, to see which way works better and is safer for children.