Systemic lupus erythematosus (SLE) research hub
8 indexed studies · 6 currently recruiting
- authorisedHuman Pharmacology (Phase I)- Other
A prospective, open-label, single-arm, multicenter pharmacokinetic study evaluating the placental transfer of dapirolizumab pegol to the infant(s) from pregnant study participants with active systemic lupus erythematosus who are administered dapirolizumab pegol
This study looks at a lupus medicine called dapirolizumab pegol in pregnant women. Researchers want to find out how much of the medicine passes through the placenta to the baby during pregnancy and birth, and monitor the health and safety of both mother and newborn.
Greece · Italy · Netherlands - recruitingHuman Pharmacology (Phase I)- Other
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Subcutaneously Administered Mosunetuzumab to Participants with Systemic Lupus Erythematosus
This study is looking into a new medicine called mosunetuzumab for people with lupus. Researchers want to see if it's safe, how the body handles it, and how it works to help lupus. It's an early-stage study, checking basic effects.
Poland - not yet recruitingPHASE1
Study Investigating the Safety of Anti-CD19 CAR-T Cells Therapy Produced at Gustave Roussy for Adults With Severe and Refractory Systemic Autoimmune Rheumatic Diseases
This study is testing a new cell therapy called CAR-T for severe autoimmune diseases like rheumatoid arthritis and lupus. It's looking to see if the treatment is safe and helpful for adults when other treatments haven't worked, using a new method developed at Gustave Roussy.
France - active not recruitingPHASE3
3TR (Taxonomy, Treatment, Targets and Remission) Systemic Lupus Erithematosus Study Protocol
This study looks at lupus (SLE) to understand why some people get flares and how treatments work. Researchers will collect samples like blood and urine to find better ways to predict flares and personalise treatments.
France - enrolling by invitationPHASE3
A Study to Learn More About the Long-Term Safety of Litifilimab (BIIB059) Injections and it's Effects on Symptoms in Adults With Systemic Lupus Erythematosus (SLE)
This study looks at the long-term safety and effects of a new drug, litifilimab, for adults with lupus. It's for people who were in earlier studies of the drug and aims to see if it helps manage symptoms and is safe over a longer period.
United States · Argentina · Belgium - recruitingPHASE1
A Phase 1 Study of FT819 in B-cell Mediated Autoimmune Disease
This study is testing a new medicine called FT819 for serious autoimmune diseases like lupus and vasculitis. It's looking at how safe it is and how well it works to reduce disease activity, especially in those who haven't responded to other treatments.
United States · France · Sweden - recruitingPHASE1
An Ascending Dose Study of PIT565 in Participants With Systemic Lupus Erythematosus (SLE).
This study is testing a new medicine called PIT565 for people with Systemic Lupus Erythematosus (SLE). It aims to see if PIT565 is safe, how well the body handles it, and how much is needed to work. This is an early-stage study.
Bulgaria · China · Germany - recruiting
A Study in Participants With Active Systemic Lupus Erythematosus With Inadequate Response to Glucocorticoids and ≥2 Immunosuppressants
This study looks at standard treatments for people with severe lupus that hasn't responded well to usual medicines. Researchers want to understand how effective and safe these treatments are for patients, including those with kidney involvement.
United States · Argentina · Brazil