- not yet recruiting
Implementation of Networked Continuous Glucose Monitoring With Telemetry Within the Intensive Care Unit (ICU-TeleCGM)
This study looks at how a new type of glucose monitor (Dexcom G7) works in intensive care units (ICUs) for patients with high blood sugar who need insulin. It aims to see if it's safe and practical to use, showing blood sugar levels constantly and sending alerts if they get too high or low.
United Kingdom - recruiting
Evaluation of Security and Efficacy of Medtrum Hybrid Closed Loop System
This study looks at a new 'artificial pancreas' system (Medtrum Hybrid Closed Loop) for people with Type 1 diabetes aged 7 to 75. It compares how well it helps keep blood sugar levels stable at home compared to standard insulin pump use.
France - recruitingPHASE2, PHASE3
Alleviating Carbohydrate Counting for Patients with Type-1 Diabetes Using a Closed Loop System with Weekly Subcutaneous Semaglutide
This study looks into whether a weekly injection, Semaglutide, combined with an 'artificial pancreas' system, can help people with Type 1 Diabetes manage their blood sugar without needing to count carbohydrates every meal.
Canada - recruiting
Canadian Bone Strength Development Study
This study looks at how bones develop differently in children aged 10-12 with and without type-1 diabetes. Researchers want to understand why differences happen and track bone growth, strength, and activity for up to four years.
Canada - recruitingNA
Liom Non-invasive Continuous Glucose Monitor "Clinical Demo" (niCGM)
This study is testing a new, non-invasive device called Liom Clinical Demo 2.0 designed to monitor blood sugar levels without needles. It's for people with type 1 or type 2 diabetes aged 18-65, who are already using insulin or other diabetes medications.
Germany - recruiting
French Prospective Multicentric Study in Real World
This study looks at how a device called Omnipod 5 helps people with Type 1 diabetes in France. It checks blood sugar control, how it affects their daily lives, and how happy they are with the system, over 12 months.
France - recruiting
Balancing "bad" and "good" immune cells: testing a novel method for monitoring an immunosuppression strategy in people with Type 1 diabetes
This study is testing a new way to quickly check if treatments for Type 1 diabetes are working. It involves two medicines to help balance immune cells and aims to find better ways to stop the body from attacking insulin-producing cells.
United Kingdom · England · Wales - active not recruitingNA
MyDiaMate For Remission Of Diabetes Distress In Type 1 Diabetes (MyREMEDY)
This study looks at whether a self-help app called MyDiaMate can improve the mental well-being of adults with Type 1 diabetes. Many people with Type 1 diabetes experience stress and worry, and this study compares using the app to regular care to see if it helps.
Germany · Netherlands · Spain - recruitingNA
Pilot Study Evaluating Safety of ExOlin® in Patients With Poorly Controlled Type 1 Diabetes
This study is testing a new treatment called ExOlin® for adults with type 1 diabetes whose blood sugar levels are hard to control, even with insulin pumps. It's looking to see if ExOlin® is safe and can help manage blood sugar better, especially for those who often have very low or very high sugar levels.
France - completedPhase II
Exploratory effect of long-term Verapamil therapy in adults with Type 1 diabetes mellitus (Ver-A-Long)
This study looks at whether a blood pressure medicine called Verapamil can help adults with Type 1 diabetes. It explores if taking it long-term helps the body make more insulin and checks its safety. This is for people already in a related Verapamil study.
United Kingdom · England · Scotland - recruitingNot Applicable
Non-invasive glucose monitoring study
We're testing a new, painless 'Glucopatch' device for children and young people with Type 1 diabetes. It measures sugar levels without needles, sitting on the skin. We want to see if it works as well as current devices, hoping to make diabetes management easier. No direct benefit, but could improve future care.
United Kingdom · England - recruiting
Vascular Complications in Children From T1D Diagnosis
This study looks at how Type 1 diabetes affects the heart and blood vessels in children and teenagers (8-18). Researchers want to find out when and how these problems might start in the first two years after diagnosis. It's hoped this will help doctors understand and manage the condition better.
Canada - recruitingPHASE2, PHASE3
A Clinical Trial Using Tirzepatide to Help Adults With Type 1 Diabetes Automatically Control Their Blood Sugar
This study looks at whether a weekly medicine, tirzepatide, can help adults with type 1 diabetes manage their blood sugar more easily with an insulin pump, especially by reducing or removing the need to count carbs at meals.
Canada · Switzerland - recruitingPHASE2
Trial of Semaglutide for Diabetic Kidney Disease in Type 1 Diabetes
This study looks at how a new drug, semaglutide, affects kidney health in adults with Type 1 diabetes. Researchers want to see if it can protect kidneys, improve their function, and help manage blood sugar, compared to a dummy drug.
United States · Canada - active not recruitingPHASE1, PHASE2
A Safety, Tolerability, and Efficacy Study of VX-264 in Participants With Type 1 Diabetes
This study is looking at a new medicine called VX-264 for people with Type 1 Diabetes. We want to see if it's safe, how well people tolerate it, and if it helps manage the condition. It's for adults aged 18-65.
United States · Canada · Germany - enrolling by invitationNA
Diabetes Transition Coordinator Study
This study looks at how a special helper, called a transition coordinator, can support young people with Type 1 diabetes as they move from children's doctors to adult doctors. It checks if this support improves their health, how they feel, and if it's a good way to help.
Canada - ongoing, recruitingHuman Pharmacology (Phase I)- Other
Influence of various fast-acting mealtime insulin preparations in individuals with type 1 diabetes, with slow, moderate, and rapid gastric emptying, on postprandial blood glucose and the formation of reactive oxygen species
This study looks at how different fast-acting insulins affect blood sugar levels after meals in people with Type 1 diabetes. It compares insulins like Lyumjev and Humalog to see which works best depending on how quickly food leaves the stomach.
Germany - recruiting
Hybrid closed loop insulin pumps and early worsening of diabetic retinopathy in Type 1 diabetes
This study looks at how new insulin pumps, called hybrid closed-loop systems, affect the eyes of people with Type 1 diabetes. We want to see if quick blood sugar improvements might temporarily worsen eye health and compare this with other diabetes treatments.
United Kingdom · England - recruitingPHASE2
SAFety and Efficacy of Human Anti-thymocyte ImmunoGlobUlin SAB-142 ARresting Progression of Type 1 Diabetes
This study is testing a new drug, SAB-142, for people with recently diagnosed Type 1 Diabetes. It aims to see if SAB-142 can slow down the disease, and if it's safe to use. Participants will receive high dose, low dose, or a dummy drug.
United States · Australia · Austria - recruiting
Aniracetam for prevention of hypoglycemia in type 1 diabetes
This study looks at a supplement called aniracetam to help people with Type 1 diabetes manage low blood sugar (hypoglycaemia). It aims to find new ways to prevent this common and sometimes dangerous side effect of insulin, potentially improving daily life.
United Kingdom · Scotland - not yet recruitingPhase III
Semaglutide as an add-on treatment to optimise glycaemic control in children and young people with type 1 diabetes (Smile T1D)
This study, called SMILE T1D, is looking at whether a medicine called semaglutide (also known as Ozempic) can help young people aged 10-24 with Type 1 diabetes better manage their blood sugar. Participants would continue their usual diabetes care, with some also receiving the study medicine.
United Kingdom · England - recruiting
Capillary markers to predict type 1 diabetes
This study is looking for easier, less painful ways to test children for early signs of type 1 diabetes, like using finger-prick tests instead of needles. The goal is to make these important tests possible at home, removing the need for hospital visits.
United Kingdom · England · Czech Republic - not yet recruitingNA
UK MyREMEDY Clinical Trial
The UK MyREMEDY study is looking at an online program called MyDiaMate. It aims to help adults in the UK with type 1 diabetes better manage the emotional challenges of their condition. Researchers want to see if MyDiaMate improves mental health compared to usual care.
United Kingdom - active not recruitingNA
Targeted Assessment in High-Risk paTients With dIAbetes to ideNtify Undiagnosed Heart Failure
This study looks at a new way to find hidden heart failure in people with diabetes who are at higher risk. We're testing if checking a specific blood marker helps doctors discover heart problems earlier, so people can get the right care sooner.
United Kingdom - recruitingPHASE2
Sotagliflozin in Patients With Heart Failure Symptoms and Type 1 Diabetes
This study looks at whether a tablet called sotagliflozin can help people with type 1 diabetes and heart failure feel better. We're testing if it improves their quality of life and is safe, compared to a dummy pill.
United Kingdom - recruiting
Real-World Study of Patients With Type 1 Diabetes Treated With Teplizumab as Part of Managed Access Programs (MAPs)
This study looks back at people in the UK and other countries who received a treatment called teplizumab for Type 1 diabetes through special early access schemes. It aims to understand how the treatment was used and the characteristics of the patients.
Belgium · France · Italy - recruitingNot Applicable
Evaluating the effect of automated insulin pumps on pain levels in people with diabetes-related nerve damage
This study looks at whether a special insulin pump, called a hybrid closed-loop system, can help reduce nerve pain in people with type 1 diabetes. Researchers want to see if these 'artificial pancreas' devices can make daily pain, sleep, and overall well-being better.
United Kingdom · England