Traumatic brain injury research hub
14 indexed studies · 12 currently recruiting
- authorisedTherapeutic exploratory (Phase II)
Cosmos Trial: Cerebroprotection Of AST-004 in Mild Complicated Traumatic Brain Injuries
The Cosmos Trial is studying a new medicine, AST-004, for people who have had a mild but complicated brain injury. Researchers want to see if AST-004 is safe and if it helps protect the brain. They are comparing it to a dummy medicine to understand its effects.
Netherlands - recruiting
Traumatic brain injury related changes in military veterans
This UK study looks at how head injuries affect military veterans and civilians over time. Researchers will test blood, saliva, eyesight, and mental health. The aim is to find early signs of long-term problems, helping doctors provide better support, treatments, and rehabilitation for people recovering from brain injuries.
United Kingdom · England - recruitingPhase II
A trial to test tocilizumab, an anti-inflammatory medication, in understanding how controlling the whole body's inflammation can prevent inflammation damage to the brain following head injury
This study is looking at whether an anti-inflammatory medicine called tocilizumab could help people with a severe head injury. It's hoped that by reducing inflammation in the brain, it might help with recovery. This is an early study to see if the medicine works in this way, with plans for a bigger trial later.
United Kingdom · England - recruitingNot Applicable
Biomarkers for RAtional Investigation for Neurological Decision Support in traumatic brain injury (BRaINS-TBI): cohort study with a nested pragmatic randomised controlled trial
This study looks at a new blood test for people with head injuries in A&E. It aims to see if this test can help doctors make better decisions, reduce unnecessary scans, and improve care. It involves blood samples and follow-up.
United Kingdom · England · Scotland - recruitingNA
MUSic Therapy In Complex Specialist Neurorehabilitation
This study looks at whether adding music therapy to standard rehabilitation helps people recover better after serious brain or spinal cord injuries. It compares music therapy to usual care to see if it improves daily activities and well-being in patients aged 16-80.
United Kingdom - not yet recruitingNA
Clinical Feasibility & Validation of the Augmented Reality GlenxRose Acquired Brain Injury Rehabilitation Programs
This study looks at using fun, game-like virtual reality activities for people recovering from brain injury. It explores if these engaging new therapies help people stick with their exercises, enjoy their recovery more, and get better results than standard care alone.
Canada - recruitingPHASE3
PROphylaxis for Venous ThromboEmbolism in Severe Traumatic Brain Injury (PROTEST)
This study looks at the best way to stop dangerous blood clots forming in people with severe head injuries. It compares a special massage for the legs with massage plus a blood-thinning medicine called Dalteparin, to see which is safer and more effective at preventing clots without causing more bleeding in the brain.
Canada - recruiting
An Exploration of Sleep Disturbance and Outcomes in TBI (SLEEP-TBI)
This study looks at how sleep problems affect people who've had a brain injury. It aims to understand the link between sleep and recovery to improve care. Researchers are studying sleep patterns and how they impact daily life and mental well-being after a brain injury.
United Kingdom - recruiting
Glial Fibrillary Acidic Protein (GFAP) and Ubiquitin Carboxy-terminal Hydrolase L1 (UCH-L1) to Exclude Lesions Linked to Significant Traumatic Brain Injuries
This study looks at whether a simple blood test can help emergency doctors decide if a brain scan (CT scan) is needed after a mild head injury, within 12 hours of it happening. Researchers are testing two substances in the blood, UCH-L1 and GFAP, to see if they can reliably show that there's no major brain injury.
France · Monaco - recruitingNA
Effects of Moderate/Severe Traumatic Brain Injury in the Subacute or Chronic Phase on Locomotor Strategies Involved in Navigation in Complex Virtual Environments
This study looks at how people with moderate to severe head injuries navigate everyday places. It uses virtual reality to understand difficulties with walking and moving around in busy environments, helping us learn more about real-life challenges.
France - recruitingPHASE3
Clinical Randomisation of an Anti-fibrinolytic in Symptomatic Mild Head Injury in Older Adults
This study, called CRASH-4, is looking at a medicine called tranexamic acid (TXA) for older adults who have had a mild head injury. It wants to see if giving TXA reduces serious problems like bleeding in the brain, long-term disability, thinking problems, and death.
United Kingdom - recruitingNA
Crainio Non-invasive ICP Monitor for TBI
Researchers are testing a new device called Crainio that can check pressure in the brain without needing surgery, especially for people with head injuries. This study will see how well it works compared to current methods, hoping to make brain pressure monitoring safer and easier.
United Kingdom - active not recruiting
Cerebral Oxygenation and Metabolism and Severe Head Injury in Paediatrics (COMetSHIP)
This study looks at how brain injuries affect children by checking oxygen and chemical levels in the brain. The aim is to understand what causes further damage after an injury and improve future care for children with severe head injuries.
United Kingdom - enrolling by invitation
Age Related Thresholds for Management of Severe Head Injury in Paediatrics: An Extension of STARSHIP
This study aims to improve care for children with serious head injuries. By combining data from many hospitals, researchers hope to find the best ways to manage brain pressure and blood flow for different age groups, leading to more tailored and effective treatments for young patients.
United Kingdom