Systemic Lupus Erythematosus research hub
45 indexed studies · 28 currently recruiting
- authorisedHuman Pharmacology (Phase I)- Other
A trial to learn how safe anifrolumab is, how it moves throughout the body over time, and how it affects the body of adults with systemic lupus erythematosus
This clinical study looks at a medicine called anifrolumab in adults with systemic lupus erythematosus (lupus). Researchers want to see how safe the drug is, how it moves through the bloodstream, and how it affects the body. The goal is to improve future treatment options for people with lupus.
Poland · Hungary - authorisedTherapeutic exploratory (Phase II)
A Multicenter, Open-Label, Phase II Study to Evaluate the Pharmacokinetics, Pharmacodynamics, and Safety of Subcutaneous Anifrolumab in Pediatric Participants 5 to < 18 Years of Age with Systemic Lupus Erythematosus.
This study looks at a medicine called anifrolumab (Saphnelo) in children and young people aged 5 to 17 with lupus. Researchers want to find out how the body handles the medicine given as an injection under the skin, and to check that it is safe for younger patients.
Belgium · Portugal · Netherlands - authorisedTherapeutic exploratory (Phase II)
A Phase 2, multicentre, randomised, double-blind, placebo-controlled trial to evaluate the efficacy and safety of LAD603 in patients with systemic lupus erythematosus
This clinical trial is testing a new study medicine called LAD603 for adults with systemic lupus erythematosus (lupus). Researchers want to find out how safe the medicine is and how well it helps calm lupus symptoms, especially skin problems, compared to a dummy treatment (placebo).
Poland · Spain · Hungary - recruitingTherapeutic exploratory (Phase II)
A Multi-center, Randomized Parallel Group, Placebo-Controlled Double-Blind Trial to Evaluate the Safety, Efficacy, and Pharmacokinetics of Belimumab, a Human Monoclonal Anti-BLyS Antibody, Plus Standard Therapy in Pediatric Patients with Systemic Lupus Erythematosus (SLE)
This study is looking at a new medicine called belimumab (Benlysta) for children and teenagers with lupus. We want to see if it's safe, helps manage the condition, and how the body uses it, when given alongside their usual lupus treatments.
Spain - recruitingHuman Pharmacology (Phase I)- Other
A study to investigate the safety and pharmacological effect of a single intravenous infusion of GSK2857914 in male and female participants aged 18 to 75 with moderate to severe systemic lupus erythematosus
This study is looking into a new treatment, GSK2857914, for people aged 18 to 75 with moderate to severe lupus. It's an early stage trial to understand if the treatment is safe and how it works in the body after one dose given into a vein.
Spain · France - active not recruitingPHASE3
Subcutaneous Anifrolumab in Adult Patients With Systemic Lupus Erythematosus
This study is testing a new injection, anifrolumab, for adults aged 18-70 with moderate to severe lupus (SLE) in the UK. Researchers want to see if it's safe and helps improve symptoms when added to their usual lupus treatment. Half get the new drug, half get a dummy drug.
United States · Argentina · Bulgaria - active not recruitingPHASE3
Phase 3 Study to Evaluate Ianalumab on Top of Standard-of-care Therapy in Patients With Systemic Lupus Erythematosus (SIRIUS-SLE 2)
This study is testing a new drug called ianalumab for people with lupus (SLE). It aims to see if ianalumab, given alongside usual lupus treatments, is safe and helps improve symptoms. It's for adults and some teenagers with active lupus.
United States · Argentina · Australia - recruitingPHASE2
A Study to Test Whether Different Doses of BI 3000202 Help People With Systemic Lupus Erythematosus (SLE)
This study investigates a new medicine, BI 3000202, for Systemic Lupus Erythematosus (SLE). It aims to find the most effective dose by comparing different doses with a dummy medicine (placebo). Participants will continue their current SLE treatments.
United States · Argentina · Australia - recruitingPHASE3
An Efficacy and Safety Study of Intravenous Anifrolumab to Treat Systemic Lupus Erythematosus in Pediatric Participants
This study is looking into a new medicine called Anifrolumab for children aged 5 to 17 with a serious form of lupus. It aims to see if it's safe and helps control lupus symptoms, compared to a dummy medicine, over a long period.
United States · Argentina · Brazil - active not recruitingPHASE3
A Study to Evaluate Effectiveness and Safety of Deucravacitinib (BMS-986165) Compared With Placebo in Participants With Active Systemic Lupus Erythematosus
This study is looking at a new medicine called deucravacitinib to see if it's safe and helps people with a type of lupus called Systemic Lupus Erythematosus (SLE). It compares the new medicine to a dummy pill (placebo).
United States · Argentina · Australia - not yet recruitingPhase III
A Phase III trial evaluating the response to belimumab after rituximab in lupus patients who have high levels of IgA2 anti-DNA antibodies
This clinical trial looks at whether a medicine called belimumab helps people with lupus after they have rituximab treatment. Researchers want to see if testing for a specific antibody can identify who will benefit most from this drug combination, helping to prevent painful symptom flare-ups in the future.
United Kingdom · England · Wales - recruitingPhase II and Phase III (Integrated)
A Phase 2a, Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of MK-6194 in Adult Participants With Systemic Lupus Erythematosus
This study is looking into a new medicine called MK-6194 for adults with lupus (Systemic Lupus Erythematosus). It compares the new medicine to a dummy medicine (placebo) to see if it helps improve lupus symptoms and if it's safe to use.
France · Spain · Poland - recruitingPhase III
A study of nipocalimab in adults with moderate to severe systemic lupus erythematosus
This study is testing a new drug called nipocalimab for adults with moderate to severe lupus (SLE). Researchers want to see if it works better than a dummy drug to reduce symptoms. It involves regular visits and monitoring over several years.
United Kingdom · England · Argentina - recruitingTherapeutic exploratory (Phase II)
A randomized, double-blind, placebo-controlled, multicenter study to evaluate the efficacy, safety, tolerability, pharmacokinetics and pharmacodynamics of orally administered GLPG3667 in adult subjects with active systemic lupus erythematosus.
This study is testing a new medicine called GLPG3667 for adults with active lupus (SLE). Researchers want to see if it helps reduce lupus symptoms, if it's safe, and how the body handles it. Some people will get the medicine, and others will get a dummy pill.
Germany · France · Spain - recruitingTherapeutic exploratory (Phase II)
A Multi-Center, Open-Label Trial to Evaluate the Pharmacokinetics, Safety, and Pharmacodynamics of Subcutaneously Administered Belimumab, a Human Monoclonal Anti-BLyS Antibody, Plus Standard Therapy in Pediatric Participants with Systemic Lupus Erythematosus (SLE)
This study is looking at a medicine called Benlysta for children and young people with lupus. It wants to see how the body handles the medicine and if it's safe. This is an early study to learn more about this treatment in younger patients.
Spain · Germany - recruitingTherapeutic exploratory (Phase II)
A Multi-Center Study to Characterize the Long-Term Safety and Efficacy of BMS-986165 in Subjects with Systemic Lupus Erythematosus
This study is looking at a new tablet treatment, BMS-986165, for people with lupus (Systemic Lupus Erythematosus). It aims to understand its long-term safety and how well it works, compared to a dummy tablet, over time.
Romania · Hungary · Spain - recruitingHuman Pharmacology (Phase I)- Other
A Phase 1b Study of Imvotamab in Severe Systemic Lupus Erythematosus
This study is looking at a new medicine called Imvotamab for people with severe lupus. It's an early-stage study to check if the medicine is safe and how it works in the body. If you are 18 or older and have severe lupus, you might be able to take part.
Poland - recruitingPHASE1
A Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD5492 in Adult Participants With Systemic Lupus Erythematosus or Idiopathic Inflammatory Myopathies or Rheumatoid Arthritis.
This study looks at a new treatment called AZD5492 for lupus, myositis, and rheumatoid arthritis. It checks how safe it is, how well the body handles it, and how it works in adults.
United States · Canada · China - recruitingPHASE3
A Study to Evaluate the Efficacy and Safety of Dapirolizumab Pegol in Study Participants With Moderately to Severely Active Systemic Lupus Erythematosus
This study is testing a new medication called dapirolizumab pegol (DZP) for people with moderate to severe lupus (SLE). It aims to see if DZP, when added to usual treatments, can safely improve their symptoms over a long time.
United States · Argentina · Belgium - active not recruitingPHASE3
Program to Assess Adverse Events and Change in Disease Activity of Oral Upadacitinib in Adult Participants With Moderate to Severe Systemic Lupus Erythematosus
This study looks at a new tablet treatment, upadacitinib, for adults with moderate to severe lupus. It checks how safe and effective the medicine is and aims to reduce symptoms. Some people will get the active drug, others a dummy pill.
United States · Argentina · Australia - authorisedHuman Pharmacology (Phase I)- Other
A study to investigate the safety, pharmacokinetics, pharmacodynamics, and immunogenicity of a CD19/CD20 T-cell engager in participants with B-cell driven ARD.
This early-stage study is looking at a new medicine for Systemic Lupus Erythematosus (SLE), an autoimmune condition. Researchers want to see if it's safe, how it moves through the body, and how the body reacts to it. It's for adults with SLE.
Germany · France · Italy - active not recruitingPHASE1
A First-in-Human Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of RO7507062 in Participants With Systemic Lupus Erythematosus
This study is looking at a new medicine called RO7507062 for people with Systemic Lupus Erythematosus (SLE). It aims to see how safe the medicine is, how well bodies cope with it, and what it does in the body. This is an early stage study.
Colombia · France · Germany - recruitingPHASE2
A Study of Obexelimab in Patients With Systemic Lupus Erythematosus
This study is testing a new medicine called Obexelimab for people with lupus. It aims to see if the medicine is safe and helps improve symptoms. Participants will either receive Obexelimab or a dummy medicine for 24 weeks, followed by a check-up period.
United States · Belgium · Bulgaria - active not recruitingPHASE2
Study of Subcutaneous (SC) Belimumab in Pediatric Participants With Systemic Lupus Erythematosus (SLE)
This study is looking at a new way to give a medicine called belimumab to children aged 5 to 17 with lupus. It aims to see how safe and effective a new injection form of the medicine is, similar to how adults use it.
United States · Argentina · Germany - recruiting
Predictors of Pregnancy Outcome in Systemic Lupus Erythematosus (SLE) and Antiphospholipid Syndrome (APS)
This study looks at pregnant women with Lupus or Antiphospholipid Syndrome to understand why some have problems during pregnancy. Researchers hope to find early warning signs in the blood that could predict difficulties, helping doctors provide better care and potentially prevent issues in the future.
United States · Canada · United Kingdom - recruitingNA
Systemic Lupus Erythematosus Within the Framework of the Multidisciplinary Consultation
This study in Brest, France, looks at how doctors diagnose and manage Systemic Lupus Erythematosus (SLE) in adults. It involves a group of patients attending a specialist clinic to improve understanding and care for lupus.
France - active not recruitingPHASE1
Obe-cel in Adolescent [Applicable in UK Only] and Adult Severe, Refractory Systemic Lupus Erythematosus
This study is testing a new type of cell therapy called obe-cel for severe lupus. It's a very early stage trial to see if it's safe and how well it works. Doctors hope it could be a new way to treat lupus.
Spain · United Kingdom - recruitingPHASE2
A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Phase 2a Study With an Open-Label Extension Evaluating the Efficacy and Safety of VENT-03 in Adult Participants With Active Cutaneous Lupus Erythematosus With or Without Systemic Lupus Erythematosus
This study is testing a new medicine, VENT-03, for adults with a skin condition called cutaneous lupus (CLE), who may also have systemic lupus (SLE). Researchers want to see if VENT-03 helps reduce symptoms and if it's safe.
United States · Bulgaria · France - authorisedTherapeutic exploratory (Phase II)
Randomised, placebo-controlled, double-blind, parallel-group Phase II study to evaluate the efficacy and safety of oral BI 3000202 in patients with moderate to severe systemic lupus erythematosus (SLE)
This study is testing a new medicine, BI 3000202, for people with moderate to severe lupus. Researchers want to see if it helps reduce lupus symptoms and is safe. Some people will get the new medicine, others a dummy pill. It lasts about 32 weeks.
Bulgaria · Romania · Germany - recruitingNA
LUPUS-BEST - Treat-to-target in Systemic Lupus Erythematosus
This study looks at a new way to treat lupus (SLE) called "treat-to-target." Doctors aim to get your lupus into remission quickly and keep it there by checking in often and adjusting treatment. It compares this new approach to standard care to see if it improves life for people with lupus.
Germany - active not recruitingPHASE1, PHASE2
An Open-label, Study to Assess Safety, Efficacy and Cellular Kinetics of YTB323 in Severe, Refractory Systemic Lupus Erythematosus
This study is testing a new treatment called YTB323 for severe lupus that hasn't responded to other medicines. Researchers want to see if it's safe, how well it works, and how it affects the body's cells in people aged 18-65.
Australia · France · Germany - active not recruitingPHASE3
A Study to Evaluate the Efficacy and Safety of Obinutuzumab in Participants With Systemic Lupus Erythematosus
This study is looking into a new treatment called Obinutuzumab for a condition called lupus (Systemic Lupus Erythematosus). It compares this new treatment with a dummy treatment (placebo) to see if it's safe and effective for people already getting standard lupus care.
United States · Argentina · Brazil - recruitingPHASE1
Study Evaluating Safety, Tolerability, PK/PD of Surovatamig in Adult RA or SLE Participants
This study is testing a new medicine, surovatamig, for rheumatoid arthritis (RA) and lupus (SLE). We want to see if it's safe, how it works in the body, and what dose is best. It's an early-stage study in adults.
United States · Australia · Belgium - recruiting
Study of Neonatal IgG Fc Receptor Expression in Natural Killer T Cells Expressing an Invariant T Receptor : Implication in the Pathophysiology of Systemic Lupus
This study looks at certain immune cells and proteins in people with lupus. We want to understand how these cells change in active lupus compared to inactive lupus to learn more about the disease and how new treatments might work.
France - active not recruitingPHASE2
A Study Evaluating the Efficacy and Safety of Afimetoran Compared With Placebo in Participants With Active Systemic Lupus Erythematosus (SLE)
This study is testing a new medicine, Afimetoran, for people with lupus (SLE). It aims to see how well it works, if it's safe, and if people can tolerate it compared to a sugar pill (placebo).
United States · Argentina · Australia - active not recruitingPHASE2
Two-period Crossover Study to Demonstrate the Comparability of Pharmacokinetics of Subcutaneous Ianalumab Between 2mL Auto-injector/2mL PFS with1mL Pre-filled Syringe in Adult Participants With Autoimmune Disease
This study is testing a new way to give a drug called ianalumab for autoimmune diseases like lupus, Sjögren's, and rheumatoid arthritis. We are comparing different devices (pre-filled syringes and auto-injectors) to make sure they deliver the drug in the same way and are safe.
United States · Argentina · Canada - recruiting
ROLE of PLATELETS in the PATHOPHYSIOLOGY of SYSTEMIC LUPUS
This study looks at how tiny blood cells called platelets might be involved in conditions like lupus and arthritis. Researchers want to understand if platelets make these conditions worse and if targeting them could lead to new treatments. It could help us find better ways to diagnose and treat these illnesses.
France - recruitingPHASE1
A Study of GSK4527363 in Healthy Participants, Systemic Lupus Erythematosus (SLE) Participants, Healthy Chinese, and Japanese Participants and CTD-ILD Participants
This study is testing a new medicine, GSK4527363, for lupus and lung conditions related to connective tissue diseases. It's looking at how safe it is, how the body handles it, and if it causes side effects in healthy people and those with these conditions.
United States · Argentina · Brazil - recruitingPHASE3
Phase 3 Extension Study to Evaluate Long-term Safety of Ianalumab in Participants With Systemic Lupus Erythematosus (SIRIUS-SLE Extension).
This study looks at the long-term safety of a new medicine, ianalumab, for people with lupus. It's for those who have already been in an earlier ianalumab study and continues to check how safe and well the medicine is tolerated over time.
United States · Argentina · Australia - recruitingPHASE2
A Phase 2 Master Protocol Assessing Inebilizumab and Blinatumomab in Autoimmune Diseases
This study looks at new treatments (inebilizumab and blinatumomab) for people with Systemic Lupus Erythematosus (SLE) and Rheumatoid Arthritis (RA). It mainly checks how safe these medicines are and if they help reduce symptoms of these conditions.
United States · Australia · Belgium - recruitingPHASE1
A Study of CC-97540, CD-19-Targeted Nex-T CAR T Cells, in Participants With Severe, Refractory Autoimmune Diseases (Breakfree-1)
This study is testing a new cell therapy called CC-97540 for severe autoimmune diseases like lupus and rheumatoid arthritis. It aims to see if it's safe, how well it works, and how the body handles it, especially when other treatments haven't helped.
United States · Belgium · France - recruiting
Follow-up of the Systemic Lupus Erythematosus Cohort as Part of the Multidisciplinary Consultation at Brest CHRU
This study in Brest, France, follows adults with lupus (Systemic Lupus Erythematosus) who attend a special clinic with different doctors working together. Researchers want to understand how lupus affects patients over time and improve their care locally and beyond.
France - recruitingPHASE4
A Study Describing the Efficacy and Safety of Belimumab Administered in Adult Participants With Early Systemic Lupus Erythematosus (SLE)
This study looks at a medicine called Belimumab for people with Systemic Lupus Erythematosus (SLE), also known as lupus. It aims to see how well and how safely it works over three years in people who have had lupus for a short time and whose current treatment isn't fully controlling their symptoms.
United States · Argentina · Brazil - authorisedTherapeutic confirmatory (Phase III)
Multinational, Interventional, 52-week, Open-label, Single-arm Study to Evaluate the Treatment Outcomes of Anifrolumab 120 mg Subcutaneous Once Weekly in Immunosuppressant-naïve and Biologic-naïve Systemic Lupus Erythematosus (SUNFLOWER)
This study is testing a new way to treat lupus, called Saphnelo. Doctors want to see if Saphnelo can help people with lupus achieve and stay in remission, meaning their symptoms are well controlled. It's for adults new to certain lupus medicines.
Poland · Germany · Italy - recruitingNA
Fatigue in Lupus Intervention Programmes (FLIP)
This study looks at how to best help people with Lupus manage tiredness. It compares a booklet with online group sessions, aiming to find the most effective and accessible way to reduce how much fatigue affects daily life.
United Kingdom